{"id":"https://openalex.org/W7223177340","doi":"https://doi.org/10.3389/fimmu.2026.1869338","title":"Decoding pyroptosis at single-cell resolution: heterogeneity, microenvironment remodeling and potential translational insights","display_name":"Decoding pyroptosis at single-cell resolution: heterogeneity, microenvironment remodeling and potential translational insights","publication_year":2026,"publication_date":"2026-10-22","ids":{"openalex":"https://openalex.org/W7223177340","doi":"https://doi.org/10.3389/fimmu.2026.1869338","pmid":"https://pubmed.ncbi.nlm.nih.gov/42991405","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13735913"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1869338","doi":"https://doi.org/10.3389/fimmu.2026.1869338","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1869338","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1869338/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1869338/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159227098","display_name":"Lingyan Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingyan Xiang","raw_affiliation_strings":["Department of Pathology, Renmin Hospital of Wuhan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Renmin Hospital of Wuhan University","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159249569","display_name":"Na Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Tang","raw_affiliation_strings":["Department of Pathology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159243538","display_name":"Yaqi Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaqi Deng","raw_affiliation_strings":["Department of Pathology, Renmin Hospital of Wuhan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Renmin Hospital of Wuhan University","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133084796","display_name":"Jingping Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingping Yuan","raw_affiliation_strings":["Department of Pathology, Renmin Hospital of Wuhan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Renmin Hospital of Wuhan University","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102048209","display_name":"Jie Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Rao","raw_affiliation_strings":["Department of Pathology, Renmin Hospital of Wuhan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Renmin Hospital of Wuhan University","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133110223","display_name":"Aolong Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aolong Ma","raw_affiliation_strings":["Department of Pathology, Renmin Hospital of Wuhan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Renmin Hospital of Wuhan University","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138682154","display_name":"Qianwen Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianwen Wang","raw_affiliation_strings":["Department of Pathology, Renmin Hospital of Wuhan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Renmin Hospital of Wuhan University","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159249767","display_name":"Li Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Li Xu","raw_affiliation_strings":["Department of Pathology, Renmin Hospital of Wuhan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Renmin Hospital of Wuhan University","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101272049","display_name":"Lina Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lina Zhao","raw_affiliation_strings":["Department of Pathology, Renmin Hospital of Wuhan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Renmin Hospital of Wuhan University","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100644377","display_name":"Hong Yan","orcid":"https://orcid.org/0000-0002-7475-0109","observed_orcids":["https://orcid.org/0000-0002-7475-0109"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Honglin Yan","raw_affiliation_strings":["Department of Pathology, Renmin Hospital of Wuhan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Renmin Hospital of Wuhan University","institution_ids":["https://openalex.org/I4210140357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100644377","https://openalex.org/A5101272049","https://openalex.org/A5159249767"],"corresponding_institution_ids":["https://openalex.org/I4210140357"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.48192687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1869338","last_page":"1869338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":1.0},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.871999979019165},{"id":"https://openalex.org/keywords/gasdermin","display_name":"gasdermin","score":0.6050000190734863},{"id":"https://openalex.org/keywords/inflammatory-caspases","display_name":"inflammatory caspases","score":0.9800000190734863},{"id":"https://openalex.org/keywords/transcriptional-heterogeneity","display_name":"transcriptional heterogeneity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/tumor-microenvironment-remodeling","display_name":"tumor microenvironment remodeling","score":0.9760000109672546},{"id":"https://openalex.org/keywords/immune-polarization","display_name":"immune polarization","score":0.9020000100135803},{"id":"https://openalex.org/keywords/prognostic-gene-signature","display_name":"prognostic gene signature","score":0.9300000071525574},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7860000133514404},{"id":"https://openalex.org/keywords/inflammation-associated-diseases","display_name":"inflammation-associated diseases","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C17172800","wikidata":"https://www.wikidata.org/wiki/Q7263707","display_name":"Pyroptosis","level":4,"score":0.8561000227928162},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6481999754905701},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5866000056266785},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5188000202178955},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.4255000054836273},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40849998593330383},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.3889000117778778},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3758000135421753},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36880001425743103},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.3684999942779541},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3400999903678894},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.3303999900817871},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.3271999955177307},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3190000057220459},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3179999887943268},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.3176000118255615},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.30959999561309814},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2994000017642975},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.29679998755455017},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.2962000072002411},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2935999929904938},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2935999929904938},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2924000024795532},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.2921000123023987},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.2919999957084656},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.29109999537467957},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.2827000021934509},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28200000524520874},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.2754000127315521},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.27239999175071716},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.257099986076355},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.25609999895095825}],"mesh":[{"descriptor_ui":"D000069292","descriptor_name":"Pyroptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060833","descriptor_name":"Cellular Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1869338","doi":"https://doi.org/10.3389/fimmu.2026.1869338","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1869338","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1869338/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:42991405","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42991405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13735913","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13735913/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:abb4dad980d54cda96a186c0bde9f5be","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/abb4dad980d54cda96a186c0bde9f5be","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1869338","doi":"https://doi.org/10.3389/fimmu.2026.1869338","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1869338","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1869338/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3813322673","display_name":null,"funder_award_id":"2025AFB684","funder_id":"https://openalex.org/F4320322186","funder_display_name":"Natural Science Foundation of Hubei Province"},{"id":"https://openalex.org/G996962971","display_name":null,"funder_award_id":"RMQNZD2024046","funder_id":"https://openalex.org/F4320322186","funder_display_name":"Natural Science Foundation of Hubei Province"}],"funders":[{"id":"https://openalex.org/F4320317798","display_name":"Health Commission of Hubei Province","ror":null},{"id":"https://openalex.org/F4320322186","display_name":"Natural Science Foundation of Hubei Province","ror":null},{"id":"https://openalex.org/F4320336485","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223177340.pdf","grobid_xml":"https://content.openalex.org/works/W7223177340.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W1864325817","https://openalex.org/W3018541786","https://openalex.org/W3033024816","https://openalex.org/W3183286210","https://openalex.org/W3191507597","https://openalex.org/W3206106029","https://openalex.org/W4205952785","https://openalex.org/W4224861460","https://openalex.org/W4285243914","https://openalex.org/W4285493052","https://openalex.org/W4291285913","https://openalex.org/W4297103166","https://openalex.org/W4297229202","https://openalex.org/W4304842665","https://openalex.org/W4306157776","https://openalex.org/W4307628785","https://openalex.org/W4309409794","https://openalex.org/W4311955174","https://openalex.org/W4312196583","https://openalex.org/W4313439076","https://openalex.org/W4313649737","https://openalex.org/W4318917836","https://openalex.org/W4322742056","https://openalex.org/W4323666553","https://openalex.org/W4366742375","https://openalex.org/W4375859751","https://openalex.org/W4377012077","https://openalex.org/W4377193457","https://openalex.org/W4378212976","https://openalex.org/W4381548955","https://openalex.org/W4382724949","https://openalex.org/W4385145788","https://openalex.org/W4386117348","https://openalex.org/W4386134044","https://openalex.org/W4386253340","https://openalex.org/W4386504059","https://openalex.org/W4387730389","https://openalex.org/W4388074511","https://openalex.org/W4388075710","https://openalex.org/W4388085834","https://openalex.org/W4388733926","https://openalex.org/W4388892311","https://openalex.org/W4389209912","https://openalex.org/W4389266053","https://openalex.org/W4389792409","https://openalex.org/W4389856882","https://openalex.org/W4389889826","https://openalex.org/W4390245624","https://openalex.org/W4390704378","https://openalex.org/W4390711245","https://openalex.org/W4390769511","https://openalex.org/W4390876401","https://openalex.org/W4390954054","https://openalex.org/W4391449916","https://openalex.org/W4391596244","https://openalex.org/W4391597510","https://openalex.org/W4391616478","https://openalex.org/W4392197161","https://openalex.org/W4392359921","https://openalex.org/W4392626596","https://openalex.org/W4392984448","https://openalex.org/W4393405138","https://openalex.org/W4394892430","https://openalex.org/W4395112221","https://openalex.org/W4396585059","https://openalex.org/W4399083570","https://openalex.org/W4399261913","https://openalex.org/W4399321646","https://openalex.org/W4399360868","https://openalex.org/W4399363718","https://openalex.org/W4399535090","https://openalex.org/W4400587794","https://openalex.org/W4401154446","https://openalex.org/W4401876299","https://openalex.org/W4402146400","https://openalex.org/W4402197103","https://openalex.org/W4402827480","https://openalex.org/W4403117515","https://openalex.org/W4403308831","https://openalex.org/W4403978224","https://openalex.org/W4404046814","https://openalex.org/W4404239858","https://openalex.org/W4404522195","https://openalex.org/W4404635562","https://openalex.org/W4404893535","https://openalex.org/W4405953943","https://openalex.org/W4407895105","https://openalex.org/W4409737167","https://openalex.org/W4410006368","https://openalex.org/W4411865943","https://openalex.org/W4411926372","https://openalex.org/W4411929280","https://openalex.org/W4412508496","https://openalex.org/W4413384129","https://openalex.org/W4415494653"],"related_works":["https://openalex.org/W4376506383","https://openalex.org/W7202342308","https://openalex.org/W3191181180","https://openalex.org/W4292308691","https://openalex.org/W4409290127","https://openalex.org/W4380551011","https://openalex.org/W7167585866","https://openalex.org/W7169583196","https://openalex.org/W4362662731","https://openalex.org/W7092115760"],"abstract_inverted_index":{"Pyroptosis,":[0],"a":[1,53,194],"pro-inflammatory":[2],"programmed":[3],"cell":[4,73,103,110,177],"death":[5],"mediated":[6],"by":[7],"inflammatory":[8],"caspases":[9],"and":[10,21,36,66,76,105,112,125,151,173,204,214],"Gasdermin":[11],"(GSDM)":[12],"family":[13],"proteins,":[14],"exerts":[15],"dual":[16],"roles":[17],"in":[18,32,90,128],"host":[19],"defense":[20],"pathological":[22,129],"damage.":[23],"Traditional":[24],"bulk":[25,148],"RNA":[26,47],"sequencing":[27,48],"(bulk":[28],"RNA-seq)":[29],"is":[30],"limited":[31],"capturing":[33],"single-cell":[34,64],"heterogeneity":[35,101],"dissecting":[37,98],"intercellular":[38,78],"communication,":[39],"impeding":[40],"in-depth":[41],"mechanistic":[42],"exploration":[43],"of":[44,63,69,88,161,166,170,208],"pyroptosis.":[45],"Single-cell":[46],"(scRNA-seq)":[49],"has":[50],"emerged":[51],"as":[52],"powerful":[54],"tool":[55],"to":[56,134,192],"address":[57],"these":[58],"limitations,":[59],"enabling":[60],"high-throughput":[61],"profiling":[62],"transcriptomes":[65],"precise":[67],"characterization":[68],"gene":[70,138],"expression":[71],"heterogeneity,":[72],"subset":[74],"features,":[75],"putative":[77,153],"interaction":[79],"networks.":[80],"Here,":[81],"we":[82],"comprehensively":[83],"summarize":[84],"the":[85,201],"cutting-edge":[86],"applications":[87],"scRNA-seq":[89,133,188],"pyroptosis":[91,196],"research":[92,185],"from":[93],"four":[94],"core":[95,162],"aspects:":[96],"(1)":[97],"pyroptosis-related":[99,137],"transcriptional":[100],"with":[102,147,189],"subtype":[104],"state":[106],"specificity":[107],"across":[108],"diverse":[109],"types":[111],"diseases;":[113],"(2)":[114],"exploring":[115],"candidate":[116,142],"mechanisms":[117],"underlying":[118],"pyroptosis-associated":[119],"microenvironment":[120],"remodeling":[121],"(including":[122],"immune":[123],"polarization":[124],"stromal":[126],"reorganization)":[127],"progression;":[130],"(3)":[131],"harnessing":[132],"construct":[135,193],"prognostic":[136],"signatures":[139],"(PRGS)":[140],"for":[141,211],"risk":[143],"stratification":[144],"via":[145],"integration":[146],"RNA-seq":[149],"data;":[150],"(4)":[152],"targeted":[154],"therapeutic":[155],"strategies":[156],"(preclinical-stage":[157],"evidence),":[158],"including":[159],"modulation":[160],"pyroptotic":[163],"nodes,":[164],"regulation":[165],"endogenous":[167],"modulators,":[168],"exploitation":[169],"exogenous":[171],"compounds,":[172],"indirect":[174],"interventions":[175],"through":[176],"function":[178],"optimization":[179],"or":[180],"gut":[181],"microbiota":[182],"modulation.":[183],"Future":[184],"should":[186],"integrate":[187],"multi-omics":[190],"technologies":[191],"multi-dimensional":[195],"regulatory":[197],"network,":[198],"thereby":[199],"supporting":[200],"preclinical":[202],"development":[203],"potential":[205],"clinical":[206],"translation":[207],"pyroptosis-targeted":[209],"therapies":[210],"inflammation-associated":[212],"diseases":[213],"tumors.":[215]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}