{"id":"https://openalex.org/W7223152146","doi":"https://doi.org/10.20944/preprints202610.2035.v1","title":"Ferroptosis and Cuproptosis in the Pathogenesis of Breast Cancer: Molecular Mechanisms, Crosstalk, and Therapeutic Perspectives","display_name":"Ferroptosis and Cuproptosis in the Pathogenesis of Breast Cancer: Molecular Mechanisms, Crosstalk, and Therapeutic Perspectives","publication_year":2026,"publication_date":"2026-10-21","ids":{"openalex":"https://openalex.org/W7223152146","doi":"https://doi.org/10.20944/preprints202610.2035.v1"},"language":"en","primary_location":{"id":"doi:10.20944/preprints202610.2035.v1","doi":"https://doi.org/10.20944/preprints202610.2035.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202610.2035.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.20944/preprints202610.2035.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041121533","display_name":"V. V. Ivchuk","orcid":"https://orcid.org/0000-0001-9822-5192","observed_orcids":["https://orcid.org/0000-0001-9822-5192"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vitalii Ivchuk","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9822-5192","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041121533"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":1.0},{"id":"https://openalex.org/keywords/cuproptosis","display_name":"cuproptosis","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9359999895095825},{"id":"https://openalex.org/keywords/regulated-cell-death","display_name":"regulated cell death","score":0.9290000200271606},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/proteotoxicity","display_name":"proteotoxicity","score":0.7179999947547913},{"id":"https://openalex.org/keywords/glutathione-metabolism","display_name":"glutathione metabolism","score":0.9330000281333923},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.9639999866485596},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.9610000252723694},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.8740000128746033},{"id":"https://openalex.org/keywords/doxorubicin-resistance","display_name":"doxorubicin resistance","score":0.9850000143051147},{"id":"https://openalex.org/keywords/taxane-resistance","display_name":"taxane resistance","score":0.953000009059906},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":1.0},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.8410000205039978},{"id":"https://openalex.org/keywords/disulfiram","display_name":"disulfiram","score":0.9399999976158142},{"id":"https://openalex.org/keywords/elesclomol","display_name":"elesclomol","score":1.0},{"id":"https://openalex.org/keywords/copper-chelators","display_name":"copper chelators","score":0.9909999966621399},{"id":"https://openalex.org/keywords/co-targeting","display_name":"co-targeting","score":0.6169999837875366},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6629999876022339},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6467000246047974},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5878000259399414},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5684999823570251},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4918000102043152},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.46869999170303345},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.45570001006126404},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4399999976158142},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4278999865055084},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41429999470710754},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.40470001101493835},{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.38960000872612},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3330000042915344},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.3248000144958496},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.31299999356269836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2897000014781952},{"id":"https://openalex.org/C158086472","wikidata":"https://www.wikidata.org/wiki/Q21103287","display_name":"GPX4","level":5,"score":0.28540000319480896},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.2847999930381775},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.2500999867916107}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.20944/preprints202610.2035.v1","doi":"https://doi.org/10.20944/preprints202610.2035.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202610.2035.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:zenodo.org:23533282","doi":null,"is_oa":true,"landing_page_url":"https://www.preprints.org/frontend/manuscript/5c8a9947d363cffa4bb5c8c392f71627/download_pub","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/preprint"}],"best_oa_location":{"id":"doi:10.20944/preprints202610.2035.v1","doi":"https://doi.org/10.20944/preprints202610.2035.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202610.2035.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4406254731","https://openalex.org/W7172542482","https://openalex.org/W4390600556","https://openalex.org/W4391230213","https://openalex.org/W7160949730","https://openalex.org/W7119521010","https://openalex.org/W4407596202","https://openalex.org/W4399812413","https://openalex.org/W4410220897","https://openalex.org/W4412153786"],"abstract_inverted_index":{"The":[0,30],"essay":[1],"reviews":[2],"current":[3],"understanding":[4],"of":[5,8,11,23,32,41,68,82,119,147,152,162,165,176,183,188,219],"the":[6,21,33,38,50,60,80,109,145,160,172,181,186],"role":[7],"metal-dependent":[9],"forms":[10],"regulated":[12],"cell":[13],"death":[14],"\u2013":[15,19],"ferroptosis":[16,153,199],"and":[17,26,48,76,93,108,128,154,168,191,200,217],"cuproptosis":[18,155,201],"in":[20,79,102,131],"pathogenesis":[22],"breast":[24,137],"cancer":[25],"their":[27,53,77],"therapeutic":[28,140],"potential.":[29],"aim":[31],"work":[34,61],"was":[35],"to":[36,56,73,125],"analyze":[37],"molecular":[39],"mechanisms":[40],"both":[42,120],"processes,":[43],"identify":[44],"common":[45,99],"regulatory":[46,100],"nodes,":[47,101],"assess":[49],"prospects":[51],"for":[52,149],"joint":[54],"targeting":[55],"overcome":[57],"chemoresistance.":[58],"Methodologically,":[59],"is":[62,195,202],"based":[63],"on":[64],"a":[65,203],"critical":[66],"review":[67],"peer-reviewed":[69],"scientific":[70],"sources":[71],"devoted":[72],"ferroptosis,":[74,89],"cuproptosis,":[75,94],"cross-talk":[78],"context":[81],"oncology.":[83],"It":[84,113,194],"has":[85,114],"been":[86,115],"shown":[87],"that":[88,117,197],"iron-dependent":[90],"lipid":[91],"peroxidation,":[92],"copper-dependent":[95],"proteotoxic":[96],"death,":[97],"have":[98],"particular,":[103],"glutathione":[104],"metabolism,":[105],"mitochondrial":[106],"respiration,":[107],"p53":[110],"signaling":[111],"pathway.":[112],"established":[116],"induction":[118],"processes":[121],"allows":[122],"overcoming":[123],"resistance":[124],"cisplatin,":[126],"doxorubicin,":[127],"taxanes,":[129],"especially":[130],"aggressive":[132],"subtypes":[133],"such":[134],"as":[135,157,159],"triple-negative":[136],"cancer.":[138],"Current":[139],"strategies":[141],"are":[142,179],"reviewed,":[143],"including":[144],"use":[146],"nanocarriers":[148],"targeted":[150,220],"delivery":[151],"inducers,":[156],"well":[158],"results":[161],"clinical":[163,177,209],"trials":[164],"disulfiram,":[166],"elesclomol,":[167],"copper":[169],"chelators.":[170],"At":[171],"same":[173],"time,":[174],"limitations":[175],"translation":[178],"emphasized:":[180],"lack":[182],"validated":[184],"biomarkers,":[185],"risk":[187],"systemic":[189],"toxicity,":[190],"tumor":[192],"heterogeneity.":[193],"concluded":[196],"co-targeting":[198],"promising":[204],"strategy,":[205],"but":[206],"its":[207],"widespread":[208],"application":[210],"requires":[211],"further":[212],"prospective":[213],"studies,":[214],"biomarker":[215],"identification,":[216],"development":[218],"nanosystems.":[221]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-22T00:00:00"}
