{"id":"https://openalex.org/W7223153193","doi":"https://doi.org/10.64898/2026.10.19.760052","title":"Biosurfactant production under cold-saline stress is a strain specific trait independent from phylogeny and biosynthetic gene content","display_name":"Biosurfactant production under cold-saline stress is a strain specific trait independent from phylogeny and biosynthetic gene content","publication_year":2026,"publication_date":"2026-10-21","ids":{"openalex":"https://openalex.org/W7223153193","doi":"https://doi.org/10.64898/2026.10.19.760052"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.19.760052","doi":"https://doi.org/10.64898/2026.10.19.760052","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.19.760052","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/21/2026.10.19.760052.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/21/2026.10.19.760052.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101828660","display_name":"Habib Ullah","orcid":"https://orcid.org/0000-0002-7675-8681","observed_orcids":["https://orcid.org/0000-0002-7675-8681","https://orcid.org/0000-0003-4276-6752"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210154862","display_name":"Institute of Deep-Sea Science and Engineering","ror":"https://ror.org/050spgz68","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210154862"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Habib Ullah","raw_affiliation_strings":["Department of Extraterrestrial Ocean Systems, Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya, China","University of Chinese Academy of Sciences, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-4276-6752","affiliations":[{"raw_affiliation_string":"Department of Extraterrestrial Ocean Systems, Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210154862"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158817524","display_name":"Zhuang Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuang Han","raw_affiliation_strings":["University of Chinese Academy of Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078644298","display_name":"Maggie C. Y. Lau","orcid":"https://orcid.org/0000-0003-2812-9749","observed_orcids":["https://orcid.org/0000-0003-2812-9749"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210154862","display_name":"Institute of Deep-Sea Science and Engineering","ror":"https://ror.org/050spgz68","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210154862"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Maggie C. Y. Lau Vetter","raw_affiliation_strings":["Department of Extraterrestrial Ocean Systems, Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya, China"],"raw_orcid":"https://orcid.org/0000-0003-2812-9749","affiliations":[{"raw_affiliation_string":"Department of Extraterrestrial Ocean Systems, Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210154862"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5078644298"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210154862"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10324","display_name":"Microbial bioremediation and biosurfactants","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10324","display_name":"Microbial bioremediation and biosurfactants","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.03519999980926514,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosurfactant-production","display_name":"biosurfactant production","score":0.9120000004768372},{"id":"https://openalex.org/keywords/strain-specific-response","display_name":"strain-specific response","score":0.5789999961853027},{"id":"https://openalex.org/keywords/bacterial-stress-response","display_name":"bacterial stress response","score":0.5059999823570251},{"id":"https://openalex.org/keywords/surface-tension","display_name":"surface tension","score":0.6140000224113464},{"id":"https://openalex.org/keywords/regulatory-genes","display_name":"regulatory genes","score":0.5709999799728394},{"id":"https://openalex.org/keywords/biosynthetic-gene-clusters","display_name":"biosynthetic gene clusters","score":0.828000009059906},{"id":"https://openalex.org/keywords/extreme-environments","display_name":"extreme environments","score":0.5640000104904175},{"id":"https://openalex.org/keywords/qaidam-basin","display_name":"Qaidam Basin","score":0.7559999823570251},{"id":"https://openalex.org/keywords/mars-analog","display_name":"Mars analog","score":0.5370000004768372},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.42100000381469727},{"id":"https://openalex.org/keywords/phylogenetic-signal","display_name":"phylogenetic signal","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8052999973297119},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.6583999991416931},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6502000093460083},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.623199999332428},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.6166999936103821},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.5688999891281128},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.5185999870300293},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48100000619888306},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.44209998846054077},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4092000126838684},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4025000035762787},{"id":"https://openalex.org/C175605896","wikidata":"https://www.wikidata.org/wiki/Q39833","display_name":"Microorganism","level":3,"score":0.3635999858379364},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3562999963760376},{"id":"https://openalex.org/C129513315","wikidata":"https://www.wikidata.org/wiki/Q179615","display_name":"Salinity","level":2,"score":0.34790000319480896},{"id":"https://openalex.org/C3742359","wikidata":"https://www.wikidata.org/wiki/Q4839988","display_name":"Bacterial genome size","level":4,"score":0.3393000066280365},{"id":"https://openalex.org/C93642007","wikidata":"https://www.wikidata.org/wiki/Q5422399","display_name":"Extreme environment","level":3,"score":0.33230000734329224},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.3312000036239624},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.3019999861717224},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.29829999804496765},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.29490000009536743},{"id":"https://openalex.org/C7386963","wikidata":"https://www.wikidata.org/wiki/Q3954859","display_name":"Negative selection","level":4,"score":0.2825999855995178},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.27469998598098755},{"id":"https://openalex.org/C78604142","wikidata":"https://www.wikidata.org/wiki/Q1640582","display_name":"Fight-or-flight response","level":3,"score":0.2590999901294708}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.19.760052","doi":"https://doi.org/10.64898/2026.10.19.760052","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.19.760052","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/21/2026.10.19.760052.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.19.760052","doi":"https://doi.org/10.64898/2026.10.19.760052","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.19.760052","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/21/2026.10.19.760052.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6548766382","display_name":null,"funder_award_id":"202501","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"}],"funders":[{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320332035","display_name":"Alliance of International Science Organizations","ror":"https://ror.org/01c6a8q83"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223153193.pdf","grobid_xml":"https://content.openalex.org/works/W7223153193.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W1827213771","https://openalex.org/W2990471452","https://openalex.org/W3045244624","https://openalex.org/W3203343200"],"related_works":["https://openalex.org/W7223065723","https://openalex.org/W2750182167","https://openalex.org/W2917610189","https://openalex.org/W2349618616","https://openalex.org/W2901919578","https://openalex.org/W4205305640","https://openalex.org/W7215049755","https://openalex.org/W2766392724","https://openalex.org/W2786168456","https://openalex.org/W4292254515"],"abstract_inverted_index":{"Abstract":[0],"Microbial":[1],"genomes":[2,52],"code":[3],"for":[4,98],"far":[5],"more":[6],"biosynthetic":[7],"potential":[8,230],"than":[9,160],"a":[10,112,117,198],"single":[11],"cell":[12],"typically":[13],"expresses,":[14],"but":[15,56,116,208],"the":[16,24,61,69,90,139,143,223],"environmental":[17],"and":[18,41,80,101,126,174,177],"cellular":[19,210,224],"controls":[20],"that":[21,64,107,121,212,226,229],"determine":[22,227],"whether":[23,228],"latent":[25],"capacity":[26,47,137],"is":[27,48,57,110,131,231],"realised":[28,155],"remain":[29],"poorly":[30],"understood.":[31],"Biosurfactants,":[32],"surface-active":[33],"metabolites":[34],"proposed":[35],"to":[36,60,222],"aid":[37],"survival":[38],"in":[39,68,186,194],"cold":[40,125],"saline":[42],"habitats,":[43],"exemplify":[44],"this":[45],"gap:":[46],"often":[49],"inferred":[50],"from":[51,89],"or":[53],"detected":[54],"chemically,":[55],"rarely":[58],"linked":[59],"specific":[62],"conditions":[63],"stimulate":[65],"its":[66,214],"production":[67,109,165],"same":[70],"organisms.":[71],"Here":[72],"we":[73],"combine":[74],"whole-genome":[75],"sequencing,":[76],"untargeted":[77],"LC-MS/MS":[78],"metabolomics,":[79],"quantitative":[81],"surface-tension":[82],"assays":[83],"across":[84,166],"25":[85],"bacterial":[86],"isolates":[87],"isolated":[88],"cold,":[91],"hypersaline":[92],"Qaidam":[93],"Basin":[94],"(a":[95],"terrestrial":[96],"analogue":[97],"ancient":[99],"Mars)":[100],"contrasting":[102],"marine":[103],"environments.":[104],"We":[105],"show":[106],"biosurfactant":[108],"not":[111,203],"fixed":[113],"lineage":[114],"trait":[115],"regulated,":[118],"strain-specific":[119],"response":[120,130],"emerges":[122],"under":[123],"combined":[124],"salt":[127],"stress.":[128],"This":[129],"structured":[132],"into":[133],"three":[134],"tiers:":[135],"genomic":[136,144,206],"defines":[138],"accessible":[140],"chemical":[141],"space;":[142],"complement":[145],"of":[146,200,205,209],"pathway-regulator":[147],"genes":[148],"tracks":[149],"responsiveness;":[150],"strain-level":[151],"physiological":[152],"state":[153],"determines":[154],"output.":[156],"Regulatory-gene":[157],"content,":[158],"rather":[159],"biosynthetic-cluster":[161],"count,":[162],"predicted":[163],"surfactant":[164],"strains.":[167],"Production":[168],"was":[169],"amplified":[170],"by":[171],"low":[172],"temperature":[173],"high":[175],"salinity":[176],"showed":[178],"little":[179],"phylogenetic":[180],"signal,":[181],"with":[182],"near-clonal":[183],"strains":[184],"differing":[185],"their":[187],"stress-response.":[188],"These":[189],"findings":[190],"reshape":[191],"biochemical":[192],"adaptation":[193],"extreme":[195],"environments":[196],"as":[197],"problem":[199],"conditional":[201],"activation,":[202],"only":[204],"potential,":[207],"systems":[211],"permit":[213],"expression,":[215],"which":[216],"requires":[217],"looking":[218],"beyond":[219],"biosynthetic-gene":[220],"content":[221],"factors":[225],"expressed.":[232]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-22T00:00:00"}
