{"id":"https://openalex.org/W7223169385","doi":"https://doi.org/10.1002/jnr.70162","title":"Knockdown of CLEC7A Alleviates Ischemic Brain Injury by an Anti\u2010Inflammatory Microglial Phenotype via the CXCL1 / CXCR2 Axis","display_name":"Knockdown of CLEC7A Alleviates Ischemic Brain Injury by an Anti\u2010Inflammatory Microglial Phenotype via the CXCL1 / CXCR2 Axis","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223169385","doi":"https://doi.org/10.1002/jnr.70162","pmid":"https://pubmed.ncbi.nlm.nih.gov/42910573","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13688411"},"language":"en","primary_location":{"id":"doi:10.1002/jnr.70162","doi":"https://doi.org/10.1002/jnr.70162","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jnr.70162","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1002/jnr.70162","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159229885","display_name":"Min Xi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Xi","raw_affiliation_strings":["Department of Neurology Hainan West Central Hospital  Danzhou Hainan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Hainan West Central Hospital  Danzhou Hainan China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159244725","display_name":"Meipin Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meipin Yang","raw_affiliation_strings":["Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China","institution_ids":["https://openalex.org/I79731167"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124226680","display_name":"Tianyi Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianyi Xu","raw_affiliation_strings":["Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China","institution_ids":["https://openalex.org/I79731167"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159252366","display_name":"Chunhua Yun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunhua Yun","raw_affiliation_strings":["Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China","institution_ids":["https://openalex.org/I79731167"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049363288","display_name":"Hui L\u00fc","orcid":"https://orcid.org/0000-0002-5472-2960","observed_orcids":["https://orcid.org/0000-0002-5472-2960"]},"institutions":[{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Lu","raw_affiliation_strings":["Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China","institution_ids":["https://openalex.org/I79731167"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059906228","display_name":"Zhenqiang Zhao","orcid":"https://orcid.org/0000-0001-6947-1626","observed_orcids":["https://orcid.org/0000-0001-6947-1626"]},"institutions":[{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenqiang Zhao","raw_affiliation_strings":["Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China","institution_ids":["https://openalex.org/I79731167"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078121821","display_name":"\u674e\u7ee7\u82f1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiying Li","raw_affiliation_strings":["Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China","institution_ids":["https://openalex.org/I79731167"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159248173","display_name":"Jijun Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jijun Li","raw_affiliation_strings":["Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China","institution_ids":["https://openalex.org/I79731167"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147315041","display_name":"Yingting Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingting Fu","raw_affiliation_strings":["Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China","institution_ids":["https://openalex.org/I79731167"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159250491","display_name":"Yunyu Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunyu Li","raw_affiliation_strings":["Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China","institution_ids":["https://openalex.org/I79731167"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100318296","display_name":"Wei Li","orcid":"https://orcid.org/0000-0001-7247-2478","observed_orcids":["https://orcid.org/0000-0001-7247-2478"]},"institutions":[{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Li","raw_affiliation_strings":["Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China"],"raw_orcid":"https://orcid.org/0000-0001-7247-2478","affiliations":[{"raw_affiliation_string":"Key Laboratory of Reproductive Health Diseases Research and Translation of Ministry of Education, Department of Neurology The First Affiliated Hospital, Hainan Medical University  Haikou Hainan China","institution_ids":["https://openalex.org/I79731167"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100318296"],"corresponding_institution_ids":["https://openalex.org/I79731167"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":{"value":4840,"currency":"USD","value_usd":4840},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.75779078,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dectin-1","display_name":"Dectin-1","score":1.0},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9639999866485596},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/microglial-polarization","display_name":"microglial polarization","score":0.9959999918937683},{"id":"https://openalex.org/keywords/anti-inflammatory-microglia","display_name":"anti-inflammatory microglia","score":0.8119999766349792},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.8999999761581421},{"id":"https://openalex.org/keywords/oxygen-glucose-deprivation","display_name":"oxygen-glucose deprivation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.796999990940094},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.7649999856948853},{"id":"https://openalex.org/keywords/chemokine-signaling","display_name":"chemokine signaling","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.8095999956130981},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.7831000089645386},{"id":"https://openalex.org/C96525457","wikidata":"https://www.wikidata.org/wiki/Q5014879","display_name":"CXCL1","level":4,"score":0.7713000178337097},{"id":"https://openalex.org/C84913492","wikidata":"https://www.wikidata.org/wiki/Q5014892","display_name":"CXC chemokine receptors","level":5,"score":0.6317999958992004},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.5792999863624573},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5566999912261963},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5012999773025513},{"id":"https://openalex.org/C179661763","wikidata":"https://www.wikidata.org/wiki/Q21113119","display_name":"CXCL2","level":5,"score":0.4941999912261963},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4153999984264374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41449999809265137},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39070001244544983},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.3896999955177307},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3871999979019165},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3847000002861023},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3822000026702881},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.38089999556541443},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.3458999991416931},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33809998631477356},{"id":"https://openalex.org/C2778486448","wikidata":"https://www.wikidata.org/wiki/Q494066","display_name":"Experimental autoimmune encephalomyelitis","level":3,"score":0.3303000032901764},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3271999955177307},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32710000872612},{"id":"https://openalex.org/C57236427","wikidata":"https://www.wikidata.org/wiki/Q5382987","display_name":"Epileptogenesis","level":3,"score":0.3208000063896179},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.320499986410141},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.320499986410141},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3093999922275543},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.29120001196861267},{"id":"https://openalex.org/C206615009","wikidata":"https://www.wikidata.org/wiki/Q4035572","display_name":"CCR2","level":5,"score":0.2904999852180481},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2881999909877777},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.28790000081062317},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.28279998898506165},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2825999855995178},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.2768999934196472},{"id":"https://openalex.org/C2777682930","wikidata":"https://www.wikidata.org/wiki/Q1531490","display_name":"Gliosis","level":2,"score":0.2743000090122223},{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.2718000113964081},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.2646999955177307}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020244","descriptor_name":"Infarction, Middle Cerebral Artery","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054360","descriptor_name":"Chemokine CXCL1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054387","descriptor_name":"Receptors, CXCR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/jnr.70162","doi":"https://doi.org/10.1002/jnr.70162","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jnr.70162","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},{"id":"pmid:42910573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42910573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroscience research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13688411","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13688411/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/jnr.70162","doi":"https://doi.org/10.1002/jnr.70162","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jnr.70162","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W2187001175","https://openalex.org/W2748818757","https://openalex.org/W3008066115","https://openalex.org/W3081983295","https://openalex.org/W3120193638","https://openalex.org/W3127530509","https://openalex.org/W3175405706","https://openalex.org/W3183946929","https://openalex.org/W3206469715","https://openalex.org/W3217271430","https://openalex.org/W4206323688","https://openalex.org/W4221060468","https://openalex.org/W4229020257","https://openalex.org/W4281390890","https://openalex.org/W4311671148","https://openalex.org/W4327743854","https://openalex.org/W4378512819","https://openalex.org/W4384401359","https://openalex.org/W4384664137","https://openalex.org/W4385234020","https://openalex.org/W4387427299","https://openalex.org/W4387704725","https://openalex.org/W4387711209","https://openalex.org/W4389130532","https://openalex.org/W4391304201","https://openalex.org/W4392591367","https://openalex.org/W4395112054","https://openalex.org/W4401046731","https://openalex.org/W4403871189","https://openalex.org/W4404026462","https://openalex.org/W4405887282","https://openalex.org/W4409148295","https://openalex.org/W4410126404","https://openalex.org/W4416796741"],"related_works":["https://openalex.org/W4405887282","https://openalex.org/W4401213254","https://openalex.org/W4402781812","https://openalex.org/W4327677037","https://openalex.org/W4389374516","https://openalex.org/W2499511364","https://openalex.org/W7204000696","https://openalex.org/W4410561514","https://openalex.org/W2590458460","https://openalex.org/W2802131732"],"abstract_inverted_index":{"Microglial":[0],"polarization":[1,101],"critically":[2],"influences":[3],"neuroinflammation":[4,223],"and":[5,60,76,86,99,109,134,139,143,162,224],"recovery":[6,226],"after":[7,227],"ischemic":[8,200],"stroke.":[9,228],"The":[10],"role":[11,45],"of":[12,32,90,179],"C-type":[13],"lectin":[14],"domain":[15],"family":[16],"7":[17],"member":[18],"A":[19],"(CLEC7A),":[20],"a":[21,40,217],"potential":[22],"regulator":[23],"in":[24,49,55,61,74,77,137,146,160,163],"this":[25],"process,":[26],"remains":[27],"unclear.":[28],"Integrated":[29],"bioinformatics":[30],"analysis":[31],"Gene":[33],"Expression":[34],"Omnibus":[35],"datasets":[36],"identified":[37],"CLEC7A":[38,70,125,149,198,210],"as":[39,186],"hub":[41],"gene.":[42],"Its":[43],"functional":[44],"was":[46,71,119,168],"investigated":[47],"using":[48],"vitro":[50,75],"oxygen-glucose":[51],"deprivation":[52],"(OGD)":[53],"models":[54],"BV2":[56],"microglia/HT22":[57],"neuron":[58],"co-cultures":[59],"vivo":[62,161],"rat":[63],"middle":[64],"cerebral":[65],"artery":[66],"occlusion":[67],"(MCAO)":[68],"models.":[69],"knocked":[72],"down":[73],"vivo.":[78],"Functional":[79],"outcomes":[80],"were":[81,93,103,189],"assessed":[82,104],"via":[83,177],"infarct":[84,129],"volume":[85],"neurobehavioral":[87],"scores.":[88],"Levels":[89],"inflammation":[91],"factors":[92],"evaluated":[94],"by":[95,105,191,203],"enzyme-linked":[96],"immunosorbent":[97],"assay,":[98],"microglial":[100,153,207],"markers":[102,155,159],"western":[106],"blot,":[107],"immunohistochemistry,":[108],"immunofluorescence.":[110],"Recombinant":[111],"Chemokine":[112],"(C-X-C":[113],"motif)":[114],"ligand":[115],"1":[116],"(CXCL1)":[117],"agonist":[118],"employed":[120],"for":[121,221],"rescue":[122],"experiments.":[123],"Herein,":[124],"knockdown":[126,150],"reduced":[127,144],"MCAO-induced":[128],"size,":[130],"attenuated":[131],"brain":[132,201],"injury,":[133],"neurological":[135],"deficits":[136],"vivo,":[138],"improved":[140],"cell":[141],"viability":[142],"apoptosis":[145],"vitro.":[147,164],"Furthermore,":[148],"suppressed":[151],"pro-inflammatory":[152],"phenotypic":[154],"while":[156],"enhancing":[157],"anti-inflammatory":[158,206],"This":[165],"protective":[166],"effect":[167],"mediated":[169],"through":[170],"the":[171,187,213],"Cytokine-cytokine":[172],"receptor":[173,183],"interaction":[174],"pathway,":[175],"specifically":[176],"downregulation":[178],"CXCL1/C-X-C":[180],"motif":[181],"chemokine":[182],"2":[184],"(CXCR2),":[185],"benefits":[188],"reversed":[190],"recombinant":[192],"CXCL1":[193],"treatment.":[194],"In":[195],"summary,":[196],"silencing":[197],"alleviates":[199],"injury":[202],"promoting":[204],"an":[205],"phenotype.":[208],"Targeting":[209],"to":[211],"inhibit":[212],"CXCL1/CXCR2":[214],"axis":[215],"represents":[216],"promising":[218],"therapeutic":[219],"strategy":[220],"mitigating":[222],"improving":[225]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}
