{"id":"https://openalex.org/W7223149173","doi":"https://doi.org/10.2147/ijgm.s639020","title":"Factors Associated with Early Sepsis-Associated Liver Injury and Predictors of 30-Day Mortality: A Retrospective Cohort Study","display_name":"Factors Associated with Early Sepsis-Associated Liver Injury and Predictors of 30-Day Mortality: A Retrospective Cohort Study","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223149173","doi":"https://doi.org/10.2147/ijgm.s639020","pmid":"https://pubmed.ncbi.nlm.nih.gov/42928790","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13695970"},"language":"en","primary_location":{"id":"doi:10.2147/ijgm.s639020","doi":"https://doi.org/10.2147/ijgm.s639020","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijgm.s639020","pdf_url":"https://www.dovepress.com/article/download/121167","source":{"id":"https://openalex.org/S123199335","display_name":"International Journal of General Medicine","issn_l":"1178-7074","issn":["1178-7074"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of General Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/121167","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067326229","display_name":"\u0130lk\u00e7e Akg\u00fcn Kurtulmu\u015f","orcid":"https://orcid.org/0000-0002-2661-8525","observed_orcids":["https://orcid.org/0000-0002-2661-8525"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u0130lkce Akgun Kurtulmus","raw_affiliation_strings":["Division of Intensive Care Medicine, Department of Internal Medicine, Faculty of Medicine, Ege University, Izmir, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-2661-8525","affiliations":[{"raw_affiliation_string":"Division of Intensive Care Medicine, Department of Internal Medicine, Faculty of Medicine, Ege University, Izmir, T\u00fcrkiye","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029482322","display_name":"\u015e\u00fckriye Miray K\u0131l\u0131n\u00e7er Bozg\u00fcl","orcid":"https://orcid.org/0000-0002-3995-5096","observed_orcids":["https://orcid.org/0000-0002-3995-5096"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Sukriye Miray Kilincer Bozgul","raw_affiliation_strings":["Division of Intensive Care Medicine, Department of Internal Medicine, Faculty of Medicine, Ege University, Izmir, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-3995-5096","affiliations":[{"raw_affiliation_string":"Division of Intensive Care Medicine, Department of Internal Medicine, Faculty of Medicine, Ege University, Izmir, T\u00fcrkiye","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074119627","display_name":"Caner Acar","orcid":"https://orcid.org/0000-0002-9782-6807","observed_orcids":["https://orcid.org/0000-0002-9782-6807"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Caner Acar","raw_affiliation_strings":["Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Ege University, Izmir, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-9782-6807","affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Ege University, Izmir, T\u00fcrkiye","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157837010","display_name":"G\u00fcne\u015f Ak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Gunes Ak","raw_affiliation_strings":["Department of Clinical Biochemistry, Faculty of Medicine, Ege University, Izmir, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Faculty of Medicine, Ege University, Izmir, T\u00fcrkiye","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127803369","display_name":"Rabia Ozmen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Rabia Ozmen","raw_affiliation_strings":["Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Ege University, Izmir, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Ege University, Izmir, T\u00fcrkiye","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000844713","display_name":"Hande Dik Avc\u0131","orcid":"https://orcid.org/0000-0003-2072-9395","observed_orcids":["https://orcid.org/0000-0003-2072-9395"]},"institutions":[{"id":"https://openalex.org/I4405265970","display_name":"Bursa City Hospital","ror":"https://ror.org/02ynkzm22","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4405265970"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hande Dik Avc\u0131","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Internal Medicine, Bursa City Hospital, Bursa, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Bursa City Hospital, Bursa, T\u00fcrkiye","institution_ids":["https://openalex.org/I4405265970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107512014","display_name":"Merve Do\u011fru Efgan","orcid":"https://orcid.org/0000-0003-1355-876X","observed_orcids":["https://orcid.org/0000-0003-1355-876X"]},"institutions":[{"id":"https://openalex.org/I4210135971","display_name":"Izmir Atat\u00fcrk E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/03max4q92","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I250383648","https://openalex.org/I4210135971"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Merve Dogru Efgan","raw_affiliation_strings":["Department of Internal Medicine, Izmir Atat\u00fcrk Training and Research Hospital, Izmir, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Izmir Atat\u00fcrk Training and Research Hospital, Izmir, T\u00fcrkiye","institution_ids":["https://openalex.org/I4210135971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117292334","display_name":"\u00c7a\u011fr\u0131 Uslu","orcid":"https://orcid.org/0009-0008-8765-2912","observed_orcids":["https://orcid.org/0009-0008-8765-2912"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Cagr\u0131 Uslu","raw_affiliation_strings":["Faculty of Medicine, Ege University, Izmir, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0009-0008-8765-2912","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Ege University, Izmir, T\u00fcrkiye","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092518586","display_name":"Zehra Tuba Karaman","orcid":"https://orcid.org/0000-0001-6787-3752","observed_orcids":["https://orcid.org/0000-0001-6787-3752"]},"institutions":[{"id":"https://openalex.org/I3133171086","display_name":"Band\u0131rma Onyedi Eyl\u00fcl University","ror":"https://ror.org/02mtr7g38","country_code":"TR","type":"education","lineage":["https://openalex.org/I3133171086"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Zehra Tuba Karaman","raw_affiliation_strings":["Department of Internal Medicine, Faculty of Medicine, Band\u0131rma Onyedi Eyl\u00fcl University, Bal\u0131kesir, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Faculty of Medicine, Band\u0131rma Onyedi Eyl\u00fcl University, Bal\u0131kesir, T\u00fcrkiye","institution_ids":["https://openalex.org/I3133171086"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000628871","display_name":"Devrim Bozkurt","orcid":"https://orcid.org/0000-0003-4557-3390","observed_orcids":["https://orcid.org/0000-0003-4557-3390"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Devrim Bozkurt","raw_affiliation_strings":["Division of Intensive Care Medicine, Department of Internal Medicine, Faculty of Medicine, Ege University, Izmir, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Intensive Care Medicine, Department of Internal Medicine, Faculty of Medicine, Ege University, Izmir, T\u00fcrkiye","institution_ids":["https://openalex.org/I41641357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5029482322"],"corresponding_institution_ids":["https://openalex.org/I41641357"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.80666547,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 19","issue":null,"first_page":"1","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis-associated-liver-injury","display_name":"sepsis-associated liver injury","score":0.9940000176429749},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/30-day-mortality","display_name":"30-day mortality","score":0.949999988079071},{"id":"https://openalex.org/keywords/disseminated-intravascular-coagulation","display_name":"disseminated intravascular coagulation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.8840000033378601},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9300000071525574},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/activated-partial-thromboplastin-time","display_name":"activated partial thromboplastin time","score":0.8550000190734863},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.3569999933242798},{"id":"https://openalex.org/keywords/mortality-prediction-model","display_name":"mortality prediction model","score":0.6389999985694885},{"id":"https://openalex.org/keywords/sepsis-3","display_name":"Sepsis-3","score":0.7829999923706055},{"id":"https://openalex.org/keywords/intensive-care-unit-patients","display_name":"intensive care unit patients","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9603000283241272},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.7480000257492065},{"id":"https://openalex.org/C2778261982","wikidata":"https://www.wikidata.org/wiki/Q1755136","display_name":"Partial thromboplastin time","level":3,"score":0.611299991607666},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6057999730110168},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.5509999990463257},{"id":"https://openalex.org/C2780434524","wikidata":"https://www.wikidata.org/wiki/Q1144385","display_name":"Prothrombin time","level":2,"score":0.4837999939918518},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.47369998693466187},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.46239998936653137},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.4154999852180481},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4036000072956085},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.38269999623298645},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.36570000648498535},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.34470000863075256},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.32989999651908875},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.3125999867916107},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.30959999561309814},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.30160000920295715},{"id":"https://openalex.org/C2777465075","wikidata":"https://www.wikidata.org/wiki/Q7392039","display_name":"SOFA score","level":3,"score":0.29330000281333923},{"id":"https://openalex.org/C2781090800","wikidata":"https://www.wikidata.org/wiki/Q776030","display_name":"Systemic inflammatory response syndrome","level":3,"score":0.2856000065803528},{"id":"https://openalex.org/C2777984932","wikidata":"https://www.wikidata.org/wiki/Q7336293","display_name":"Risk of mortality","level":2,"score":0.2800999879837036},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.27720001339912415},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2694000005722046},{"id":"https://openalex.org/C2777051993","wikidata":"https://www.wikidata.org/wiki/Q124072","display_name":"Rifle","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C2778734968","wikidata":"https://www.wikidata.org/wiki/Q823027","display_name":"Disseminated intravascular coagulation","level":2,"score":0.26109999418258667},{"id":"https://openalex.org/C2992872382","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine aminotransferase","level":2,"score":0.2605000138282776},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.25360000133514404},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2517000138759613},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.25130000710487366}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/ijgm.s639020","doi":"https://doi.org/10.2147/ijgm.s639020","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijgm.s639020","pdf_url":"https://www.dovepress.com/article/download/121167","source":{"id":"https://openalex.org/S123199335","display_name":"International Journal of General Medicine","issn_l":"1178-7074","issn":["1178-7074"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of General Medicine","raw_type":"journal-article"},{"id":"pmid:42928790","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42928790","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of general medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13695970","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42928790/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Gen Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:af028f58e1544541b6ea576aedd7cafc","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/af028f58e1544541b6ea576aedd7cafc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"International Journal of General Medicine, Vol Volume 19, Iss Issue 1, Pp 1-23 (2026)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/121167","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/factors-associated-with-early-sepsis-associated-liver-injury-and-predi-peer-reviewed-fulltext-article-IJGM","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ijgm.s639020","doi":"https://doi.org/10.2147/ijgm.s639020","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijgm.s639020","pdf_url":"https://www.dovepress.com/article/download/121167","source":{"id":"https://openalex.org/S123199335","display_name":"International Journal of General Medicine","issn_l":"1178-7074","issn":["1178-7074"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of General Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223149173.pdf","grobid_xml":"https://content.openalex.org/works/W7223149173.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W335124151","https://openalex.org/W1505641753","https://openalex.org/W1898928487","https://openalex.org/W1966560770","https://openalex.org/W1985305532","https://openalex.org/W2015329932","https://openalex.org/W2026274122","https://openalex.org/W2045499771","https://openalex.org/W2078129874","https://openalex.org/W2083513831","https://openalex.org/W2115098571","https://openalex.org/W2123859227","https://openalex.org/W2142343447","https://openalex.org/W2151311812","https://openalex.org/W2166190627","https://openalex.org/W2280404143","https://openalex.org/W2537880370","https://openalex.org/W2756170974","https://openalex.org/W2784019442","https://openalex.org/W2911371912","https://openalex.org/W2950811882","https://openalex.org/W2998853022","https://openalex.org/W3034365691","https://openalex.org/W3203103016","https://openalex.org/W4211143120","https://openalex.org/W4292229870","https://openalex.org/W4298008123","https://openalex.org/W4307072289","https://openalex.org/W4390768774","https://openalex.org/W4401829261","https://openalex.org/W4403906684","https://openalex.org/W4405123014","https://openalex.org/W4405954906","https://openalex.org/W4408840512","https://openalex.org/W4409309759","https://openalex.org/W4410742354","https://openalex.org/W4412520578","https://openalex.org/W4415379963","https://openalex.org/W4415849000","https://openalex.org/W4417292726","https://openalex.org/W7125775540"],"related_works":["https://openalex.org/W3123786864","https://openalex.org/W7167347670","https://openalex.org/W4408955743","https://openalex.org/W4401829261","https://openalex.org/W4298008123","https://openalex.org/W4323050655","https://openalex.org/W7155051038","https://openalex.org/W7019021880","https://openalex.org/W7114933657","https://openalex.org/W4206837854"],"abstract_inverted_index":{"Background:":[0],"Sepsis-associated":[1],"liver":[2,253],"injury":[3,153],"(SALI)":[4],"is":[5],"associated":[6,13,81,128,204,236,246,277],"with":[7,14,24,38,56,82,85,101,129,178,205,237,247,252,278,288],"higher":[8,121,238,270],"mortality,":[9],"but":[10,228],"the":[11,18,67,113,172,244],"factors":[12,245],"early":[15],"SALI":[16,25,48,83,89,114,130,234,248],"and":[17,84,98,116,158,165,192,273,290],"determinants":[19],"of":[20,71,76],"mortality":[21,87,119,207,220,240,280],"in":[22,41,88,241,281],"patients":[23,37,177],"remain":[26],"incompletely":[27],"understood.":[28],"Methods:":[29],"This":[30],"retrospective":[31],"cohort":[32],"study":[33],"included":[34],"524":[35],"consecutive":[36],"sepsis":[39],"(Sepsis-3)":[40],"a":[42,184,214,267],"tertiary":[43],"intensive":[44],"care":[45],"unit":[46],"(ICU).":[47],"was":[49,120,235],"defined":[50],"as":[51],"total":[52],"bilirubin":[53],"\u22652":[54],"mg/dL":[55],"international":[57],"normalized":[58],"ratio":[59],"\u22651.5,":[60],"or":[61],"alanine":[62],"aminotransferase":[63],"\u226568":[64],"U/L":[65],"(twice":[66],"local":[68],"upper":[69],"limit":[70],"normal),":[72],"within":[73],"24":[74],"hours":[75],"ICU":[77],"admission.":[78],"Factors":[79,126],"independently":[80,127,203],"30-day":[86,118,206,239,279],"were":[90,131,202,249,276],"identified":[91],"by":[92],"logistic":[93],"regression":[94],"after":[95],"multiple":[96],"imputation":[97],"elastic-net":[99],"selection,":[100],"bootstrap":[102],"internal":[103],"validation.":[104,293],"Results:":[105],"Of":[106],"523":[107],"evaluable":[108],"patients,":[109],"135":[110],"(25.8%)":[111],"met":[112],"definition,":[115],"their":[117],"(63.4%":[122],"vs":[123],"50.0%,":[124],"p=0.010).":[125],"macrophage":[132],"activation-like":[133],"syndrome":[134],"(MALS)":[135],"(aOR:":[136,141,149,156,160],"5.33),":[137],"an":[138],"abdominal":[139],"focus":[140,186],"4.03),":[142],"disseminated":[143],"intravascular":[144],"coagulation":[145],"(DIC)":[146],"score":[147],"\u22655":[148],"3.07),":[150],"acute":[151],"kidney":[152],"on":[154],"admission":[155],"2.29)":[157],"log-ferritin":[159,189],"1.31;":[161],"1.48":[162],"without":[163],"MALS":[164],"DIC)":[166],"(all":[167,208],"p<0.05;":[168],"optimism-corrected":[169],"area":[170],"under":[171],"curve":[173],"[AUC]:":[174],"0.770).":[175],"Among":[176],"SALI,":[179],"immunosuppressive":[180],"therapy":[181,212],"(OR:":[182,187,190,198],"8.13),":[183],"thoracic":[185,268],"8.62),":[188],"2.04)":[191],"activated":[193],"partial":[194],"thromboplastin":[195],"time":[196],"(aPTT)":[197],"1.08":[199],"per":[200],"second)":[201],"p<0.05);":[209],"appropriate":[210],"antibiotic":[211],"showed":[213,222],"non-significant":[215],"protective":[216],"trend":[217],"(p=0.076).":[218],"The":[219],"model":[221],"good":[223],"discrimination":[224],"(optimism-corrected":[225],"AUC:":[226],"0.857)":[227],"limited":[229],"calibration":[230],"(slope:":[231],"0.562).":[232],"Conclusion:":[233],"sepsis.":[242],"Because":[243],"assessed":[250],"concurrently":[251],"injury,":[254],"they":[255],"describe":[256],"its":[257,263],"clinical":[258],"profile":[259],"rather":[260],"than":[261],"predict":[262],"development.":[264],"Immunosuppressive":[265],"therapy,":[266],"focus,":[269],"ferritin":[271],"levels":[272],"prolonged":[274],"aPTT":[275],"SALI.":[282],"These":[283],"findings":[284],"should":[285],"be":[286],"interpreted":[287],"caution":[289],"require":[291],"external":[292]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}