{"id":"https://openalex.org/W7223174992","doi":"https://doi.org/10.1111/cas.70569","title":"Higher LSD1 in Non\u2010Seminomatous Germ Cell Tumors and LSD1 Inhibition by NCL1 Suppresses Embryonal Carcinoma Growth","display_name":"Higher LSD1 in Non\u2010Seminomatous Germ Cell Tumors and LSD1 Inhibition by NCL1 Suppresses Embryonal Carcinoma Growth","publication_year":2026,"publication_date":"2026-10-21","ids":{"openalex":"https://openalex.org/W7223174992","doi":"https://doi.org/10.1111/cas.70569","pmid":"https://pubmed.ncbi.nlm.nih.gov/42908320","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13687810"},"language":"en","primary_location":{"id":"doi:10.1111/cas.70569","doi":"https://doi.org/10.1111/cas.70569","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.70569","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.70569","source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.70569","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047741508","display_name":"Nobuhiko Shimizu","orcid":"https://orcid.org/0000-0001-7280-2481","observed_orcids":["https://orcid.org/0000-0001-7280-2481"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuhiko Shimizu","raw_affiliation_strings":["Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067957872","display_name":"Toshiki Etani","orcid":"https://orcid.org/0000-0002-2841-7006","observed_orcids":["https://orcid.org/0000-0002-2841-7006"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiki Etani","raw_affiliation_strings":["Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026753886","display_name":"Taku Naiki","orcid":"https://orcid.org/0000-0002-7638-6048","observed_orcids":["https://orcid.org/0000-0002-7638-6048"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Taku Naiki","raw_affiliation_strings":["Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"],"raw_orcid":"https://orcid.org/0000-0002-7638-6048","affiliations":[{"raw_affiliation_string":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041675745","display_name":"Aya Naiki\u2010Ito","orcid":"https://orcid.org/0000-0003-0828-2033","observed_orcids":["https://orcid.org/0000-0003-0828-2033"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Aya Naiki\u2010Ito","raw_affiliation_strings":["Department of Experimental Pathology and Tumor Biology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"],"raw_orcid":"https://orcid.org/0000-0003-0828-2033","affiliations":[{"raw_affiliation_string":"Department of Experimental Pathology and Tumor Biology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078136909","display_name":"Yosuke Sugiyama","orcid":"https://orcid.org/0000-0001-8436-5872","observed_orcids":["https://orcid.org/0000-0001-8436-5872"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yosuke Sugiyama","raw_affiliation_strings":["Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159245655","display_name":"Takashi Nagai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Nagai","raw_affiliation_strings":["Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038196196","display_name":"Akihiro Murakami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiro Murakami","raw_affiliation_strings":["Department of Experimental Pathology and Tumor Biology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pathology and Tumor Biology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080903282","display_name":"Hiroyuki Kato","orcid":"https://orcid.org/0000-0002-5888-6217","observed_orcids":["https://orcid.org/0000-0002-5888-6217"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Kato","raw_affiliation_strings":["Department of Experimental Pathology and Tumor Biology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"],"raw_orcid":"https://orcid.org/0000-0002-5888-6217","affiliations":[{"raw_affiliation_string":"Department of Experimental Pathology and Tumor Biology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022608257","display_name":"Toshiharu Morikawa","orcid":"https://orcid.org/0009-0006-4430-0277","observed_orcids":["https://orcid.org/0009-0006-4430-0277"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiharu Morikawa","raw_affiliation_strings":["Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139795034","display_name":"Maria Aoki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Maria Aoki","raw_affiliation_strings":["Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051590352","display_name":"Masakazu Gonda","orcid":"https://orcid.org/0009-0002-9514-1561","observed_orcids":["https://orcid.org/0009-0002-9514-1561"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masakazu Gonda","raw_affiliation_strings":["Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103333579","display_name":"Hiroko Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroko Suzuki","raw_affiliation_strings":["Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015527920","display_name":"Yohei Tsubouchi","orcid":"https://orcid.org/0009-0007-5395-662X","observed_orcids":["https://orcid.org/0009-0007-5395-662X"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yohei Tsubouchi","raw_affiliation_strings":["Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121977105","display_name":"Daiki Ishikawa","orcid":"https://orcid.org/0009-0007-7975-2983","observed_orcids":["https://orcid.org/0009-0007-7975-2983"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daiki Ishikawa","raw_affiliation_strings":["Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159233433","display_name":"Takayoshi Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287424","display_name":"The Institute of Scientific and Industrial Research, The University of Osaka","ror":"https://ror.org/053t3hh85","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287424","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayoshi Suzuki","raw_affiliation_strings":["Department of Complex Molecular Chemistry, SANKEN The University of Osaka  Ibaraki Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Complex Molecular Chemistry, SANKEN The University of Osaka  Ibaraki Japan","institution_ids":["https://openalex.org/I4405287424","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007636706","display_name":"Satoru Takahashi","orcid":"https://orcid.org/0000-0002-8139-8158","observed_orcids":["https://orcid.org/0000-0002-8139-8158"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Takahashi","raw_affiliation_strings":["Department of Experimental Pathology and Tumor Biology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pathology and Tumor Biology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066401468","display_name":"Takahiro Yasui","orcid":"https://orcid.org/0000-0003-2197-2477","observed_orcids":["https://orcid.org/0000-0003-2197-2477"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Yasui","raw_affiliation_strings":["Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan"],"raw_orcid":"https://orcid.org/0000-0003-2197-2477","affiliations":[{"raw_affiliation_string":"Department of Nephro\u2010urology Nagoya City University, Graduate School of Medical Sciences  Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026753886","https://openalex.org/A5041675745"],"corresponding_institution_ids":["https://openalex.org/I33858575"],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":{"value":2600,"currency":"USD","value_usd":2600},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82736463,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.04969999939203262,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lsd1","display_name":"LSD1","score":0.9380000233650208},{"id":"https://openalex.org/keywords/nonseminomatous-germ-cell-tumors","display_name":"non-seminoma","score":0.8930000066757202},{"id":"https://openalex.org/keywords/testicular-germ-cell-tumors","display_name":"testicular germ cell tumors","score":0.9509999752044678},{"id":"https://openalex.org/keywords/lsd1-inhibitors","display_name":"LSD1 inhibitors","score":0.875},{"id":"https://openalex.org/keywords/embryonal-carcinoma","display_name":"embryonal carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/teratoma","display_name":"teratoma","score":0.8209999799728394},{"id":"https://openalex.org/keywords/yolk-sac-tumor","display_name":"yolk sac tumor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/seminoma","display_name":"seminoma","score":0.9110000133514404},{"id":"https://openalex.org/keywords/h3k9me2","display_name":"H3K9me2","score":0.8870000243186951},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.8529999852180481},{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6499999761581421},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.7390000224113464},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.8569999933242798},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C2780327976","wikidata":"https://www.wikidata.org/wiki/Q1451877","display_name":"Embryonal carcinoma","level":4,"score":0.8019000291824341},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.5956000089645386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5494999885559082},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5429999828338623},{"id":"https://openalex.org/C2779122487","wikidata":"https://www.wikidata.org/wiki/Q281579","display_name":"Germ cell","level":3,"score":0.5080000162124634},{"id":"https://openalex.org/C2777043721","wikidata":"https://www.wikidata.org/wiki/Q369887","display_name":"Yolk sac","level":3,"score":0.4918000102043152},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4855000078678131},{"id":"https://openalex.org/C2776057878","wikidata":"https://www.wikidata.org/wiki/Q200741","display_name":"Teratoma","level":2,"score":0.46700000762939453},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4487999975681305},{"id":"https://openalex.org/C2776938808","wikidata":"https://www.wikidata.org/wiki/Q1737977","display_name":"Germ cell tumors","level":3,"score":0.43959999084472656},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3986000120639801},{"id":"https://openalex.org/C2777933648","wikidata":"https://www.wikidata.org/wiki/Q21114866","display_name":"SOX2","level":4,"score":0.3903999924659729},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3817000091075897},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.36399999260902405},{"id":"https://openalex.org/C2778074268","wikidata":"https://www.wikidata.org/wiki/Q1786953","display_name":"Seminoma","level":3,"score":0.3598000109195709},{"id":"https://openalex.org/C207701140","wikidata":"https://www.wikidata.org/wiki/Q420522","display_name":"Homeobox protein NANOG","level":5,"score":0.3564999997615814},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3319000005722046},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.299699991941452},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.289900004863739},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2793999910354614},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.2615000009536743},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.2590999901294708},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2578999996185303}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1111/cas.70569","doi":"https://doi.org/10.1111/cas.70569","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.70569","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.70569","source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13687810","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13687810/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13687810/pdf/CAS-9999-0.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Sci","raw_type":"Text"},{"id":"pmid:42908320","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42908320","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/cas.70569","doi":"https://doi.org/10.1111/cas.70569","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.70569","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.70569","source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325453","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223174992.pdf","grobid_xml":"https://content.openalex.org/works/W7223174992.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1830559800","https://openalex.org/W1975317476","https://openalex.org/W1987769185","https://openalex.org/W2005253752","https://openalex.org/W2014021851","https://openalex.org/W2019620912","https://openalex.org/W2021541624","https://openalex.org/W2054621094","https://openalex.org/W2065461424","https://openalex.org/W2090333443","https://openalex.org/W2139553968","https://openalex.org/W2170095887","https://openalex.org/W2294310720","https://openalex.org/W2789326366","https://openalex.org/W2929389128","https://openalex.org/W3036750427","https://openalex.org/W3039637402","https://openalex.org/W3088749091","https://openalex.org/W4210956264","https://openalex.org/W4226059983","https://openalex.org/W4293870416","https://openalex.org/W4313485265","https://openalex.org/W4321377852","https://openalex.org/W4378229604","https://openalex.org/W4391029848","https://openalex.org/W4400337039"],"related_works":["https://openalex.org/W3191582780","https://openalex.org/W2789326366","https://openalex.org/W4249529927","https://openalex.org/W2163656014","https://openalex.org/W2903214649","https://openalex.org/W7067324442","https://openalex.org/W2332523009","https://openalex.org/W4313320628","https://openalex.org/W4210956264","https://openalex.org/W4235432140"],"abstract_inverted_index":{"Lysine-specific":[0],"demethylase":[1],"1":[2],"(LSD1/KDM1A)":[3],"is":[4],"a":[5,184],"potential":[6,185],"therapeutic":[7,186],"target":[8,187],"in":[9,22,43,51,130,141,177,191,195],"non-seminomatous":[10,53],"testicular":[11,32],"germ":[12,33],"cell":[13,34,120,124],"tumors":[14,35,149,202],"(NSGCTs).":[15],"We":[16],"assessed":[17],"LSD1":[18,40,47,71,89,182],"and":[19,36,64,105,112,114,118,133,174,199],"Ki-67":[20,93],"immunostaining":[21],"74":[23],"histologically":[24],"distinct":[25],"tumor":[26,67],"components":[27,56,68],"from":[28],"53":[29],"patients":[30],"with":[31,92,139],"studied":[37],"the":[38,76,167,171],"selective":[39],"inhibitor":[41],"NCL1":[42,99,126,193],"embryonal":[44,77,96,178],"carcinoma":[45,97,179],"models.":[46],"positivity":[48,72,90],"was":[49],"higher":[50,70],"pooled":[52],"than":[54,73],"seminomatous":[55],"(p":[57],"=":[58,87],"0.0104).":[59],"Following":[60],"Bonferroni":[61],"correction,":[62],"teratoma":[63],"yolk":[65],"sac":[66],"showed":[69],"seminoma,":[74],"whereas":[75,156],"carcinoma-seminoma":[78],"comparison":[79],"did":[80,161],"not":[81,162],"reach":[82],"statistical":[83],"significance":[84],"(adjusted":[85],"p":[86],"0.08).":[88],"correlated":[91],"positivity.":[94],"In":[95,144],"cells,":[98],"increased":[100,115],"H3K9me2":[101],"enrichment":[102],"at":[103,166],"SOX2":[104],"OCT4":[106],"promoter":[107],"regions,":[108],"decreased":[109],"pluripotency-associated":[110],"proteins":[111],"survivin,":[113],"cleaved":[116],"caspase-3":[117],"apoptotic":[119],"populations":[121],"while":[122],"reducing":[123],"viability.":[125],"also":[127],"reduced":[128,135],"viability":[129,136],"cisplatin-adapted":[131],"cells":[132],"further":[134,189],"when":[137],"combined":[138],"cisplatin":[140],"parental":[142],"cells.":[143],"vivo,":[145],"treatment":[146,157],"initiated":[147],"before":[148],"became":[150],"measurable":[151],"suppressed":[152],"subsequent":[153],"xenograft":[154],"outgrowth,":[155],"of":[158],"established":[159,201],"xenografts":[160],"significantly":[163],"inhibit":[164],"growth":[165],"doses":[168],"tested.":[169],"Together,":[170],"histological":[172,197],"findings":[173],"responses":[175],"observed":[176],"models":[180],"support":[181],"as":[183],"for":[188],"investigation":[190],"NSGCT;":[192],"efficacy":[194],"other":[196],"subtypes":[198],"against":[200],"remains":[203],"to":[204],"be":[205],"established.":[206]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}