{"id":"https://openalex.org/W7223185161","doi":"https://doi.org/10.3389/fbioe.2026.1977317","title":"Engineered delivery of Chinese herbal medicine-derived therapeutics for diabetic wound healing: a focus on NF-\u03baB cascade modulation","display_name":"Engineered delivery of Chinese herbal medicine-derived therapeutics for diabetic wound healing: a focus on NF-\u03baB cascade modulation","publication_year":2026,"publication_date":"2026-10-22","ids":{"openalex":"https://openalex.org/W7223185161","doi":"https://doi.org/10.3389/fbioe.2026.1977317","pmid":"https://pubmed.ncbi.nlm.nih.gov/42991065","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13736087"},"language":"en","primary_location":{"id":"doi:10.3389/fbioe.2026.1977317","doi":"https://doi.org/10.3389/fbioe.2026.1977317","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2026.1977317","pdf_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1977317/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1977317/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159224233","display_name":"Boxun Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Boxun Chen","raw_affiliation_strings":["Beijing University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159230618","display_name":"Qing Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Wang","raw_affiliation_strings":["Beijing University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159245587","display_name":"Jialun Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jialun Zhang","raw_affiliation_strings":["Beijing University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159231313","display_name":"Xiaoshan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoshan Li","raw_affiliation_strings":["Beijing University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159253780","display_name":"Ning Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]},{"id":"https://openalex.org/I4210121586","display_name":"Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine","ror":"https://ror.org/02yacz525","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121586"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Wang","raw_affiliation_strings":["Dongzhimen Hospital, Beijing University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dongzhimen Hospital, Beijing University of Chinese Medicine","institution_ids":["https://openalex.org/I17747738","https://openalex.org/I4210121586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159242496","display_name":"Meiling Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meiling Zou","raw_affiliation_strings":["Beijing University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101547685","display_name":"Zhichao Huang","orcid":"https://orcid.org/0000-0002-1222-4613","observed_orcids":["https://orcid.org/0000-0002-1222-4613"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhichao Huang","raw_affiliation_strings":["Beijing University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100605509","display_name":"Jiayue Feng","orcid":"https://orcid.org/0000-0003-3746-2877","observed_orcids":["https://orcid.org/0000-0003-3746-2877"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayue Feng","raw_affiliation_strings":["Beijing University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152171578","display_name":"Guangheng Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guangheng Zhang","raw_affiliation_strings":["Chengdu University of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103206444","display_name":"Shang Ju","orcid":"https://orcid.org/0009-0004-5067-1061","observed_orcids":["https://orcid.org/0009-0004-5067-1061","https://orcid.org/0000-0002-5263-7404"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]},{"id":"https://openalex.org/I4210121586","display_name":"Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine","ror":"https://ror.org/02yacz525","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121586"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shang Ju","raw_affiliation_strings":["Dongzhimen Hospital, Beijing University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dongzhimen Hospital, Beijing University of Chinese Medicine","institution_ids":["https://openalex.org/I17747738","https://openalex.org/I4210121586"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5103206444","https://openalex.org/A5152171578"],"corresponding_institution_ids":["https://openalex.org/I17747738","https://openalex.org/I4210121586","https://openalex.org/I53411278"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.65851983,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":"1977317","last_page":"1977317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-wound-healing","display_name":"diabetic wound healing","score":0.984000027179718},{"id":"https://openalex.org/keywords/chinese-herbal-medicine","display_name":"Chinese herbal medicine","score":0.8370000123977661},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9430000185966492},{"id":"https://openalex.org/keywords/wound-inflammation","display_name":"wound inflammation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/ikappabalpha-phosphorylation","display_name":"I\u03baB\u03b1 phosphorylation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/nf-kappab-p65","display_name":"NF-\u03baB p65","score":0.746999979019165},{"id":"https://openalex.org/keywords/ikappab-kinase","display_name":"I\u03baB kinase","score":0.8529999852180481},{"id":"https://openalex.org/keywords/local-drug-delivery","display_name":"local drug delivery","score":0.6650000214576721},{"id":"https://openalex.org/keywords/topical-preparations","display_name":"topical formulation","score":0.5},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5130000114440918},{"id":"https://openalex.org/keywords/immune-dysregulation","display_name":"immune dysregulation","score":0.6190000176429749},{"id":"https://openalex.org/keywords/wound-exudate","display_name":"wound exudate","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7247999906539917},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6154999732971191},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.5902000069618225},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5450000166893005},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.477400004863739},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37380000948905945},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3714999854564667},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.35510000586509705},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.32280001044273376},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.30250000953674316},{"id":"https://openalex.org/C191172861","wikidata":"https://www.wikidata.org/wiki/Q7899321","display_name":"Upstream (networking)","level":2,"score":0.28929999470710754},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2720000147819519},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.2676999866962433},{"id":"https://openalex.org/C2991678113","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immune modulation","level":3,"score":0.2624000012874603},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2581999897956848},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.25529998540878296},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.2535000145435333}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fbioe.2026.1977317","doi":"https://doi.org/10.3389/fbioe.2026.1977317","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2026.1977317","pdf_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1977317/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13736087","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13736087/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13736087/pdf/fbioe-14-1977317.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Bioeng Biotechnol","raw_type":"Text"},{"id":"pmid:42991065","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42991065","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioengineering and biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:59282a50f01a4fddb8cc9a6177bf41b2","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/59282a50f01a4fddb8cc9a6177bf41b2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioengineering and Biotechnology, Vol 14 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fbioe.2026.1977317","doi":"https://doi.org/10.3389/fbioe.2026.1977317","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2026.1977317","pdf_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1977317/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320329860","display_name":"National Science and Technology Major Project","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223185161.pdf","grobid_xml":"https://content.openalex.org/works/W7223185161.grobid-xml"},"referenced_works_count":125,"referenced_works":["https://openalex.org/W1501881225","https://openalex.org/W1913879859","https://openalex.org/W1973668238","https://openalex.org/W1976194786","https://openalex.org/W1983486452","https://openalex.org/W2027604422","https://openalex.org/W2030686490","https://openalex.org/W2069356140","https://openalex.org/W2071296698","https://openalex.org/W2079167630","https://openalex.org/W2110231257","https://openalex.org/W2115001670","https://openalex.org/W2120472250","https://openalex.org/W2124343538","https://openalex.org/W2134161094","https://openalex.org/W2138934663","https://openalex.org/W2140053284","https://openalex.org/W2149411404","https://openalex.org/W2159979956","https://openalex.org/W2164481653","https://openalex.org/W2275879522","https://openalex.org/W2335887725","https://openalex.org/W2400239628","https://openalex.org/W2612887604","https://openalex.org/W2621934018","https://openalex.org/W2735527928","https://openalex.org/W2766083858","https://openalex.org/W2792943924","https://openalex.org/W2888404374","https://openalex.org/W2891902778","https://openalex.org/W2903038942","https://openalex.org/W2908752885","https://openalex.org/W2914966375","https://openalex.org/W2939058834","https://openalex.org/W2955708813","https://openalex.org/W2962755997","https://openalex.org/W2972889424","https://openalex.org/W2983788305","https://openalex.org/W2985821601","https://openalex.org/W3008530588","https://openalex.org/W3013389260","https://openalex.org/W3022523137","https://openalex.org/W3047528017","https://openalex.org/W3080558899","https://openalex.org/W3091175966","https://openalex.org/W3093267837","https://openalex.org/W3095836826","https://openalex.org/W3108747702","https://openalex.org/W3111019520","https://openalex.org/W3128240809","https://openalex.org/W3144604921","https://openalex.org/W3163579061","https://openalex.org/W3170519482","https://openalex.org/W3193255303","https://openalex.org/W3199890004","https://openalex.org/W3200719170","https://openalex.org/W3213026722","https://openalex.org/W4213141283","https://openalex.org/W4220692232","https://openalex.org/W4224435961","https://openalex.org/W4280504106","https://openalex.org/W4283747149","https://openalex.org/W4290730359","https://openalex.org/W4296774167","https://openalex.org/W4307396539","https://openalex.org/W4310071377","https://openalex.org/W4312067453","https://openalex.org/W4365480615","https://openalex.org/W4367050187","https://openalex.org/W4379520444","https://openalex.org/W4379742203","https://openalex.org/W4380484481","https://openalex.org/W4382751627","https://openalex.org/W4382918816","https://openalex.org/W4385379264","https://openalex.org/W4386170384","https://openalex.org/W4387564088","https://openalex.org/W4388014261","https://openalex.org/W4390453057","https://openalex.org/W4390753001","https://openalex.org/W4390919366","https://openalex.org/W4391097014","https://openalex.org/W4391262143","https://openalex.org/W4391364180","https://openalex.org/W4392343318","https://openalex.org/W4392473192","https://openalex.org/W4393382978","https://openalex.org/W4396616077","https://openalex.org/W4396920908","https://openalex.org/W4399355376","https://openalex.org/W4400314146","https://openalex.org/W4400363613","https://openalex.org/W4400690502","https://openalex.org/W4401371927","https://openalex.org/W4402758474","https://openalex.org/W4402761600","https://openalex.org/W4402853246","https://openalex.org/W4402864502","https://openalex.org/W4404290294","https://openalex.org/W4404459763","https://openalex.org/W4404828298","https://openalex.org/W4406675616","https://openalex.org/W4407418924","https://openalex.org/W4408373155","https://openalex.org/W4408380434","https://openalex.org/W4408726398","https://openalex.org/W4409195166","https://openalex.org/W4409851900","https://openalex.org/W4411030394","https://openalex.org/W4411619062","https://openalex.org/W4412391658","https://openalex.org/W4413328503","https://openalex.org/W4413790625","https://openalex.org/W4414616265","https://openalex.org/W4414618933","https://openalex.org/W4414877501","https://openalex.org/W7118536376","https://openalex.org/W7135064601","https://openalex.org/W7140294025","https://openalex.org/W7143445182","https://openalex.org/W7154147020","https://openalex.org/W7156630329","https://openalex.org/W7161379444","https://openalex.org/W7163752762","https://openalex.org/W7170071445"],"related_works":["https://openalex.org/W3215536639","https://openalex.org/W4388116830","https://openalex.org/W3194304345","https://openalex.org/W4362716691","https://openalex.org/W7172409654","https://openalex.org/W4400314146","https://openalex.org/W2335335487","https://openalex.org/W7136086591","https://openalex.org/W4415328284","https://openalex.org/W1980343965"],"abstract_inverted_index":{"Diabetic":[0],"wounds":[1,312],"are":[2,202],"chronic,":[3],"difficult-to-heal":[4],"injuries":[5],"of":[6,32,118,130,145,167,179,199,207,226,268,276,286,289,311],"the":[7,58,61,83,113,149,164,177,188,196,241,263,274,309,314,318],"skin":[8],"and":[9,25,30,45,56,86,106,121,162,247,265,272,282,307],"soft":[10],"tissues":[11],"in":[12,71,124,172],"people":[13],"with":[14,262],"diabetes.":[15],"Their":[16],"impaired":[17,69],"healing":[18,70],"involves":[19],"metabolic":[20,41],"disturbances,":[21],"oxidative":[22],"stress,":[23,42],"vascular":[24],"neural":[26],"injury,":[27],"immune":[28,43],"dysregulation,":[29],"dysfunction":[31],"reparative":[33,62,197],"cells.":[34],"Nuclear":[35],"factor":[36],"kappa":[37],"B":[38],"(NF-\u03baB)":[39],"links":[40],"responses,":[44],"tissue":[46,107,319],"repair.":[47],"Its":[48],"persistent":[49,304],"pathological":[50,305],"activation":[51,271,306],"can":[52,78,111],"maintain":[53],"wound":[54,104,150],"inflammation":[55],"impede":[57],"transition":[59,310],"to":[60,296,301,317],"phase,":[63],"representing":[64],"a":[65,218,231],"key":[66],"mechanism":[67],"underlying":[68],"diabetic":[72,173],"wounds.":[73],"Chinese":[74,168,290],"herbal":[75,169,291],"medicine-derived":[76,170,292],"therapeutics":[77,120,171,293],"modulate":[79,122],"upstream":[80,208],"NF-\u03baB":[81,209,270,298],"stimuli,":[82],"core":[84,242],"cascade,":[85,246],"downstream":[87,213],"inflammatory":[88,214,315],"output,":[89,215],"but":[90,142,300],"their":[91,123],"local":[92,135,146,165,239,259],"application":[93,166],"is":[94,294],"limited":[95],"by":[96,103,205],"poor":[97],"dispersibility":[98,114],"or":[99,115,211,228],"chemical":[100],"stability,":[101],"washout":[102],"exudate,":[105],"barriers.":[108],"Engineered":[109],"delivery":[110,136,158,160,260,288],"improve":[112],"formulation":[116],"stability":[117],"these":[119],"vitro":[125],"release.":[126],"A":[127],"small":[128],"number":[129],"studies":[131,193,220,256],"have":[132,221],"further":[133,222],"evaluated":[134],"processes":[137,261],"such":[138],"as":[139,182],"cellular":[140,266],"uptake,":[141],"direct":[143],"assessment":[144],"exposure":[147],"within":[148],"remains":[151],"limited.":[152],"This":[153],"review":[154],"examines":[155],"how":[156],"engineered":[157,200,287],"addresses":[159],"barriers":[161],"alters":[163],"wounds,":[174],"while":[175],"using":[176],"depth":[178],"NF-\u03baB-related":[180],"evidence":[181,234],"an":[183],"important":[184],"dimension":[185],"for":[186],"evaluating":[187],"reported":[189],"biological":[190],"effects.":[191],"Existing":[192],"show":[194],"that":[195],"effects":[198],"formulations":[201],"often":[203],"accompanied":[204],"attenuation":[206],"stimuli":[210],"reduced":[212,224],"whereas":[216],"only":[217],"few":[219],"detected":[223],"phosphorylation":[225],"I\u03baB\u03b1":[227],"p65.":[229],"However,":[230],"complete":[232],"causal":[233],"chain":[235],"linking":[236],"material":[237],"properties,":[238],"exposure,":[240],"I\u03baB":[243],"kinase":[244],"(IKK)\u2013I\u03baB\u03b1\u2013p65":[245],"wound-healing":[248],"outcomes":[249],"has":[250],"not":[251,295],"yet":[252],"been":[253],"established.":[254],"Future":[255],"should":[257],"align":[258],"temporal":[264],"distribution":[267],"aberrant":[269],"strengthen":[273],"evaluation":[275],"therapeutic":[277],"attribution,":[278],"critical":[279],"quality":[280],"attributes,":[281],"biocompatibility.":[283],"The":[284],"goal":[285],"suppress":[297],"continuously,":[299],"limit":[302],"its":[303],"promote":[308],"from":[313],"phase":[316],"repair":[320],"phase.":[321]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-22T00:00:00"}