{"id":"https://openalex.org/W7223210366","doi":"https://doi.org/10.1016/j.mtbio.2026.103773","title":"Hyaluronic acid-based nanoparticles in cancer diagnosis and therapy: Molecular weight matters","display_name":"Hyaluronic acid-based nanoparticles in cancer diagnosis and therapy: Molecular weight matters","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223210366","doi":"https://doi.org/10.1016/j.mtbio.2026.103773","pmid":"https://pubmed.ncbi.nlm.nih.gov/42990567","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13734796"},"language":"en","primary_location":{"id":"doi:10.1016/j.mtbio.2026.103773","doi":"https://doi.org/10.1016/j.mtbio.2026.103773","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mtbio.2026.103773","pdf_url":null,"source":{"id":"https://openalex.org/S4210219546","display_name":"Materials Today Bio","issn_l":"2590-0064","issn":["2590-0064"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Today Bio","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.mtbio.2026.103773","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101685929","display_name":"Zhining Zhang","orcid":"https://orcid.org/0000-0002-1202-2333","observed_orcids":["https://orcid.org/0000-0002-1202-2333"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhining Zhang","raw_affiliation_strings":["Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, 130033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, 130033, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159267514","display_name":"Mengshi Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengshi Ma","raw_affiliation_strings":["Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, 130033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, 130033, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159286510","display_name":"Yunpeng Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunpeng Dai","raw_affiliation_strings":["Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, 130033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, 130033, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159282636","display_name":"Minglong Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Minglong Chen","raw_affiliation_strings":["Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, 130033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, 130033, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101767028","display_name":"Lei Zhu","orcid":"https://orcid.org/0000-0002-1820-4795","observed_orcids":["https://orcid.org/0000-0002-1820-4795"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lei Zhu","raw_affiliation_strings":["Department of Surgery, Emory University School of Medicine, Atlanta, GA, 30322, United States"],"raw_orcid":"https://orcid.org/0000-0002-1820-4795","affiliations":[{"raw_affiliation_string":"Department of Surgery, Emory University School of Medicine, Atlanta, GA, 30322, United States","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058023429","display_name":"Shi Gao","orcid":"https://orcid.org/0000-0002-4692-0115","observed_orcids":["https://orcid.org/0000-0002-4692-0115"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shi Gao","raw_affiliation_strings":["Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, 130033, China"],"raw_orcid":"https://orcid.org/0000-0002-4692-0115","affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, 130033, China","institution_ids":["https://openalex.org/I194450716"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058023429","https://openalex.org/A5101767028","https://openalex.org/A5159282636"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I194450716"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":{"value":3400,"currency":"USD","value_usd":3400},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.40491071,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":null,"first_page":"103773","last_page":"103773"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.6333000063896179,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.6333000063896179,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.18529999256134033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.07810000330209732,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.996999979019165},{"id":"https://openalex.org/keywords/molecular-weight-dependence","display_name":"molecular weight dependence","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cancer-nanomedicine","display_name":"cancer nanomedicine","score":0.9100000262260437},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.7200000286102295},{"id":"https://openalex.org/keywords/nanoparticle-self-assembly","display_name":"nanoparticle self-assembly","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.8190000057220459},{"id":"https://openalex.org/keywords/multimodal-cancer-treatment","display_name":"multimodal cancer therapy","score":0.9259999990463257},{"id":"https://openalex.org/keywords/phototherapy","display_name":"phototherapy","score":0.6919999718666077},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.7490000128746033},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6934999823570251},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.644599974155426},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4885999858379364},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48339998722076416},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40119999647140503},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.38199999928474426},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.30390000343322754},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2833999991416931},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.24609999358654022},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.23770000040531158}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.mtbio.2026.103773","doi":"https://doi.org/10.1016/j.mtbio.2026.103773","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mtbio.2026.103773","pdf_url":null,"source":{"id":"https://openalex.org/S4210219546","display_name":"Materials Today Bio","issn_l":"2590-0064","issn":["2590-0064"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Today Bio","raw_type":"journal-article"},{"id":"pmid:42990567","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42990567","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials today. Bio","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13734796","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13734796/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mater Today Bio","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:80c82cfa60c34e73ae583866475bd7eb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/80c82cfa60c34e73ae583866475bd7eb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Materials Today Bio, Vol 41, Iss , Pp 103773- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.mtbio.2026.103773","doi":"https://doi.org/10.1016/j.mtbio.2026.103773","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mtbio.2026.103773","pdf_url":null,"source":{"id":"https://openalex.org/S4210219546","display_name":"Materials Today Bio","issn_l":"2590-0064","issn":["2590-0064"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Today Bio","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335953","display_name":"Jilin Scientific and Technological Development Program","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":148,"referenced_works":["https://openalex.org/W1186835836","https://openalex.org/W1537174520","https://openalex.org/W1544256999","https://openalex.org/W1724971981","https://openalex.org/W1794039655","https://openalex.org/W1966420327","https://openalex.org/W1977784832","https://openalex.org/W1980671328","https://openalex.org/W1983883185","https://openalex.org/W1987329859","https://openalex.org/W1994729079","https://openalex.org/W1996462110","https://openalex.org/W1999847859","https://openalex.org/W2000688089","https://openalex.org/W2010480948","https://openalex.org/W2012727362","https://openalex.org/W2019288471","https://openalex.org/W2023675877","https://openalex.org/W2027092476","https://openalex.org/W2041401385","https://openalex.org/W2047469624","https://openalex.org/W2048300493","https://openalex.org/W2051265595","https://openalex.org/W2075500360","https://openalex.org/W2081054982","https://openalex.org/W2081496297","https://openalex.org/W2084764446","https://openalex.org/W2089753996","https://openalex.org/W2098063340","https://openalex.org/W2117507908","https://openalex.org/W2118409856","https://openalex.org/W2120262777","https://openalex.org/W2122341168","https://openalex.org/W2137967850","https://openalex.org/W2138983075","https://openalex.org/W2139966914","https://openalex.org/W2142011208","https://openalex.org/W2150504395","https://openalex.org/W2150516757","https://openalex.org/W2157344438","https://openalex.org/W2161946327","https://openalex.org/W2300451775","https://openalex.org/W2324415512","https://openalex.org/W2399620944","https://openalex.org/W2503229927","https://openalex.org/W2512913434","https://openalex.org/W2537847790","https://openalex.org/W2592565933","https://openalex.org/W2747262245","https://openalex.org/W2754361149","https://openalex.org/W2787989660","https://openalex.org/W2791518895","https://openalex.org/W2799463041","https://openalex.org/W2889159350","https://openalex.org/W2898599332","https://openalex.org/W2902459470","https://openalex.org/W2903290586","https://openalex.org/W2905489395","https://openalex.org/W2913224919","https://openalex.org/W2916367612","https://openalex.org/W2948478358","https://openalex.org/W2949354361","https://openalex.org/W2958685672","https://openalex.org/W2964538931","https://openalex.org/W2965489340","https://openalex.org/W3005527137","https://openalex.org/W3006740752","https://openalex.org/W3012995558","https://openalex.org/W3015958849","https://openalex.org/W3023714525","https://openalex.org/W3039695295","https://openalex.org/W3043828730","https://openalex.org/W3047508677","https://openalex.org/W3082886885","https://openalex.org/W3088362179","https://openalex.org/W3091211717","https://openalex.org/W3092248543","https://openalex.org/W3092554978","https://openalex.org/W3108044785","https://openalex.org/W3109746568","https://openalex.org/W3110991216","https://openalex.org/W3111776460","https://openalex.org/W3128760394","https://openalex.org/W3152748912","https://openalex.org/W3185665502","https://openalex.org/W3203542101","https://openalex.org/W4206029259","https://openalex.org/W4206180686","https://openalex.org/W4225262705","https://openalex.org/W4244406676","https://openalex.org/W4296742295","https://openalex.org/W4297394801","https://openalex.org/W4306693839","https://openalex.org/W4306737895","https://openalex.org/W4307342899","https://openalex.org/W4308186121","https://openalex.org/W4308953751","https://openalex.org/W4310772613","https://openalex.org/W4312187552","https://openalex.org/W4362472210","https://openalex.org/W4365814286","https://openalex.org/W4377011958","https://openalex.org/W4379112968","https://openalex.org/W4381158282","https://openalex.org/W4385614625","https://openalex.org/W4385717757","https://openalex.org/W4386099632","https://openalex.org/W4388033513","https://openalex.org/W4389309797","https://openalex.org/W4392195154","https://openalex.org/W4392467997","https://openalex.org/W4394688894","https://openalex.org/W4394857483","https://openalex.org/W4395078019","https://openalex.org/W4396768735","https://openalex.org/W4400081365","https://openalex.org/W4400354433","https://openalex.org/W4400614988","https://openalex.org/W4400856144","https://openalex.org/W4401726745","https://openalex.org/W4401905304","https://openalex.org/W4403403000","https://openalex.org/W4404141634","https://openalex.org/W4404839070","https://openalex.org/W4405041673","https://openalex.org/W4405191939","https://openalex.org/W4405655695","https://openalex.org/W4407223507","https://openalex.org/W4408293948","https://openalex.org/W4409633943","https://openalex.org/W4409885403","https://openalex.org/W4410252688","https://openalex.org/W4410300973","https://openalex.org/W4410349196","https://openalex.org/W4410415246","https://openalex.org/W4410766040","https://openalex.org/W4410960471","https://openalex.org/W4411167469","https://openalex.org/W4414570234","https://openalex.org/W4414830227","https://openalex.org/W7091333895","https://openalex.org/W7119535543","https://openalex.org/W7127882773","https://openalex.org/W7152468604","https://openalex.org/W7155683242","https://openalex.org/W7160401476","https://openalex.org/W7162800658","https://openalex.org/W7165413222"],"related_works":["https://openalex.org/W7140212554","https://openalex.org/W7117886725","https://openalex.org/W4379112968","https://openalex.org/W2904761624","https://openalex.org/W2157344438","https://openalex.org/W2118409856","https://openalex.org/W7202292966","https://openalex.org/W2944552251","https://openalex.org/W4411048542","https://openalex.org/W7155554037"],"abstract_inverted_index":{"Hyaluronic":[0],"acid":[1],"(HA)-based":[2],"nanomaterials":[3],"have":[4],"emerged":[5],"as":[6,75,96],"promising":[7],"platforms":[8],"for":[9,122,190,243],"cancer":[10,245],"therapy":[11],"owing":[12],"to":[13,92,213,227],"their":[14],"excellent":[15],"biocompatibility,":[16],"biodegradability,":[17],"and":[18,63,70,82,106,140,165,175,193,199,207],"intrinsic":[19,24,216],"tumor-targeting":[20],"capability.":[21],"However,":[22],"the":[23,123,132,151,204,211,215],"biological":[25,104,134,168,217],"functions":[26,53],"of":[27,126,136,219],"HAs":[28],"are":[29],"profoundly":[30],"affected":[31],"by":[32],"molecular":[33],"weight":[34],"(MW),":[35],"a":[36,97,119,144,240],"factor":[37],"that":[38,48,54,78],"remains":[39],"underappreciated":[40],"in":[41,150,186],"current":[42],"nanocarrier":[43,222],"design.":[44],"Accumulating":[45],"evidence":[46],"indicates":[47],"HA":[49,57,72,94,137,188,220],"exhibits":[50],"distinct":[51],"MW-dependent":[52,103,133],"high":[55],"MW":[56,68,159],"(HMW-HA)":[58],"primarily":[59],"supports":[60],"tissue":[61],"homeostasis":[62],"anti-inflammatory":[64],"signaling,":[65],"whereas":[66],"low":[67],"(LMW-HA)":[69],"oligomeric":[71],"(oligo-HA)":[73],"act":[74],"bioactive":[76,237],"mediators":[77],"promote":[79],"inflammation,":[80],"angiogenesis,":[81],"tumor":[83,152,191],"progression.":[84],"Currently,":[85],"most":[86],"HA-based":[87,127,229],"drug":[88],"delivery":[89,233],"strategies":[90],"continue":[91],"treat":[93],"mainly":[95],"passive":[98,232],"carrier,":[99],"largely":[100],"neglecting":[101],"its":[102,107,148],"activity":[105,218],"impact":[108],"on":[109,147,179],"therapeutic":[110,176],"outcomes.":[111],"To":[112],"address":[113],"this":[114,116],"gap,":[115],"review":[117,225],"proposes":[118],"MW-structure-function":[120],"framework":[121],"rational":[124],"design":[125],"nanomedicines.":[128],"We":[129,155],"first":[130],"summarize":[131],"behaviors":[135],"across":[138],"physiological":[139],"pathological":[141],"contexts,":[142],"with":[143,167],"particular":[145],"focus":[146],"role":[149],"microenvironment":[153],"(TME).":[154],"then":[156],"examine":[157],"how":[158],"regulates":[160],"nanoparticle":[161],"self-assembly,":[162],"physicochemical":[163],"properties,":[164],"interactions":[166],"systems,":[169],"thereby":[170],"influencing":[171],"biodistribution,":[172],"cellular":[173],"uptake,":[174],"efficacy.":[177],"Building":[178],"these":[180],"insights,":[181],"we":[182,202],"highlight":[183],"recent":[184],"advances":[185],"MW-optimized":[187],"nanoplatforms":[189],"imaging":[192],"multimodal":[194],"therapies,":[195],"including":[196],"chemotherapy,":[197],"phototherapy,":[198],"immunotherapy.":[200],"Lastly,":[201],"discuss":[203],"key":[205],"challenges":[206],"future":[208],"directions,":[209],"emphasizing":[210],"need":[212],"integrate":[214],"into":[221,235],"engineering.":[223],"This":[224],"aims":[226],"redefine":[228],"nanoparticles":[230],"from":[231],"vehicles":[234],"programmable":[236],"nanoplatforms,":[238],"providing":[239],"conceptual":[241],"foundation":[242],"next-generation":[244],"nanomedicine.":[246]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-23T00:00:00"}
