{"id":"https://openalex.org/W7223202841","doi":"https://doi.org/10.1248/bpb.b26-00361","title":"Incidence of Acute Kidney Injury in the Model-Based AUC-Guided Dosing of Vancomycin Compared with Conventional Trough-Guided Dosing in Patients with Severely Impaired Renal Function","display_name":"Incidence of Acute Kidney Injury in the Model-Based AUC-Guided Dosing of Vancomycin Compared with Conventional Trough-Guided Dosing in Patients with Severely Impaired Renal Function","publication_year":2026,"publication_date":"2026-10-22","ids":{"openalex":"https://openalex.org/W7223202841","doi":"https://doi.org/10.1248/bpb.b26-00361","pmid":"https://pubmed.ncbi.nlm.nih.gov/42927892"},"language":"en","primary_location":{"id":"doi:10.1248/bpb.b26-00361","doi":"https://doi.org/10.1248/bpb.b26-00361","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.b26-00361","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/49/10/49_b26-00361/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/bpb/49/10/49_b26-00361/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084313756","display_name":"Kohei Fujita","orcid":"https://orcid.org/0000-0002-6902-9085","observed_orcids":["https://orcid.org/0000-0002-6902-9085"]},"institutions":[{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohei Fujita","raw_affiliation_strings":["Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan","institution_ids":["https://openalex.org/I4210089895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159259531","display_name":"Kazuhiro Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]},{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Yamamoto","raw_affiliation_strings":["Department of Integrated Clinical and Basic Pharmaceutical Sciences, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1\u20131\u20131 Tsushima-naka, Kita-ku, Okayama 700\u20138558, Japan","Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrated Clinical and Basic Pharmaceutical Sciences, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1\u20131\u20131 Tsushima-naka, Kita-ku, Okayama 700\u20138558, Japan","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan","institution_ids":["https://openalex.org/I4210089895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027417086","display_name":"Kotaro Itohara","orcid":"https://orcid.org/0000-0002-7982-7881","observed_orcids":["https://orcid.org/0000-0002-7982-7881"]},"institutions":[{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kotaro Itohara","raw_affiliation_strings":["Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan","institution_ids":["https://openalex.org/I4210089895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159282550","display_name":"Takashi Ogihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Ogihara","raw_affiliation_strings":["Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan","institution_ids":["https://openalex.org/I4210089895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077756851","display_name":"Tomoyuki Sakaue","orcid":"https://orcid.org/0009-0003-9810-1810","observed_orcids":["https://orcid.org/0009-0003-9810-1810"]},"institutions":[{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Sakaue","raw_affiliation_strings":["Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan","institution_ids":["https://openalex.org/I4210089895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027777310","display_name":"Atsushi Uda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Uda","raw_affiliation_strings":["Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan","institution_ids":["https://openalex.org/I4210089895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091708534","display_name":"Asami Morioka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Asami Morioka","raw_affiliation_strings":["Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan","institution_ids":["https://openalex.org/I4210089895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101636782","display_name":"Kazuhiko Yamashita","orcid":"https://orcid.org/0000-0003-1268-7260","observed_orcids":["https://orcid.org/0000-0003-1268-7260"]},"institutions":[{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiko Yamashita","raw_affiliation_strings":["Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan","institution_ids":["https://openalex.org/I4210089895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043626693","display_name":"Tomohiro Omura","orcid":"https://orcid.org/0000-0001-5520-253X","observed_orcids":["https://orcid.org/0000-0001-5520-253X"]},"institutions":[{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiro Omura","raw_affiliation_strings":["Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan","institution_ids":["https://openalex.org/I4210089895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059944980","display_name":"Ikuko Yano","orcid":"https://orcid.org/0000-0001-9517-5628","observed_orcids":["https://orcid.org/0000-0001-9517-5628"]},"institutions":[{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ikuko Yano","raw_affiliation_strings":["Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Kobe University Hospital, 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe 650\u20130017, Japan","institution_ids":["https://openalex.org/I4210089895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.76596819,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"49","issue":"10","first_page":"1709","last_page":"1717"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9599999785423279},{"id":"https://openalex.org/keywords/trough-concentration","display_name":"trough concentration","score":0.7549999952316284},{"id":"https://openalex.org/keywords/pharmacokinetic-modeling","display_name":"pharmacokinetic modeling","score":0.7490000128746033},{"id":"https://openalex.org/keywords/severe-renal-impairment","display_name":"severe renal impairment","score":0.8019999861717224},{"id":"https://openalex.org/keywords/precision-dosing","display_name":"precision dosing","score":0.8109999895095825},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5540000200271606},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9053999781608582},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.8977000117301941},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.6585999727249146},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6496000289916992},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.57669997215271},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.5612999796867371},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.38909998536109924},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.37959998846054077},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.36570000648498535},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.35740000009536743},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34380000829696655},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3366999924182892},{"id":"https://openalex.org/C2908822073","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Impaired renal function","level":3,"score":0.32350000739097595},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.31470000743865967},{"id":"https://openalex.org/C2777350860","wikidata":"https://www.wikidata.org/wiki/Q2425407","display_name":"Acute tubular necrosis","level":3,"score":0.29899999499320984},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.2888000011444092},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2547999918460846}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1248/bpb.b26-00361","doi":"https://doi.org/10.1248/bpb.b26-00361","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.b26-00361","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/49/10/49_b26-00361/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:42927892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42927892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological & pharmaceutical bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/bpb.b26-00361","doi":"https://doi.org/10.1248/bpb.b26-00361","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.b26-00361","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/49/10/49_b26-00361/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223202841.pdf","grobid_xml":"https://content.openalex.org/works/W7223202841.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4372298761","https://openalex.org/W4286790185","https://openalex.org/W3216258848","https://openalex.org/W4408543183","https://openalex.org/W4200232187","https://openalex.org/W4402274738","https://openalex.org/W4391145076","https://openalex.org/W4387966666","https://openalex.org/W2911774236","https://openalex.org/W4311614964"],"abstract_inverted_index":{"Vancomycin":[0],"dosing":[1,25,53,58,187,191,232],"guided":[2,26],"by":[3,27],"the":[4,7,16,48,102,118,127,136,142,154,164,171,197,206,220,227,234],"area":[5],"under":[6],"time\u2013concentration":[8],"curve":[9],"(AUC)":[10],"has":[11],"been":[12,76],"reported":[13],"to":[14,46],"lower":[15],"incidence":[17,138,173,213],"of":[18,50,94,139,174,194,205,237],"acute":[19],"kidney":[20],"injury":[21],"(AKI)":[22],"compared":[23,54],"with":[24,32,55,61,66,170,202,219],"trough":[28,156,222],"concentration":[29,157,223],"in":[30,59,101,113,117,122,126,135,192,242],"patients":[31,60,87,98,115,124],"normal":[33],"renal":[34,38,63],"function":[35],"and":[36,96,104,121,158,188,224],"mild-to-moderate":[37],"impairment.":[39,64],"In":[40,147,176],"this":[41,243],"retrospective":[42],"study,":[43],"we":[44],"aimed":[45],"evaluate":[47],"safety":[49],"model-based":[51,185],"AUC-guided":[52,105,128,186],"conventional":[56,189],"trough-guided":[57,119,190],"severe":[62],"Patients":[65],"an":[67],"estimated":[68,159],"glomerular":[69],"filtration":[70],"rate":[71],"<30":[72],"mL/min/1.73m2":[73],"who":[74],"have":[75],"receiving":[77],"vancomycin":[78,221],"for":[79],"at":[80,163,226],"least":[81],"4":[82],"d":[83,111,216],"were":[84,90,99,167],"included,":[85],"whereas":[86],"undergoing":[88],"dialysis":[89],"excluded.":[91],"A":[92],"total":[93],"44":[95],"20":[97],"included":[100],"trough-":[103],"groups,":[106],"respectively.":[107],"AKI":[108,140,212],"within":[109,214],"14":[110,215],"occurred":[112],"10":[114],"(22.7%)":[116],"group":[120],"2":[123],"(10.0%)":[125],"group;":[129],"no":[130,178],"significant":[131,180],"difference":[132,181],"was":[133,182,217],"observed":[134,155,183],"cumulative":[137,172],"between":[141,184],"groups":[143],"(p":[144],"=":[145],"0.29).":[146],"univariate":[148],"Cox":[149],"proportional":[150],"hazards":[151],"regression":[152],"analysis,":[153],"steady-state":[160],"AUC":[161],"(eAUCss)":[162],"first":[165,228],"measurement":[166],"significantly":[168],"associated":[169,218],"AKI.":[175],"conclusion,":[177],"statistically":[179],"terms":[193],"safety,":[195],"although":[196],"results":[198],"should":[199],"be":[200,240],"interpreted":[201],"caution":[203],"because":[204],"small":[207],"sample":[208],"size.":[209],"Considering":[210],"that":[211],"eAUCss":[225],"measurement,":[229],"model-informed":[230],"precision":[231],"during":[233],"early":[235],"phase":[236],"treatment":[238],"may":[239],"warranted":[241],"population.":[244]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-23T00:00:00"}