{"id":"https://openalex.org/W7223189059","doi":"https://doi.org/10.3390/biom16101537","title":"Platelet Membrane Transporters in Health and Disease: Basic Biology and Clinical Relevance","display_name":"Platelet Membrane Transporters in Health and Disease: Basic Biology and Clinical Relevance","publication_year":2026,"publication_date":"2026-10-21","ids":{"openalex":"https://openalex.org/W7223189059","doi":"https://doi.org/10.3390/biom16101537","pmid":"https://pubmed.ncbi.nlm.nih.gov/42939791","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13702257"},"language":"en","primary_location":{"id":"doi:10.3390/biom16101537","doi":"https://doi.org/10.3390/biom16101537","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom16101537","pdf_url":null,"source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biom16101537","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056260151","display_name":"Deepa Gautam","orcid":"https://orcid.org/0000-0003-2437-6136","observed_orcids":["https://orcid.org/0000-0003-2437-6136"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepa Gautam","raw_affiliation_strings":["Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054051906","display_name":"Ana Kasirer\u2010Friede","orcid":"https://orcid.org/0000-0001-5970-828X","observed_orcids":["https://orcid.org/0000-0001-5970-828X"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ana Kasirer-Friede","raw_affiliation_strings":["Department of Medicine, University of California, La Jolla, CA 92037, USA"],"raw_orcid":"https://orcid.org/0000-0001-5970-828X","affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I2803209242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054051906"],"corresponding_institution_ids":["https://openalex.org/I2803209242"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62537538,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"10","first_page":"1537","last_page":"1537"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.6244999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.6244999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.3564000129699707,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.925000011920929},{"id":"https://openalex.org/keywords/solute-carriers","display_name":"solute carrier transporters","score":0.9670000076293945},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/platelet-metabolism","display_name":"platelet metabolism","score":0.7670000195503235},{"id":"https://openalex.org/keywords/megakaryocytes","display_name":"megakaryocytes","score":0.8999999761581421},{"id":"https://openalex.org/keywords/mitochondrial-transporters","display_name":"mitochondrial transporters","score":0.9010000228881836},{"id":"https://openalex.org/keywords/secretory-granules","display_name":"secretory granules","score":0.8190000057220459},{"id":"https://openalex.org/keywords/drug-transporters","display_name":"drug transporters","score":0.6539999842643738},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7710000276565552},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.7519999742507935},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.7584999799728394},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.730400025844574},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5353000164031982},{"id":"https://openalex.org/C168785527","wikidata":"https://www.wikidata.org/wiki/Q1401099","display_name":"Solute carrier family","level":4,"score":0.4740999937057495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46480000019073486},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4025999903678894},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39329999685287476},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.3869999945163727},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.37619999051094055},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3547999858856201},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.35339999198913574},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.3465000092983246},{"id":"https://openalex.org/C159973064","wikidata":"https://www.wikidata.org/wiki/Q3740205","display_name":"Platelet factor 4","level":3,"score":0.3427000045776367},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.32339999079704285},{"id":"https://openalex.org/C2781295650","wikidata":"https://www.wikidata.org/wiki/Q5259304","display_name":"Dense granule","level":4,"score":0.31619998812675476},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.3154999911785126},{"id":"https://openalex.org/C57947595","wikidata":"https://www.wikidata.org/wiki/Q7886088","display_name":"Membrane transport","level":3,"score":0.30550000071525574},{"id":"https://openalex.org/C115335371","wikidata":"https://www.wikidata.org/wiki/Q142943","display_name":"Membrane transport protein","level":4,"score":0.29760000109672546},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.29670000076293945},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.27869999408721924},{"id":"https://openalex.org/C2910090564","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet disorder","level":3,"score":0.27799999713897705},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27720001339912415},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.2526000142097473}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/biom16101537","doi":"https://doi.org/10.3390/biom16101537","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom16101537","pdf_url":null,"source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13702257","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13702257/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13702257/pdf/biomolecules-16-01537.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Text"},{"id":"pmid:42939791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42939791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ffa9c1e1d7764adcba0e4350d742eff2","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ffa9c1e1d7764adcba0e4350d742eff2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomolecules, Vol 16, Iss 10, p 1537 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biom16101537","doi":"https://doi.org/10.3390/biom16101537","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom16101537","pdf_url":null,"source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223189059.pdf","grobid_xml":"https://content.openalex.org/works/W7223189059.grobid-xml"},"referenced_works_count":178,"referenced_works":["https://openalex.org/W158708483","https://openalex.org/W169471785","https://openalex.org/W1487573233","https://openalex.org/W1490935970","https://openalex.org/W1518083799","https://openalex.org/W1566320782","https://openalex.org/W1593020520","https://openalex.org/W1595731264","https://openalex.org/W1634875980","https://openalex.org/W1875036886","https://openalex.org/W1877088739","https://openalex.org/W1921096966","https://openalex.org/W1957718603","https://openalex.org/W1965375035","https://openalex.org/W1966171520","https://openalex.org/W1966974462","https://openalex.org/W1968600119","https://openalex.org/W1969393140","https://openalex.org/W1973115281","https://openalex.org/W1973609285","https://openalex.org/W1979438759","https://openalex.org/W1986246195","https://openalex.org/W1986473204","https://openalex.org/W1994195073","https://openalex.org/W1994440886","https://openalex.org/W1996120254","https://openalex.org/W1997432723","https://openalex.org/W2001248844","https://openalex.org/W2003151061","https://openalex.org/W2003313355","https://openalex.org/W2006774891","https://openalex.org/W2013961293","https://openalex.org/W2016026530","https://openalex.org/W2020628354","https://openalex.org/W2024833137","https://openalex.org/W2036021040","https://openalex.org/W2040163154","https://openalex.org/W2044784385","https://openalex.org/W2050173346","https://openalex.org/W2050701385","https://openalex.org/W2053896453","https://openalex.org/W2060756682","https://openalex.org/W2065240905","https://openalex.org/W2065965392","https://openalex.org/W2070239715","https://openalex.org/W2071235465","https://openalex.org/W2074707530","https://openalex.org/W2079750295","https://openalex.org/W2089840961","https://openalex.org/W2096965078","https://openalex.org/W2103888323","https://openalex.org/W2107156397","https://openalex.org/W2107789427","https://openalex.org/W2109173430","https://openalex.org/W2111383481","https://openalex.org/W2111935912","https://openalex.org/W2113787373","https://openalex.org/W2117061040","https://openalex.org/W2120287434","https://openalex.org/W2124549431","https://openalex.org/W2124558063","https://openalex.org/W2129100727","https://openalex.org/W2135745360","https://openalex.org/W2150650800","https://openalex.org/W2154026883","https://openalex.org/W2155766871","https://openalex.org/W2161713635","https://openalex.org/W2161983628","https://openalex.org/W2167213283","https://openalex.org/W2264953651","https://openalex.org/W2326139126","https://openalex.org/W2334701002","https://openalex.org/W2416476767","https://openalex.org/W2462290158","https://openalex.org/W2480879280","https://openalex.org/W2514448720","https://openalex.org/W2526653747","https://openalex.org/W2532290661","https://openalex.org/W2553460821","https://openalex.org/W2559666645","https://openalex.org/W2719511353","https://openalex.org/W2730423879","https://openalex.org/W2733907738","https://openalex.org/W2736776512","https://openalex.org/W2745650245","https://openalex.org/W2746416419","https://openalex.org/W2766704126","https://openalex.org/W2782193680","https://openalex.org/W2782225074","https://openalex.org/W2788865076","https://openalex.org/W2792316622","https://openalex.org/W2795810461","https://openalex.org/W2797346936","https://openalex.org/W2808299042","https://openalex.org/W2810841942","https://openalex.org/W2811095894","https://openalex.org/W2886216008","https://openalex.org/W2887932420","https://openalex.org/W2890423459","https://openalex.org/W2893755068","https://openalex.org/W2942872262","https://openalex.org/W3002056211","https://openalex.org/W3016449273","https://openalex.org/W3030323428","https://openalex.org/W3035636651","https://openalex.org/W3036186038","https://openalex.org/W3037444348","https://openalex.org/W3041322354","https://openalex.org/W3081327317","https://openalex.org/W3082822457","https://openalex.org/W3089281398","https://openalex.org/W3093377868","https://openalex.org/W3110506885","https://openalex.org/W3111946351","https://openalex.org/W3134947063","https://openalex.org/W3138622311","https://openalex.org/W3156356623","https://openalex.org/W3183336909","https://openalex.org/W3184388347","https://openalex.org/W3199406508","https://openalex.org/W3211795435","https://openalex.org/W3217417474","https://openalex.org/W4200261294","https://openalex.org/W4220920153","https://openalex.org/W4221011693","https://openalex.org/W4241801356","https://openalex.org/W4247741685","https://openalex.org/W4248872138","https://openalex.org/W4291017913","https://openalex.org/W4297817894","https://openalex.org/W4306836025","https://openalex.org/W4310589076","https://openalex.org/W4318065352","https://openalex.org/W4318480592","https://openalex.org/W4320489702","https://openalex.org/W4321186876","https://openalex.org/W4323665826","https://openalex.org/W4366824502","https://openalex.org/W4367050069","https://openalex.org/W4377030359","https://openalex.org/W4381190188","https://openalex.org/W4381190317","https://openalex.org/W4381716090","https://openalex.org/W4384522429","https://openalex.org/W4385072463","https://openalex.org/W4388491013","https://openalex.org/W4391109671","https://openalex.org/W4391146453","https://openalex.org/W4391322572","https://openalex.org/W4391847965","https://openalex.org/W4394682776","https://openalex.org/W4399979090","https://openalex.org/W4403896234","https://openalex.org/W4408020348","https://openalex.org/W4408089258","https://openalex.org/W4410384141","https://openalex.org/W4411367476","https://openalex.org/W4411535632","https://openalex.org/W4411900588","https://openalex.org/W4412458880","https://openalex.org/W4412728973","https://openalex.org/W4414444398","https://openalex.org/W4414644603","https://openalex.org/W4415069855","https://openalex.org/W4415897511","https://openalex.org/W4416716851","https://openalex.org/W4416887711","https://openalex.org/W4416969011","https://openalex.org/W7115193864","https://openalex.org/W7117158482","https://openalex.org/W7123804940","https://openalex.org/W7125543153","https://openalex.org/W7130406910","https://openalex.org/W7140077370","https://openalex.org/W7140125677","https://openalex.org/W7163806042","https://openalex.org/W7167514843","https://openalex.org/W7168464568"],"related_works":["https://openalex.org/W1986246195","https://openalex.org/W2003313355","https://openalex.org/W2719511353","https://openalex.org/W4381190317","https://openalex.org/W2416476767","https://openalex.org/W2065965392","https://openalex.org/W2417210717","https://openalex.org/W3045198913","https://openalex.org/W2070923993","https://openalex.org/W2725207539"],"abstract_inverted_index":{"Platelet":[0],"surface":[1],"adhesion":[2],"receptors":[3],"and":[4,27,33,39,74,91,98,102,114,134,169,176,193,213],"intracellular":[5],"signaling":[6],"proteins":[7,85],"have":[8,41,185],"been":[9,186],"the":[10,18,75,88,123,143],"focus":[11],"of":[12,20,55,62,93,96,145,181,190,208],"platelet":[13,115,126,146,156,164,218],"research":[14],"for":[15,49],"decades,":[16],"with":[17,166,172],"aim":[19],"understanding":[21],"how":[22],"they":[23],"contribute":[24],"to":[25,119,131,139,151,154,161],"hemostatic":[26],"thrombotic":[28],"functions.":[29],"However,":[30],"membrane":[31,84],"transporters":[32,63,120,127,147],"their":[34,47,66],"respective":[35],"roles":[36],"in":[37,65,122],"platelets":[38],"megakaryocytes":[40],"received":[42],"relatively":[43],"little":[44],"attention,":[45],"despite":[46],"importance":[48],"cellular":[50,112],"regulation.":[51],"Platelets":[52],"harbor":[53],"members":[54,81,180],"two":[56,183],"principal":[57],"structurally":[58],"dissimilar":[59],"large":[60],"families":[61,184],"differing":[64],"energy":[67],"source:":[68],"ABC":[69],"(ATP-binding":[70],"cassette)":[71],"transporter":[72,203,214],"family":[73],"solute":[76],"carrier":[77],"(SLC)":[78],"family.":[79],"Family":[80],"comprise":[82],"integral":[83],"that":[86],"control":[87],"uptake,":[89],"distribution":[90],"excretion":[92],"a":[94,217],"variety":[95],"nutrients":[97],"metabolites,":[99],"lipids,":[100],"iron":[101],"drugs":[103],"across":[104],"concentration":[105],"gradients,":[106],"thereby":[107],"exerting":[108],"significant":[109],"influence":[110],"over":[111],"metabolism":[113],"activation.":[116],"In":[117,198],"addition":[118],"found":[121],"plasma":[124],"membrane,":[125],"may":[128,159],"also":[129],"localize":[130],"lysosomal,":[132],"mitochondrial":[133],"secretion":[135],"granule":[136],"membranes":[137],"or":[138],"additional":[140],"organelles.":[141],"Interestingly,":[142],"impact":[144],"does":[148],"not":[149],"appear":[150],"be":[152],"limited":[153],"canonical":[155],"functions":[157],"but":[158],"extend":[160],"recently":[162],"established":[163],"interactions":[165],"immune":[167],"cells":[168],"selected":[170],"tissues,":[171],"repercussions":[173],"on":[174],"health":[175],"disease.":[177],"More":[178],"recently,":[179],"these":[182],"recognized":[187],"as":[188,195],"modulators":[189],"drug":[191],"efficacy":[192],"proposed":[194],"therapeutic":[196],"targets.":[197],"this":[199],"review":[200],"we":[201],"describe":[202],"structure,":[204],"corresponding":[205],"molecular":[206],"mechanisms":[207],"cargo":[209],"transport,":[210],"functional":[211],"significance,":[212],"regulation,":[215],"within":[216],"framework.":[219]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-22T00:00:00"}
