{"id":"https://openalex.org/W7223175503","doi":"https://doi.org/10.1016/j.jrras.2026.102731","title":"Identification of ionizing-radiation-exposure-associated hub genes and a five-gene prognostic signature for pediatric medulloblastoma: An integrated bioinformatics study","display_name":"Identification of ionizing-radiation-exposure-associated hub genes and a five-gene prognostic signature for pediatric medulloblastoma: An integrated bioinformatics study","publication_year":2026,"publication_date":"2026-10-22","ids":{"openalex":"https://openalex.org/W7223175503","doi":"https://doi.org/10.1016/j.jrras.2026.102731"},"language":"en","primary_location":{"id":"doi:10.1016/j.jrras.2026.102731","doi":"https://doi.org/10.1016/j.jrras.2026.102731","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jrras.2026.102731","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1687850726005741/pdf","source":{"id":"https://openalex.org/S2764632503","display_name":"Journal of Radiation Research and Applied Sciences","issn_l":"1687-8507","issn":["1687-8507","2314-7164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Radiation Research and Applied Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1687850726005741/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015069487","display_name":"Xinquan Sang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinquan Sang","raw_affiliation_strings":["Department of Pediatrics, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159255147","display_name":"Yishuai Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yishuai Ren","raw_affiliation_strings":["Department of Pediatrics, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125925597","display_name":"Duoduo Li","orcid":"https://orcid.org/0009-0003-8377-5716","observed_orcids":["https://orcid.org/0009-0003-8377-5716"]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Duoduo Li","raw_affiliation_strings":["Department of Pediatrics, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159250182","display_name":"Zhenxiao Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenxiao Li","raw_affiliation_strings":["Department of Pediatrics, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159253548","display_name":"Wei Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Han","raw_affiliation_strings":["Department of Pediatrics, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159254300","display_name":"Muyu Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Muyu Zhang","raw_affiliation_strings":["Department of Pediatrics, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159230826","display_name":"Fenglian Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fenglian Zhu","raw_affiliation_strings":["Department of Pediatrics, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159237721","display_name":"Shujun Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shujun Li","raw_affiliation_strings":["Department of Pediatrics, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, 453100, China","institution_ids":["https://openalex.org/I80626142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5125925597","https://openalex.org/A5159230826","https://openalex.org/A5159237721","https://openalex.org/A5159250182"],"corresponding_institution_ids":["https://openalex.org/I80626142"],"apc_list":{"value":1400,"currency":"USD","value_usd":1400},"apc_paid":{"value":1400,"currency":"USD","value_usd":1400},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.77935067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"4","first_page":"102731","last_page":"102731"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-medulloblastoma","display_name":"pediatric medulloblastoma","score":0.9599999785423279},{"id":"https://openalex.org/keywords/ionizing-radiation-exposure","display_name":"ionizing radiation exposure","score":0.9750000238418579},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.675000011920929},{"id":"https://openalex.org/keywords/prognostic-signature","display_name":"prognostic signature","score":0.7760000228881836},{"id":"https://openalex.org/keywords/hub-genes","display_name":"hub genes","score":0.972000002861023},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7699999809265137},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.7590000033378601},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cyclin-b1","display_name":"cyclin B1","score":0.7699999809265137},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rrm2","display_name":"RRM2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/topoisomerase-ii-alpha","display_name":"TOP2A","score":1.0},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lymphoblastoid-cell-lines","display_name":"lymphoblastoid cell lines","score":0.6470000147819519},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.713100016117096},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5680000185966492},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.5411999821662903},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5252000093460083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4458000063896179},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.435699999332428},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3763999938964844},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30489999055862427},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.29330000281333923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2734000086784363},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.25760000944137573}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jrras.2026.102731","doi":"https://doi.org/10.1016/j.jrras.2026.102731","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jrras.2026.102731","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1687850726005741/pdf","source":{"id":"https://openalex.org/S2764632503","display_name":"Journal of Radiation Research and Applied Sciences","issn_l":"1687-8507","issn":["1687-8507","2314-7164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Radiation Research and Applied Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:3fa221cc3fef41c4acafe17ff37276bf","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3fa221cc3fef41c4acafe17ff37276bf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Radiation Research and Applied Sciences, Vol 19, Iss 4, Pp 102731- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jrras.2026.102731","doi":"https://doi.org/10.1016/j.jrras.2026.102731","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jrras.2026.102731","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1687850726005741/pdf","source":{"id":"https://openalex.org/S2764632503","display_name":"Journal of Radiation Research and Applied Sciences","issn_l":"1687-8507","issn":["1687-8507","2314-7164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Radiation Research and Applied Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223175503.pdf","grobid_xml":"https://content.openalex.org/works/W7223175503.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W2110529088","https://openalex.org/W2145200068","https://openalex.org/W2151252396","https://openalex.org/W2295672901","https://openalex.org/W2323101409","https://openalex.org/W2338116242","https://openalex.org/W2626440326","https://openalex.org/W2979765245","https://openalex.org/W2991944835","https://openalex.org/W2994675377","https://openalex.org/W3003515985","https://openalex.org/W3083523601","https://openalex.org/W3086559433","https://openalex.org/W3213819329","https://openalex.org/W4211218067","https://openalex.org/W4301595791","https://openalex.org/W4383186571","https://openalex.org/W4393343754","https://openalex.org/W4411056794"],"related_works":["https://openalex.org/W3083523601","https://openalex.org/W3033078926","https://openalex.org/W3016319044","https://openalex.org/W7202049173","https://openalex.org/W4226216883","https://openalex.org/W2943100392","https://openalex.org/W4393068119","https://openalex.org/W7166858467","https://openalex.org/W2140085836","https://openalex.org/W7120718790"],"abstract_inverted_index":{"Background":[0],"Medulloblastoma":[1],"is":[2,12],"the":[3,155,165],"most":[4],"common":[5],"pediatric":[6,56,206],"malignant":[7],"brain":[8],"tumor,":[9],"and":[10,24,34,61,73,102,114,122,131,136,147,154,169,197,231],"radiotherapy":[11],"an":[13,68],"important":[14],"component":[15],"of":[16,86,128],"treatment.":[17],"Molecular":[18],"features":[19],"associated":[20,94,180],"with":[21,95,118,181,212,220],"radiation-exposure":[22],"responses":[23],"prognosis":[25],"remain":[26],"incompletely":[27],"characterized.":[28],"Methods":[29],"We":[30],"analyzed":[31],"paired":[32],"irradiated":[33],"unexposed":[35],"human":[36],"lymphoblastoid":[37],"samples":[38],"from":[39,58],"GSE197236":[40],"(6":[41],"pairs)":[42],"to":[43,66],"identify":[44],"ionizing-radiation-exposure-associated":[45],"differentially":[46,88,194],"expressed":[47,89,195],"genes,":[48],"then":[49],"evaluated":[50,70],"their":[51],"prognostic":[52,71,107,201],"associations":[53],"in":[54,164,186],"103":[55],"medulloblastomas":[57],"GSE85217.":[59],"Cox":[60],"LASSO":[62],"regression":[63],"were":[64,91,144,162,179],"used":[65,77],"construct":[67],"internally":[69,124],"signature,":[72,218],"PPI":[74],"analysis":[75],"was":[76,152,158],"for":[78],"exploratory":[79,187],"network-based":[80],"candidate":[81],"prioritization.":[82],"Results":[83],"A":[84,105],"total":[85],"947":[87],"genes":[90,196],"identified,":[92],"predominantly":[93],"p53":[96],"signaling,":[97],"cell-cycle":[98],"regulation,":[99],"DNA-damage":[100],"repair,":[101],"apoptotic":[103],"pathways.":[104],"five-gene":[106,200],"model":[108],"comprising":[109],"CCNB1,":[110],"CDKN1A,":[111],"RRM2,":[112],"TOP2A,":[113],"BIRC5":[115],"separated":[116],"patients":[117,208],"different":[119],"overall":[120,210],"survival":[121,185],"showed":[123],"estimated":[125],"time-dependent":[126],"AUCs":[127],"0.834,":[129],"0.812,":[130],"0.786":[132],"at":[133],"1,":[134],"3,":[135],"5":[137],"years,":[138],"respectively.":[139],"Bootstrap":[140],"95%":[141],"confidence":[142],"intervals":[143],"0.764-0.901,":[145],"0.730-0.879,":[146],"0.681-0.862.":[148],"The":[149,217],"apparent":[150],"C-index":[151,157],"0.781":[153],"optimism-corrected":[156],"0.748.":[159],"These":[160],"values":[161],"generated":[163],"same":[166],"development":[167],"cohort":[168],"are":[170],"not":[171],"independent":[172],"validation":[173],"estimates.":[174],"Six":[175],"network-prioritized":[176,222],"hub-gene":[177,223],"candidates":[178],"molecular":[182],"subgroup":[183],"or":[184],"analyses.":[188],"Conclusion":[189],"Our":[190],"study":[191],"identified":[192],"ionizing-radiation-exposure-related":[193],"developed":[198],"a":[199],"signature":[202],"that":[203],"robustly":[204],"stratifies":[205],"medulloblastoma":[207],"by":[209],"survival,":[211],"promising":[213],"internal":[214],"predictive":[215],"performance.":[216],"along":[219],"six":[221],"candidates,":[224],"may":[225],"inform":[226],"future":[227],"risk-adapted":[228],"treatment":[229],"strategies":[230],"therapeutic":[232],"target":[233],"discovery.":[234]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}