{"id":"https://openalex.org/W7223196874","doi":"https://doi.org/10.7570/jomes25076","title":"Comparison of Data-Driven Phenotyping Systems for Metabolic Dysfunction-Associated Steatotic Liver Disease: Implications for Treatment Response","display_name":"Comparison of Data-Driven Phenotyping Systems for Metabolic Dysfunction-Associated Steatotic Liver Disease: Implications for Treatment Response","publication_year":2026,"publication_date":"2026-10-23","ids":{"openalex":"https://openalex.org/W7223196874","doi":"https://doi.org/10.7570/jomes25076","pmid":"https://pubmed.ncbi.nlm.nih.gov/42918741","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13744986"},"language":"en","primary_location":{"id":"doi:10.7570/jomes25076","doi":"https://doi.org/10.7570/jomes25076","is_oa":true,"landing_page_url":"https://doi.org/10.7570/jomes25076","pdf_url":"https://www.jomes.org/journal/download_pdf.php?doi=10.7570/jomes25076","source":{"id":"https://openalex.org/S4210201552","display_name":"Journal of Obesity & Metabolic Syndrome","issn_l":"2508-6235","issn":["2508-6235","2508-7576"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","kci-registered","medline","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319516","host_organization_name":"Korean Society for the Study of Obesity","host_organization_lineage":["https://openalex.org/P4310319516"],"host_organization_lineage_names":["Korean Society for the Study of Obesity"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Obesity &amp; Metabolic Syndrome","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jomes.org/journal/download_pdf.php?doi=10.7570/jomes25076","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159269506","display_name":"Ling Luo","orcid":"https://orcid.org/0000-0002-2104-0031","observed_orcids":["https://orcid.org/0000-0002-2104-0031"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Luo","raw_affiliation_strings":["Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-2104-0031","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019021403","display_name":"Congxiang Shao","orcid":"https://orcid.org/0000-0001-9628-6426","observed_orcids":["https://orcid.org/0000-0001-9628-6426"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Congxiang Shao","raw_affiliation_strings":["Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0001-9628-6426","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041836339","display_name":"Tingfeng Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4210105573","display_name":"Foshan Hospital of TCM","ror":"https://ror.org/01dw0ab98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105573"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingfeng Wu","raw_affiliation_strings":["Department of Gastroenterology, Guangzhou University of Traditional Chinese Medicine Affiliated Foshan Hospital of Traditional Chinese Medicine, Foshan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Guangzhou University of Traditional Chinese Medicine Affiliated Foshan Hospital of Traditional Chinese Medicine, Foshan, China","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151989275","display_name":"Long Teng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Long Teng","raw_affiliation_strings":["Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075766071","display_name":"Jiaming Lai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaming Lai","raw_affiliation_strings":["Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159261694","display_name":"Shuyu Zhuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuyu Zhuo","raw_affiliation_strings":["Department of Nutrition, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148583470","display_name":"Zhi Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi Dong","raw_affiliation_strings":["Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159282379","display_name":"Wei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Department of Ultrasound, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrasound, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056151772","display_name":"Junzhao Ye","orcid":"https://orcid.org/0000-0003-3163-4164","observed_orcids":["https://orcid.org/0000-0003-3163-4164"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Junzhao Ye","raw_affiliation_strings":["Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0003-3163-4164","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075172546","display_name":"Bihui Zhong","orcid":"https://orcid.org/0000-0002-4638-7699","observed_orcids":["https://orcid.org/0000-0002-4638-7699","https://orcid.org/0000-0002-8483-6854","https://orcid.org/0000-0002-3089-8152"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bihui Zhong","raw_affiliation_strings":["Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-4638-7699","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5056151772","https://openalex.org/A5075172546"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"4","first_page":"478","last_page":"498"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9779999852180481},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.609000027179718},{"id":"https://openalex.org/keywords/lipoprotein-a","display_name":"lipoprotein(a)","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mixed-dyslipidemia","display_name":"mixed dyslipidemia","score":0.9449999928474426},{"id":"https://openalex.org/keywords/liver-fat-reduction","display_name":"liver fat reduction","score":0.6660000085830688},{"id":"https://openalex.org/keywords/liver-stiffness","display_name":"liver stiffness","score":0.777999997138977},{"id":"https://openalex.org/keywords/lifestyle-management","display_name":"lifestyle management","score":0.7080000042915344},{"id":"https://openalex.org/keywords/treatment-response-stratification","display_name":"treatment response stratification","score":0.7590000033378601},{"id":"https://openalex.org/keywords/proton-density-fat-fraction","display_name":"proton density fat fraction","score":0.6589999794960022},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6306999921798706},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.350600004196167},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.33709999918937683},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.31839999556541443},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30559998750686646},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.3052000105381012},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.299699991941452},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2881999909877777},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.2784999907016754},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.25130000710487366}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.7570/jomes25076","doi":"https://doi.org/10.7570/jomes25076","is_oa":true,"landing_page_url":"https://doi.org/10.7570/jomes25076","pdf_url":"https://www.jomes.org/journal/download_pdf.php?doi=10.7570/jomes25076","source":{"id":"https://openalex.org/S4210201552","display_name":"Journal of Obesity & Metabolic Syndrome","issn_l":"2508-6235","issn":["2508-6235","2508-7576"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","kci-registered","medline","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319516","host_organization_name":"Korean Society for the Study of Obesity","host_organization_lineage":["https://openalex.org/P4310319516"],"host_organization_lineage_names":["Korean Society for the Study of Obesity"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Obesity &amp; Metabolic Syndrome","raw_type":"journal-article"},{"id":"pmid:42918741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42918741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of obesity & metabolic syndrome","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13744986","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13744986/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Obes Metab Syndr","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:bd65b9f3450f4b8e806e5f2606151311","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bd65b9f3450f4b8e806e5f2606151311","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Obesity & Metabolic Syndrome, Vol 35, Iss 4, Pp 478-498 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7570/jomes25076","doi":"https://doi.org/10.7570/jomes25076","is_oa":true,"landing_page_url":"https://doi.org/10.7570/jomes25076","pdf_url":"https://www.jomes.org/journal/download_pdf.php?doi=10.7570/jomes25076","source":{"id":"https://openalex.org/S4210201552","display_name":"Journal of Obesity & Metabolic Syndrome","issn_l":"2508-6235","issn":["2508-6235","2508-7576"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","kci-registered","medline","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319516","host_organization_name":"Korean Society for the Study of Obesity","host_organization_lineage":["https://openalex.org/P4310319516"],"host_organization_lineage_names":["Korean Society for the Study of Obesity"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Obesity &amp; Metabolic Syndrome","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1764981848","display_name":null,"funder_award_id":"2022A1515012369","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G4192921774","display_name":null,"funder_award_id":"82370587","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G5409146124","display_name":null,"funder_award_id":"82100648","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G5609174243","display_name":null,"funder_award_id":"82370587","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G598266113","display_name":null,"funder_award_id":"82100648","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6566627402","display_name":null,"funder_award_id":"82400663","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321160","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223196874.pdf","grobid_xml":"https://content.openalex.org/works/W7223196874.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1963682935","https://openalex.org/W2066139762","https://openalex.org/W2091106363","https://openalex.org/W2563118732","https://openalex.org/W2622132351","https://openalex.org/W2810712951","https://openalex.org/W2997944188","https://openalex.org/W3041546131","https://openalex.org/W3082261340","https://openalex.org/W3110769583","https://openalex.org/W3111342436","https://openalex.org/W3185652898","https://openalex.org/W4214587189","https://openalex.org/W4292854044","https://openalex.org/W4318923555","https://openalex.org/W4322761764","https://openalex.org/W4365138589","https://openalex.org/W4386704735","https://openalex.org/W4387079277","https://openalex.org/W4391592880","https://openalex.org/W4392231023","https://openalex.org/W4392303931","https://openalex.org/W4394808499","https://openalex.org/W4395001909","https://openalex.org/W4399435116","https://openalex.org/W4401712318","https://openalex.org/W4401882456","https://openalex.org/W4402210752","https://openalex.org/W4404353474","https://openalex.org/W4405194816","https://openalex.org/W4405260951","https://openalex.org/W4405979592","https://openalex.org/W4408089674","https://openalex.org/W4412185834"],"related_works":["https://openalex.org/W7130491101","https://openalex.org/W4405194816","https://openalex.org/W4395001909","https://openalex.org/W7125948085","https://openalex.org/W4417202771","https://openalex.org/W4405194369","https://openalex.org/W4413607686","https://openalex.org/W4412156552","https://openalex.org/W4413983485","https://openalex.org/W7203479832"],"abstract_inverted_index":{"Background:":[0],"Although":[1],"emerging":[2],"classification":[3,55],"systems":[4,56,148],"address":[5],"the":[6,16,128,140,173,189,199,203,214,224,232,248],"pathophysiological":[7],"heterogeneity":[8],"of":[9,18,51,250],"metabolic":[10,59,251],"dysfunction-associated":[11],"steatotic":[12],"liver":[13,111,121],"disease":[14],"(MASLD),":[15],"implications":[17],"these":[19],"subtypes":[20,240],"for":[21,31],"treatment":[22],"responses":[23,33,99,212,243],"remain":[24],"unclear.We":[25],"systematically":[26],"evaluated":[27],"three":[28],"phenotyping":[29],"frameworks":[30],"stratifying":[32],"to":[34,170,186,198,244,256],"lifestyle":[35,53,245],"management.Methods:":[36],"This":[37],"prospective":[38],"observational":[39],"cohort":[40],"study":[41],"included":[42],"618":[43],"patients":[44],"with":[45,223],"MASLD":[46,62,65,73,79,239],"who":[47],"received":[48],"48":[49],"weeks":[50],"guideline-based":[52],"management.The":[54],"assessed":[57],"were":[58,98],"clusters-mild":[60],"obesity/dyslipidemia-associated":[61],"(MODM),":[63],"age-related":[64],"(AM),":[66],"severe":[67,76],"insulin":[68],"resistance-associated":[69],"MASLD,":[70],"high":[71],"lipoprotein(a)-associated":[72],"(HLPAM),":[74],"and":[75,82,87,89,94,120,142,145,188,210,234],"mixed":[77,233],"hyperlipidemia-associated":[78],"(SMHLM);":[80],"hepatic":[81,141],"cardiometabolic":[83,143],"traits":[84],"(control,":[85],"liver-specific,":[86],"cardiometabolic);":[88],"biochemical":[90,146,217],"patterns":[91,218],"(hepatocellular,":[92],"mixed,":[93],"cholestatic).The":[95],"primary":[96],"endpoints":[97],"in":[100,127],"magnetic":[101],"resonance":[102],"imaging-derived":[103],"proton":[104],"density":[105],"fat":[106,112],"fraction":[107],"(MRI-PDFF)":[108],"(\u226530%":[109],"relative":[110],"reduction),":[113],"alanine":[114],"aminotransferase":[115],"(ALT)":[116],"(\u226517":[117],"IU/L":[118],"decrease),":[119],"stiffness":[122],"measurements":[123],"(LSM)":[124],"(\u22651-stage":[125],"improvement":[126],"LSM-defined":[129],"fibrosis":[130],"stage).Results:":[131],"Metabolic":[132,237],"clusters":[133],"demonstrated":[134,156],"significantly":[135],"greater":[136,229],"temporal":[137],"stability":[138],"than":[139,213,231],"trait":[144],"pattern":[147,226],"(62.8%":[149],"vs.":[150,152],"56.6%":[151],"53.4%,P=0.003).The":[153],"HLPAM":[154],"cluster":[155,175,191,205],"an":[157],"attenuated":[158],"MRI-PDFF":[159],"response":[160,180,196,230],"(odds":[161],"ratio":[162],"[OR],":[163],"0.35;":[164],"95%":[165,183],"confidence":[166],"interval":[167],"[CI],":[168],"0.15":[169],"0.79),":[171],"while":[172],"AM":[174],"showed":[176,206],"a":[177,193,228],"lower":[178],"ALT":[179,221],"(OR,":[181],"0.33;":[182],"CI,":[184],"0.18":[185],"0.62),":[187],"MODM":[190],"displayed":[192],"superior":[194],"LSM":[195,211],"compared":[197],"others":[200],"(all":[201],"P<0.05).Moreover,":[202],"liver-specific":[204],"better":[207],"MRI-PDFF,":[208],"ALT,":[209],"control":[215],"cluster.However,":[216],"selectively":[219],"stratified":[220],"responses,":[222],"hepatocellular":[225],"demonstrating":[227],"cholestatic":[235],"patterns.Conclusion:":[236],"cluster-based":[238],"exhibited":[241],"differential":[242],"management,":[246],"supporting":[247],"integration":[249],"subtyping":[252],"into":[253],"clinical":[254],"algorithms":[255],"optimize":[257],"management.":[258]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-10-23T00:00:00"}