{"id":"https://openalex.org/W7223197929","doi":"https://doi.org/10.1371/journal.pntd.0014810","title":"Transgenic Plasmodium berghei expressing P. vivax pre-erythrocytic antigens SSP3 and SPECT1 to elucidate their efficacy towards vaccine development","display_name":"Transgenic Plasmodium berghei expressing P. vivax pre-erythrocytic antigens SSP3 and SPECT1 to elucidate their efficacy towards vaccine development","publication_year":2026,"publication_date":"2026-10-22","ids":{"openalex":"https://openalex.org/W7223197929","doi":"https://doi.org/10.1371/journal.pntd.0014810","pmid":"https://pubmed.ncbi.nlm.nih.gov/42911959","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13739220"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pntd.0014810","doi":"https://doi.org/10.1371/journal.pntd.0014810","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0014810","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0014810&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0014810&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027919976","display_name":"Surendra Kumar Kolli","orcid":"https://orcid.org/0000-0001-6125-0036","observed_orcids":["https://orcid.org/0000-0001-6125-0036"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Surendra Kumar Kolli","raw_affiliation_strings":["Center for Global Health and Interdisciplinary Research, College of Public Health, University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Global Health and Interdisciplinary Research, College of Public Health, University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070503509","display_name":"Pradeep Annamalai Subramani","orcid":"https://orcid.org/0000-0001-8685-0900","observed_orcids":["https://orcid.org/0000-0001-8685-0900"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pradeep Annamalai Subramani","raw_affiliation_strings":["Center for Global Health and Interdisciplinary Research, College of Public Health, University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Global Health and Interdisciplinary Research, College of Public Health, University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074017466","display_name":"Jai Ramesar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jai Ramesar","raw_affiliation_strings":["Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030799896","display_name":"Justin Nicholas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Nicholas","raw_affiliation_strings":["Center for Global Health and Interdisciplinary Research, College of Public Health, University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Global Health and Interdisciplinary Research, College of Public Health, University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093216083","display_name":"Madison M. Ogbondah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madison M. Ogbondah","raw_affiliation_strings":["Center for Global Health and Interdisciplinary Research, College of Public Health, University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Global Health and Interdisciplinary Research, College of Public Health, University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088983533","display_name":"Samantha J. Barnes","orcid":"https://orcid.org/0000-0002-4784-4409","observed_orcids":["https://orcid.org/0000-0002-4784-4409"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha J. Barnes","raw_affiliation_strings":["Center for Global Health and Interdisciplinary Research, College of Public Health, University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Global Health and Interdisciplinary Research, College of Public Health, University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002448303","display_name":"Pooya Mahdavi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pooya Mahdavi","raw_affiliation_strings":["Center for Global Health and Interdisciplinary Research, College of Public Health, University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Global Health and Interdisciplinary Research, College of Public Health, University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002563506","display_name":"Ahmed M. Salman","orcid":"https://orcid.org/0000-0002-9259-7339","observed_orcids":["https://orcid.org/0000-0002-9259-7339"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210153742","display_name":"Jenner Institute","ror":"https://ror.org/05kwhph67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210153742"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ahmed M. Salman","raw_affiliation_strings":["The Jenner Institute, University of Oxford"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jenner Institute, University of Oxford","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210153742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014868248","display_name":"Francis Babila Ntumngia","orcid":"https://orcid.org/0000-0001-9867-3534","observed_orcids":["https://orcid.org/0000-0001-9867-3534"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis Babila Ntumngia","raw_affiliation_strings":["Center for Global Health and Interdisciplinary Research, College of Public Health, University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Global Health and Interdisciplinary Research, College of Public Health, University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052922407","display_name":"Chris J. Janse","orcid":"https://orcid.org/0000-0002-6410-6205","observed_orcids":["https://orcid.org/0000-0002-6410-6205"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Chris J. Janse","raw_affiliation_strings":["Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052828429","display_name":"John H. Adams","orcid":"https://orcid.org/0000-0003-3707-7979","observed_orcids":["https://orcid.org/0000-0003-3707-7979"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John H. Adams","raw_affiliation_strings":["Center for Global Health and Interdisciplinary Research, College of Public Health, University of South Florida"],"raw_orcid":"https://orcid.org/0000-0003-3707-7979","affiliations":[{"raw_affiliation_string":"Center for Global Health and Interdisciplinary Research, College of Public Health, University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5052828429"],"corresponding_institution_ids":["https://openalex.org/I2613432"],"apc_list":{"value":2670,"currency":"USD","value_usd":2670},"apc_paid":{"value":2670,"currency":"USD","value_usd":2670},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82529055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"10","first_page":"e0014810","last_page":"e0014810"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-vivax","display_name":"Plasmodium vivax","score":0.9679999947547913},{"id":"https://openalex.org/keywords/pre-erythrocytic-antigens","display_name":"pre-erythrocytic antigens","score":0.8370000123977661},{"id":"https://openalex.org/keywords/ssp3","display_name":"SSP3","score":0.984000027179718},{"id":"https://openalex.org/keywords/vaccine-candidate","display_name":"vaccine candidate","score":0.550000011920929},{"id":"https://openalex.org/keywords/sporozoite-invasion","display_name":"sporozoite invasion","score":0.6380000114440918},{"id":"https://openalex.org/keywords/hepatocyte-infection","display_name":"hepatocyte infection","score":0.5860000252723694},{"id":"https://openalex.org/keywords/hypnozoites","display_name":"hypnozoites","score":0.8610000014305115},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.6579999923706055},{"id":"https://openalex.org/keywords/sterile-protection","display_name":"sterile protection","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2777237215","wikidata":"https://www.wikidata.org/wiki/Q65021","display_name":"Plasmodium berghei","level":3,"score":0.805400013923645},{"id":"https://openalex.org/C2781074509","wikidata":"https://www.wikidata.org/wiki/Q24778282","display_name":"Circumsporozoite protein","level":4,"score":0.7976999878883362},{"id":"https://openalex.org/C2779997623","wikidata":"https://www.wikidata.org/wiki/Q311376","display_name":"Plasmodium vivax","level":4,"score":0.7742999792098999},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7585999965667725},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7120000123977661},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.6908000111579895},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6502000093460083},{"id":"https://openalex.org/C2781034427","wikidata":"https://www.wikidata.org/wiki/Q6741353","display_name":"Malaria vaccine","level":4,"score":0.5979999899864197},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.5343999862670898},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4332999885082245},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41940000653266907},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.4120999872684479},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.3862999975681305},{"id":"https://openalex.org/C99389464","wikidata":"https://www.wikidata.org/wiki/Q3319949","display_name":"Gametocyte","level":4,"score":0.38339999318122864},{"id":"https://openalex.org/C2781152039","wikidata":"https://www.wikidata.org/wiki/Q7318278","display_name":"Reverse vaccinology","level":4,"score":0.37070000171661377},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.35830000042915344},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.3443000018596649},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.33410000801086426},{"id":"https://openalex.org/C2778675580","wikidata":"https://www.wikidata.org/wiki/Q614956","display_name":"Plasmodium (life cycle)","level":3,"score":0.33309999108314514},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.31220000982284546},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.28459998965263367},{"id":"https://openalex.org/C2781375639","wikidata":"https://www.wikidata.org/wiki/Q158597","display_name":"Anopheles","level":3,"score":0.28110000491142273},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.2687000036239624},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.2667999863624573},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.26260000467300415},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.2621999979019165},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2599000036716461},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.25699999928474426}],"mesh":[{"descriptor_ui":"D000087506","descriptor_name":"Vaccine Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000096202","descriptor_name":"Protein Subunit Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000913","descriptor_name":"Antibodies, Protozoan","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000913","descriptor_name":"Antibodies, Protozoan","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000953","descriptor_name":"Antigens, Protozoan","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000953","descriptor_name":"Antigens, Protozoan","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010962","descriptor_name":"Plasmodium berghei","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010962","descriptor_name":"Plasmodium berghei","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010966","descriptor_name":"Plasmodium vivax","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010966","descriptor_name":"Plasmodium vivax","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016780","descriptor_name":"Malaria, Vivax","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016780","descriptor_name":"Malaria, Vivax","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D016780","descriptor_name":"Malaria, Vivax","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017780","descriptor_name":"Malaria Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1371/journal.pntd.0014810","doi":"https://doi.org/10.1371/journal.pntd.0014810","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0014810","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0014810&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13739220","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13739220/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13739220/pdf/pntd.0014810.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Negl Trop Dis","raw_type":"Text"},{"id":"pmid:42911959","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42911959","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS neglected tropical diseases","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pntd.0014810","doi":"https://doi.org/10.1371/journal.pntd.0014810","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0014810","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0014810&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223197929.pdf","grobid_xml":"https://content.openalex.org/works/W7223197929.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W102715436","https://openalex.org/W1654763393","https://openalex.org/W1973529656","https://openalex.org/W1976078373","https://openalex.org/W1983531823","https://openalex.org/W1995866374","https://openalex.org/W1997681499","https://openalex.org/W2021528981","https://openalex.org/W2024290332","https://openalex.org/W2029131750","https://openalex.org/W2036799765","https://openalex.org/W2040611232","https://openalex.org/W2047798716","https://openalex.org/W2063096721","https://openalex.org/W2065778348","https://openalex.org/W2069999816","https://openalex.org/W2083522591","https://openalex.org/W2087528731","https://openalex.org/W2130373733","https://openalex.org/W2132953753","https://openalex.org/W2133357376","https://openalex.org/W2150989648","https://openalex.org/W2154031783","https://openalex.org/W2157058601","https://openalex.org/W2160091950","https://openalex.org/W2165981082","https://openalex.org/W2168317585","https://openalex.org/W2274234437","https://openalex.org/W2574688908","https://openalex.org/W2586539213","https://openalex.org/W2602015085","https://openalex.org/W2614627769","https://openalex.org/W2615148436","https://openalex.org/W2739788388","https://openalex.org/W2769440160","https://openalex.org/W2770626798","https://openalex.org/W2797545748","https://openalex.org/W2800362720","https://openalex.org/W2887745587","https://openalex.org/W2900710686","https://openalex.org/W2913893387","https://openalex.org/W2950607694","https://openalex.org/W2954785814","https://openalex.org/W2982372086","https://openalex.org/W3104998596","https://openalex.org/W3122178751","https://openalex.org/W3173704168","https://openalex.org/W3177569215","https://openalex.org/W4283399455","https://openalex.org/W4295633071","https://openalex.org/W4316362699","https://openalex.org/W4377011923","https://openalex.org/W4386699703","https://openalex.org/W4386878626","https://openalex.org/W4388462266","https://openalex.org/W4390841227","https://openalex.org/W4391251781","https://openalex.org/W4391671314","https://openalex.org/W4406520599","https://openalex.org/W4415841317","https://openalex.org/W7118364547"],"related_works":["https://openalex.org/W2027799840","https://openalex.org/W4386699703","https://openalex.org/W7005334528","https://openalex.org/W4312066989","https://openalex.org/W2605485144","https://openalex.org/W7086599523","https://openalex.org/W3198280972","https://openalex.org/W2343774197","https://openalex.org/W2100733023","https://openalex.org/W2506970692"],"abstract_inverted_index":{"The":[0,66,163],"development":[1,171],"of":[2,22,116,153,198,205,220,261],"an":[3],"efficacious":[4],"vaccine":[5,74,113,158,265],"against":[6,184],"Plasmodium":[7],"vivax":[8,17,156],"malaria":[9,41,59,85],"remains":[10],"a":[11,33],"top":[12],"global":[13],"health":[14],"priority.":[15],"P.":[16,83,97,141,155,246],"forms":[18,21,77],"hypnozoites,":[19],"dormant":[20],"the":[23,26,50,54,71,78,81,104,129,150,173,241,244,259],"parasite":[24,143,174],"in":[25,96,177,195,200,218,250],"liver":[27],"that":[28,95],"can":[29],"become":[30],"reactivated":[31],"after":[32],"few":[34],"months":[35],"or":[36],"even":[37],"years,":[38],"causing":[39],"relapse":[40,64],"and":[42,63,76,89,127,161,166,180,187,207,271],"enhancing":[43],"transmission.":[44],"Therefore,":[45],"targeting":[46],"antigens":[47,110,263],"expressed":[48],"during":[49],"pre-erythrocytic":[51,73,109,157],"stages":[52],"offers":[53],"potential":[55,151],"to":[56,106,111,148],"prevent":[57],"clinical":[58],"from":[60],"both":[61,178],"primary":[62],"infections.":[65],"circumsporozoite":[67],"protein":[68],"(CSP)":[69],"is":[70],"leading":[72],"candidate":[75],"basis":[79],"for":[80,131,237,257],"current":[82],"falciparum":[84],"vaccines":[86],"RTS,":[87],"S":[88],"R21/Matrix":[90],"M.":[91],"Studies":[92],"have":[93],"shown":[94],"vivax,":[98],"CSP":[99],"attributes":[100],"limited":[101],"protection,":[102],"highlighting":[103,128],"need":[105,130],"identify":[107],"additional":[108],"improve":[112],"efficacy.":[114],"Evaluation":[115],"new":[117],"candidates":[118,266],"often":[119],"requires":[120],"human":[121],"volunteers,":[122],"making":[123],"initial":[124],"screening":[125],"complex":[126],"robust":[132],"preclinical":[133],"models.":[134],"In":[135,210],"this":[136,251],"study,":[137],"we":[138],"generated":[139,249],"transgenic":[140,245],"berghei":[142,247],"lines":[144,168,248],"as":[145,254,264],"research":[146],"tools":[147],"investigate":[149],"efficacy":[152,260],"two":[154],"candidates,":[159],"SSP3":[160],"SPECT1.":[162],"chimeric":[164],"Pb-PvSSP3":[165],"Pb-PvSPECT1":[167],"showed":[169,215],"normal":[170],"throughout":[172],"life":[175],"cycle,":[176],"mice":[179,221],"mosquitoes.":[181],"Antisera":[182],"raised":[183],"recombinant":[185],"PvSSP3":[186],"PvSPECT1":[188],"using":[189],"TitreMax":[190],"Gold":[191],"adjuvant":[192],"exhibited":[193],"reduction":[194],"sporozoite":[196,212],"invasion":[197],"hepatocytes":[199],"vitro,":[201],"with":[202,223],"mean":[203],"inhibitions":[204],"27%":[206],"14%,":[208],"respectively.":[209],"vivo":[211],"challenge":[213],"studies":[214],"sterile":[216],"protection":[217,233],"10%":[219],"immunized":[222],"rPvSPECT1,":[224],"whereas":[225],"rPvSSP3":[226],"provided":[227],"no":[228],"detectable":[229],"protection.":[230],"Although":[231],"substantial":[232],"was":[234],"not":[235],"observed":[236],"either":[238],"antigen":[239],"under":[240],"conditions":[242],"tested,":[243],"study":[252],"serve":[253],"useful":[255],"platforms":[256],"evaluating":[258],"these":[262],"across":[267],"different":[268],"delivery":[269],"systems":[270],"adjuvanted":[272],"formulations.":[273]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-23T00:00:00"}
