{"id":"https://openalex.org/W7223209689","doi":"https://doi.org/10.21037/qims-2026-1339","title":"Combined quantitative speed-of-sound imaging and shear-wave elastography for differentiating benign and malignant breast lesions: development of a multimodal ultrasound nomogram","display_name":"Combined quantitative speed-of-sound imaging and shear-wave elastography for differentiating benign and malignant breast lesions: development of a multimodal ultrasound nomogram","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223209689","doi":"https://doi.org/10.21037/qims-2026-1339","pmid":"https://pubmed.ncbi.nlm.nih.gov/42997928","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13743307"},"language":"en","primary_location":{"id":"doi:10.21037/qims-2026-1339","doi":"https://doi.org/10.21037/qims-2026-1339","is_oa":true,"landing_page_url":"https://doi.org/10.21037/qims-2026-1339","pdf_url":null,"source":{"id":"https://openalex.org/S2764457454","display_name":"Quantitative Imaging in Medicine and Surgery","issn_l":"2223-4292","issn":["2223-4292","2223-4306"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Imaging in Medicine and Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21037/qims-2026-1339","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159267140","display_name":"Chunyan Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]},{"id":"https://openalex.org/I4210109381","display_name":"Affiliated Hospital of Guizhou Medical University","ror":"https://ror.org/02kstas42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunyan Liao","raw_affiliation_strings":["Department of Ultrasound Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, China","Guizhou Medical University, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrasound Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, China","institution_ids":["https://openalex.org/I4210109381"]},{"raw_affiliation_string":"Guizhou Medical University, Guiyang, China","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157828910","display_name":"lina zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]},{"id":"https://openalex.org/I4210109381","display_name":"Affiliated Hospital of Guizhou Medical University","ror":"https://ror.org/02kstas42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lina Zhao","raw_affiliation_strings":["Department of Ultrasound Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, China","Guizhou Medical University, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrasound Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, China","institution_ids":["https://openalex.org/I4210109381"]},{"raw_affiliation_string":"Guizhou Medical University, Guiyang, China","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159284637","display_name":"Dan Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Huang","raw_affiliation_strings":["Guizhou Medical University, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guizhou Medical University, Guiyang, China","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060573022","display_name":"Sha Li","orcid":"https://orcid.org/0000-0002-9415-1576","observed_orcids":["https://orcid.org/0000-0002-9415-1576"]},"institutions":[{"id":"https://openalex.org/I4210109381","display_name":"Affiliated Hospital of Guizhou Medical University","ror":"https://ror.org/02kstas42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109381"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Sha Li","raw_affiliation_strings":["Department of Ultrasound Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrasound Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, China","institution_ids":["https://openalex.org/I4210109381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159276454","display_name":"Bei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]},{"id":"https://openalex.org/I4210109381","display_name":"Affiliated Hospital of Guizhou Medical University","ror":"https://ror.org/02kstas42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109381"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bei Zhang","raw_affiliation_strings":["Department of Ultrasound Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, China","Guizhou Medical University, Guiyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrasound Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, China","institution_ids":["https://openalex.org/I4210109381"]},{"raw_affiliation_string":"Guizhou Medical University, Guiyang, China","institution_ids":["https://openalex.org/I149137203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060573022","https://openalex.org/A5159276454"],"corresponding_institution_ids":["https://openalex.org/I149137203","https://openalex.org/I4210109381"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.77715179,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"11","first_page":"880","last_page":"880"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-lesions","display_name":"breast lesions","score":0.7319999933242798},{"id":"https://openalex.org/keywords/benign-versus-malignant-differentiation","display_name":"benign versus malignant differentiation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/shear-wave-elastography","display_name":"shear wave elastography","score":0.9089999794960022},{"id":"https://openalex.org/keywords/breast-cancer-diagnosis","display_name":"breast cancer diagnosis","score":0.6639999747276306},{"id":"https://openalex.org/keywords/microcalcifications","display_name":"microcalcifications","score":0.7490000128746033},{"id":"https://openalex.org/keywords/lesion-size","display_name":"lesion size","score":0.7049999833106995},{"id":"https://openalex.org/keywords/lasso","display_name":"LASSO","score":0.7099999785423279},{"id":"https://openalex.org/keywords/internal-validation","display_name":"internal validation","score":0.5289999842643738},{"id":"https://openalex.org/keywords/decision-curve-analysis","display_name":"decision curve analysis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/unnecessary-biopsy-reduction","display_name":"unnecessary biopsy reduction","score":0.8360000252723694},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.41100001335144043},{"id":"https://openalex.org/keywords/perilesional-tissue","display_name":"perilesional tissue","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8059999942779541},{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.7964000105857849},{"id":"https://openalex.org/C2909095640","wikidata":"https://www.wikidata.org/wiki/Q1324974","display_name":"Ultrasound elastography","level":4,"score":0.7764999866485596},{"id":"https://openalex.org/C2777690781","wikidata":"https://www.wikidata.org/wiki/Q1324974","display_name":"Elastography","level":3,"score":0.7613999843597412},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.7240999937057495},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.567300021648407},{"id":"https://openalex.org/C529618451","wikidata":"https://www.wikidata.org/wiki/Q234904","display_name":"Ultrasonography","level":2,"score":0.39820000529289246},{"id":"https://openalex.org/C4441509","wikidata":"https://www.wikidata.org/wiki/Q6418787","display_name":"Multimodal therapy","level":2,"score":0.36550000309944153},{"id":"https://openalex.org/C2986892559","wikidata":"https://www.wikidata.org/wiki/Q234904","display_name":"Ultrasound imaging","level":3,"score":0.296099990606308},{"id":"https://openalex.org/C2780910867","wikidata":"https://www.wikidata.org/wiki/Q1952416","display_name":"Multimodality","level":2,"score":0.2648000121116638},{"id":"https://openalex.org/C71472368","wikidata":"https://www.wikidata.org/wiki/Q676880","display_name":"Text mining","level":2,"score":0.258899986743927}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21037/qims-2026-1339","doi":"https://doi.org/10.21037/qims-2026-1339","is_oa":true,"landing_page_url":"https://doi.org/10.21037/qims-2026-1339","pdf_url":null,"source":{"id":"https://openalex.org/S2764457454","display_name":"Quantitative Imaging in Medicine and Surgery","issn_l":"2223-4292","issn":["2223-4292","2223-4306"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Imaging in Medicine and Surgery","raw_type":"journal-article"},{"id":"pmid:42997928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42997928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative imaging in medicine and surgery","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/qims-2026-1339","doi":"https://doi.org/10.21037/qims-2026-1339","is_oa":true,"landing_page_url":"https://doi.org/10.21037/qims-2026-1339","pdf_url":null,"source":{"id":"https://openalex.org/S2764457454","display_name":"Quantitative Imaging in Medicine and Surgery","issn_l":"2223-4292","issn":["2223-4292","2223-4306"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Imaging in Medicine and Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4319016497","https://openalex.org/W7213992973","https://openalex.org/W4406192656","https://openalex.org/W2223831863","https://openalex.org/W4205323536","https://openalex.org/W1981917708","https://openalex.org/W3091674169","https://openalex.org/W2799632868","https://openalex.org/W4408129920","https://openalex.org/W3092808742"],"abstract_inverted_index":{"Background:":[0],"Accurate":[1],"differentiation":[2],"of":[3,35,248,265,342],"benign":[4,177],"and":[5,15,39,44,73,85,93,100,114,119,157,173,233,251,267,291,304,322,326,331,349,360,372],"malignant":[6,72],"breast":[7,60,69,338,369],"lesions":[8,70,164,178],"is":[9],"essential":[10],"for":[11,59,154,337,367],"guiding":[12],"clinical":[13,327,373],"management":[14],"reducing":[16],"unnecessary":[17],"biopsies.":[18],"However,":[19],"conventional":[20,56,81,285,312,343],"ultrasound":[21,49,57,286,313,344],"alone":[22,315],"often":[23],"has":[24],"limited":[25],"specificity.":[26,306],"This":[27,64],"study":[28,66],"aimed":[29],"to":[30,45,276,317],"evaluate":[31],"the":[32,261,274,311,318],"diagnostic":[33,133,256,358],"performance":[34,136,359],"shear-wave":[36],"elastography":[37],"(SWE)":[38],"quantitative":[40,52,335,347,364],"speed-of-sound":[41],"(QSOS)":[42],"imaging":[43,53,87],"develop":[46],"a":[47,132,353,363],"multimodal":[48,282,354],"nomogram":[50,283,308,355],"integrating":[51,284],"parameters":[54,95],"with":[55,106,258,301,346],"features":[58,345],"lesion":[61,198,339,370],"characterization.":[62,340],"Methods:":[63],"retrospective":[65],"included":[67],"108":[68,77],"(43":[71],"65":[74],"benign)":[75],"from":[76,98],"women":[78],"who":[79],"underwent":[80],"B-mode":[82],"ultrasound,":[83],"SWE,":[84],"QSOS":[86,94,174,234,250,292,332],"before":[88],"histopathological":[89],"confirmation.":[90],"Quantitative":[91],"SWE":[92,330],"were":[96,108,129],"obtained":[97],"intralesional":[99],"perilesional":[101],"regions.":[102],"Imaging":[103],"predictors":[104,128,247],"associated":[105],"malignancy":[107],"selected":[109],"through":[110],"least":[111],"absolute":[112],"shrinkage":[113],"selection":[115],"operator":[116],"(LASSO)":[117],"regression":[118,125],"subsequently":[120],"evaluated":[121],"using":[122,139],"multivariable":[123],"logistic":[124],"analysis.":[126],"Independent":[127],"incorporated":[130],"into":[131],"nomogram.":[134],"Model":[135],"was":[137],"assessed":[138],"receiver":[140],"operating":[141],"characteristic":[142],"(ROC)":[143],"curve":[144,159,263],"analysis,":[145],"DeLong":[146,319],"test,":[147],"calibration":[148,325],"curves,":[149],"bootstrap":[150],"resampling":[151],"(1,000":[152],"repetitions)":[153],"internal":[155],"validation,":[156],"decision":[158],"analysis":[160,196],"(DCA).":[161],"Results:":[162],"Malignant":[163],"exhibited":[165],"significantly":[166,309],"higher":[167],"maximum":[168],"elasticity":[169],"(E":[170],"max":[171,180,226,253,289],")":[172],"values":[175],"than":[176],"[E":[179],":":[181],"70.6\u00b133.5":[182],"vs.":[183,189],"40.9\u00b121.4":[184],"kPa;":[185],"QSOS:":[186],"1,557.1":[187],"(1,535.8\u20131,564.9)":[188],"1,529.7":[190],"(1,506.1\u20131,543.9)":[191],"m/s;":[192],"both":[193],"P<0.001].":[194],"Multivariable":[195],"identified":[197],"size":[199],"[odds":[200],"ratio":[201],"(OR)":[202],"=1.12,":[203],"95%":[204,214,221,229,241,298],"confidence":[205],"interval":[206],"(CI):":[207],"1.02\u20131.26,":[208],"P=0.030],":[209],"non-parallel":[210],"orientation":[211],"(OR":[212,219,227,239],"=18.93,":[213],"CI:":[215,222,230,242,279,299],"2.00\u2013303.26,":[216],"P=0.019),":[217],"calcification":[218],"=20.18,":[220],"3.44\u2013187.76,":[223],"P=0.002),":[224],"E":[225,252,288],"=1.05,":[228],"1.02\u20131.10,":[231],"P=0.007),":[232],"per":[235],"10":[236],"m/s":[237],"increase":[238],"=1.71,":[240],"1.13\u20132.93,":[243],"P=0.024)":[244],"as":[245],"independent":[246],"malignancy.":[249],"showed":[254],"moderate":[255],"performance,":[257],"areas":[259],"under":[260],"ROC":[262],"(AUCs)":[264],"0.776":[266],"0.775,":[268],"respectively,":[269],"whereas":[270],"their":[271],"combination":[272],"improved":[273],"AUC":[275],"0.850":[277],"(95%":[278],"0.774\u20130.926).":[280],"The":[281,307],"features,":[287],",":[290],"achieved":[293],"excellent":[294,357],"discrimination":[295],"(AUC":[296],"=0.969;":[297],"0.943\u20130.994),":[300],"88.4%":[302],"sensitivity":[303],"92.3%":[305],"outperformed":[310],"model":[314],"according":[316],"test":[320],"(P=0.030)":[321],"demonstrated":[323,356],"favorable":[324],"utility.":[328],"Conclusions:":[329],"provide":[333,362],"complementary":[334],"information":[336,351],"Integration":[341],"stiffness":[348],"sound-speed":[350],"in":[352],"may":[361],"adjunctive":[365],"approach":[366],"improving":[368],"assessment":[371],"decision-making.":[374]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-23T00:00:00"}