{"id":"https://openalex.org/W7223138682","doi":"https://doi.org/10.1016/j.htct.2026.107562","title":"BIOLOGICAL ROLE OF MITOCHONDRIAL RIBOSOMAL PROTEIN MRPL21 IN ACUTE MYELOID LEUKEMIA","display_name":"BIOLOGICAL ROLE OF MITOCHONDRIAL RIBOSOMAL PROTEIN MRPL21 IN ACUTE MYELOID LEUKEMIA","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223138682","doi":"https://doi.org/10.1016/j.htct.2026.107562"},"language":"en","primary_location":{"id":"doi:10.1016/j.htct.2026.107562","doi":"https://doi.org/10.1016/j.htct.2026.107562","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107562","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1016/j.htct.2026.107562","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123393391","display_name":"Isabelle Caroline Santos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Isabelle Caroline SANTOS","raw_affiliation_strings":["Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086447272","display_name":"Juan Luiz Coelho\u2010Silva","orcid":"https://orcid.org/0000-0001-8384-6551","observed_orcids":["https://orcid.org/0000-0001-8384-6551"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Juan Luiz COELHO-SILVA","raw_affiliation_strings":["Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076320885","display_name":"Diego A. Pereira\u2010Martins","orcid":"https://orcid.org/0000-0002-3302-4311","observed_orcids":["https://orcid.org/0000-0002-3302-4311"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Diego Antonio PEREIRA-MARTINS","raw_affiliation_strings":["University Medical Center Groningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Medical Center Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159216600","display_name":"J\u00f5ao Agostinho MACHADO-NETO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Agostinho MACHADO-NETO","raw_affiliation_strings":["Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.79640116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":null,"first_page":"107562","last_page":"107562"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mitochondrial-ribosomal-proteins","display_name":"mitochondrial ribosomal proteins","score":0.8299999833106995},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/mitochondrial-dna-copy-number","display_name":"mitochondrial DNA copy number","score":0.8069999814033508},{"id":"https://openalex.org/keywords/rna-metabolism","display_name":"RNA metabolism","score":0.5059999823570251},{"id":"https://openalex.org/keywords/translation-biology","display_name":"translation (biology)","score":0.5429999828338623},{"id":"https://openalex.org/keywords/erythroid-cells","display_name":"erythroid cells","score":0.7620000243186951},{"id":"https://openalex.org/keywords/leukemia-stem-cells","display_name":"leukemia stem cells","score":0.9380000233650208},{"id":"https://openalex.org/keywords/bone-marrow-transcriptome","display_name":"bone marrow transcriptome","score":0.7149999737739563},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6610000133514404},{"id":"https://openalex.org/keywords/mitochondrial-homeostasis","display_name":"mitochondrial homeostasis","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.8338000178337097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6435999870300293},{"id":"https://openalex.org/C38062823","wikidata":"https://www.wikidata.org/wiki/Q3408228","display_name":"Ribosomal protein","level":5,"score":0.544700026512146},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.515999972820282},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4724999964237213},{"id":"https://openalex.org/C6393950","wikidata":"https://www.wikidata.org/wiki/Q17855994","display_name":"RUNX1T1","level":4,"score":0.44510000944137573},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.43689998984336853},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42289999127388},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.390500009059906},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.38179999589920044},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.3497999906539917},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.32600000500679016},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25360000133514404}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.htct.2026.107562","doi":"https://doi.org/10.1016/j.htct.2026.107562","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107562","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:829514984fcd43c6887606baac1e3876","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/829514984fcd43c6887606baac1e3876","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 48, Iss , Pp 107562- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.htct.2026.107562","doi":"https://doi.org/10.1016/j.htct.2026.107562","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107562","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7223148154","https://openalex.org/W2961134298","https://openalex.org/W4415457276","https://openalex.org/W4297348442","https://openalex.org/W4405052050","https://openalex.org/W4405044064","https://openalex.org/W4407727620","https://openalex.org/W2943868341","https://openalex.org/W2013130094","https://openalex.org/W2408468753"],"abstract_inverted_index":{"Background":[0],"Acute":[1],"myeloid":[2,35,202],"leukemia":[3],"(AML)":[4],"exhibits":[5],"enhanced":[6],"oxidative":[7],"phosphorylation":[8],"(OXPHOS)":[9],"capacity":[10],"dependent":[11],"on":[12,26],"mitochondrial":[13,128,177,245],"DNA":[14,242],"(mtDNA)":[15],"copy":[16],"number.":[17],"We":[18],"previously":[19],"developed":[20],"a":[21],"prognostic":[22],"risk":[23],"score":[24],"based":[25],"mtDNA":[27],"modulators,":[28],"including":[29,75],"MRPL21,":[30],"which":[31],"is":[32,293],"essential":[33],"for":[34,70],"cell":[36,268],"viability;":[37],"however,":[38,204],"its":[39,306],"specific":[40],"biological":[41,51,307],"roles":[42,52],"in":[43,55,134,152,162,174,191,210,217,234,254,267,279,309],"AML":[44,87,211],"remain":[45],"underexplored.":[46],"Aim":[47],"To":[48],"investigate":[49],"the":[50,188,228,250],"of":[53,147,187,231,241],"MRPL21":[54,116,198,264,291],"AML.":[56,310],"Methods":[57],"Three":[58],"independent":[59],"public":[60,114],"cohorts":[61],"(TCGA,":[62],"BeatAML,":[63],"and":[64,72,80,86,96,105,107,110,120,129,132,137,159,165,176,182,184,219,244,276,282,302],"CPTAC":[65],"multi-omic":[66],"cohort)":[67],"were":[68,91,265],"used":[69],"transcriptomic":[71,98,136],"proteomic":[73,138],"analyses,":[74],"WGCNA,":[76],"Gene":[77],"Ontology,":[78],"GSEA,":[79],"CIBERSORTx.":[81],"scRNA-seq":[82,195],"data":[83],"from":[84],"healthy":[85,166,214,281],"bone":[88,284],"marrow":[89],"(BM)":[90],"analyzed":[92],"to":[93,125,213,296],"identify":[94],"DEGs":[95],"MRPL21-associated":[97],"signatures.":[99],"Significance":[100],"was":[101,208],"set":[102],"at":[103],"p-value":[104],"FDR<0.05,":[106],"|NES|>1.5.":[108],"Results":[109],"discussion":[111],"Across":[112],"all":[113,201],"cohorts,":[115],"overexpression":[117,292],"upregulated":[118],"rRNA":[119],"tRNA":[121],"metabolism":[122,278],"(from":[123],"processing":[124,181],"quality":[126],"control),":[127],"cytoplasmic":[130],"translation,":[131,178,301],"OXPHOS":[133,303],"both":[135,163,280],"profiles.":[139],"Furthermore,":[140],"cellular":[141],"deconvolution":[142],"analysis":[143],"showed":[144],"an":[145],"enrichment":[146,173],"quiescent":[148],"leukemic":[149,164,283],"stem":[150],"cells":[151,171,233,238],"MRPL21-high":[153,170,232],"samples.":[154],"scGSEA":[155],"confirmed":[156],"these":[157,237],"biosynthetic":[158],"energetic":[160],"signatures":[161],"BM.":[167],"Within":[168],"AML,":[169,235],"exhibited":[172],"global":[175],"constitutive":[179,298],"RNA":[180,299],"replication,":[183],"positive":[185],"regulation":[186],"cytoskeleton,":[189],"particularly":[190],"erythroid":[192,221,225],"clusters.":[193],"The":[194,223],"revealed":[196],"diffuse":[197],"expression":[199,207],"across":[200],"clusters;":[203],"target":[205],"gene":[206],"decreased":[209],"compared":[212],"BM,":[215],"peaking":[216],"early":[218,224],"late":[220],"cells.":[222],"cluster":[226],"retained":[227],"highest":[229],"proportion":[230],"with":[236,249,263],"showing":[239],"upregulation":[240],"maintenance":[243],"homeostasis":[246],"genes,":[247],"aligning":[248],"top":[251],"correlated":[252],"genes":[253,261],"bulk":[255],"RNA-seq":[256],"findings.":[257],"Other":[258],"differentially":[259],"expressed":[260],"associated":[262],"involved":[266],"cycle":[269],"progression":[270],"as":[271,273],"well":[272],"nucleic":[274],"acid":[275],"protein":[277],"marrow.":[285],"Conclusion":[286],"These":[287],"findings":[288],"suggest":[289],"that":[290],"closely":[294],"linked":[295],"increased":[297],"metabolism,":[300],"signatures,":[304],"highlighting":[305],"relevance":[308]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}
