{"id":"https://openalex.org/W7223129406","doi":"https://doi.org/10.1016/j.htct.2026.107560","title":"AVALIA\u00c7\u00c3O PR\u00c9-CL\u00cdNICA DOS INIBIDORES SELETIVOS DE HCK EM MODELOS DE LEUCEMIA PROMIELOC\u00cdTICA AGUDA","display_name":"AVALIA\u00c7\u00c3O PR\u00c9-CL\u00cdNICA DOS INIBIDORES SELETIVOS DE HCK EM MODELOS DE LEUCEMIA PROMIELOC\u00cdTICA AGUDA","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223129406","doi":"https://doi.org/10.1016/j.htct.2026.107560"},"language":"en","primary_location":{"id":"doi:10.1016/j.htct.2026.107560","doi":"https://doi.org/10.1016/j.htct.2026.107560","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107560","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926013076/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciencedirect.com/science/article/pii/S2531137926013076/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159184700","display_name":"Isabella Mazzaro FEHER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Isabella Mazzaro FEHER","raw_affiliation_strings":["Universidade de S\u00e3o Paulo (USP), Instituto de Ci\u00eancias Biom\u00e9dicas (ICB), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo (USP), Instituto de Ci\u00eancias Biom\u00e9dicas (ICB), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121548368","display_name":"Keli Lima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Keli LIMA","raw_affiliation_strings":["Universidade de S\u00e3o Paulo (USP), Faculdade de Medicina (FMUSP), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo (USP), Faculdade de Medicina (FMUSP), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027695219","display_name":"Carmen Silvia Moreno Serra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carmen Silvia Moreno SERRA","raw_affiliation_strings":["Universidade de S\u00e3o Paulo (USP), Instituto de Ci\u00eancias Biom\u00e9dicas (ICB), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo (USP), Instituto de Ci\u00eancias Biom\u00e9dicas (ICB), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041497834","display_name":"Eduardo Magalh\u00e3es Rego","orcid":"https://orcid.org/0000-0003-1567-4086","observed_orcids":["https://orcid.org/0000-0003-1567-4086"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Eduardo Magalh\u00e3es REGO","raw_affiliation_strings":["Universidade de S\u00e3o Paulo (USP), Faculdade de Medicina (FMUSP), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo (USP), Faculdade de Medicina (FMUSP), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159216600","display_name":"J\u00f5ao Agostinho MACHADO-NETO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"J\u00f5ao Agostinho MACHADO-NETO","raw_affiliation_strings":["Universidade de S\u00e3o Paulo (USP), Instituto de Ci\u00eancias Biom\u00e9dicas (ICB), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo (USP), Instituto de Ci\u00eancias Biom\u00e9dicas (ICB), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.75940495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":null,"first_page":"107560","last_page":"107560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.1648000031709671,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.046799998730421066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hematopoietic-cell-kinase","display_name":"hematopoietic cell kinase","score":0.8690000176429749},{"id":"https://openalex.org/keywords/pml-rara-fusion","display_name":"PML-RARA fusion","score":0.6980000138282776},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid-resistance","display_name":"all-trans retinoic acid resistance","score":0.9319999814033508},{"id":"https://openalex.org/keywords/nb4-cells","display_name":"NB4 cells","score":0.7429999709129333},{"id":"https://openalex.org/keywords/clonogenicity","display_name":"clonogenicity","score":0.6589999794960022},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.609000027179718},{"id":"https://openalex.org/keywords/leukemia-stem-cells","display_name":"leukemia stem cells","score":0.5690000057220459},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.39500001072883606},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9359999895095825},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34389999508857727},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2913999855518341},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2874999940395355},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2524000108242035},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2198999971151352},{"id":"https://openalex.org/C2780405999","wikidata":"https://www.wikidata.org/wiki/Q3483597","display_name":"Co-stimulation","level":5,"score":0.21490000188350677},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.2143000066280365},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.19179999828338623},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.17720000445842743}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.htct.2026.107560","doi":"https://doi.org/10.1016/j.htct.2026.107560","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107560","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926013076/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:09c16ce64bba40d9ae7f927b3fb2b3bb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/09c16ce64bba40d9ae7f927b3fb2b3bb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 48, Iss , Pp 107560- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.htct.2026.107560","doi":"https://doi.org/10.1016/j.htct.2026.107560","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107560","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926013076/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223129406.pdf","grobid_xml":"https://content.openalex.org/works/W7223129406.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4306254489","https://openalex.org/W4310096570","https://openalex.org/W4387748294","https://openalex.org/W1972534022","https://openalex.org/W4387748287","https://openalex.org/W4415669641","https://openalex.org/W2014506560","https://openalex.org/W7020587562","https://openalex.org/W4205940652","https://openalex.org/W3208707237"],"abstract_inverted_index":{"Introdu\u00e7\u00e3o":[0],"A":[1,71,148,313],"leucemia":[2,12],"promieloc\u00edtica":[3],"aguda":[4],"(LPA)":[5],"\u00e9":[6],"um":[7,340],"subtipo":[8],"molecularmente":[9],"definido":[10],"de":[11,20,43,67,98,130,138,161,170,203,205,210,221,231,264,293,325],"mieloide":[13,27],"aguda,":[14],"caracterizado":[15],"pela":[16],"presen\u00e7a":[17],"do":[18,35,41,151,154,168,276,307],"gene":[19],"fus\u00e3o":[21],"PML::RARA,":[22],"que":[23,277,285,348],"compromete":[24],"a":[25,30,33,65,107,208,224,256,260,297,335],"diferencia\u00e7\u00e3o":[26,225],"e":[28,40,95,133,141,146,153,164,219,237,259,270,295,311,328,346,371,381],"promove":[29],"leucemog\u00eanese.":[31],"Embora":[32],"introdu\u00e7\u00e3o":[34],"\u00e1cido":[36],"all-trans":[37],"retinoico":[38],"(ATRA)":[39],"tri\u00f3xido":[42],"ars\u00eanio":[44],"(ATO)":[45],"tenha":[46],"melhorado":[47],"significativamente":[48,255],"os":[49,184,368],"desfechos":[50],"cl\u00ednicos,":[51],"parte":[52],"dos":[53,127,180],"pacientes":[54],"permanece":[55],"refrat\u00e1ria":[56],"ao":[57,143,330],"tratamento":[58,119,176,251],"ou":[59],"apresenta":[60],"recidiva":[61],"da":[62,81,110,120,186,188,300,316,337],"doen\u00e7a,":[63],"evidenciando":[64],"necessidade":[66],"novas":[68],"estrat\u00e9gias":[69],"terap\u00eauticas.":[70],"hematopoietic":[72],"cell":[73],"kinase":[74],"(HCK),":[75],"uma":[76,113,353],"tirosina":[77],"quinase":[78],"n\u00e3o":[79],"receptora":[80],"fam\u00edlia":[82],"Src":[83],"predominantemente":[84],"expressa":[85],"em":[86,135,243,291,323,378],"c\u00e9lulas":[87,99,197],"hematopo\u00e9ticas,":[88],"tem":[89],"sido":[90],"implicada":[91],"na":[92,104,305,344],"sobreviv\u00eancia,":[93],"prolifera\u00e7\u00e3o":[94],"resist\u00eancia":[96],"terap\u00eautica":[97],"leuc\u00eamicas,":[100],"incluindo":[101],"c\u00e9lulas-tronco":[102],"leuc\u00eamicas":[103,198],"LPA.":[105,121],"Assim,":[106],"inibi\u00e7\u00e3o":[108,187,314,350],"farmacol\u00f3gica":[109],"HCK":[111,189,304,317,338],"representa":[112],"abordagem":[114,377],"potencialmente":[115],"promissora":[116],"para":[117,366],"o":[118,124,193,234,278,286,373],"Objetivo":[122],"Caracterizar":[123],"potencial":[125,194,341,374],"terap\u00eautico":[126,343,375],"inibidores":[128],"seletivos":[129],"HCK,":[131],"HCKi-37":[132,155],"BT424,":[134],"modelos":[136,292,324,379],"experimentais":[137],"LPA":[139,162,294,326,345],"sens\u00edveis":[140,327],"resistentes":[142,329],"ATRA.":[144,331],"Material":[145],"m\u00e9todos":[147],"atividade":[149,274,289,321],"antileuc\u00eamica":[150,275,322],"BT424":[152,191,253,287,319],"foi":[156,212,227],"investigada":[157],"nas":[158,267],"linhagens":[159,268],"celulares":[160],"NB4":[163,269],"NB4-R2":[165],"por":[166,173,201,214,229,247,303],"meio":[167],"ensaio":[169,202],"viabilidade":[171,257],"celular":[172,226,258],"MTT,":[174],"ap\u00f3s":[175],"com":[177,216,252],"concentra\u00e7\u00f5es":[178],"crescentes":[179],"f\u00e1rmacos.":[181],"Em":[182,280],"seguida,":[183],"efeitos":[185],"pelo":[190,318],"sobre":[192],"clonog\u00eanico":[195],"das":[196],"foram":[199,241],"avaliados":[200],"forma\u00e7\u00e3o":[204],"col\u00f4nias.":[206],"Adicionalmente,":[207],"indu\u00e7\u00e3o":[209],"apoptose":[211,266],"analisada":[213],"marca\u00e7\u00e3o":[215],"anexina":[217],"V":[218],"iodeto":[220],"prop\u00eddio":[222],"(PI),":[223],"avaliada":[228],"citometria":[230],"fluxo":[232],"utilizando":[233],"marcador":[235],"CD11b,":[236],"as":[238],"altera\u00e7\u00f5es":[239],"morfol\u00f3gicas":[240],"examinadas":[242],"prepara\u00e7\u00f5es":[244],"citol\u00f3gicas":[245],"obtidas":[246],"cytospin.":[248],"Resultados":[249],"O":[250],"reduziu":[254],"capacidade":[261],"clonog\u00eanica,":[262],"al\u00e9m":[263],"induzir":[265],"NB4-R2,":[271],"apresentando":[272],"maior":[273],"HCKi-37.":[279],"conjunto,":[281],"esses":[282],"achados":[283,333],"sugerem":[284,347],"exerce":[288],"antitumoral":[290],"refor\u00e7am":[296],"poss\u00edvel":[298],"participa\u00e7\u00e3o":[299],"sinaliza\u00e7\u00e3o":[301],"mediada":[302],"manuten\u00e7\u00e3o":[306],"fen\u00f3tipo":[308],"leuc\u00eamico.":[309],"Discuss\u00e3o":[310],"Conclus\u00e3o":[312],"seletiva":[315],"apresentou":[320],"Esses":[332],"apoiam":[334],"investiga\u00e7\u00e3o":[336],"como":[339],"alvo":[342],"sua":[349],"possa":[351],"representar":[352],"estrat\u00e9gia":[354],"complementar":[355],"aos":[356],"tratamentos":[357],"atualmente":[358],"dispon\u00edveis.":[359],"No":[360],"entanto,":[361],"estudos":[362],"adicionais":[363],"s\u00e3o":[364],"necess\u00e1rios":[365],"elucidar":[367],"mecanismos":[369],"envolvidos":[370],"validar":[372],"dessa":[376],"pr\u00e9-cl\u00ednicos":[380],"cl\u00ednicos.":[382]},"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2026-10-22T00:00:00"}