{"id":"https://openalex.org/W7223157948","doi":"https://doi.org/10.1016/j.htct.2026.108279","title":"EFEITOS DA FOTOBIOMODULA\u00c7\u00c3O NA PREVEN\u00c7\u00c3O DA MUCOSITE ORAL INDUZIDA POR METOTREXATO EM UM MODELO PR\u00c9-CL\u00cdNICO","display_name":"EFEITOS DA FOTOBIOMODULA\u00c7\u00c3O NA PREVEN\u00c7\u00c3O DA MUCOSITE ORAL INDUZIDA POR METOTREXATO EM UM MODELO PR\u00c9-CL\u00cdNICO","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223157948","doi":"https://doi.org/10.1016/j.htct.2026.108279"},"language":"en","primary_location":{"id":"doi:10.1016/j.htct.2026.108279","doi":"https://doi.org/10.1016/j.htct.2026.108279","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.108279","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1016/j.htct.2026.108279","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114328409","display_name":"Raissa Baisso ESPINHOSA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Raissa Baisso ESPINHOSA","raw_affiliation_strings":["Centro de Oncologia Bucal e Departamento de Diagn\u00f3stico e Cirurgia, Faculdade de Odontologia de Ara\u00e7atuba, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d (FOA-Unesp), Ara\u00e7atuba, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Oncologia Bucal e Departamento de Diagn\u00f3stico e Cirurgia, Faculdade de Odontologia de Ara\u00e7atuba, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d (FOA-Unesp), Ara\u00e7atuba, SP, Brasil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159213489","display_name":"St\u00e9ffani Nascimento DA SILVA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"St\u00e9ffani Nascimento DA SILVA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048649602","display_name":"Mariana Aparecida Sanches Pereira","orcid":"https://orcid.org/0009-0004-5025-1032","observed_orcids":["https://orcid.org/0009-0004-5025-1032"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mariana Aparecida Sanches PEREIRA","raw_affiliation_strings":["Centro de Oncologia Bucal e Departamento de Diagn\u00f3stico e Cirurgia, Faculdade de Odontologia de Ara\u00e7atuba, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d (FOA-Unesp), Ara\u00e7atuba, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Oncologia Bucal e Departamento de Diagn\u00f3stico e Cirurgia, Faculdade de Odontologia de Ara\u00e7atuba, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d (FOA-Unesp), Ara\u00e7atuba, SP, Brasil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037034050","display_name":"Marcelo Macedo Crivelini","orcid":"https://orcid.org/0000-0002-0174-439X","observed_orcids":["https://orcid.org/0000-0002-0174-439X"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo Macedo CRIVELINI","raw_affiliation_strings":["Departamento de Diagn\u00f3stico e Cirurgia, Faculdade de Odontologia de Ara\u00e7atuba, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d (FOA-Unesp), Ara\u00e7atuba, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Diagn\u00f3stico e Cirurgia, Faculdade de Odontologia de Ara\u00e7atuba, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d (FOA-Unesp), Ara\u00e7atuba, SP, Brasil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066132915","display_name":"Renata Callestini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Renata CALLESTINI","raw_affiliation_strings":["Departamento de Diagn\u00f3stico e Cirurgia, Faculdade de Odontologia de Ara\u00e7atuba, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d (FOA-Unesp), Ara\u00e7atuba, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Diagn\u00f3stico e Cirurgia, Faculdade de Odontologia de Ara\u00e7atuba, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d (FOA-Unesp), Ara\u00e7atuba, SP, Brasil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106367356","display_name":"Mariana Stuchi Urazaki","orcid":"https://orcid.org/0009-0004-4547-0230","observed_orcids":["https://orcid.org/0009-0004-4547-0230"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariana Stuchi URAZAKI","raw_affiliation_strings":["Centro de Tratamento Oncol\u00f3gico, Hospital Santa Casa de Ara\u00e7atuba, Ara\u00e7atuba, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Tratamento Oncol\u00f3gico, Hospital Santa Casa de Ara\u00e7atuba, Ara\u00e7atuba, SP, Brasil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042633425","display_name":"Gabriel Macedo Cortopassi","orcid":"https://orcid.org/0000-0003-0533-2242","observed_orcids":["https://orcid.org/0000-0003-0533-2242"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel Macedo CORTOPASSI","raw_affiliation_strings":["Centro de Tratamento Oncol\u00f3gico, Hospital Santa Casa de Ara\u00e7atuba, Ara\u00e7atuba, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Tratamento Oncol\u00f3gico, Hospital Santa Casa de Ara\u00e7atuba, Ara\u00e7atuba, SP, Brasil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036155503","display_name":"Glauco Issamu Miyahara","orcid":"https://orcid.org/0000-0002-5748-9412","observed_orcids":["https://orcid.org/0000-0002-5748-9412"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Glauco Issamu MIYAHARA","raw_affiliation_strings":["Centro de Oncologia Bucal e Departamento de Diagn\u00f3stico e Cirurgia, Faculdade de Odontologia de Ara\u00e7atuba, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d (FOA-Unesp), Ara\u00e7atuba, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Oncologia Bucal e Departamento de Diagn\u00f3stico e Cirurgia, Faculdade de Odontologia de Ara\u00e7atuba, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d (FOA-Unesp), Ara\u00e7atuba, SP, Brasil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154519229","display_name":"Daniel Galera Bernab\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Daniel Galera BERNAB\u00c9","raw_affiliation_strings":["Centro de Oncologia Bucal e Departamento de Diagn\u00f3stico e Cirurgia, Faculdade de Odontologia de Ara\u00e7atuba, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d (FOA-Unesp), Ara\u00e7atuba, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Oncologia Bucal e Departamento de Diagn\u00f3stico e Cirurgia, Faculdade de Odontologia de Ara\u00e7atuba, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d (FOA-Unesp), Ara\u00e7atuba, SP, Brasil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008367262","display_name":"Giseli Mitsuy Kayahara","orcid":"https://orcid.org/0000-0003-1341-4520","observed_orcids":["https://orcid.org/0000-0003-1341-4520"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Giseli Mitsuy KAYAHARA","raw_affiliation_strings":["Centro de Oncologia Bucal e Departamento de Diagn\u00f3stico e Cirurgia, Faculdade de Odontologia de Ara\u00e7atuba, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d (FOA-Unesp), Ara\u00e7atuba, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Oncologia Bucal e Departamento de Diagn\u00f3stico e Cirurgia, Faculdade de Odontologia de Ara\u00e7atuba, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d (FOA-Unesp), Ara\u00e7atuba, SP, Brasil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051689320","display_name":"V\u00edtor Bonetti Valente","orcid":"https://orcid.org/0000-0003-4434-6057","observed_orcids":["https://orcid.org/0000-0003-4434-6057"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vitor Bonetti VALENTE","raw_affiliation_strings":["Centro de Oncologia Bucal e Departamento de Diagn\u00f3stico e Cirurgia, Faculdade de Odontologia de Ara\u00e7atuba, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d (FOA-Unesp), Ara\u00e7atuba, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Oncologia Bucal e Departamento de Diagn\u00f3stico e Cirurgia, Faculdade de Odontologia de Ara\u00e7atuba, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d (FOA-Unesp), Ara\u00e7atuba, SP, Brasil","institution_ids":["https://openalex.org/I879563668"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82791134,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":null,"first_page":"108279","last_page":"108279"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-mucositis","display_name":"oral mucositis","score":0.875},{"id":"https://openalex.org/keywords/low-level-laser-therapy","display_name":"low-level laser therapy","score":0.9269999861717224},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9670000076293945},{"id":"https://openalex.org/keywords/chemotherapy-induced-mucositis","display_name":"chemotherapy-induced mucositis","score":0.8270000219345093},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.4959999918937683},{"id":"https://openalex.org/keywords/oral-epithelium","display_name":"oral epithelium","score":0.6140000224113464},{"id":"https://openalex.org/keywords/lamina-propria","display_name":"lamina propria","score":0.890999972820282},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.37599998712539673},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.5070000290870667},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5460000038146973},{"id":"https://openalex.org/keywords/660-nm-red-light","display_name":"660 nm red light","score":0.675000011920929},{"id":"https://openalex.org/keywords/leukocyte-infiltration","display_name":"leukocyte infiltration","score":0.3919999897480011},{"id":"https://openalex.org/keywords/leukocyte-adhesion","display_name":"leukocyte adhesion","score":0.3479999899864197},{"id":"https://openalex.org/keywords/leukocyte-extravasation","display_name":"leukocyte transmigration","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8589000105857849},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45820000767707825},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4287000000476837},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2583000063896179},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23180000483989716},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.21619999408721924},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.21230000257492065},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.20350000262260437},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.1979999989271164},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.18479999899864197}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.htct.2026.108279","doi":"https://doi.org/10.1016/j.htct.2026.108279","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.108279","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:63a85c6ab977455cb3dbeb511a3ad6fb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/63a85c6ab977455cb3dbeb511a3ad6fb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 48, Iss , Pp 108279- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.htct.2026.108279","doi":"https://doi.org/10.1016/j.htct.2026.108279","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.108279","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7130674151","https://openalex.org/W4415873113","https://openalex.org/W4386388702","https://openalex.org/W2993806153","https://openalex.org/W7223143874","https://openalex.org/W6992628637","https://openalex.org/W7080184452","https://openalex.org/W4283691119","https://openalex.org/W3116824600","https://openalex.org/W7213232676"],"abstract_inverted_index":{"O":[0,110,168],"metotrexato":[1],"(MTX)":[2],"\u00e9":[3,42],"um":[4],"quimioter\u00e1pico":[5,30],"utilizado":[6],"no":[7,16,138,213,302,340,354,372],"tratamento":[8,430],"de":[9,20,36,55,101,194,211,369,394],"leucemias":[10],"agudas":[11],"devido":[12],"\u00e0":[13,146,209,233,243,347],"sua":[14],"efic\u00e1cia":[15],"controle":[17],"da":[18,72,96,119,123,215,275,304,326,333,349,351,356,414,420],"prolifera\u00e7\u00e3o":[19],"blastos":[21],"malignos.":[22],"Apesar":[23],"dos":[24,57,277,306,358,401,431],"benef\u00edcios":[25],"terap\u00eauticos,":[26],"a":[27,53,82,99,174,187,225,438],"administra\u00e7\u00e3o":[28,192],"do":[29,112,237,256,279,308,315,320,328,331,380,388,426,441],"est\u00e1":[31],"frequentemente":[32],"associada":[33],"ao":[34,148,293],"desenvolvimento":[35],"mucosite":[37,73,102,124,188,226,291,415],"oral.":[38],"Esta":[39],"condi\u00e7\u00e3o":[40],"inflamat\u00f3ria":[41,440],"caracterizada":[43],"por":[44,75,105,127,176,217,248,250],"les\u00f5es":[45,285,412],"dolorosas":[46],"na":[47,121,142,418],"mucosa":[48],"bucal":[49],"que":[50,91,295,336],"podem":[51],"comprometer":[52],"qualidade":[54],"vida":[56],"pacientes":[58],"acometidos.":[59],"A":[60,406],"fotobiomodula\u00e7\u00e3o":[61],"(FBM)":[62],"tem":[63],"sido":[64],"considerada":[65],"uma":[66,345],"estrat\u00e9gia":[67],"eficaz":[68],"para":[69,268],"o":[70,77,199,377,409,424],"manejo":[71],"oral":[74,103,125,193,227,292,416],"estimular":[76],"reparo":[78,425],"tecidual":[79],"e":[80,141,166,185,263,271,287,404],"modular":[81],"resposta":[83,439],"inflamat\u00f3ria.":[84],"No":[85],"entanto,":[86],"s\u00e3o":[87],"escassos":[88],"os":[89,93,117,205,259,318,386],"estudos":[90],"investigaram":[92],"efeitos":[94,118],"preventivos":[95],"FBM":[97,120,244,407],"sobre":[98],"ocorr\u00eancia":[100],"induzida":[104,126,190],"quimioter\u00e1picos":[106],"em":[107,129,160,228],"modelos":[108,229],"pr\u00e9-cl\u00ednicos.":[109],"objetivo":[111],"presente":[113],"estudo":[114,153],"foi":[115,189,300,338,365],"avaliar":[116],"preven\u00e7\u00e3o":[122],"MTX":[128,165,184,195,281,322],"ratos.":[130],"Al\u00e9m":[131],"disso,":[132],"tamb\u00e9m":[133],"foram":[134,207,240,261,266],"investigadas":[135],"altera\u00e7\u00f5es":[136],"microsc\u00f3picas":[137],"tecido":[139,329,427],"epitelial":[140,330,428],"l\u00e2mina":[143],"pr\u00f3pria":[144],"associadas":[145],"exposi\u00e7\u00e3o":[147,232],"quimioter\u00e1pico.":[149],"Foram":[150],"utilizados":[151],"neste":[152],"18":[154],"ratos":[155,236,314,319,387],"machos":[156],"Wistar":[157],"distribu\u00eddos":[158],"igualmente":[159],"tr\u00eas":[161,179],"grupos":[162,183,402],"experimentais:":[163],"Salina,":[164,317],"MTX+FBM.":[167,310],"grupo":[169,238,280,309,316,321,341,373,389],"Salina":[170,403],"recebeu":[171],"solu\u00e7\u00e3o":[172],"salina":[173],"0,9%":[175],"gavagem":[177],"durante":[178,198],"dias":[180,219,252],"consecutivos.":[181,220,253],"Nos":[182],"MTX+FBM,":[186],"pela":[191],"(5":[196],"mg/kg/dia)":[197],"mesmo":[200],"per\u00edodo.":[201],"Em":[202,311],"seguida,":[203],"todos":[204,258],"animais":[206,260,278,307,359,400,432],"submetidos":[208,242],"realiza\u00e7\u00e3o":[210],"ranhuras":[212],"dorso":[214,303,332,355],"l\u00edngua":[216,305,357],"dois":[218],"Este":[221,363],"procedimento":[222],"pode":[223],"desencadear":[224],"pr\u00e9-cl\u00ednicos":[230],"ap\u00f3s":[231,429],"quimioter\u00e1picos.":[234],"Os":[235],"MTX+FBM":[239,342,374],"ent\u00e3o":[241],"(660\u00b110":[245],"nm;":[246],"2J":[247],"ponto)":[249],"quatro":[251],"Ao":[254],"t\u00e9rmino":[255],"experimento,":[257],"eutanasiados":[262],"as":[264],"l\u00ednguas":[265],"coletadas":[267],"avalia\u00e7\u00e3o":[269],"cl\u00ednica":[270],"an\u00e1lise":[272],"histopatol\u00f3gica.":[273],"Metade":[274],"amostra":[276],"(n=3;":[282],"50%)":[283],"apresentou":[284],"erosivas":[286],"ulcerativas":[288],"compat\u00edveis":[289],"com":[290,361,433],"passo":[294],"nenhuma":[296],"les\u00e3o":[297],"clinicamente":[298],"detect\u00e1vel":[299],"observada":[301],"rela\u00e7\u00e3o":[312],"aos":[313,399],"apresentaram":[323],"redu\u00e7\u00e3o":[324],"significativa":[325],"espessura":[327,350],"l\u00edngua,":[334],"altera\u00e7\u00e3o":[335],"n\u00e3o":[337],"identificada":[339],"(p<0.05).":[343],"Houve":[344],"tend\u00eancia":[346],"diminui\u00e7\u00e3o":[348],"camada":[352],"c\u00f3rnea":[353],"tratados":[360],"MTX.":[362,405,434],"efeito":[364],"revertido":[366],"pelo":[367],"laser":[368],"baixa":[370],"pot\u00eancia":[371],"(p>0.05).":[375],"Embora":[376],"infiltrado":[378],"inflamat\u00f3rio":[379],"estroma":[381],"tenha":[382],"recebido":[383],"classifica\u00e7\u00e3o":[384],"leve,":[385],"MTX+LASER":[390],"exibiram":[391],"maior":[392],"n\u00famero":[393],"c\u00e9lulas":[395],"inflamat\u00f3rias":[396],"quando":[397],"comparado":[398],"preveniu":[408],"aparecimento":[410],"das":[411],"caracter\u00edsticas":[413],"contribuindo":[417],"preserva\u00e7\u00e3o":[419],"integridade":[421],"ou":[422],"estimulando":[423],"Tamb\u00e9m":[435],"atuou":[436],"modulando":[437],"estroma.":[442]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}