{"id":"https://openalex.org/W7223205585","doi":"https://doi.org/10.1016/j.htct.2026.107669","title":"QUERCETIN DISRUPTS NUCLEAR FACTOR ERYTHROID 2\u2013RELATED FACTOR 2 SURVIVAL SIGNALING AND ACTIVATES A PRO-APOPTOTIC MICRORNA PROGRAM IN ACUTE MYELOID LEUKEMIA","display_name":"QUERCETIN DISRUPTS NUCLEAR FACTOR ERYTHROID 2\u2013RELATED FACTOR 2 SURVIVAL SIGNALING AND ACTIVATES A PRO-APOPTOTIC MICRORNA PROGRAM IN ACUTE MYELOID LEUKEMIA","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223205585","doi":"https://doi.org/10.1016/j.htct.2026.107669"},"language":"en","primary_location":{"id":"doi:10.1016/j.htct.2026.107669","doi":"https://doi.org/10.1016/j.htct.2026.107669","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107669","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926014161/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciencedirect.com/science/article/pii/S2531137926014161/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101416950","display_name":"Marisa Claudia Alvarez","orcid":"https://orcid.org/0000-0001-5804-1962","observed_orcids":["https://orcid.org/0000-0001-5804-1962"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]},{"id":"https://openalex.org/I81009624","display_name":"Universidade S\u00e3o Francisco","ror":"https://ror.org/045ae7j03","country_code":"BR","type":"education","lineage":["https://openalex.org/I81009624"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marisa Claudia ALVAREZ","raw_affiliation_strings":["Centro de Hematologia e Hemoterapia (Hemocentro), Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil","Universidade S\u00e3o Francisco (USF), Campinas, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Hematologia e Hemoterapia (Hemocentro), Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"Universidade S\u00e3o Francisco (USF), Campinas, SP, Brazil","institution_ids":["https://openalex.org/I81009624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159270344","display_name":"Karla Priscila FERRO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Karla Priscila FERRO","raw_affiliation_strings":["Centro de Hematologia e Hemoterapia (Hemocentro), Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Hematologia e Hemoterapia (Hemocentro), Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159167521","display_name":"Irene Marisa SANTOS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Irene Marisa SANTOS","raw_affiliation_strings":["Centro de Hematologia e Hemoterapia (Hemocentro), Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Hematologia e Hemoterapia (Hemocentro), Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044078596","display_name":"Cristiane Okuda Torello","orcid":"https://orcid.org/0000-0002-1611-020X","observed_orcids":["https://orcid.org/0000-0002-1611-020X"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Cristiane Okuda TORELLO","raw_affiliation_strings":["Centro de Hematologia e Hemoterapia (Hemocentro), Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Hematologia e Hemoterapia (Hemocentro), Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159271283","display_name":"Myriam Marisa SALAZAR","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Myriam Marisa SALAZAR","raw_affiliation_strings":["Centro de Hematologia e Hemoterapia (Hemocentro), Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Hematologia e Hemoterapia (Hemocentro), Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159295138","display_name":"Adriana Marisa DUARTE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adriana Marisa DUARTE","raw_affiliation_strings":["Centro de Hematologia e Hemoterapia (Hemocentro), Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Hematologia e Hemoterapia (Hemocentro), Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052529953","display_name":"Sara Teresinha Olalla Saad","orcid":"https://orcid.org/0000-0003-0809-8068","observed_orcids":["https://orcid.org/0000-0003-0809-8068"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sara Teresinha Olalla SAAD","raw_affiliation_strings":["Centro de Hematologia e Hemoterapia (Hemocentro), Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Hematologia e Hemoterapia (Hemocentro), Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.68137597,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":null,"first_page":"107669","last_page":"107669"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.796999990940094},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.984000027179718},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7919999957084656},{"id":"https://openalex.org/keywords/mir-206","display_name":"miR-206","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mir-133","display_name":"miR-133","score":0.800000011920929},{"id":"https://openalex.org/keywords/mir-1","display_name":"miR-1","score":0.828000009059906},{"id":"https://openalex.org/keywords/hdac4","display_name":"HDAC4","score":0.7419999837875366},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9570000171661377},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/ubiquitin","display_name":"ubiquitin","score":0.6380000114440918},{"id":"https://openalex.org/keywords/nf-kb","display_name":"NF-kB","score":0.42100000381469727},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.3959999978542328},{"id":"https://openalex.org/keywords/leukemia-cell-survival","display_name":"leukemia cell survival","score":0.328000009059906},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.5879999995231628},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8187000155448914},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7439000010490417},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.704200029373169},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.663100004196167},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.5489000082015991},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.40779998898506165},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.3188999891281128},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.26820001006126404},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2502000033855438},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.22910000383853912}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.htct.2026.107669","doi":"https://doi.org/10.1016/j.htct.2026.107669","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107669","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926014161/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:d740915797984824a8fcc84be19a3cd1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d740915797984824a8fcc84be19a3cd1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 48, Iss , Pp 107669- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.htct.2026.107669","doi":"https://doi.org/10.1016/j.htct.2026.107669","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107669","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926014161/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223205585.pdf","grobid_xml":"https://content.openalex.org/works/W7223205585.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2989013143","https://openalex.org/W7099015519","https://openalex.org/W3112422024","https://openalex.org/W1967881866","https://openalex.org/W2197539219","https://openalex.org/W2026131638","https://openalex.org/W4388680242","https://openalex.org/W3155253854","https://openalex.org/W2980734026","https://openalex.org/W2055196208"],"abstract_inverted_index":{"Background":[0],"Nuclear":[1],"factor":[2,5],"erythroid":[3],"2\u2013related":[4],"2":[6],"(NRF2)":[7],"promotes":[8],"antioxidant":[9],"defense":[10],"but,":[11],"when":[12],"constitutively":[13],"activated":[14],"in":[15,31,48,72,91,157,199,211,301,340],"malignant":[16],"cells,":[17,80,164],"can":[18],"support":[19,270],"survival":[20,299],"and":[21,61,75,78,88,102,112,132,143,146,168,175,192,207,213,233,242,250,262,279,292,310,320,331],"therapy":[22],"resistance.":[23],"We":[24],"previously":[25],"demonstrated":[26],"that":[27],"quercetin":[28,57,165,219],"induces":[29],"apoptosis":[30,142,248],"leukemia":[32,51,163],"through":[33],"epigenetic":[34],"modulation.":[35],"Here,":[36],"we":[37],"investigated":[38],"an":[39],"additional":[40],"mechanism":[41],"linking":[42],"NRF2":[43,59,63,96,140,154,167,172,184,191,236,260,277,291,318,333],"regulation":[44],"to":[45,246,290],"apoptosis-related":[46,224],"microRNAs":[47,126],"acute":[49],"myeloid":[50],"(AML).":[52],"Aim":[53],"To":[54],"determine":[55],"how":[56],"modulates":[58],"signaling":[60,278],"whether":[62],"suppression":[64,275,319],"is":[65],"functionally":[66,288],"associated":[67,326],"with":[68,181,226,286,327],"pro-apoptotic":[69,283],"microRNA":[70,284],"responses":[71,300],"AML.":[73,341],"Materials":[74],"Methods:":[76],"HL-60":[77,212],"U937":[79,214,244],"primary":[81,200],"CD34+":[82,201],"cells":[83,215,245],"from":[84],"untreated":[85],"AML":[86,159,202,302],"patients,":[87],"HL-60/U937":[89],"xenografts":[90],"NOD/SCID":[92],"mice":[93],"were":[94,105,120,127,196],"studied.":[95],"expression,":[97],"subcellular":[98],"localization,":[99,174,306],"ubiquitin":[100,194],"association,":[101],"proteasome-dependent":[103,187,308],"degradation":[104],"assessed":[106],"by":[107,122,129,134,303],"Western":[108],"blotting,":[109],"confocal":[110],"microscopy,":[111],"imaging":[113],"flow":[114,123],"cytometry.":[115,124],"Reactive":[116],"oxygen":[117],"species":[118],"(ROS)":[119],"measured":[121],"Apoptosis-related":[125],"screened":[128],"PCR":[130],"array":[131],"validated":[133],"RT-qPCR.":[135],"Functional":[136],"studies":[137],"included":[138],"stable":[139],"silencing,":[141],"viability":[144,253],"assays,":[145],"ectopic":[147,256],"miR-206":[148,234,239,257,287,321],"expression.":[149],"Results":[150],"Quercetin":[151,204,296],"significantly":[152],"reduced":[153,259],"protein":[155,265],"levels":[156],"both":[158],"xenograft":[160],"models.":[161],"In":[162,217],"decreased":[166,205],"phosphorylated":[169],"NRF2,":[170],"restricted":[171],"nuclear":[173,190,305],"increased":[176,193,208,238],"ubiquitin-associated":[177],"signal;":[178],"proteasome":[179],"inhibition":[180],"MG132":[182],"restored":[183],"accumulation,":[185],"supporting":[186],"degradation.":[188],"Reduced":[189],"association":[195],"also":[197],"observed":[198],"cells.":[203],"HDAC4":[206],"intracellular":[209],"ROS":[210],"(p<0.05).":[216,235],"vivo,":[218],"altered":[220],"16":[221],"of":[222,229,252,276,281],"84":[223],"microRNAs,":[225],"significant":[227],"upregulation":[228],"miR-1,":[230],"miR-133a,":[231],"miR-133b,":[232],"silencing":[237],"expression":[240,258],"(p<0.05)":[241,249,264],"sensitized":[243],"quercetin-induced":[247],"loss":[251],"(p<0.001).":[254],"Conversely,":[255],"(p<0.001)":[261],"BCL2":[263,293],"levels.":[266],"Discussion":[267],"These":[268],"findings":[269],"two":[271],"converging":[272],"mechanisms:":[273],"post-translational":[274],"activation":[280],"a":[282,323,336],"program,":[285],"linked":[289],"regulation.":[294],"Conclusion":[295],"disrupts":[297],"NRF2-dependent":[298],"restricting":[304],"promoting":[307],"degradation,":[309],"increasing":[311],"oxidative":[312],"stress.":[313],"The":[314],"functional":[315],"interplay":[316],"between":[317],"identifies":[322],"regulatory":[324],"vulnerability":[325],"enhanced":[328],"apoptotic":[329],"sensitivity":[330],"supports":[332],"modulation":[334],"as":[335],"potential":[337],"therapeutic":[338],"strategy":[339]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-23T00:00:00"}