{"id":"https://openalex.org/W7223176236","doi":"https://doi.org/10.3389/fnut.2026.1812940","title":"Acute changes in saliva metabolomic profile after drinking water instead of apple juice or no drink signal improved insulin-related metabolism in healthy children: a randomized controlled trial","display_name":"Acute changes in saliva metabolomic profile after drinking water instead of apple juice or no drink signal improved insulin-related metabolism in healthy children: a randomized controlled trial","publication_year":2026,"publication_date":"2026-10-22","ids":{"openalex":"https://openalex.org/W7223176236","doi":"https://doi.org/10.3389/fnut.2026.1812940","pmid":"https://pubmed.ncbi.nlm.nih.gov/42991265","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13736761"},"language":"en","primary_location":{"id":"doi:10.3389/fnut.2026.1812940","doi":"https://doi.org/10.3389/fnut.2026.1812940","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2026.1812940","pdf_url":"https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1812940/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1812940/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088237151","display_name":"Jodi Dunmeyer Stookey","orcid":"https://orcid.org/0000-0001-9604-2392","observed_orcids":["https://orcid.org/0000-0001-9604-2392"]},"institutions":[{"id":"https://openalex.org/I4210100173","display_name":"San Francisco Department of Public Health","ror":"https://ror.org/017ztfb41","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210100173"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jodi D. Stookey","raw_affiliation_strings":["Epidemiology Unit, Maternal, Child, & Adolescent Health, San Francisco Department of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology Unit, Maternal, Child, & Adolescent Health, San Francisco Department of Public Health","institution_ids":["https://openalex.org/I4210100173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012902591","display_name":"Mimansa Cholera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mimansa Cholera","raw_affiliation_strings":["Department of Orofacial Sciences Pediatric Dentistry, University of California San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orofacial Sciences Pediatric Dentistry, University of California San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5099686656","display_name":"Rowena Cape","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100173","display_name":"San Francisco Department of Public Health","ror":"https://ror.org/017ztfb41","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210100173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rowena Cape","raw_affiliation_strings":["Epidemiology Unit, Maternal, Child, & Adolescent Health, San Francisco Department of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology Unit, Maternal, Child, & Adolescent Health, San Francisco Department of Public Health","institution_ids":["https://openalex.org/I4210100173"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088237151"],"corresponding_institution_ids":["https://openalex.org/I4210100173"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.8108639,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"1812940","last_page":"1812940"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.18469999730587006,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10010","display_name":"Obesity, Physical Activity, Diet","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drinking-water","display_name":"drinking water","score":0.7879999876022339},{"id":"https://openalex.org/keywords/apple-juice","display_name":"apple juice","score":0.9980000257492065},{"id":"https://openalex.org/keywords/saliva-metabolomics","display_name":"saliva metabolomics","score":0.8420000076293945},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.6600000262260437},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.5270000100135803},{"id":"https://openalex.org/keywords/childhood-obesity","display_name":"childhood obesity","score":0.5669999718666077},{"id":"https://openalex.org/keywords/overweight","display_name":"overweight","score":0.5839999914169312},{"id":"https://openalex.org/keywords/school-based-intervention","display_name":"school-based intervention","score":0.625},{"id":"https://openalex.org/keywords/metabolic-pathways","display_name":"metabolic pathways","score":0.7059999704360962},{"id":"https://openalex.org/keywords/unstimulated-saliva","display_name":"unstimulated saliva","score":0.781000018119812},{"id":"https://openalex.org/keywords/bmi-percentiles","display_name":"body mass index percentiles","score":0.37599998712539673}],"concepts":[{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.9027000069618225},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.708299994468689},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6581000089645386},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6252999901771545},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4634000062942505},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.42239999771118164},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.39989998936653137},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.39410001039505005},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.3686999976634979},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.366100013256073},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.34540000557899475},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3452000021934509},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.3343000113964081},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.3124000132083893},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.29829999804496765},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.29260000586509705},{"id":"https://openalex.org/C193230392","wikidata":"https://www.wikidata.org/wiki/Q1663054","display_name":"Ingestion","level":2,"score":0.289000004529953},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2851000130176544},{"id":"https://openalex.org/C2779422640","wikidata":"https://www.wikidata.org/wiki/Q3241451","display_name":"Childhood obesity","level":4,"score":0.2825999855995178},{"id":"https://openalex.org/C102959455","wikidata":"https://www.wikidata.org/wiki/Q7313954","display_name":"Repeated measures design","level":2,"score":0.2522999942302704},{"id":"https://openalex.org/C46254838","wikidata":"https://www.wikidata.org/wiki/Q5156536","display_name":"Completely randomized design","level":2,"score":0.2513999938964844}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnut.2026.1812940","doi":"https://doi.org/10.3389/fnut.2026.1812940","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2026.1812940","pdf_url":"https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1812940/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13736761","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13736761/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13736761/pdf/fnut-13-1812940.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Nutr","raw_type":"Text"},{"id":"pmid:42991265","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42991265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in nutrition","raw_type":"Clinical Trial"},{"id":"pmh:oai:doaj.org/article:9cf3c12d10314b9e833fa1f3264e42ca","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9cf3c12d10314b9e833fa1f3264e42ca","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Nutrition, Vol 13 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnut.2026.1812940","doi":"https://doi.org/10.3389/fnut.2026.1812940","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2026.1812940","pdf_url":"https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1812940/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6245908341","display_name":null,"funder_award_id":"UL1 TR001872","funder_id":"https://openalex.org/F4320332622","funder_display_name":"University of California, San Francisco"}],"funders":[{"id":"https://openalex.org/F4320308602","display_name":"Water Research Foundation","ror":"https://ror.org/05rbdsb19"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223176236.pdf","grobid_xml":"https://content.openalex.org/works/W7223176236.grobid-xml"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W1673751863","https://openalex.org/W1858360348","https://openalex.org/W1927591950","https://openalex.org/W1949944365","https://openalex.org/W1963750940","https://openalex.org/W1966522524","https://openalex.org/W1969900856","https://openalex.org/W1970653898","https://openalex.org/W1976072516","https://openalex.org/W1981460639","https://openalex.org/W1986115510","https://openalex.org/W1992967451","https://openalex.org/W2000054651","https://openalex.org/W2001649002","https://openalex.org/W2005693445","https://openalex.org/W2014887370","https://openalex.org/W2017703988","https://openalex.org/W2017771330","https://openalex.org/W2034566229","https://openalex.org/W2038961236","https://openalex.org/W2056587840","https://openalex.org/W2063814893","https://openalex.org/W2066445481","https://openalex.org/W2068009433","https://openalex.org/W2068256216","https://openalex.org/W2075397364","https://openalex.org/W2098757654","https://openalex.org/W2104604816","https://openalex.org/W2113927476","https://openalex.org/W2114234262","https://openalex.org/W2118593955","https://openalex.org/W2121399513","https://openalex.org/W2122367003","https://openalex.org/W2125024696","https://openalex.org/W2132066552","https://openalex.org/W2132216789","https://openalex.org/W2139374484","https://openalex.org/W2153745157","https://openalex.org/W2154760228","https://openalex.org/W2159255279","https://openalex.org/W2165038904","https://openalex.org/W2197489360","https://openalex.org/W2213788280","https://openalex.org/W2224021986","https://openalex.org/W2295182096","https://openalex.org/W2315927491","https://openalex.org/W2334288341","https://openalex.org/W2341031032","https://openalex.org/W2346597670","https://openalex.org/W2405174010","https://openalex.org/W2549245522","https://openalex.org/W2625109982","https://openalex.org/W2725788675","https://openalex.org/W2736294384","https://openalex.org/W2744839294","https://openalex.org/W2766103518","https://openalex.org/W2906909679","https://openalex.org/W2907192562","https://openalex.org/W2911484039","https://openalex.org/W3012790024","https://openalex.org/W3032976905","https://openalex.org/W3044476287","https://openalex.org/W3073572811","https://openalex.org/W3087767629","https://openalex.org/W3096573278","https://openalex.org/W3155923438","https://openalex.org/W3159995035","https://openalex.org/W3165338098","https://openalex.org/W3165790874","https://openalex.org/W4200203344","https://openalex.org/W4206757179","https://openalex.org/W4225749347","https://openalex.org/W4254444674","https://openalex.org/W4307425304","https://openalex.org/W4312221289","https://openalex.org/W4312221298","https://openalex.org/W4313388799","https://openalex.org/W4313949138","https://openalex.org/W4321787752","https://openalex.org/W4353015956","https://openalex.org/W4364366228","https://openalex.org/W4376611836","https://openalex.org/W4388638691","https://openalex.org/W4390776359","https://openalex.org/W4391482506","https://openalex.org/W4394578957","https://openalex.org/W4396553441","https://openalex.org/W4396812895","https://openalex.org/W4396870332","https://openalex.org/W4399508430","https://openalex.org/W4399983582","https://openalex.org/W4400056676","https://openalex.org/W4400090874","https://openalex.org/W4400092361","https://openalex.org/W4406868789","https://openalex.org/W4407064008","https://openalex.org/W4409533594","https://openalex.org/W4410070752","https://openalex.org/W4411191594","https://openalex.org/W4413543900","https://openalex.org/W4414084082","https://openalex.org/W4414302252","https://openalex.org/W7221061215"],"related_works":["https://openalex.org/W7170495383","https://openalex.org/W4400149787","https://openalex.org/W4400149803","https://openalex.org/W7168259667","https://openalex.org/W7112128800","https://openalex.org/W2987576044","https://openalex.org/W4416202766","https://openalex.org/W7112769437","https://openalex.org/W2982169156","https://openalex.org/W3173431713"],"abstract_inverted_index":{"Objective:":[0],"In":[1,248],"the":[2,33,123],"Saliva":[3],"Insulin":[4],"as":[5],"Biomarker":[6],"(SIB)":[7],"randomized":[8],"controlled":[9],"trial":[10,299],"(RCT),":[11],"saliva":[12,114,143,192,267],"insulin":[13],"increased":[14],"more,":[15],"within":[16],"60":[17],"min,":[18],"after":[19,28,36,233],"one":[20,37],"serving":[21,38],"of":[22,39,208,222,236,244,259,295],"apple":[23,162],"juice,":[24],"and":[25,69,169,175,211,276],"normalized":[26],"less,":[27],"no":[29,166],"drink,":[30],"compared":[31,196],"to":[32,76,96,131,154,290],"acute":[34,264],"change":[35,190],"drinking":[40,73,104,282,296],"water.":[41,297],"This":[42],"paper":[43],"tested":[44],"for":[45,71,103,113,273,281],"corresponding":[46],"drink":[47,88,155,167,277],"treatment":[48,89,187],"effects":[49,55,63,188],"on":[50,56,64,136,189],"metabolomic":[51,109,193,268],"profile,":[52],"recognizing":[53],"that":[54,270],"insulin,":[57],"a":[58,132,137],"metabolic":[59,66,101,245,279,293],"switch,":[60],"imply":[61],"co-occurring":[62],"many":[65],"pathways,":[67],"simultaneously,":[68],"potential":[70,100,272,292],"school-based":[72],"water":[74,105,158,283],"interventions":[75],"efficiently":[77],"target":[78],"risk":[79],"factor":[80],"profiles.":[81],"Metabolic":[82],"pathways":[83],"potentially":[84,241],"impacted":[85,242],"by":[86,92,179],"each":[87],"were":[90,111,151,177,195],"described":[91],"baseline":[93],"weight":[94],"condition":[95],"generate":[97],"hypotheses":[98],"about":[99],"targets":[102,280],"intervention.":[106,284],"Methods:":[107],"Untargeted":[108],"assays":[110],"completed":[112],"from":[115],"105":[116],"healthy":[117,249],"children":[118],"(5-10y),":[119],"who":[120],"participated":[121],"in":[122,191,226,266],"3-arm":[124],"parallel":[125],"group":[126],"SIB":[127],"RCT":[128],"(NCT05211843),":[129],"prior":[130],"routine":[133],"dental":[134],"check-up":[135],"weekday":[138],"morning":[139],"or":[140,165,184,220,224,239,255,261],"afternoon.":[141],"Unstimulated":[142],"was":[144],"collected,":[145],"at":[146],"baseline,":[147],"before":[148],"study":[149],"participants":[150],"randomly":[152],"assigned":[153],"500":[156],"mL":[157,161],"(W),":[159],"200":[160],"juice":[163],"(AJ),":[164],"(ND),":[168],"45-60":[170],"min":[171],"post-drink":[172],"treatment.":[173],"Randomization":[174],"analysis":[176,203,207],"stratified":[178],"age-and-sex-specific":[180],"BMI":[181],"percentile":[182],"(5-85th":[183],">85th).":[185],"Drink":[186],"profiles":[194],"using":[197],"orthogonal":[198],"partial":[199],"least":[200],"squares":[201],"discriminant":[202],"(OPLS-DA),":[204],"permutational":[205],"multivariate":[206],"variance":[209],"(PERMANOVA),":[210],"Metaboanalyst":[212],"6.0":[213],"pathway":[214],"module.":[215],"Results:":[216],"=":[217],"0.02).":[218],"Increases":[219],"decreases":[221],"1.5-fold":[223],"more":[225],"over":[227],"100":[228],"metabolites":[229],"with":[230,251],"KEGG":[231],"IDs,":[232],"W":[234,257],"instead":[235,258],"either":[237],"AJ":[238,260],"ND,":[240],"dozens":[243],"pathways.":[246],"Conclusion:":[247],"children,":[250],"normal":[252],"weight,":[253],"overweight":[254],"obesity,":[256],"ND":[262],"caused":[263],"changes":[265],"profile":[269],"signal":[271],"multiple":[274],"weight-":[275],"treatment-specific":[278],"The":[285],"results":[286],"warrant":[287],"further":[288],"research":[289],"pursue":[291],"benefits":[294],"Clinical":[298],"registration:":[300],"NCT05211843,":[301],"clinicaltrials.gov.":[302]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-22T00:00:00"}
