{"id":"https://openalex.org/W7223178804","doi":"https://doi.org/10.3389/fphar.2026.1928244","title":"Quercetin ameliorates gestational diabetes mellitus-induced placental dysfunction by modulating the AGE-RAGE-associated oxidative and inflammatory signaling network","display_name":"Quercetin ameliorates gestational diabetes mellitus-induced placental dysfunction by modulating the AGE-RAGE-associated oxidative and inflammatory signaling network","publication_year":2026,"publication_date":"2026-10-22","ids":{"openalex":"https://openalex.org/W7223178804","doi":"https://doi.org/10.3389/fphar.2026.1928244"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2026.1928244","doi":"https://doi.org/10.3389/fphar.2026.1928244","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1928244","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1928244/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1928244/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159251119","display_name":"Xinying Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210086589","display_name":"Fujian Women and Children Hospital","ror":"https://ror.org/001bzc417","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086589"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinying Liu","raw_affiliation_strings":["College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital","Fujian Clinical Research Center for Maternal-Fetal Medicine","Laboratory of Maternal-Fetal Medicine, Fujian Maternity and Child Health Hospital","National Key Obstetric Clinical Specialty Construction Institution"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Fujian Clinical Research Center for Maternal-Fetal Medicine","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Maternal-Fetal Medicine, Fujian Maternity and Child Health Hospital","institution_ids":["https://openalex.org/I4210086589"]},{"raw_affiliation_string":"National Key Obstetric Clinical Specialty Construction Institution","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112899446","display_name":"Xingyi Qi","orcid":"https://orcid.org/0009-0006-6654-0888","observed_orcids":["https://orcid.org/0009-0006-6654-0888"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210086589","display_name":"Fujian Women and Children Hospital","ror":"https://ror.org/001bzc417","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086589"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingyi Qi","raw_affiliation_strings":["College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital","Fujian Clinical Research Center for Maternal-Fetal Medicine","Laboratory of Maternal-Fetal Medicine, Fujian Maternity and Child Health Hospital","National Key Obstetric Clinical Specialty Construction Institution"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Fujian Clinical Research Center for Maternal-Fetal Medicine","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Maternal-Fetal Medicine, Fujian Maternity and Child Health Hospital","institution_ids":["https://openalex.org/I4210086589"]},{"raw_affiliation_string":"National Key Obstetric Clinical Specialty Construction Institution","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015118683","display_name":"Zewei Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210086589","display_name":"Fujian Women and Children Hospital","ror":"https://ror.org/001bzc417","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086589"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zewei Liang","raw_affiliation_strings":["College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital","Fujian Clinical Research Center for Maternal-Fetal Medicine","Laboratory of Maternal-Fetal Medicine, Fujian Maternity and Child Health Hospital","National Key Obstetric Clinical Specialty Construction Institution"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Fujian Clinical Research Center for Maternal-Fetal Medicine","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Maternal-Fetal Medicine, Fujian Maternity and Child Health Hospital","institution_ids":["https://openalex.org/I4210086589"]},{"raw_affiliation_string":"National Key Obstetric Clinical Specialty Construction Institution","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037642048","display_name":"Chengcheng Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210086589","display_name":"Fujian Women and Children Hospital","ror":"https://ror.org/001bzc417","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086589"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengcheng Jin","raw_affiliation_strings":["College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital","Fujian Clinical Research Center for Maternal-Fetal Medicine","Laboratory of Maternal-Fetal Medicine, Fujian Maternity and Child Health Hospital","National Key Obstetric Clinical Specialty Construction Institution"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Fujian Clinical Research Center for Maternal-Fetal Medicine","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Maternal-Fetal Medicine, Fujian Maternity and Child Health Hospital","institution_ids":["https://openalex.org/I4210086589"]},{"raw_affiliation_string":"National Key Obstetric Clinical Specialty Construction Institution","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136829371","display_name":"Xiuli Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210086589","display_name":"Fujian Women and Children Hospital","ror":"https://ror.org/001bzc417","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086589"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiuli Li","raw_affiliation_strings":["College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital","Fujian Clinical Research Center for Maternal-Fetal Medicine","Laboratory of Maternal-Fetal Medicine, Fujian Maternity and Child Health Hospital","National Key Obstetric Clinical Specialty Construction Institution"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Fujian Clinical Research Center for Maternal-Fetal Medicine","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Maternal-Fetal Medicine, Fujian Maternity and Child Health Hospital","institution_ids":["https://openalex.org/I4210086589"]},{"raw_affiliation_string":"National Key Obstetric Clinical Specialty Construction Institution","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159231643","display_name":"Xia Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210086589","display_name":"Fujian Women and Children Hospital","ror":"https://ror.org/001bzc417","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086589"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xia Xu","raw_affiliation_strings":["College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital","Fujian Clinical Research Center for Maternal-Fetal Medicine","Laboratory of Maternal-Fetal Medicine, Fujian Maternity and Child Health Hospital","National Key Obstetric Clinical Specialty Construction Institution"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Fujian Clinical Research Center for Maternal-Fetal Medicine","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Maternal-Fetal Medicine, Fujian Maternity and Child Health Hospital","institution_ids":["https://openalex.org/I4210086589"]},{"raw_affiliation_string":"National Key Obstetric Clinical Specialty Construction Institution","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103058509","display_name":"Jianying Yan","orcid":"https://orcid.org/0000-0002-0795-3862","observed_orcids":["https://orcid.org/0000-0002-0795-3862","https://orcid.org/0009-0009-2757-8658"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210086589","display_name":"Fujian Women and Children Hospital","ror":"https://ror.org/001bzc417","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086589"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianying Yan","raw_affiliation_strings":["College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital","Fujian Clinical Research Center for Maternal-Fetal Medicine","Laboratory of Maternal-Fetal Medicine, Fujian Maternity and Child Health Hospital","National Key Obstetric Clinical Specialty Construction Institution"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Fujian Clinical Research Center for Maternal-Fetal Medicine","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Maternal-Fetal Medicine, Fujian Maternity and Child Health Hospital","institution_ids":["https://openalex.org/I4210086589"]},{"raw_affiliation_string":"National Key Obstetric Clinical Specialty Construction Institution","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103058509","https://openalex.org/A5159231643"],"corresponding_institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210086589"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.80083312,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10673","display_name":"Gestational Diabetes Research and Management","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/gestational-diabetes-mellitus","display_name":"gestational diabetes mellitus","score":1.0},{"id":"https://openalex.org/keywords/placental-insufficiency","display_name":"placental insufficiency","score":0.9990000128746033},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.871999979019165},{"id":"https://openalex.org/keywords/rage","display_name":"RAGE","score":0.8270000219345093},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8650000095367432},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9779999852180481},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5699999928474426},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7559999823570251},{"id":"https://openalex.org/keywords/serpine1","display_name":"SERPINE1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9620000123977661},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.7870000004768372},{"id":"https://openalex.org/keywords/fps-zm1","display_name":"FPS-ZM1","score":0.7459999918937683},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.559499979019165},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.5593000054359436},{"id":"https://openalex.org/C2779434492","wikidata":"https://www.wikidata.org/wiki/Q126691","display_name":"Gestational diabetes","level":4,"score":0.5550000071525574},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5329999923706055},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.45680001378059387},{"id":"https://openalex.org/C2778857457","wikidata":"https://www.wikidata.org/wiki/Q153641","display_name":"Rage (emotion)","level":2,"score":0.42590001225471497},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42340001463890076},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.4050999879837036},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3790999948978424},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36039999127388},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3424000144004822},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3384999930858612},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32760000228881836},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3264000117778778},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.30970001220703125},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3075999915599823},{"id":"https://openalex.org/C2777495146","wikidata":"https://www.wikidata.org/wiki/Q1889778","display_name":"Trophoblast","level":5,"score":0.2856999933719635},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C2778298627","wikidata":"https://www.wikidata.org/wiki/Q415957","display_name":"Genistein","level":2,"score":0.2766000032424927},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.2757999897003174},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2678000032901764},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.2623000144958496},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2615000009536743}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fphar.2026.1928244","doi":"https://doi.org/10.3389/fphar.2026.1928244","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1928244","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1928244/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:0d51ef4875184e84ac46adeb5dc30e05","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0d51ef4875184e84ac46adeb5dc30e05","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2026.1928244","doi":"https://doi.org/10.3389/fphar.2026.1928244","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1928244","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1928244/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.979200005531311}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3586891232","display_name":null,"funder_award_id":"2024 ZD 0532100","funder_id":"https://openalex.org/F4320329860","funder_display_name":"National Science and Technology Major Project"},{"id":"https://openalex.org/G7824742084","display_name":null,"funder_award_id":"2024ZD01005","funder_id":"https://openalex.org/F4320336588","funder_display_name":"Fujian Provincial Health Technology Project"}],"funders":[{"id":"https://openalex.org/F4320321878","display_name":"Natural Science Foundation of Fujian Province","ror":null},{"id":"https://openalex.org/F4320328113","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64"},{"id":"https://openalex.org/F4320329860","display_name":"National Science and Technology Major Project","ror":null},{"id":"https://openalex.org/F4320336588","display_name":"Fujian Provincial Health Technology Project","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223178804.pdf","grobid_xml":"https://content.openalex.org/works/W7223178804.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W978308701","https://openalex.org/W1598235393","https://openalex.org/W1966700699","https://openalex.org/W1980739328","https://openalex.org/W2000118672","https://openalex.org/W2029655631","https://openalex.org/W2032218106","https://openalex.org/W2033591223","https://openalex.org/W2042742088","https://openalex.org/W2044437167","https://openalex.org/W2079815081","https://openalex.org/W2084141237","https://openalex.org/W2086667809","https://openalex.org/W2093221728","https://openalex.org/W2108762011","https://openalex.org/W2109334664","https://openalex.org/W2117800935","https://openalex.org/W2120559894","https://openalex.org/W2134967712","https://openalex.org/W2136961309","https://openalex.org/W2146558971","https://openalex.org/W2471605942","https://openalex.org/W2523087930","https://openalex.org/W2553659869","https://openalex.org/W2767678580","https://openalex.org/W2771538940","https://openalex.org/W2892113269","https://openalex.org/W2898266729","https://openalex.org/W2961520387","https://openalex.org/W4248078302","https://openalex.org/W7098958697"],"related_works":["https://openalex.org/W4297426550","https://openalex.org/W3130425975","https://openalex.org/W2964695589","https://openalex.org/W2016119430","https://openalex.org/W2995773845","https://openalex.org/W2145386156","https://openalex.org/W4416587266","https://openalex.org/W2213734217","https://openalex.org/W4383998715","https://openalex.org/W1424465049"],"abstract_inverted_index":{"Background":[0],"Gestational":[1],"diabetes":[2],"mellitus":[3],"(GDM)":[4],"induces":[5],"placental":[6,68,172,247,254,292],"structural":[7],"and":[8,16,39,58,98,100,121,148,152,191,203,224,246,262,273,286,290],"functional":[9],"disturbances":[10],"associated":[11,62,160,212],"with":[12,180,213,228],"dysregulated":[13],"AGE-RAGE/ROS":[14],"signaling":[15,64,141,161,288],"inflammatory":[17,146,263,287],"responses.":[18,264],"Existing":[19],"flavonoid-related":[20],"studies":[21],"merely":[22],"observed":[23],"changes":[24,65],"in":[25,52,66,142,231],"pathway":[26,150,183],"protein":[27,153],"levels,":[28],"lacking":[29],"direct":[30],"experimental":[31],"proof":[32],"of":[33,50,56,110,171,207],"molecular":[34,101,192],"binding":[35],"between":[36,96,201,271],"candidate":[37],"compounds":[38],"core":[40,177],"receptors.":[41],"This":[42],"study":[43],"aimed":[44],"to":[45,59,75,91,106,138,157],"investigate":[46],"the":[47,53,61,87,93,108,111,159,176,181,185,204,283],"potential":[48,94,269],"involvement":[49],"RAGE":[51,89,217],"protective":[54],"effects":[55],"quercetin":[57,97,202,235,272,280],"characterize":[60,158],"AGE-RAGE/ROS/NF-\u03baB-related":[63],"GDM":[67,118,209],"injury.":[69],"Methods":[70],"Network":[71,164],"pharmacology":[72,165],"was":[73,84,104,132,211],"used":[74,133],"screen":[76],"quercetin\u2019s":[77],"therapeutic":[78],"targets":[79],"for":[80],"GDM.":[81],"Molecular":[82,189],"docking":[83,190],"performed":[85],"using":[86],"human":[88],"structure":[90],"predict":[92],"interaction":[95,270],"RAGE,":[99],"dynamics":[102,193],"simulation":[103],"conducted":[105],"evaluate":[107],"stability":[109],"predicted":[112,195],"complex.":[113],"A":[114],"combined":[115],"streptozotocin-high-fat":[116],"diet":[117],"rat":[119],"model":[120,128],"30":[122],"mM":[123],"high-glucose":[124],"HTR-8/SVneo":[125],"trophoblast":[126],"injury":[127],"were":[129,155],"constructed.":[130],"FPS-ZM1":[131],"as":[134,175],"a":[135,196,268],"pharmacological":[136],"tool":[137],"perturb":[139],"RAGE-associated":[140],"vitro":[143],".":[144],"ROS,":[145],"cytokines,":[147],"key":[149],"gene":[151],"expression":[154],"examined":[156],"changes.":[162,249],"Results":[163],"identified":[166],"SERPINE1":[167,225],"(a":[168],"critical":[169],"regulator":[170],"vascular":[173],"remodeling)":[174],"hub":[178],"gene,":[179],"AGE-RAGE":[182],"showing":[184],"highest":[186],"enrichment":[187],"score.":[188],"simulations":[194],"dynamically":[197],"stable":[198],"complex":[199],"formed":[200],"ligand-binding":[205],"domain":[206],"RAGE.":[208,274],"induction":[210],"increased":[214],"AGE":[215],"accumulation,":[216],"expression,":[218,226,233],"ROS":[219],"production,":[220],"phosphorylated":[221],"NF-\u03baB":[222],"p65,":[223],"together":[227],"an":[229],"increase":[230],"Nrf2":[232],"whereas":[234],"treatment":[236],"attenuated":[237],"these":[238],"alterations.":[239],"Quercetin":[240,251],"intervention":[241],"also":[242],"improved":[243],"glucose":[244],"tolerance":[245],"pathological":[248],"Conclusion":[250],"alleviates":[252],"GDM-associated":[253],"dysfunction":[255],"by":[256],"improving":[257],"metabolic":[258],"abnormalities,":[259],"oxidative":[260,285],"imbalance,":[261],"Computational":[265],"analysis":[266],"suggests":[267],"These":[275],"findings":[276],"provide":[277],"evidence":[278],"that":[279],"may":[281],"regulate":[282],"AGE-RAGE-associated":[284],"network":[289],"improve":[291],"homeostasis":[293],"under":[294],"diabetic":[295],"conditions.":[296]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-22T00:00:00"}
