{"id":"https://openalex.org/W7223180459","doi":"https://doi.org/10.1038/s41598-026-75860-y","title":"Inter-individual variation in cisplatin-induced liver injury is associated with hepatic platinum accumulation and GSH/GST-dependent defense in male mice","display_name":"Inter-individual variation in cisplatin-induced liver injury is associated with hepatic platinum accumulation and GSH/GST-dependent defense in male mice","publication_year":2026,"publication_date":"2026-10-22","ids":{"openalex":"https://openalex.org/W7223180459","doi":"https://doi.org/10.1038/s41598-026-75860-y"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-75860-y","doi":"https://doi.org/10.1038/s41598-026-75860-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-75860-y","pdf_url":"https://www.nature.com/articles/s41598-026-75860-y_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-75860-y_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159245971","display_name":"Se-Yeong Jeon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Se-Yeong Jeon","raw_affiliation_strings":["Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, 08826, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, 08826, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159250453","display_name":"Ki-Hoan Nam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ki-Hoan Nam","raw_affiliation_strings":["Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungchengbukdo, 28116, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungchengbukdo, 28116, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071577367","display_name":"Youngseo Park","orcid":"https://orcid.org/0000-0002-6329-8110","observed_orcids":["https://orcid.org/0000-0002-6329-8110"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Youngseo Park","raw_affiliation_strings":["Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, 08826, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, 08826, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159243796","display_name":"Doug-Young Ryu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Doug-Young Ryu","raw_affiliation_strings":["Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, 08826, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, 08826, Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5159243796"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.79742069,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.5952000021934509,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.5952000021934509,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.3278999924659729,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.949999988079071},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.9570000171661377},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.925000011920929},{"id":"https://openalex.org/keywords/gamma-glutamylcysteine-synthetase","display_name":"gamma-glutamylcysteine synthetase","score":0.9549999833106995},{"id":"https://openalex.org/keywords/oxidative-protein-damage","display_name":"oxidative protein damage","score":0.7419999837875366},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.8309999704360962},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.652899980545044},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.6517999768257141},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5462999939918518},{"id":"https://openalex.org/C518104683","wikidata":"https://www.wikidata.org/wiki/Q880","display_name":"Platinum","level":3,"score":0.5151000022888184},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4999000132083893},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48190000653266907},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32899999618530273},{"id":"https://openalex.org/C3018561737","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver damage","level":2,"score":0.3043000102043152},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.30300000309944153},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2727999985218048},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25999999046325684},{"id":"https://openalex.org/C2908801736","wikidata":"https://www.wikidata.org/wiki/Q9368","display_name":"Liver metabolism","level":2,"score":0.2551000118255615},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2533000111579895}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41598-026-75860-y","doi":"https://doi.org/10.1038/s41598-026-75860-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-75860-y","pdf_url":"https://www.nature.com/articles/s41598-026-75860-y_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-75860-y","doi":"https://doi.org/10.1038/s41598-026-75860-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-75860-y","pdf_url":"https://www.nature.com/articles/s41598-026-75860-y_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337008","display_name":"College of Veterinary Medicine, Seoul National University","ror":null},{"id":"https://openalex.org/F4320338236","display_name":"Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University","ror":"https://ror.org/04h6qvc91"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223180459.pdf","grobid_xml":"https://content.openalex.org/works/W7223180459.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2052544801","https://openalex.org/W2997260008","https://openalex.org/W2077904098","https://openalex.org/W2466148681","https://openalex.org/W2347779537","https://openalex.org/W2020003158","https://openalex.org/W88841968","https://openalex.org/W2381615186","https://openalex.org/W2963797103","https://openalex.org/W2080735998"],"abstract_inverted_index":{"Cisplatin":[0,60],"is":[1,9],"a":[2,43],"platinum-based":[3],"chemotherapeutic":[4],"agent":[5],"whose":[6],"clinical":[7],"use":[8],"limited":[10],"by":[11],"toxicity":[12],"in":[13,166,178,189],"non-tumor":[14],"tissues.":[15],"Even":[16],"among":[17,70],"genetically":[18],"homogeneous":[19],"mice":[20,41],"receiving":[21],"the":[22,32,74,144,157,183],"same":[23],"dose,":[24],"hepatic":[25,50,85,167],"responses":[26],"to":[27],"cisplatin":[28],"vary":[29],"considerably,":[30],"but":[31],"biochemical":[33,150],"basis":[34],"of":[35,47,186],"this":[36],"variability":[37,69,177,188],"remains":[38],"unclear.":[39],"Male":[40],"received":[42],"single":[44],"intraperitoneal":[45],"dose":[46],"cisplatin,":[48],"and":[49,88,117,120,126,136,146,170,181],"injury":[51],"was":[52,81,97],"evaluated":[53],"using":[54],"serum":[55,63,78,94],"alanine":[56],"aminotransferase":[57],"(ALT)":[58],"activity.":[59],"significantly":[61],"increased":[62,109],"ALT":[64,79,95],"activity,":[65,138],"with":[66,83,99,176],"marked":[67],"inter-individual":[68,164],"treated":[71],"mice.":[72],"Within":[73],"cisplatin-treated":[75,147],"group,":[76],"higher":[77,84,100,112],"activity":[80,96,125],"associated":[82,98,175],"platinum":[86,168],"retention":[87],"oxidative":[89],"protein":[90],"damage,":[91],"whereas":[92],"lower":[93],"glutathione":[101,114],"S":[102],"-transferase":[103],"(GST)":[104],"activities":[105],"toward":[106],"multiple":[107],"substrates,":[108],"GSTP1/2":[110],"expression,":[111],"reduced":[113,133],"(GSH)":[115],"content":[116,135],"GSH/GSSG":[118],"ratio,":[119],"greater":[121],"glutamate-cysteine":[122],"ligase":[123],"(GCL)":[124],"GCLC":[127],"expression.":[128],"Notably,":[129],"several":[130],"parameters,":[131],"including":[132],"GSH":[134],"GCL":[137],"showed":[139],"no":[140],"significant":[141],"differences":[142,165],"between":[143],"control":[145],"groups,":[148],"highlighting":[149],"patterns":[151],"that":[152,163],"were":[153],"apparent":[154],"primarily":[155],"at":[156],"individual":[158],"level.":[159],"These":[160],"findings":[161],"suggest":[162],"handling":[169],"GSH/GST-dependent":[171],"defense":[172],"capacity":[173],"are":[174],"cisplatin-induced":[179],"hepatotoxicity":[180],"emphasize":[182],"biological":[184],"significance":[185],"within-group":[187],"experimental":[190],"toxicology.":[191]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}
