{"id":"https://openalex.org/W7223137359","doi":"https://doi.org/10.1016/j.htct.2026.106877","title":"IMPACT OF ABATACEPT-BASED GRAFT-VERSUS-HOST DISEASE PROPHYLAXIS ON TRANSPLANT OUTCOMES IN CHILDREN WITH HEMOGLOBINOPATHIES: A SYSTEMATIC REVIEW","display_name":"IMPACT OF ABATACEPT-BASED GRAFT-VERSUS-HOST DISEASE PROPHYLAXIS ON TRANSPLANT OUTCOMES IN CHILDREN WITH HEMOGLOBINOPATHIES: A SYSTEMATIC REVIEW","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223137359","doi":"https://doi.org/10.1016/j.htct.2026.106877"},"language":"en","primary_location":{"id":"doi:10.1016/j.htct.2026.106877","doi":"https://doi.org/10.1016/j.htct.2026.106877","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.106877","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1016/j.htct.2026.106877","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159188519","display_name":"Pedro Henrique Rodrigues VIANA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107309","display_name":"Faculdade de Ci\u00eancias M\u00e9dicas de Minas Gerais","ror":"https://ror.org/01p7p3890","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210107309"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Pedro Henrique Rodrigues VIANA","raw_affiliation_strings":["Faculdade Ci\u00eancias M\u00e9dicas de Minas Gerais (FCM-MG), Belo Horizonte, MG, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade Ci\u00eancias M\u00e9dicas de Minas Gerais (FCM-MG), Belo Horizonte, MG, Brazil","institution_ids":["https://openalex.org/I4210107309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080022502","display_name":"Lucas de Barros Anast\u00e1cio","orcid":"https://orcid.org/0000-0002-7458-3005","observed_orcids":["https://orcid.org/0000-0002-7458-3005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucas De Barros ANAST\u00c1CIO","raw_affiliation_strings":["Instituto de Oncologia Ci\u00eancias M\u00e9dicas (IONCM-CMMG), Belo Horizonte, MG, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Oncologia Ci\u00eancias M\u00e9dicas (IONCM-CMMG), Belo Horizonte, MG, Brazil","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.79564616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":null,"first_page":"106877","last_page":"106877"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abatacept","display_name":"abatacept","score":1.0},{"id":"https://openalex.org/keywords/graft-versus-host-disease-prophylaxis","display_name":"graft-versus-host disease prophylaxis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.8679999709129333},{"id":"https://openalex.org/keywords/beta-thalassemia","display_name":"beta-thalassemia","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hemoglobinopathies","display_name":"hemoglobinopathies","score":0.890999972820282},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.7149999737739563},{"id":"https://openalex.org/keywords/acute-graft-versus-host-disease","display_name":"acute graft-versus-host disease","score":0.7870000004768372},{"id":"https://openalex.org/keywords/chronic-graft-versus-host-disease","display_name":"chronic graft-versus-host disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7279999852180481},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.8050000071525574},{"id":"https://openalex.org/keywords/haploidentical-donor","display_name":"haploidentical donor","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9883999824523926},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6628999710083008},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3682999908924103},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.35589998960494995},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34200000762939453},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.21780000627040863},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.18629999458789825},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.1858000010251999},{"id":"https://openalex.org/C2779496540","wikidata":"https://www.wikidata.org/wiki/Q7239230","display_name":"Pre-exposure prophylaxis","level":5,"score":0.17239999771118164},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.1615000069141388}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.htct.2026.106877","doi":"https://doi.org/10.1016/j.htct.2026.106877","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.106877","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:92230687e97e476da0a4e05dd1f80684","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/92230687e97e476da0a4e05dd1f80684","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 48, Iss , Pp 106877- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.htct.2026.106877","doi":"https://doi.org/10.1016/j.htct.2026.106877","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.106877","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405034627","https://openalex.org/W4411437072","https://openalex.org/W7221366636","https://openalex.org/W4409908060","https://openalex.org/W3000979577","https://openalex.org/W3030990392","https://openalex.org/W3002586737","https://openalex.org/W2790968367","https://openalex.org/W3058064889","https://openalex.org/W4310119461"],"abstract_inverted_index":{"Introduction":[0],"Sickle":[1],"cell":[2,14,119,124],"disease":[3,26,115,125],"and":[4,51,101,126,128,154,167,188,198,221,265,331,374,383,398,404,420],"transfusion-dependent":[5],"\u03b2-thalassemia":[6],"are":[7],"major":[8],"grounds":[9],"for":[10],"allogeneic":[11],"hematopoietic":[12,117],"stem":[13,118],"transplantation":[15],"(allo-HSCT)":[16],"in":[17,71,84,224,256,278,322,327,343],"children.":[18],"While":[19],"this":[20],"procedure":[21],"has":[22],"curative":[23],"potential,":[24],"graft-versus-host":[25,114],"(GVHD)":[27],"limits":[28],"its":[29,33,110],"success.":[30],"Abatacept":[31,377],"(through":[32],"inhibitory":[34],"action":[35],"on":[36,68,286,415],"T-cell":[37],"costimulation":[38],"via":[39],"the":[40,62,92,161,218,225,355,411],"CD80/CD86\u2013CD28":[41],"axis),":[42],"may":[43,366],"improve":[44,367],"GVHD":[45,238,254,288,364,368,381,391],"incidence,":[46,369],"overall":[47,370],"survival,":[48,371],"graft":[49,372],"rejection,":[50,373],"immune-mediated":[52,375],"toxicity.":[53,376],"Objective":[54],"This":[55,79],"systematic":[56,80],"review":[57,81],"aimed":[58],"to":[59,142,307,363],"critically":[60],"appraise":[61],"impact":[63],"of":[64,215,233,241,247,270,319,410,417],"abatacept-containing":[65,237],"prophylactic":[66],"regimens":[67,293,299],"transplant":[69],"outcomes":[70,422],"pediatric":[72,129,168,183],"patients":[73,230],"with":[74,86,136,179,275,302,385,392,401],"hemoglobinopathies":[75,121],"undergoing":[76,258],"allo-HSCT.":[77],"Methods":[78],"was":[82,272,289],"conducted":[83],"accordance":[85],"PRISMA":[87],"guidelines,":[88],"using":[89],"PubMed":[90],"as":[91],"sole":[93],"database.":[94],"The":[95,193,208,249,268],"search":[96,210],"strategy":[97],"combined":[98],"MeSH":[99],"terms":[100,103],"free-text":[102],"across":[104],"four":[105],"conceptual":[106],"blocks:":[107],"abatacept":[108,271,362],"(and":[109],"synonyms,":[111],"including":[112],"CTLA4-Ig),":[113],"prophylaxis,":[116],"transplantation,":[120],"(encompassing":[122],"sickle":[123],"beta-thalassemia),":[127],"population,":[130],"connected":[131],"by":[132,203],"Boolean":[133],"operators":[134],"(AND/OR),":[135],"an":[137],"additional":[138],"NOT":[139],"operator":[140],"applied":[141],"exclude":[143],"animal":[144],"studies":[145,176,178,190,251,397],"lacking":[146],"a":[147,204,244,276,347],"human":[148,164],"component.":[149],"Studies":[150],"published":[151],"between":[152,352],"2020":[153],"2026":[155],"were":[156,170,191,201,222,231,300,334],"considered":[157],"eligible.":[158],"Publications":[159],"within":[160],"date":[162],"range,":[163],"subject":[165],"studies,":[166,197,213],"populations":[169],"included.":[171],"Exclusion":[172],"criteria":[173,220],"included":[174,196,223,250],"adult-only":[175],"or":[177,181],"unextractable":[180],"qualitative":[182,205,226],"subgroup":[184],"outcome":[185],"data.":[186],"Separately":[187],"blindly,":[189],"chosen.":[192],"selection":[194],"process,":[195],"main":[199],"findings":[200],"characterized":[202],"synthesis.":[206,227],"Results":[207],"literature":[209],"identified":[211],"seven":[212],"six":[214],"which":[216],"met":[217],"eligibility":[219],"Collectively,":[228],"222":[229],"analyzed,":[232],"whom":[234],"160":[235],"received":[236],"prophylaxis;":[239],"134":[240],"these":[242],"had":[243],"confirmed":[245],"diagnosis":[246],"hemoglobinopathy.":[248],"evaluated":[252],"abatacept-based":[253],"prophylaxis":[255,365],"children":[257],"allo-HSCT":[259],"from":[260],"matched":[261,263],"related,":[262],"unrelated,":[264],"haploidentical":[266],"donors.":[267],"addition":[269],"consistently":[273],"associated":[274,301],"reduction":[277],"severe":[279,379],"(grade":[280],"III\u2013IV)":[281],"acute":[282,380],"GVHD.":[283],"Its":[284],"effect":[285],"chronic":[287,390],"more":[290,386],"heterogeneous:":[291],"extended-duration":[292],"showed":[294],"significant":[295,350],"reductions,":[296],"whereas":[297],"shorter":[298],"persistently":[303],"high":[304,312],"incidence":[305],"(up":[306],"57%).":[308],"Overall":[309],"survival":[310],"remained":[311],"(87-100%)":[313],"among":[314],"intervention":[315],"groups,":[316],"exceeding":[317],"that":[318],"control":[320],"groups":[321,345],"three":[323],"comparative":[324],"studies.":[325],"Reductions":[326],"endothelial":[328],"injury":[329],"syndromes":[330],"transplant-related":[332],"mortality":[333],"also":[335],"observed.":[336],"Viral":[337],"reactivation":[338],"(cytomegalovirus,":[339],"Epstein-Barr":[340],"virus)":[341],"occurred":[342],"both":[344],"without":[346],"consistent":[348,387],"statistically":[349],"difference":[351],"them,":[353],"representing":[354],"principal":[356],"safety":[357],"concern":[358],"identified.":[359],"Conclusion":[360],"Adding":[361],"reduced":[378],"safely":[382],"effectively,":[384],"benefit":[388],"against":[389],"prolonged-duration":[393],"regimens.":[394],"However,":[395],"observational":[396],"single-arm":[399],"cohorts":[400],"heterogeneous":[402],"protocols":[403],"small":[405],"sample":[406],"sizes":[407],"provide":[408],"most":[409],"evidence.":[412],"Insufficient":[413],"data":[414],"quality":[416],"life,":[418],"fertility,":[419],"long-term":[421],"necessitates":[423],"adequately":[424],"powered":[425],"randomized":[426],"controlled":[427],"trials.":[428]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}