{"id":"https://openalex.org/W7223145402","doi":"https://doi.org/10.1002/cbf.70326","title":"Curcuminoids and Dimethoxycurcumin as Therapeutic Agents in Melanoma: Focus on Metastasis and Primary Care Integration","display_name":"Curcuminoids and Dimethoxycurcumin as Therapeutic Agents in Melanoma: Focus on Metastasis and Primary Care Integration","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223145402","doi":"https://doi.org/10.1002/cbf.70326","pmid":"https://pubmed.ncbi.nlm.nih.gov/42905731","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13686273"},"language":"en","primary_location":{"id":"doi:10.1002/cbf.70326","doi":"https://doi.org/10.1002/cbf.70326","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cbf.70326","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbf.70326","source":{"id":"https://openalex.org/S960618578","display_name":"Cell Biochemistry and Function","issn_l":"0263-6484","issn":["0263-6484","1099-0844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biochemistry and Function","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbf.70326","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5143852823","display_name":"Tivoli Visser","orcid":"https://orcid.org/0009-0002-3294-8915","observed_orcids":["https://orcid.org/0009-0002-3294-8915"]},"institutions":[{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Tivoli Visser","raw_affiliation_strings":["Department of Physiology, School of Medicine University of Pretoria Pretoria South Africa"],"raw_orcid":"https://orcid.org/0009-0002-3294-8915","affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine University of Pretoria Pretoria South Africa","institution_ids":["https://openalex.org/I69552723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005916658","display_name":"Charlise Basson","orcid":"https://orcid.org/0000-0002-6123-9707","observed_orcids":["https://orcid.org/0000-0002-6123-9707"]},"institutions":[{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Charlise Basson","raw_affiliation_strings":["Department of Physiology, School of Medicine University of Pretoria Pretoria South Africa"],"raw_orcid":"https://orcid.org/0000-0002-6123-9707","affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine University of Pretoria Pretoria South Africa","institution_ids":["https://openalex.org/I69552723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090753220","display_name":"Priyesh Bipath","orcid":"https://orcid.org/0000-0002-5433-7069","observed_orcids":["https://orcid.org/0000-0002-5433-7069"]},"institutions":[{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Priyesh Bipath","raw_affiliation_strings":["Department of Physiology, School of Medicine University of Pretoria Pretoria South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine University of Pretoria Pretoria South Africa","institution_ids":["https://openalex.org/I69552723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058598390","display_name":"Yvette Nkondo Hlophe","orcid":"https://orcid.org/0000-0002-3112-2436","observed_orcids":["https://orcid.org/0000-0002-3112-2436"]},"institutions":[{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Yvette Nkondo Hlophe","raw_affiliation_strings":["Department of Physiology, School of Medicine University of Pretoria Pretoria South Africa"],"raw_orcid":"https://orcid.org/0000-0002-3112-2436","affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine University of Pretoria Pretoria South Africa","institution_ids":["https://openalex.org/I69552723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5058598390"],"corresponding_institution_ids":["https://openalex.org/I69552723"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":{"value":4220,"currency":"USD","value_usd":4220},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45806452,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12758","display_name":"Saffron Plant Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcuminoids","display_name":"curcuminoids","score":0.8960000276565552},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9490000009536743},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9679999947547913},{"id":"https://openalex.org/keywords/mapk-erk-pathway","display_name":"MAPK/ERK pathway","score":0.9990000128746033},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9760000109672546},{"id":"https://openalex.org/keywords/bisdemethoxycurcumin","display_name":"bisdemethoxycurcumin","score":0.9589999914169312},{"id":"https://openalex.org/keywords/demethoxycurcumin","display_name":"demethoxycurcumin","score":0.996999979019165},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.8669999837875366},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7889999747276306},{"id":"https://openalex.org/keywords/primary-care","display_name":"primary care","score":0.906000018119812},{"id":"https://openalex.org/keywords/sustainable-development-goals","display_name":"Sustainable Development Goals","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7620000243186951},{"id":"https://openalex.org/C3018449070","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signalling pathways","level":3,"score":0.5949000120162964},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5774999856948853},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5425000190734863},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.538100004196167},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5103999972343445},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4691999852657318},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4526999890804291},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4415999948978424},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3707999885082245},{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.35510000586509705},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.3458999991416931},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.33889999985694885},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3352000117301941},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.33250001072883606},{"id":"https://openalex.org/C2984752397","wikidata":"https://www.wikidata.org/wiki/Q3259956","display_name":"Primary care","level":2,"score":0.3228999972343445},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.296999990940094},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.29679998755455017},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.29100000858306885},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2906999886035919},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2863999903202057},{"id":"https://openalex.org/C2993469326","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural compound","level":2,"score":0.2782999873161316},{"id":"https://openalex.org/C163432668","wikidata":"https://www.wikidata.org/wiki/Q623543","display_name":"Primary health care","level":3,"score":0.27300000190734863},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.27140000462532043},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.27140000462532043},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2551000118255615}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D036381","descriptor_name":"Diarylheptanoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D036381","descriptor_name":"Diarylheptanoids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/cbf.70326","doi":"https://doi.org/10.1002/cbf.70326","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cbf.70326","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbf.70326","source":{"id":"https://openalex.org/S960618578","display_name":"Cell Biochemistry and Function","issn_l":"0263-6484","issn":["0263-6484","1099-0844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biochemistry and Function","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13686273","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13686273/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13686273/pdf/CBF-44-e70326.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biochem Funct","raw_type":"Text"},{"id":"pmid:42905731","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42905731","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell biochemistry and function","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/cbf.70326","doi":"https://doi.org/10.1002/cbf.70326","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cbf.70326","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cbf.70326","source":{"id":"https://openalex.org/S960618578","display_name":"Cell Biochemistry and Function","issn_l":"0263-6484","issn":["0263-6484","1099-0844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biochemistry and Function","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320672","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223145402.pdf","grobid_xml":"https://content.openalex.org/works/W7223145402.grobid-xml"},"referenced_works_count":138,"referenced_works":["https://openalex.org/W346818887","https://openalex.org/W853817335","https://openalex.org/W1485232905","https://openalex.org/W1495945591","https://openalex.org/W1590243782","https://openalex.org/W1644518467","https://openalex.org/W1826487857","https://openalex.org/W1839036473","https://openalex.org/W1916042004","https://openalex.org/W1964847767","https://openalex.org/W1965615208","https://openalex.org/W1965766554","https://openalex.org/W1972155784","https://openalex.org/W1976020443","https://openalex.org/W1988117419","https://openalex.org/W1988626790","https://openalex.org/W1988734777","https://openalex.org/W1992465162","https://openalex.org/W1994032164","https://openalex.org/W1998956865","https://openalex.org/W2006549981","https://openalex.org/W2006771504","https://openalex.org/W2006901327","https://openalex.org/W2008616879","https://openalex.org/W2008710925","https://openalex.org/W2011769377","https://openalex.org/W2012247886","https://openalex.org/W2012869896","https://openalex.org/W2016789384","https://openalex.org/W2018502502","https://openalex.org/W2027949644","https://openalex.org/W2030098913","https://openalex.org/W2032890730","https://openalex.org/W2038657280","https://openalex.org/W2039386747","https://openalex.org/W2043825885","https://openalex.org/W2043870205","https://openalex.org/W2044914417","https://openalex.org/W2045577156","https://openalex.org/W2047069988","https://openalex.org/W2048883725","https://openalex.org/W2049433363","https://openalex.org/W2052005627","https://openalex.org/W2055869319","https://openalex.org/W2061695655","https://openalex.org/W2069909271","https://openalex.org/W2077008353","https://openalex.org/W2089158037","https://openalex.org/W2098734579","https://openalex.org/W2108468334","https://openalex.org/W2108706315","https://openalex.org/W2117692326","https://openalex.org/W2118863192","https://openalex.org/W2121166735","https://openalex.org/W2127956110","https://openalex.org/W2128151164","https://openalex.org/W2129397604","https://openalex.org/W2129623370","https://openalex.org/W2130387644","https://openalex.org/W2133097250","https://openalex.org/W2133776282","https://openalex.org/W2134405883","https://openalex.org/W2137728993","https://openalex.org/W2138508372","https://openalex.org/W2155397034","https://openalex.org/W2156410239","https://openalex.org/W2158969445","https://openalex.org/W2161658362","https://openalex.org/W2161708429","https://openalex.org/W2163815667","https://openalex.org/W2253134712","https://openalex.org/W2263768870","https://openalex.org/W2274172560","https://openalex.org/W2328757094","https://openalex.org/W2414660052","https://openalex.org/W2419413911","https://openalex.org/W2464469811","https://openalex.org/W2522813771","https://openalex.org/W2534326027","https://openalex.org/W2564936579","https://openalex.org/W2568822576","https://openalex.org/W2573730053","https://openalex.org/W2580537586","https://openalex.org/W2586407709","https://openalex.org/W2588605196","https://openalex.org/W2596133050","https://openalex.org/W2603241332","https://openalex.org/W2619974655","https://openalex.org/W2622273645","https://openalex.org/W2762842128","https://openalex.org/W2777902767","https://openalex.org/W2885517022","https://openalex.org/W2889814971","https://openalex.org/W2905320113","https://openalex.org/W2911909558","https://openalex.org/W2919467556","https://openalex.org/W2923849202","https://openalex.org/W2924741637","https://openalex.org/W2947977317","https://openalex.org/W2950011075","https://openalex.org/W2955804029","https://openalex.org/W2966111877","https://openalex.org/W2966657471","https://openalex.org/W2967805215","https://openalex.org/W2969754305","https://openalex.org/W3008499293","https://openalex.org/W3017728350","https://openalex.org/W3026325224","https://openalex.org/W3032014140","https://openalex.org/W3039385984","https://openalex.org/W3042151980","https://openalex.org/W3042321712","https://openalex.org/W3089835536","https://openalex.org/W3094973931","https://openalex.org/W3144002437","https://openalex.org/W3155992794","https://openalex.org/W3178316664","https://openalex.org/W3181611529","https://openalex.org/W3197928941","https://openalex.org/W3206880052","https://openalex.org/W4214884134","https://openalex.org/W4220974110","https://openalex.org/W4281644967","https://openalex.org/W4289781763","https://openalex.org/W4304688804","https://openalex.org/W4317358689","https://openalex.org/W4323321918","https://openalex.org/W4385641417","https://openalex.org/W4393006497","https://openalex.org/W4393935425","https://openalex.org/W4394933160","https://openalex.org/W4399237945","https://openalex.org/W4404147898","https://openalex.org/W4406666563","https://openalex.org/W4406781335","https://openalex.org/W4407253509","https://openalex.org/W4408246274","https://openalex.org/W4412595553"],"related_works":["https://openalex.org/W3004108195","https://openalex.org/W3031885384","https://openalex.org/W2590247429","https://openalex.org/W2885517022","https://openalex.org/W2161658362","https://openalex.org/W4226154831","https://openalex.org/W4385716226","https://openalex.org/W2800101692","https://openalex.org/W1899214345","https://openalex.org/W4392859410"],"abstract_inverted_index":{"ABSTRACT":[0],"Melanoma":[1,36],"is":[2,38],"a":[3,26,128],"type":[4,19],"of":[5,13,20,43,123,131,194],"skin":[6,21],"cancer":[7,22],"associated":[8],"with":[9],"the":[10,15,41,68,100,104,120,148,171,176,187,192],"uncontrolled":[11],"growth":[12],"melanocytes,":[14],"pigment\u2010producing":[16],"cells.":[17],"This":[18,115,137],"continues":[23],"to":[24,30,34,98,118],"be":[25],"major":[27],"concern":[28],"owing":[29],"its":[31],"strong":[32],"tendency":[33],"spread.":[35],"progression":[37],"influenced":[39],"by":[40,71,141,164],"activation":[42],"various":[44],"signalling":[45,149],"pathways,":[46,174],"such":[47,76],"as":[48,77],"PI3K/AKT/mTOR,":[49,172],"MAPK/ERK,":[50],"and":[51,63,66,80,109,127,144,157,191],"Wnt/\u03b2\u2010catenin":[52,112],"pathways.":[53],"Curcuminoids,":[54],"derived":[55],"from":[56],"turmeric,":[57],"are":[58],"known":[59],"for":[60,178],"their":[61],"anti\u2010inflammatory":[62],"antioxidant":[64],"properties":[65],"influence":[67],"PI3K/AKT/mTOR":[69],"pathway":[70,91,113],"acting":[72],"on":[73],"key":[74,166],"molecules,":[75],"mTORC1,":[78],"PI3K,":[79],"AKT.":[81],"Curcuminoids":[82],"have":[83,95,160],"demonstrated":[84],"reduced":[85],"ERK":[86],"phosphorylation,":[87],"which":[88],"lowers":[89],"MAPK":[90],"activity.":[92],"Additionally,":[93,183],"curcuminoids":[94,146,156,195],"been":[96],"shown":[97,161],"block":[99],"cell":[101],"cycle":[102],"at":[103],"G":[105],"2":[106],"/M":[107],"phase":[108],"consequently":[110],"inhibit":[111],"signalling.":[114],"review":[116,138,185],"aims":[117],"explore":[119],"potential":[121,163,179],"use":[122],"curcumin,":[124,132],"bisdemethoxycurcumin,":[125],"demethoxycurcumin,":[126],"synthetic":[129,145,158],"analogue":[130,159],"dimethoxycurcumin,":[133],"in":[134,170,196],"combating":[135],"melanoma.":[136,153],"stands":[139],"out":[140],"comparing":[142],"natural":[143],"against":[147],"pathways":[150],"that":[151],"drive":[152],"The":[154],"abovementioned":[155],"anti\u2010cancer":[162],"targeting":[165],"molecular":[167],"targets":[168],"implicated":[169],"MAPK/ERK":[173],"paving":[175],"way":[177],"novel":[180],"treatment":[181],"approaches.":[182],"this":[184],"addresses":[186],"sustainable":[188],"development":[189],"goals":[190],"role":[193],"primary":[197],"health":[198],"care.":[199]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-22T00:00:00"}
