{"id":"https://openalex.org/W7223168693","doi":"https://doi.org/10.3389/fonc.2026.1989277","title":"The CP-STPG3-AS1 axis regulates lipoylation and cuproptosis in castration-resistant prostate cancer","display_name":"The CP-STPG3-AS1 axis regulates lipoylation and cuproptosis in castration-resistant prostate cancer","publication_year":2026,"publication_date":"2026-10-22","ids":{"openalex":"https://openalex.org/W7223168693","doi":"https://doi.org/10.3389/fonc.2026.1989277","pmid":"https://pubmed.ncbi.nlm.nih.gov/42991319","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13735617"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2026.1989277","doi":"https://doi.org/10.3389/fonc.2026.1989277","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1989277","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1989277/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1989277/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037567572","display_name":"Jia Wei He","orcid":"https://orcid.org/0009-0009-9493-5424","observed_orcids":["https://orcid.org/0009-0009-9493-5424"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jia Wei He","raw_affiliation_strings":["Department of Urology, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100738723","display_name":"Pei Zhen Li","orcid":"https://orcid.org/0000-0002-2870-7484","observed_orcids":["https://orcid.org/0000-0002-2870-7484"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pei Zhen Li","raw_affiliation_strings":["Department of Orthopedics, Dongguan Eighth People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Dongguan Eighth People\u2019s Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159227917","display_name":"Zhen Zhao Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Zhao Zhang","raw_affiliation_strings":["Department of Rehabilitation Medicine, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation Medicine, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University","institution_ids":["https://openalex.org/I176834541"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037567572"],"corresponding_institution_ids":["https://openalex.org/I176834541"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73570864,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"1989277","last_page":"1989277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.6366999745368958,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.6366999745368958,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.24619999527931213,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.06019999831914902,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cuproptosis","display_name":"cuproptosis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ceruloplasmin","display_name":"ceruloplasmin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.8270000219345093},{"id":"https://openalex.org/keywords/lipoylation","display_name":"lipoylation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.7760000228881836},{"id":"https://openalex.org/keywords/fdx1","display_name":"FDX1","score":0.7519999742507935},{"id":"https://openalex.org/keywords/dihydrolipoamide-s-acetyltransferase","display_name":"DLAT","score":0.7509999871253967},{"id":"https://openalex.org/keywords/dlst","display_name":"DLST","score":0.6159999966621399},{"id":"https://openalex.org/keywords/early-jurassic","display_name":"Lower Jurassic","score":0.9779999852180481},{"id":"https://openalex.org/keywords/dld","display_name":"DLD","score":0.6970000267028809},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6179999709129333},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.8422999978065491},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7993999719619751},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7822999954223633},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6772000193595886},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.47870001196861267},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42989999055862427},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40470001101493835},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.39010000228881836},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.38679999113082886},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3596000075340271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3573000133037567},{"id":"https://openalex.org/C165135838","wikidata":"https://www.wikidata.org/wiki/Q133895","display_name":"Citric acid cycle","level":3,"score":0.3384000062942505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33799999952316284},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.32829999923706055},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.32690000534057617},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.31349998712539673},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.31290000677108765},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.310699999332428},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.30169999599456787},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29829999804496765},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2858000099658966},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2703000009059906},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.26840001344680786},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.26350000500679016},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2630000114440918},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.257999986410141},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2502000033855438}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2026.1989277","doi":"https://doi.org/10.3389/fonc.2026.1989277","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1989277","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1989277/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13735617","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13735617/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13735617/pdf/fonc-16-1989277.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:42991319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42991319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a02529c69b0e48518d474a8ef67736dc","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a02529c69b0e48518d474a8ef67736dc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 16 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2026.1989277","doi":"https://doi.org/10.3389/fonc.2026.1989277","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1989277","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1989277/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223168693.pdf","grobid_xml":"https://content.openalex.org/works/W7223168693.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1536507853","https://openalex.org/W1985415914","https://openalex.org/W1990287298","https://openalex.org/W2023097049","https://openalex.org/W2036180531","https://openalex.org/W2082922390","https://openalex.org/W2120292596","https://openalex.org/W2128486725","https://openalex.org/W2148643283","https://openalex.org/W2463858258","https://openalex.org/W2472221373","https://openalex.org/W2565078952","https://openalex.org/W2625255317","https://openalex.org/W2900909713","https://openalex.org/W3035358843","https://openalex.org/W3047050788","https://openalex.org/W3086825172","https://openalex.org/W3097317789","https://openalex.org/W3105565614","https://openalex.org/W3130934287","https://openalex.org/W3191772847","https://openalex.org/W3212006797","https://openalex.org/W4220817961","https://openalex.org/W4221115671","https://openalex.org/W4224304364","https://openalex.org/W4283724260","https://openalex.org/W4289641871","https://openalex.org/W4294755075","https://openalex.org/W4297907049","https://openalex.org/W4306936962","https://openalex.org/W4308127048","https://openalex.org/W4318499598","https://openalex.org/W4362456304","https://openalex.org/W4376225667","https://openalex.org/W4385851748","https://openalex.org/W4391434010","https://openalex.org/W4391681502","https://openalex.org/W4393320570","https://openalex.org/W4393935425","https://openalex.org/W4398235154","https://openalex.org/W4399515039","https://openalex.org/W4402196843","https://openalex.org/W4403109046","https://openalex.org/W4411472572","https://openalex.org/W4411776216","https://openalex.org/W4412419798","https://openalex.org/W4412639018","https://openalex.org/W4416074731","https://openalex.org/W4416221574","https://openalex.org/W7123452202","https://openalex.org/W7159787153","https://openalex.org/W7170163744","https://openalex.org/W7204557577"],"related_works":["https://openalex.org/W7165035405","https://openalex.org/W7213776964","https://openalex.org/W4412887432","https://openalex.org/W4386493645","https://openalex.org/W4297907049","https://openalex.org/W7202208552","https://openalex.org/W4388036003","https://openalex.org/W4362456304","https://openalex.org/W7204444469","https://openalex.org/W2737749063"],"abstract_inverted_index":{"Background:":[0],"Prostate":[1],"cancer":[2],"(PCa),":[3],"particularly":[4],"metastatic":[5],"castration-resistant":[6],"PCa":[7,27,40,98],"(mCRPC),":[8],"remains":[9],"therapeutically":[10],"challenging.":[11],"Cuproptosis,":[12],"a":[13,33,172],"copper-dependent":[14],"cell":[15,53],"death":[16],"driven":[17],"by":[18],"lipoylated":[19,139],"tricarboxylic":[20],"acid":[21],"cycle":[22],"proteins,":[23],"is":[24],"implicated":[25],"in":[26,39,49,97,168],"progression,":[28],"but":[29,107],"whether":[30],"ceruloplasmin":[31],"(CP),":[32],"key":[34],"copper-binding":[35],"glycoprotein,":[36],"modulates":[37],"cuproptosis":[38],"and":[41,67,77,122,141,144,164],"the":[42],"underlying":[43],"mediators":[44],"remain":[45],"unknown.":[46],"Methods:":[47],"validation":[48],"two":[50],"androgen-independent":[51],"CRPC":[52,169],"lines:":[54],"PC-3":[55,119],"cells":[56,63],"received":[57],"exogenous":[58],"CP":[59,65,102,116,129],"gradients,":[60],"while":[61,101],"22Rv1":[62,127],"underwent":[64],"knockdown":[66,130],"rescue":[68],"experiments":[69],"with":[70,111,177],"qPCR,":[71],"Western":[72],"blot,":[73],"MitoSOX":[74],"flow":[75],"cytometry,":[76],"CCK-8":[78],"assays.":[79],"Results:":[80],"Eighty":[81],"CP-cuproptosis":[82],"intersection":[83],"genes":[84,89,113],"were":[85,94],"identified.":[86],"Cuproptosis":[87],"core":[88],"(FDX1,":[90,137],"DLST,":[91],"LIAS,":[92],"DLD)":[93],"significantly":[95],"upregulated":[96,134],"(all":[99],"p<0.001),":[100],"showed":[103,155],"no":[104],"differential":[105],"expression":[106],"weak":[108],"positive":[109],"correlations":[110],"these":[112,151],"(r=0.205-0.300).":[114],"Exogenous":[115],"concentration-dependently":[117],"reduced":[118],"metabolic":[120],"activity":[121],"induced":[123],"apoptosis-related":[124],"morphology.":[125],"In":[126],"cells,":[128,170],"downregulated":[131],"lncRNA":[132],"STPG3-AS1,":[133],"cuproptosis-related":[135],"markers":[136],"DLAT,":[138],"proteins)":[140],"mitochondrial":[142],"ROS,":[143],"inhibited":[145],"proliferation;":[146],"STPG3-AS1":[147,160],"overexpression":[148],"reversed":[149],"all":[150],"effects.":[152],"No":[153],"gene":[154],"independent":[156],"prognostic":[157],"value.":[158],"Conclusion:":[159],"mediates":[161],"CP-regulated":[162],"lipoylation":[163],"cuproptosis-associated":[165],"molecular":[166],"changes":[167],"identifying":[171],"novel":[173],"CP-STPG3-AS1-cuproptosis":[174],"regulatory":[175],"axis":[176],"therapeutic":[178],"potential":[179],"for":[180],"advanced":[181],"prostate":[182],"cancer.":[183]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-22T00:00:00"}