{"id":"https://openalex.org/W7223129694","doi":"https://doi.org/10.1016/j.htct.2026.108011","title":"EVALUATING THE PROGNOSTIC ROLE OF BASELINE THROMBOELASTOGRAPHY FOR EARLY THROMBOHEMORRHAGIC EVENTS IN PATIENTS WITH ACUTE LEUKEMIA","display_name":"EVALUATING THE PROGNOSTIC ROLE OF BASELINE THROMBOELASTOGRAPHY FOR EARLY THROMBOHEMORRHAGIC EVENTS IN PATIENTS WITH ACUTE LEUKEMIA","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223129694","doi":"https://doi.org/10.1016/j.htct.2026.108011"},"language":"en","primary_location":{"id":"doi:10.1016/j.htct.2026.108011","doi":"https://doi.org/10.1016/j.htct.2026.108011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.108011","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1016/j.htct.2026.108011","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159182131","display_name":"Luisa Vilela CARVALHO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luisa Vilela CARVALHO","raw_affiliation_strings":["Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HCFMUSP), S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HCFMUSP), S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159186029","display_name":"Marcelo HADDAD","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3017888287","display_name":"Universidade Nove de Julho","ror":"https://ror.org/005mpbw70","country_code":"BR","type":"education","lineage":["https://openalex.org/I3017888287"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo HADDAD","raw_affiliation_strings":["Universidade Nove de Julho, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Nove de Julho, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I3017888287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159161675","display_name":"Paula Ribeiro VILA\u00c7A","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paula Ribeiro VILA\u00c7A","raw_affiliation_strings":["Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HCFMUSP), S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HCFMUSP), S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159159815","display_name":"Tania Rubia Flores DA ROCHA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Tania Rubia Flores DA ROCHA","raw_affiliation_strings":["Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HCFMUSP), S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HCFMUSP), S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159168668","display_name":"Vanderson Cadiele Oliana ROCHA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vanderson Geraldo ROCHA","raw_affiliation_strings":["Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HCFMUSP), S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HCFMUSP), S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159162006","display_name":"Eduardo Magalhaes REGO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Eduardo Magalhaes REGO","raw_affiliation_strings":["Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HCFMUSP), S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HCFMUSP), S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068906142","display_name":"Fernanda Andrade Orsi","orcid":"https://orcid.org/0000-0002-7908-9073","observed_orcids":["https://orcid.org/0000-0002-7908-9073"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fernanda Loureiro de Andrade ORSI","raw_affiliation_strings":["Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075629688","display_name":"Wellington Fernandes da Silva","orcid":"https://orcid.org/0000-0001-5958-3181","observed_orcids":["https://orcid.org/0000-0001-5958-3181"]},"institutions":[{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Wellington Fernandes SILVA","raw_affiliation_strings":["Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HCFMUSP), S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (HCFMUSP), S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210145268"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.80565012,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":null,"first_page":"108011","last_page":"108011"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.09099999815225601,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.08150000125169754,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-leukemia","display_name":"acute leukemia","score":0.8650000095367432},{"id":"https://openalex.org/keywords/thromboelastography","display_name":"thromboelastography","score":0.9700000286102295},{"id":"https://openalex.org/keywords/thrombohemorrhagic-complications","display_name":"thrombohemorrhagic complications","score":0.8510000109672546},{"id":"https://openalex.org/keywords/bleeding-events","display_name":"bleeding events","score":0.675000011920929},{"id":"https://openalex.org/keywords/thrombotic-complications","display_name":"thrombotic complications","score":0.9169999957084656},{"id":"https://openalex.org/keywords/early-mortality","display_name":"early mortality","score":0.6179999709129333},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7670000195503235},{"id":"https://openalex.org/keywords/coagulation-index","display_name":"coagulation indices","score":0.8299999833106995},{"id":"https://openalex.org/keywords/hypocoagulability","display_name":"hypocoagulability","score":0.8199999928474426},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8489999771118164},{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.7570000290870667},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.7350000143051147},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9860000014305115},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9785000085830688},{"id":"https://openalex.org/C2777664302","wikidata":"https://www.wikidata.org/wiki/Q4463725","display_name":"Thromboelastography","level":3,"score":0.8510000109672546},{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.7339000105857849},{"id":"https://openalex.org/C2776863199","wikidata":"https://www.wikidata.org/wiki/Q976388","display_name":"Acute leukemia","level":3,"score":0.631600022315979},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.439300000667572},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3244999945163727},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3075000047683716},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.20880000293254852},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.19920000433921814},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.19589999318122864}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.htct.2026.108011","doi":"https://doi.org/10.1016/j.htct.2026.108011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.108011","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:f79a9cc2973d46fda67795eca6ca9560","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f79a9cc2973d46fda67795eca6ca9560","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 48, Iss , Pp 108011- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.htct.2026.108011","doi":"https://doi.org/10.1016/j.htct.2026.108011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.108011","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2950660729","https://openalex.org/W7055958920","https://openalex.org/W4412999969","https://openalex.org/W4415754661","https://openalex.org/W2795174432","https://openalex.org/W7214853821","https://openalex.org/W4384626249","https://openalex.org/W4405045514","https://openalex.org/W4413324987","https://openalex.org/W4386095938"],"abstract_inverted_index":{"Introduction":[0],"Patients":[1,291],"with":[2,73,79,92,115,173,190,292,356,385,417],"newly":[3,80,93],"diagnosed":[4,81,94],"acute":[5],"leukemia":[6],"(AL)":[7],"are":[8,19,71,501],"at":[9,101],"high":[10],"risk":[11,57,453,492],"of":[12,22,40,48,62,240,271,372],"both":[13],"bleeding":[14,293,373,387,437,480],"and":[15,51,53,110,121,132,143,152,178,187,197,262,269,281,300,334,352,363,405,440,478,495],"thrombotic":[16,133],"complications,":[17],"which":[18,241,455],"major":[20,223,488],"causes":[21],"early":[23,74,386,402,479],"morbimortality.":[24],"Conventional":[25],"coagulation":[26],"tests":[27],"have":[28],"limited":[29],"ability":[30],"to":[31,136,146],"predict":[32],"these":[33],"events,":[34],"as":[35,159,464],"they":[36],"assess":[37],"isolated":[38],"components":[39],"hemostasis.":[41],"Thromboelastography":[42],"(TEG)":[43],"provides":[44],"a":[45,86,102,253,378,410,487],"global":[46],"assessment":[47],"clot":[49,419],"formation":[50,420],"stability":[52],"may":[54],"improve":[55],"thrombohemorrhagic":[56,75,452],"stratification":[58],"in":[59,77,90,106,210,226,235,267,279,289,374,414,490,493],"the":[60,147,162,218,272],"setting":[61],"AL.":[63,82],"Objectives":[64],"To":[65],"evaluate":[66],"whether":[67],"baseline":[68,184,446],"TEG":[69,112,129,188,255,367,408,447],"parameters":[70,397,421],"associated":[72,355,384],"complications":[76],"patients":[78,205,212,237,250,423],"Methodology":[83],"This":[84,442],"was":[85,113,125,157,247,277,285,383,431],"prospective":[87],"observational":[88],"cohort":[89],"adults":[91],"AL":[95,415],"(AML,":[96],"APL":[97],"or":[98,230,401,467],"ALL)":[99],"treated":[100],"single":[103],"tertiary":[104],"center":[105],"Brazil":[107],"between":[108,169,183,474],"2018":[109],"2020.":[111],"performed":[114],"TEG\u00ae":[116],"5000":[117],"system":[118,229],"(Haemonetics":[119],"Corp),":[120],"Coagulation":[122],"Index":[123],"(CI)":[124],"calculated":[126],"based":[127,257],"on":[128,150,258],"parameters.":[130],"Bleeding":[131,208],"events":[134,215,233,294],"up":[135],"30":[137,164],"days":[138,165],"from":[139,166],"diagnosis":[140],"were":[141,171,193,206,242,265,354],"assessed,":[142],"graded":[144],"according":[145],"International":[148],"Society":[149],"Thrombosis":[151],"Haemostasis":[153],"criteria.":[154],"Early":[155,244],"death":[156,160,245],"defined":[158],"within":[161,217],"first":[163,219],"diagnosis.":[167],"Comparison":[168],"groups":[170],"made":[172],"Mann":[174],"Whitney,":[175],"Kruskal":[176],"Wallis":[177],"Fisher\u2019s":[179],"exact":[180],"test.":[181],"Associations":[182],"clinical,":[185],"laboratory,":[186],"variables":[189],"clinical":[191],"outcomes":[192],"evaluated":[194],"using":[195],"univariate":[196,344],"multivariable":[198,375],"logistic":[199],"regression":[200],"analyses.":[201],"Results":[202],"Sixty":[203],"three":[204],"included.":[207],"occurred":[209,216,234],"33":[211],"(52.4%).":[213],"27":[214],"seven":[220],"days,18.5%":[221],"being":[222],"hemorrhages,":[224],"all":[225],"central":[227],"nervous":[228],"lungs.":[231],"Thrombotic":[232],"13":[236],"(20.6%),":[238],"none":[239],"fatal.":[243],"rate":[246],"19%.":[248],"Most":[249],"(58.5%)":[251],"exhibited":[252],"hypocoagulable":[254,412],"profile":[256,413],"CI":[259,336,353,391],"calculation.":[260],"R":[261],"K":[263,306,347],"times":[264],"prolonged":[266,305],"16%":[268],"47%":[270],"cohort,":[273],"respectively;":[274],"alpha":[275,316,349],"angle":[276,317],"reduced":[278],"37.5%,":[280],"maximum":[282],"amplitude":[283],"(MA)":[284],"below":[286],"reference":[287],"range":[288],"75%.":[290],"showed":[295],"significantly":[296],"lower":[297,315,324,335],"platelet":[298,361,468],"counts":[299],"fibrinogen":[301,364],"levels,":[302,365],"higher":[303,379],"D-dimer,":[304],"time":[307],"(5.20":[308],"vs.":[309,319,328,338],"2.20":[310],"min,":[311],"p":[312,321,331,340,393],"=":[313,322,332,341,394],"0.01),":[314],"(41.9\u00b0":[318],"59.9\u00b0,":[320],"0.005),":[323],"MA":[325,351],"values":[326],"(37.6":[327],"49.9":[329],"mm,":[330],"0.003)":[333],"(-2.58":[337],"-7.31,":[339],"0.007).":[342],"In":[343],"analysis,":[345],"fibrinogen,":[346],"time,":[348],"angle,":[350],"bleeding.":[357],"After":[358],"adjustment":[359,434],"for":[360,435,451],"count":[362],"no":[366],"parameter":[368],"remained":[369],"independently":[370,398],"predictive":[371,429],"analysis.":[376],"However,":[377,427],"peripheral":[380,475],"blast":[381,476],"percentage":[382],"(OR":[388],"1.037,":[389],"95%":[390],"1.005\u20131.070;":[392],"0.023).":[395],"No":[396],"predicted":[399],"thrombosis":[400],"death.":[403],"Discussion":[404],"conclusion":[406],"Baseline":[407],"demonstrated":[409],"predominantly":[411],"patients,":[416],"impaired":[418],"among":[422],"who":[424],"experienced":[425],"hemorrhages.":[426],"its":[428],"value":[430],"attenuated":[432],"after":[433],"established":[436],"markers":[438],"(platelets":[439],"fibrinogen).":[441],"might":[443],"indicate":[444],"that":[445,482],"alone":[448],"is":[449],"insufficient":[450],"stratification,":[454],"could":[456],"be":[457],"improved":[458],"by":[459],"incorporating":[460],"complementary":[461],"biomarkers,":[462],"such":[463],"thrombin":[465],"generation":[466],"function":[469],"tests.":[470],"The":[471],"independent":[472],"association":[473],"burden":[477],"suggests":[481],"leukemia-related":[483],"biological":[484],"mechanisms":[485],"play":[486],"role":[489],"hemorrhagic":[491],"AL,":[494],"further":[496],"studies":[497],"analyzing":[498],"this":[499],"correlation":[500],"warranted.":[502]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}