{"id":"https://openalex.org/W7223169368","doi":"https://doi.org/10.2147/ijn.s622399","title":"Plasma Extracellular Vesicles Multi-Omics Signatures Reveal Dynamic Molecular Rewiring During Sepsis Progression","display_name":"Plasma Extracellular Vesicles Multi-Omics Signatures Reveal Dynamic Molecular Rewiring During Sepsis Progression","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223169368","doi":"https://doi.org/10.2147/ijn.s622399","pmid":"https://pubmed.ncbi.nlm.nih.gov/42936678","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13701122"},"language":"en","primary_location":{"id":"doi:10.2147/ijn.s622399","doi":"https://doi.org/10.2147/ijn.s622399","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s622399","pdf_url":"https://www.dovepress.com/article/download/121251","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/121251","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159235176","display_name":"Haiyue Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2802957242","display_name":"Beijing Jishuitan Hospital","ror":"https://ror.org/035t17984","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802957242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyue Zhang","raw_affiliation_strings":["Thrombosis Research Center, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2802957242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159247053","display_name":"Shuang Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2802957242","display_name":"Beijing Jishuitan Hospital","ror":"https://ror.org/035t17984","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802957242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Liang","raw_affiliation_strings":["Thrombosis Research Center, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2802957242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130404328","display_name":"Xinyang Yue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2802957242","display_name":"Beijing Jishuitan Hospital","ror":"https://ror.org/035t17984","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802957242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyang Yue","raw_affiliation_strings":["Thrombosis Research Center, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2802957242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159238490","display_name":"Xiaofei He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2802957242","display_name":"Beijing Jishuitan Hospital","ror":"https://ror.org/035t17984","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802957242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofei He","raw_affiliation_strings":["Thrombosis Research Center, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2802957242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130329065","display_name":"Huiru Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2802957242","display_name":"Beijing Jishuitan Hospital","ror":"https://ror.org/035t17984","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802957242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiru Zhao","raw_affiliation_strings":["Thrombosis Research Center, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2802957242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159227219","display_name":"Yu Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2802957242","display_name":"Beijing Jishuitan Hospital","ror":"https://ror.org/035t17984","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802957242"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Su","raw_affiliation_strings":["Thrombosis Research Center, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2802957242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029709083","display_name":"Jun Wu","orcid":"https://orcid.org/0000-0001-5178-0906","observed_orcids":["https://orcid.org/0000-0001-5178-0906"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2802957242","display_name":"Beijing Jishuitan Hospital","ror":"https://ror.org/035t17984","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802957242"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Wu","raw_affiliation_strings":["Thrombosis Research Center, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-5178-0906","affiliations":[{"raw_affiliation_string":"Thrombosis Research Center, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2802957242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029709083"],"corresponding_institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2802957242"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.68156016,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 21","issue":null,"first_page":"1","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.2168000042438507,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/sepsis-induced-coagulopathy","display_name":"sepsis-induced coagulopathy","score":0.9330000281333923},{"id":"https://openalex.org/keywords/plasma-extracellular-vesicles","display_name":"plasma extracellular vesicles","score":0.9739999771118164},{"id":"https://openalex.org/keywords/mir-34a-5p","display_name":"miR-34a-5p","score":0.9779999852180481},{"id":"https://openalex.org/keywords/microrna-biomarkers","display_name":"microRNA biomarkers","score":0.7129999995231628},{"id":"https://openalex.org/keywords/thrombomodulin","display_name":"thrombomodulin","score":0.7860000133514404},{"id":"https://openalex.org/keywords/heparan-sulfate","display_name":"heparan sulfate","score":0.7910000085830688},{"id":"https://openalex.org/keywords/syndecan-1","display_name":"syndecan-1","score":0.8550000190734863},{"id":"https://openalex.org/keywords/lps-induced-inflammation","display_name":"lipopolysaccharide-induced inflammation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/coagulopathy","display_name":"coagulopathy","score":0.7519999742507935},{"id":"https://openalex.org/keywords/multi-omics-profiling","display_name":"multi-omics profiling","score":0.734000027179718},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.4309999942779541},{"id":"https://openalex.org/keywords/vitamin-metabolism","display_name":"vitamin metabolism","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.7049000263214111},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5587999820709229},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5526999831199646},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5465999841690063},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5447999835014343},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.4244999885559082},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3928999900817871},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.3756999969482422},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3596999943256378},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.33799999952316284},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3287000060081482},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3172999918460846},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.29170000553131104},{"id":"https://openalex.org/C2776575606","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Blood plasma","level":2,"score":0.2782000005245209}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004211","descriptor_name":"Disseminated Intravascular Coagulation","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004211","descriptor_name":"Disseminated Intravascular Coagulation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2147/ijn.s622399","doi":"https://doi.org/10.2147/ijn.s622399","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s622399","pdf_url":"https://www.dovepress.com/article/download/121251","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},{"id":"pmid:42936678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42936678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nanomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13701122","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13701122/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Nanomedicine","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:445f2036c52545bc8ab5851f8ccd9151","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/445f2036c52545bc8ab5851f8ccd9151","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol Volume 21, Iss Issue 1, Pp 1-21 (2026)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/121251","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/plasma-extracellular-vesicles-multi-omics-signatures-reveal-dynamic-mo-peer-reviewed-fulltext-article-IJN","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ijn.s622399","doi":"https://doi.org/10.2147/ijn.s622399","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s622399","pdf_url":"https://www.dovepress.com/article/download/121251","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223169368.pdf","grobid_xml":"https://content.openalex.org/works/W7223169368.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W32427409","https://openalex.org/W121993330","https://openalex.org/W1561141192","https://openalex.org/W2006628131","https://openalex.org/W2050036363","https://openalex.org/W2055757389","https://openalex.org/W2065699955","https://openalex.org/W2088361238","https://openalex.org/W2092929697","https://openalex.org/W2124551895","https://openalex.org/W2147676009","https://openalex.org/W2170060707","https://openalex.org/W2296531152","https://openalex.org/W2341685911","https://openalex.org/W2443770335","https://openalex.org/W2553300030","https://openalex.org/W2745119542","https://openalex.org/W2769007196","https://openalex.org/W2808829764","https://openalex.org/W2809038450","https://openalex.org/W2941871526","https://openalex.org/W2963387556","https://openalex.org/W2994203590","https://openalex.org/W2998853022","https://openalex.org/W3097782933","https://openalex.org/W3135371803","https://openalex.org/W3165146505","https://openalex.org/W3191868262","https://openalex.org/W3214059785","https://openalex.org/W4283079659","https://openalex.org/W4313730628","https://openalex.org/W4319058199","https://openalex.org/W4366238214","https://openalex.org/W4387612662","https://openalex.org/W4391649568","https://openalex.org/W4395007044","https://openalex.org/W4400789097","https://openalex.org/W4403853942"],"related_works":["https://openalex.org/W4210774282","https://openalex.org/W4411848007","https://openalex.org/W4405009574","https://openalex.org/W2897601525","https://openalex.org/W7110610406","https://openalex.org/W4403528951","https://openalex.org/W2898551860","https://openalex.org/W4366989338","https://openalex.org/W4389098972","https://openalex.org/W4407094258"],"abstract_inverted_index":{"Background:":[0],"Sepsis":[1],"confers":[2],"persistently":[3],"high":[4],"mortality,":[5],"with":[6,60,142],"risk":[7],"escalating":[8],"markedly":[9],"upon":[10],"progression":[11],"to":[12,47],"disseminated":[13],"intravascular":[14],"coagulation":[15,137,225],"(DIC).":[16],"Although":[17],"circulating":[18],"extracellular":[19],"vesicles":[20],"(EVs)":[21],"have":[22],"emerged":[23],"as":[24,193],"potential":[25,251],"biomarker":[26,195],"reservoirs":[27],"and":[28,58,63,69,76,81,89,105,120,126,136,138,149,162,187,200,211,214,227,230,254],"pathogenic":[29],"mediators":[30],"in":[31,91,101,110,169,178,219],"sepsis-associated":[32],"DIC":[33],"(SA-DIC),":[34],"the":[35,39,143,146,238],"molecular":[36,245],"mechanisms":[37],"governing":[38],"transition":[40],"from":[41,54],"sepsis":[42,173,248],"through":[43],"sepsis-induced":[44],"coagulopathy":[45],"(SIC)":[46],"SA-DIC":[48,64,129],"remain":[49],"elusive.":[50],"Methods:":[51],"Plasma":[52],"EVs":[53,171,244],"healthy":[55],"controls":[56],"(n=3)":[57],"patients":[59],"sepsis,":[61,198],"SIC,":[62,199],"(n=6)":[65],"were":[66,85,134,151,166,176],"collected":[67],"longitudinally":[68],"profiled":[70],"by":[71,87],"multi-omics":[72,155],"analysis":[73,156],"(miRNome,":[74],"proteome,":[75],"metabolome)":[77],"using":[78,117],"RNA":[79],"sequencing":[80],"LC-MS/MS.":[82],"Key":[83],"findings":[84],"validated":[86],"qRT-PCR":[88],"ELISA":[90],"an":[92],"independent":[93],"longitudinal":[94],"cohort":[95],"(n=30).":[96],"The":[97],"role":[98],"of":[99,145,222,242],"miR-34a-5p":[100,132,192,204,223],"lipopolysaccharide":[102],"(LPS)-induced":[103],"inflammatory":[104,139,183],"procoagulant":[106],"responses":[107],"was":[108],"investigated":[109],"human":[111],"umbilical":[112],"vein":[113],"endothelial":[114],"cells":[115],"(HUVECs)":[116],"miRNA":[118],"agomirs":[119],"antagomirs.":[121],"In":[122,202],"a":[123,194,255],"cecal":[124],"ligation":[125],"puncture":[127],"(CLP)-induced":[128],"mouse":[130],"model,":[131],"agomirs/antagomirs":[133],"administered,":[135],"parameters,":[140],"together":[141],"histopathology":[144],"lung,":[147,228],"liver,":[148,229],"intestine,":[150],"assessed.":[152],"Results:":[153],"Integrated":[154],"identified":[157,191],"112":[158],"miRNAs,":[159],"525":[160],"proteins,":[161],"60":[163],"metabolites":[164],"that":[165],"differentially":[167],"expressed":[168],"plasma":[170,243],"during":[172,247],"progression,":[174,249],"which":[175],"enriched":[177],"blood":[179],"coagulation,":[180],"platelet":[181],"activation,":[182],"response,":[184],"energy":[185],"metabolism":[186],"vitamin":[188],"metabolism.":[189],"We":[190],"for":[196],"discriminating":[197],"SA-DIC.":[201],"vitro,":[203],"downregulation":[205],"attenuated":[206],"inflammation,":[207],"reduced":[208],"thrombomodulin":[209],"secretion,":[210],"increased":[212],"CD138":[213],"heparan":[215],"sulfate":[216],"expression.":[217],"Consistently,":[218],"vivo":[220],"modulation":[221],"ameliorated":[224],"dysfunction":[226],"intestinal":[231],"histopathological":[232],"injury.":[233],"Conclusion:":[234],"This":[235],"study":[236],"provides":[237],"first":[239],"integrative":[240],"map":[241],"reprogramming":[246],"identifying":[250],"diagnostic":[252],"biomarkers":[253],"candidate":[256],"therapeutic":[257],"target.":[258]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}