{"id":"https://openalex.org/W7223230989","doi":"https://doi.org/10.1016/j.rechem.2026.104016","title":"Huoxi Qufeng medicinal liquor alleviates rheumatoid arthritis lesions: Bioinformatic prediction of EGFR-related JAK-STAT/PI3K-Akt pathways and in vivo pharmacological validation","display_name":"Huoxi Qufeng medicinal liquor alleviates rheumatoid arthritis lesions: Bioinformatic prediction of EGFR-related JAK-STAT/PI3K-Akt pathways and in vivo pharmacological validation","publication_year":2026,"publication_date":"2026-10-22","ids":{"openalex":"https://openalex.org/W7223230989","doi":"https://doi.org/10.1016/j.rechem.2026.104016"},"language":"en","primary_location":{"id":"doi:10.1016/j.rechem.2026.104016","doi":"https://doi.org/10.1016/j.rechem.2026.104016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.rechem.2026.104016","pdf_url":null,"source":{"id":"https://openalex.org/S4210212333","display_name":"Results in Chemistry","issn_l":"2211-7156","issn":["2211-7156"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Results in Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.rechem.2026.104016","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159289711","display_name":"XiaoJie Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XiaoJie Wang","raw_affiliation_strings":["Chengdu University of Traditional Chinese Medicine, School of Pharmacy, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu University of Traditional Chinese Medicine, School of Pharmacy, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159280623","display_name":"LongLong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157155","display_name":"Sichuan Academy of Traditional Chinese Medicine","ror":"https://ror.org/05wad7k45","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210157155"]},{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"LongLong Li","raw_affiliation_strings":["Chengdu University of Traditional Chinese Medicine, School of Pharmacy, China","Institute of Traditional Chinese Medicine of Sichuan Academy of Chinese Medicine Sciences, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu University of Traditional Chinese Medicine, School of Pharmacy, China","institution_ids":["https://openalex.org/I53411278"]},{"raw_affiliation_string":"Institute of Traditional Chinese Medicine of Sichuan Academy of Chinese Medicine Sciences, China","institution_ids":["https://openalex.org/I4210157155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159267131","display_name":"Jing Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Zhong","raw_affiliation_strings":["Chengdu University of Traditional Chinese Medicine, Clinical Medical School, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu University of Traditional Chinese Medicine, Clinical Medical School, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159258898","display_name":"GuanHua Lou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157155","display_name":"Sichuan Academy of Traditional Chinese Medicine","ror":"https://ror.org/05wad7k45","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210157155"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"GuanHua Lou","raw_affiliation_strings":["Institute of Traditional Chinese Medicine of Sichuan Academy of Chinese Medicine Sciences, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Traditional Chinese Medicine of Sichuan Academy of Chinese Medicine Sciences, China","institution_ids":["https://openalex.org/I4210157155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159257911","display_name":"Ying Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157155","display_name":"Sichuan Academy of Traditional Chinese Medicine","ror":"https://ror.org/05wad7k45","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210157155"]},{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Li","raw_affiliation_strings":["Chengdu University of Traditional Chinese Medicine, School of Pharmacy, China","Institute of Traditional Chinese Medicine of Sichuan Academy of Chinese Medicine Sciences, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu University of Traditional Chinese Medicine, School of Pharmacy, China","institution_ids":["https://openalex.org/I53411278"]},{"raw_affiliation_string":"Institute of Traditional Chinese Medicine of Sichuan Academy of Chinese Medicine Sciences, China","institution_ids":["https://openalex.org/I4210157155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047552155","display_name":"Jianan Feng","orcid":"https://orcid.org/0000-0001-6987-1187","observed_orcids":["https://orcid.org/0000-0001-6987-1187"]},"institutions":[{"id":"https://openalex.org/I4210157155","display_name":"Sichuan Academy of Traditional Chinese Medicine","ror":"https://ror.org/05wad7k45","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210157155"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JianAn Feng","raw_affiliation_strings":["Institute of Traditional Chinese Medicine of Sichuan Academy of Chinese Medicine Sciences, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Traditional Chinese Medicine of Sichuan Academy of Chinese Medicine Sciences, China","institution_ids":["https://openalex.org/I4210157155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159259267","display_name":"Xi Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157155","display_name":"Sichuan Academy of Traditional Chinese Medicine","ror":"https://ror.org/05wad7k45","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210157155"]},{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xi Li","raw_affiliation_strings":["Chengdu University of Traditional Chinese Medicine, School of Pharmacy, China","Institute of Traditional Chinese Medicine of Sichuan Academy of Chinese Medicine Sciences, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu University of Traditional Chinese Medicine, School of Pharmacy, China","institution_ids":["https://openalex.org/I53411278"]},{"raw_affiliation_string":"Institute of Traditional Chinese Medicine of Sichuan Academy of Chinese Medicine Sciences, China","institution_ids":["https://openalex.org/I4210157155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159267508","display_name":"Dezhong Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dezhong Peng","raw_affiliation_strings":["Chengdu University of Traditional Chinese Medicine, College of Acupuncture, Moxibustion and Tuina, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu University of Traditional Chinese Medicine, College of Acupuncture, Moxibustion and Tuina, China","institution_ids":["https://openalex.org/I53411278"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5159259267","https://openalex.org/A5159267508"],"corresponding_institution_ids":["https://openalex.org/I4210157155","https://openalex.org/I53411278"],"apc_list":{"value":1870,"currency":"USD","value_usd":1870},"apc_paid":{"value":1870,"currency":"USD","value_usd":1870},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.8736965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":null,"first_page":"104016","last_page":"104016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.8569999933242798},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.8899999856948853},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9860000014305115},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7422000169754028},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6776999831199646},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5042999982833862},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49959999322891235},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.43459999561309814},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.3237000107765198},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.30000001192092896},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.28220000863075256},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.27469998598098755},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.271699994802475},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2696000039577484},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.25619998574256897},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25380000472068787}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.rechem.2026.104016","doi":"https://doi.org/10.1016/j.rechem.2026.104016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.rechem.2026.104016","pdf_url":null,"source":{"id":"https://openalex.org/S4210212333","display_name":"Results in Chemistry","issn_l":"2211-7156","issn":["2211-7156"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Results in Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:4d78f3daeb4d4a3e9754840d96959c81","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4d78f3daeb4d4a3e9754840d96959c81","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Results in Chemistry, Vol 31, Iss , Pp 104016- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.rechem.2026.104016","doi":"https://doi.org/10.1016/j.rechem.2026.104016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.rechem.2026.104016","pdf_url":null,"source":{"id":"https://openalex.org/S4210212333","display_name":"Results in Chemistry","issn_l":"2211-7156","issn":["2211-7156"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Results in Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W160562812","https://openalex.org/W2019642959","https://openalex.org/W2124679671","https://openalex.org/W2128952811","https://openalex.org/W2153541718","https://openalex.org/W2162151166","https://openalex.org/W2593436234","https://openalex.org/W3085095620","https://openalex.org/W3108860514","https://openalex.org/W4200100395","https://openalex.org/W4211111012","https://openalex.org/W4307468223","https://openalex.org/W4308834893","https://openalex.org/W4321491458","https://openalex.org/W4385202180","https://openalex.org/W4387541156","https://openalex.org/W4401111923","https://openalex.org/W4403118722","https://openalex.org/W4404773866","https://openalex.org/W4408072390","https://openalex.org/W4413108059","https://openalex.org/W7127649512","https://openalex.org/W7140038366","https://openalex.org/W7196955178"],"related_works":["https://openalex.org/W3197399961","https://openalex.org/W4387197459","https://openalex.org/W4393353628","https://openalex.org/W4400490849","https://openalex.org/W4206515109","https://openalex.org/W4385611837","https://openalex.org/W4405075423","https://openalex.org/W4408174054","https://openalex.org/W4233690651","https://openalex.org/W4212951396"],"abstract_inverted_index":{"Background":[0],"Rheumatoid":[1],"arthritis":[2],"(RA)":[3],"is":[4],"a":[5,103,118,247],"chronic":[6],"inflammatory":[7,64,271],"autoimmune":[8],"disorder":[9],"characterized":[10],"by":[11],"joint":[12,17,255,273],"inflammation,":[13],"pain,":[14],"and":[15,49,116,139,191,208,212,230,253,263,272,292,299],"progressive":[16],"destruction.":[18],"Despite":[19],"advancements":[20],"in":[21,96,210,213,250,275],"conventional":[22],"therapies,":[23],"many":[24],"patients":[25],"with":[26,68,289],"RA":[27,226,276],"experience":[28],"inadequate":[29],"response":[30],"or":[31],"intolerance":[32],"to":[33,44,89,108,144,156,163,170,178,187,203,303],"synthetic":[34],"drugs.":[35],"Plant-based":[36],"medicines":[37],"have":[38],"emerged":[39],"as":[40,242],"promising":[41],"alternatives":[42],"due":[43],"their":[45,283],"diverse":[46],"pharmacological":[47,92,140,198,233],"properties":[48],"relatively":[50],"fewer":[51],"side":[52],"effects.":[53],"Among":[54],"these,":[55],"HXQF":[56,95,161,176,220,262],"has":[57],"been":[58],"clinically":[59],"used":[60,155],"for":[61,121],"treating":[62],"various":[63],"conditions,":[65],"including":[66],"RA,":[67],"remarkable":[69],"efficacy.":[70],"However,":[71],"the":[72,91,97,146,172,189,194,205,305],"underlying":[73],"mechanisms":[74,93,147,209],"of":[75,85,94,99,114,148,160,175,193,239],"its":[76,112,122,222,264],"therapeutic":[77,223],"actions":[78],"remain":[79],"elusive.":[80],"Purpose":[81],"The":[82],"primary":[83],"objective":[84],"this":[86],"study":[87,129],"was":[88,142,154,167],"elucidate":[90],"treatment":[98],"RA.":[100,164],"By":[101],"utilizing":[102],"multidisciplinary":[104],"approach,":[105],"we":[106],"aimed":[107],"gain":[109],"insights":[110],"into":[111],"mode":[113],"action":[115],"provide":[117],"scientific":[119],"basis":[120],"clinical":[123],"application.":[124],"Study":[125],"design":[126,130],"A":[127],"comprehensive":[128],"combining":[131],"network":[132,152],"pharmacology,":[133],"molecular":[134,136,182],"docking,":[135],"dynamics":[137,183,192],"simulations,":[138],"experiments":[141,199],"employed":[143],"investigate":[145],"HXQF.":[149],"Methods":[150],"First,":[151],"pharmacology":[153],"identify":[157],"potential":[158],"targets":[159,207,229],"related":[162],"Molecular":[165],"docking":[166],"then":[168],"performed":[169],"assess":[171],"binding":[173],"affinity":[174],"components":[177,238],"these":[179],"targets.":[180],"Next,":[181],"simulations":[184],"were":[185,200],"conducted":[186],"explore":[188],"stability":[190],"protein-ligand":[195],"interactions.":[196],"Finally,":[197],"carried":[201],"out":[202],"validate":[204],"predicted":[206],"vitro":[211],"vivo.":[214],"Results":[215],"Our":[216],"findings":[217],"revealed":[218],"that":[219,236,261,282],"exerts":[221],"effects":[224],"on":[225],"through":[227],"multiple":[228],"pathways.":[231],"Notably,":[232],"validations":[234],"suggested":[235],"certain":[237],"HXQF,":[240],"such":[241],"isoimperatorin":[243],"(ISO),":[244],"may":[245,286],"play":[246],"significant":[248],"role":[249],"reducing":[251],"inflammation":[252],"mitigating":[254],"damage.":[256],"Conclusion":[257],"This":[258],"work":[259],"demonstrates":[260],"key":[265],"component":[266],"ISO":[267],"can":[268],"relieve":[269],"short-term":[270],"lesions":[274],"rat":[277],"models.":[278],"Bioinformatic":[279],"simulation":[280],"predicts":[281],"anti-inflammatory":[284],"performance":[285],"be":[287],"correlated":[288],"EGFR-related":[290],"JAK-STAT":[291],"PI3K-Akt":[293],"pathways,":[294],"which":[295],"requires":[296],"further":[297],"protein":[298],"cellular":[300],"experimental":[301],"verification":[302],"confirm":[304],"regulatory":[306],"mechanism.":[307]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2026-10-23T00:00:00"}