{"id":"https://openalex.org/W7223188597","doi":"https://doi.org/10.3389/fcimb.2026.1984688","title":"Isolate-level pathogenic heterogeneity in keratitis caused by the Fusarium solani species complex: corneal invasion, host immunopathology, and model fidelity","display_name":"Isolate-level pathogenic heterogeneity in keratitis caused by the Fusarium solani species complex: corneal invasion, host immunopathology, and model fidelity","publication_year":2026,"publication_date":"2026-10-22","ids":{"openalex":"https://openalex.org/W7223188597","doi":"https://doi.org/10.3389/fcimb.2026.1984688","pmid":"https://pubmed.ncbi.nlm.nih.gov/42991097","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13736035"},"language":"en","primary_location":{"id":"doi:10.3389/fcimb.2026.1984688","doi":"https://doi.org/10.3389/fcimb.2026.1984688","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1984688","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1984688/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1984688/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102061040","display_name":"Xin He","orcid":"https://orcid.org/0009-0006-7416-6179","observed_orcids":["https://orcid.org/0009-0006-7416-6179"]},"institutions":[{"id":"https://openalex.org/I167383011","display_name":"Henan University of Science and Technology","ror":"https://ror.org/05d80kz58","country_code":"CN","type":"education","lineage":["https://openalex.org/I167383011"]},{"id":"https://openalex.org/I4210113613","display_name":"Fifth Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/01wfgh551","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113613"]},{"id":"https://openalex.org/I4210134906","display_name":"First Affiliated Hospital of Henan University of Science and Technology","ror":"https://ror.org/035zbbv42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin He","raw_affiliation_strings":["Department of Clinical Laboratory, The Fifth Affiliated Hospital of Zhengzhou University","Henan Academy of Innovations in Medical Science Eye Institute","The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, The Fifth Affiliated Hospital of Zhengzhou University","institution_ids":["https://openalex.org/I4210113613"]},{"raw_affiliation_string":"Henan Academy of Innovations in Medical Science Eye Institute","institution_ids":[]},{"raw_affiliation_string":"The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology","institution_ids":["https://openalex.org/I167383011","https://openalex.org/I4210134906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128117584","display_name":"Ze Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I167383011","display_name":"Henan University of Science and Technology","ror":"https://ror.org/05d80kz58","country_code":"CN","type":"education","lineage":["https://openalex.org/I167383011"]},{"id":"https://openalex.org/I4210134906","display_name":"First Affiliated Hospital of Henan University of Science and Technology","ror":"https://ror.org/035zbbv42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ze Li","raw_affiliation_strings":["The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology","institution_ids":["https://openalex.org/I167383011","https://openalex.org/I4210134906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136110959","display_name":"Shifei Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shifei Wei","raw_affiliation_strings":["Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159251686","display_name":"Yunyun Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunyun Sun","raw_affiliation_strings":["Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084086991","display_name":"\u6587\u5728 \u5b89","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260564","display_name":"Beijing Aier Eye Hospital","ror":"https://ror.org/03yvmd717","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405260564"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenzai An","raw_affiliation_strings":["Beijing Aier-Intech Eye Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Aier-Intech Eye Hospital","institution_ids":["https://openalex.org/I4405260564"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125698179","display_name":"Qinyi Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinyi Cui","raw_affiliation_strings":["Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159223115","display_name":"Tao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I167383011","display_name":"Henan University of Science and Technology","ror":"https://ror.org/05d80kz58","country_code":"CN","type":"education","lineage":["https://openalex.org/I167383011"]},{"id":"https://openalex.org/I4210134906","display_name":"First Affiliated Hospital of Henan University of Science and Technology","ror":"https://ror.org/035zbbv42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Wang","raw_affiliation_strings":["The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology","institution_ids":["https://openalex.org/I167383011","https://openalex.org/I4210134906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128089729","display_name":"Qiuli Ming","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiuli Ming","raw_affiliation_strings":["The Third Affiliated Hospital of Henan Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Affiliated Hospital of Henan Medical University","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159223291","display_name":"Ningli Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ningli Wang","raw_affiliation_strings":["Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University","Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University","Henan Academy of Innovations in Medical Science Eye Institute","National Engineering Research Center for Ophthalmic Equipment"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]},{"raw_affiliation_string":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]},{"raw_affiliation_string":"Henan Academy of Innovations in Medical Science Eye Institute","institution_ids":[]},{"raw_affiliation_string":"National Engineering Research Center for Ophthalmic Equipment","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5159223291"],"corresponding_institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.63459379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"1984688","last_page":"1984688"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10825","display_name":"Plant Pathogens and Fungal Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fusarium-solani-species-complex","display_name":"Fusarium solani species complex","score":0.9750000238418579},{"id":"https://openalex.org/keywords/fungal-keratitis","display_name":"fungal keratitis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/corneal-invasion","display_name":"corneal invasion","score":0.9319999814033508},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/epithelial-cell-adhesion","display_name":"epithelial cell adhesion","score":0.7940000295639038},{"id":"https://openalex.org/keywords/antifungal-therapy","display_name":"antifungal therapy","score":0.6610000133514404},{"id":"https://openalex.org/keywords/model-fidelity","display_name":"model fidelity","score":0.5720000267028809},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.771399974822998},{"id":"https://openalex.org/C2778560704","wikidata":"https://www.wikidata.org/wiki/Q757838","display_name":"Keratitis","level":2,"score":0.6963000297546387},{"id":"https://openalex.org/C2778342517","wikidata":"https://www.wikidata.org/wiki/Q5509914","display_name":"Fusarium solani","level":2,"score":0.6068999767303467},{"id":"https://openalex.org/C2776079991","wikidata":"https://www.wikidata.org/wiki/Q5509171","display_name":"Fungal keratitis","level":3,"score":0.4909999966621399},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.47040000557899475},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.459199994802475},{"id":"https://openalex.org/C2778867309","wikidata":"https://www.wikidata.org/wiki/Q131672","display_name":"Fusarium","level":2,"score":0.41510000824928284},{"id":"https://openalex.org/C2780690907","wikidata":"https://www.wikidata.org/wiki/Q412236","display_name":"Voriconazole","level":3,"score":0.3878999948501587},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.38760000467300415},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.3675000071525574},{"id":"https://openalex.org/C2780908437","wikidata":"https://www.wikidata.org/wiki/Q464067","display_name":"Mycosis","level":2,"score":0.36629998683929443},{"id":"https://openalex.org/C2778394675","wikidata":"https://www.wikidata.org/wiki/Q648056","display_name":"Fungi imperfecti","level":2,"score":0.3366999924182892},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32710000872612},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.32330000400543213},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3221000134944916},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3109000027179718},{"id":"https://openalex.org/C3020564189","wikidata":"https://www.wikidata.org/wiki/Q16963978","display_name":"Host factors","level":3,"score":0.30379998683929443},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.30239999294281006},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2870999872684479},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2709999978542328},{"id":"https://openalex.org/C2779257441","wikidata":"https://www.wikidata.org/wiki/Q2040445","display_name":"Corneal epithelium","level":3,"score":0.2637999951839447},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.2551000118255615}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005670","descriptor_name":"Fusarium","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D005670","descriptor_name":"Fusarium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005670","descriptor_name":"Fusarium","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005670","descriptor_name":"Fusarium","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D005670","descriptor_name":"Fusarium","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007634","descriptor_name":"Keratitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007634","descriptor_name":"Keratitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D007634","descriptor_name":"Keratitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015821","descriptor_name":"Eye Infections, Fungal","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D015821","descriptor_name":"Eye Infections, Fungal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D060585","descriptor_name":"Fusariosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D060585","descriptor_name":"Fusariosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D060585","descriptor_name":"Fusariosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fcimb.2026.1984688","doi":"https://doi.org/10.3389/fcimb.2026.1984688","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1984688","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1984688/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13736035","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13736035/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13736035/pdf/fcimb-16-1984688.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Infect Microbiol","raw_type":"Text"},{"id":"pmid:42991097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42991097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular and infection microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:91180bf38475497c8201afa8cf68cae0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/91180bf38475497c8201afa8cf68cae0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular and Infection Microbiology, Vol 16 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcimb.2026.1984688","doi":"https://doi.org/10.3389/fcimb.2026.1984688","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2026.1984688","pdf_url":"https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1984688/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8525692691","display_name":null,"funder_award_id":"82301250","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223188597.pdf","grobid_xml":"https://content.openalex.org/works/W7223188597.grobid-xml"},"referenced_works_count":157,"referenced_works":["https://openalex.org/W875975650","https://openalex.org/W1501836292","https://openalex.org/W1807530168","https://openalex.org/W1963920406","https://openalex.org/W1968347085","https://openalex.org/W1977348918","https://openalex.org/W2000975660","https://openalex.org/W2014887968","https://openalex.org/W2052661353","https://openalex.org/W2053320686","https://openalex.org/W2091421632","https://openalex.org/W2099580227","https://openalex.org/W2116582646","https://openalex.org/W2133463731","https://openalex.org/W2138437709","https://openalex.org/W2159485287","https://openalex.org/W2170740826","https://openalex.org/W2302501749","https://openalex.org/W2315730225","https://openalex.org/W2551369376","https://openalex.org/W2558835478","https://openalex.org/W2566011678","https://openalex.org/W2566689903","https://openalex.org/W2605518749","https://openalex.org/W2610851342","https://openalex.org/W2614866628","https://openalex.org/W2617644039","https://openalex.org/W2766187621","https://openalex.org/W2788640168","https://openalex.org/W2793718976","https://openalex.org/W2799686534","https://openalex.org/W2921474489","https://openalex.org/W2980681798","https://openalex.org/W3009310564","https://openalex.org/W3019948019","https://openalex.org/W3094023869","https://openalex.org/W3122311573","https://openalex.org/W3134457799","https://openalex.org/W3136848181","https://openalex.org/W3155248431","https://openalex.org/W3194006911","https://openalex.org/W4200033491","https://openalex.org/W4200312785","https://openalex.org/W4200367194","https://openalex.org/W4205761809","https://openalex.org/W4206687462","https://openalex.org/W4210345141","https://openalex.org/W4225326949","https://openalex.org/W4281985799","https://openalex.org/W4291012206","https://openalex.org/W4297459986","https://openalex.org/W4297906944","https://openalex.org/W4300981562","https://openalex.org/W4303832790","https://openalex.org/W4304588747","https://openalex.org/W4307092072","https://openalex.org/W4313729332","https://openalex.org/W4319440349","https://openalex.org/W4323037431","https://openalex.org/W4365455942","https://openalex.org/W4368341754","https://openalex.org/W4379113910","https://openalex.org/W4379769603","https://openalex.org/W4381548826","https://openalex.org/W4386019657","https://openalex.org/W4386546747","https://openalex.org/W4387048308","https://openalex.org/W4387949691","https://openalex.org/W4388041294","https://openalex.org/W4390587750","https://openalex.org/W4390744049","https://openalex.org/W4390880971","https://openalex.org/W4391365331","https://openalex.org/W4392809275","https://openalex.org/W4392955093","https://openalex.org/W4393074876","https://openalex.org/W4394618564","https://openalex.org/W4394935650","https://openalex.org/W4396599771","https://openalex.org/W4398557627","https://openalex.org/W4399430855","https://openalex.org/W4399728391","https://openalex.org/W4400202023","https://openalex.org/W4400239580","https://openalex.org/W4400300929","https://openalex.org/W4400621078","https://openalex.org/W4401404519","https://openalex.org/W4402193984","https://openalex.org/W4402525967","https://openalex.org/W4403027352","https://openalex.org/W4404024392","https://openalex.org/W4404079626","https://openalex.org/W4404108796","https://openalex.org/W4404243876","https://openalex.org/W4405187121","https://openalex.org/W4405542596","https://openalex.org/W4405565751","https://openalex.org/W4406338827","https://openalex.org/W4406366925","https://openalex.org/W4407080807","https://openalex.org/W4407718837","https://openalex.org/W4408329815","https://openalex.org/W4409200188","https://openalex.org/W4409466454","https://openalex.org/W4409657589","https://openalex.org/W4409822961","https://openalex.org/W4410403227","https://openalex.org/W4410905510","https://openalex.org/W4411042496","https://openalex.org/W4411178225","https://openalex.org/W4411371642","https://openalex.org/W4411374239","https://openalex.org/W4412549119","https://openalex.org/W4413026260","https://openalex.org/W4413351527","https://openalex.org/W4413923362","https://openalex.org/W4413943145","https://openalex.org/W4414066242","https://openalex.org/W4414366169","https://openalex.org/W4414391120","https://openalex.org/W4414410815","https://openalex.org/W4414649785","https://openalex.org/W4415046590","https://openalex.org/W4415271210","https://openalex.org/W4415873253","https://openalex.org/W4415961622","https://openalex.org/W4416161992","https://openalex.org/W4416224833","https://openalex.org/W4416565818","https://openalex.org/W4416788473","https://openalex.org/W4416976868","https://openalex.org/W4417162246","https://openalex.org/W4417168618","https://openalex.org/W4417356097","https://openalex.org/W4417441849","https://openalex.org/W4417474244","https://openalex.org/W7124422925","https://openalex.org/W7125372991","https://openalex.org/W7125385624","https://openalex.org/W7125688441","https://openalex.org/W7127587340","https://openalex.org/W7131645090","https://openalex.org/W7133233214","https://openalex.org/W7133877787","https://openalex.org/W7143372430","https://openalex.org/W7147268324","https://openalex.org/W7147745639","https://openalex.org/W7150825701","https://openalex.org/W7151013760","https://openalex.org/W7155033706","https://openalex.org/W7160514938","https://openalex.org/W7164059298","https://openalex.org/W7165143448","https://openalex.org/W7165896539","https://openalex.org/W7166330664","https://openalex.org/W7172416235","https://openalex.org/W7172513833"],"related_works":["https://openalex.org/W4415873253","https://openalex.org/W4406430890","https://openalex.org/W7128616703","https://openalex.org/W2802711529","https://openalex.org/W2889476221","https://openalex.org/W3207401204","https://openalex.org/W4200312785","https://openalex.org/W4389272812","https://openalex.org/W2738567488","https://openalex.org/W4225326949"],"abstract_inverted_index":{"species":[0],"complex":[1],"(FSSC)":[2],"often":[3],"progresses":[4],"despite":[5],"antifungal":[6,59],"therapy":[7],"and":[8,32,40,58,93,105,115,155,169,171,176],"can":[9],"result":[10],"in":[11,46],"irreversible":[12],"visual":[13],"loss.":[14],"Yet":[15],"biological":[16],"diversity":[17],"within":[18],"FSSC":[19,132],"has":[20],"not":[21,69],"been":[22],"integrated":[23],"across":[24],"taxonomy,":[25],"isolate":[26,123],"phenotype,":[27],"corneal":[28,125],"models,":[29],"host":[30,89],"response,":[31],"clinical":[33,41,78,122,157],"outcome.":[34],"This":[35],"Review":[36],"synthesizes":[37],"taxonomic,":[38],"experimental,":[39],"evidence":[42],"on":[43],"isolate-level":[44],"variation":[45],"adhesion,":[47],"epithelial":[48,85],"entry,":[49],"stromal":[50,87],"invasion,":[51],"biofilm":[52],"formation,":[53],"tissue":[54,94,167],"damage,":[55],"immune":[56],"activation,":[57],"response.":[60],"Available":[61],"data":[62],"support":[63],"substantial":[64],"isolate-dependent":[65],"heterogeneity":[66],"but":[67],"do":[68],"justify":[70],"a":[71,138],"stable":[72],"species-":[73],"or":[74],"member-level":[75],"ranking":[76],"of":[77],"severity.":[79],"Fungal":[80],"developmental":[81],"state,":[82],"inoculation":[83],"route,":[84],"integrity,":[86],"architecture,":[88],"immunity,":[90],"treatment":[91],"timing,":[92],"drug":[95,153],"exposure":[96,168],"all":[97],"modify":[98],"the":[99,119],"phenotype":[100],"observed.":[101],"Cell,":[102],"tissue,":[103],"animal,":[104],"human-specimen":[106],"models":[107],"therefore":[108],"provide":[109],"complementary":[110],"rather":[111],"than":[112],"interchangeable":[113],"evidence,":[114],"few":[116],"studies":[117],"carry":[118],"same":[120],"authenticated":[121],"from":[124,165],"testing":[126],"to":[127],"longitudinal":[128],"patient":[129],"outcomes.":[130],"Refractory":[131],"keratitis":[133],"is":[134],"best":[135],"investigated":[136],"through":[137],"matched":[139],"isolate-model-patient":[140],"approach":[141],"integrating":[142],"multilocus":[143],"authentication,":[144],"spatial":[145],"fungal":[146],"localization,":[147],"viable":[148],"burden,":[149],"host-mediated":[150],"injury,":[151],"compartment-specific":[152],"exposure,":[154],"prespecified":[156],"endpoints.":[158],"Such":[159],"designs":[160],"could":[161],"distinguish":[162],"persistent":[163],"infection":[164],"inadequate":[166],"immunopathology":[170],"thereby":[172],"improve":[173],"risk":[174],"stratification":[175],"therapeutic":[177],"development.":[178]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-22T00:00:00"}