{"id":"https://openalex.org/W7223178971","doi":"https://doi.org/10.3892/ijmm.2026.6022","title":"HMGN5 promotes renal tubular inflammation and pyroptosis\u2011associated signaling in chronic kidney disease via the IFNAR2 axis","display_name":"HMGN5 promotes renal tubular inflammation and pyroptosis\u2011associated signaling in chronic kidney disease via the IFNAR2 axis","publication_year":2026,"publication_date":"2026-10-22","ids":{"openalex":"https://openalex.org/W7223178971","doi":"https://doi.org/10.3892/ijmm.2026.6022","pmid":"https://pubmed.ncbi.nlm.nih.gov/42924612","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13722481"},"language":"en","primary_location":{"id":"doi:10.3892/ijmm.2026.6022","doi":"https://doi.org/10.3892/ijmm.2026.6022","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.2026.6022","pdf_url":"http://www.spandidos-publications.com/10.3892/ijmm.2026.6022/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.spandidos-publications.com/10.3892/ijmm.2026.6022/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5130571913","display_name":"Xue Rong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124205","display_name":"First Hospital of Shijiazhuang","ror":"https://ror.org/02s8x1148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124205"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Rong","raw_affiliation_strings":["Medical Administration Office, Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050011, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Administration Office, Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050011, P.R. China","institution_ids":["https://openalex.org/I4210124205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159237779","display_name":"Jing Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Xu","raw_affiliation_strings":["Department of Nephrology, Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050011, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050011, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5145241173","display_name":"\u5f20\u6770\u5357","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jienan Zhang","raw_affiliation_strings":["Department of Nephrology, Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050011, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050011, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159255326","display_name":"Qi Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi Zhang","raw_affiliation_strings":["Department of Nephrology, Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050011, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050011, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159248021","display_name":"Jiangli Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiangli Wang","raw_affiliation_strings":["Department of Nephrology, Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050011, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050011, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159229216","display_name":"Guoxin Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guoxin Zhang","raw_affiliation_strings":["Department of Nephrology, Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050011, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050011, P.R. China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5128396204","display_name":"Limin Nie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Limin Nie","raw_affiliation_strings":["Department of Nephrology, Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050011, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050011, P.R. China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5128396204"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.74492142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"58","issue":"6","first_page":"1","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.2712000012397766,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.2712000012397766,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.25949999690055847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.12200000137090683,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmgn5","display_name":"HMGN5","score":1.0},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ifnar2","display_name":"IFNAR2","score":0.9150000214576721},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.722000002861023},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.7893999814987183},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7182999849319458},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6215000152587891},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.5242000222206116},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5188999772071838},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4968999922275543},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.42320001125335693},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.39989998936653137},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39800000190734863},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3727000057697296},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.336899995803833},{"id":"https://openalex.org/C138798377","wikidata":"https://www.wikidata.org/wiki/Q7312502","display_name":"Renal stem cell","level":4,"score":0.3224000036716461},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3100000023841858},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.303600013256073},{"id":"https://openalex.org/C2777632694","wikidata":"https://www.wikidata.org/wiki/Q2336077","display_name":"Kidney development","level":4,"score":0.30219998955726624},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2773999869823456},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.27459999918937683},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.2567000091075897}],"mesh":[{"descriptor_ui":"D000069292","descriptor_name":"Pyroptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007684","descriptor_name":"Kidney Tubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007684","descriptor_name":"Kidney Tubules","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D053633","descriptor_name":"Receptor, Interferon alpha-beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3892/ijmm.2026.6022","doi":"https://doi.org/10.3892/ijmm.2026.6022","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.2026.6022","pdf_url":"http://www.spandidos-publications.com/10.3892/ijmm.2026.6022/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:42924612","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42924612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13722481","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13722481/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3892/ijmm.2026.6022","doi":"https://doi.org/10.3892/ijmm.2026.6022","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.2026.6022","pdf_url":"http://www.spandidos-publications.com/10.3892/ijmm.2026.6022/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223178971.pdf","grobid_xml":"https://content.openalex.org/works/W7223178971.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4417289419","https://openalex.org/W4281971870","https://openalex.org/W7160185029","https://openalex.org/W2766305969","https://openalex.org/W4400135758","https://openalex.org/W3007827907","https://openalex.org/W4403957599","https://openalex.org/W4397045280","https://openalex.org/W2038405847","https://openalex.org/W7160672243"],"abstract_inverted_index":{"chronic":[0],"kidney":[1],"disease":[2],"(cKd)":[3],"is":[4,8],"a":[5,27,198,217],"condition":[6],"that":[7,73,212,224],"characterized":[9],"by":[10,94],"persistent":[11],"tubular":[12,37,207],"injury,":[13,97],"inflammation":[14],"and":[15,40,59,87,99,119,130,137,140,182,210],"progressive":[16],"fibrosis,":[17,174],"ultimately":[18],"leading":[19],"to":[20,36],"an":[21],"irreversible":[22],"loss":[23],"of":[24,31,49,113,128,150,167,191,201,220],"renal":[25,42,80,96,170,176,206],"function.Pyroptosis,":[26],"notably":[28],"pro-inflammatory":[29],"mode":[30],"programmed":[32],"cell":[33],"death,":[34],"contributes":[35],"epithelial":[38,208],"injury":[39],"amplifies":[41],"inflammwation.The":[43],"present":[44,70,193],"study":[45,71,194],"investigated":[46],"the":[47,111,126,148,189,192,213],"role":[48],"high":[50],"mobility":[51],"group":[52],"nucleosome-binding":[53],"protein":[54],"5":[55],"(HMGN5)":[56],"in":[57,79,106,121,186,205,222],"CKD":[58,86,223],"its":[60],"regulatory":[61,116],"relationship":[62],"with":[63,85],"interferon":[64],"(IFN)":[65],"receptor":[66],"2":[67],"(IFNAR2)":[68],"signaling.The":[69],"found":[72],"HMGN5":[74,104,155,196],"expression":[75,112],"was":[76,92],"significantly":[77],"upregulated":[78],"tissues":[81],"obtained":[82],"from":[83],"patients":[84],"CKD-model":[88,187],"mice;":[89],"this":[90],"upregulation":[91],"accompanied":[93],"enhanced":[95,125],"fibrosis":[98],"inflammatory":[100],"cytokine":[101,180],"production.In":[102],"vitro,":[103],"overexpression":[105],"HK-2":[107],"cells:":[108],"i)":[109],"Promoted":[110],"IFNAR2,":[114],"phosphorylated-interferon":[115],"factor":[117],"(IRF)3/IRF7":[118],"absent":[120],"melanoma":[122],"2;":[123],"ii)":[124],"cleavage":[127],"caspase-1":[129],"gasdermin":[131],"D;":[132],"iii)":[133],"increased":[134],"IL-1\u03b2,":[135],"IL-8":[136],"IFN-\u03b2":[138],"secretion;":[139],"iv)":[141],"promoted":[142],"lactate":[143],"dehydrogenase":[144],"release.These":[145],"findings":[146,190],"suggested":[147,211],"activation":[149],"pyroptosis-associated":[151,184,203],"cellular":[152],"responses.Conversely,":[153],"silencing":[154],"or":[156],"blocking":[157],"IFNAR2":[158,168],"signaling":[159,185,204],"markedly":[160],"attenuated":[161],"these":[162],"effects.In":[163],"vivo,":[164],"pharmacological":[165],"blockade":[166],"ameliorated":[169],"tissue":[171],"damage,":[172],"reduced":[173],"restored":[175],"function,":[177],"decreased":[178],"systemic":[179],"levels":[181],"suppressed":[183],"mice.Collectively,":[188],"identified":[195],"as":[197],"novel":[199],"regulator":[200],"IFNAR2-related":[202],"cells":[209],"HMGN5-IFNAR2":[214],"axis":[215],"represents":[216],"pathophysiological":[218],"pathway":[219],"interest":[221],"warrants":[225],"further":[226],"investigation.":[227]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-22T00:00:00"}