{"id":"https://openalex.org/W7223127366","doi":"https://doi.org/10.1016/j.htct.2026.107713","title":"S\u00cdNDROME DO DUCTO BILIAR DESAPARECENTE EM PACIENTE COM LINFOMA DE HODGKIN CONCOMITANTE A TIMOMA: RELATO DE CASO","display_name":"S\u00cdNDROME DO DUCTO BILIAR DESAPARECENTE EM PACIENTE COM LINFOMA DE HODGKIN CONCOMITANTE A TIMOMA: RELATO DE CASO","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223127366","doi":"https://doi.org/10.1016/j.htct.2026.107713"},"language":"en","primary_location":{"id":"doi:10.1016/j.htct.2026.107713","doi":"https://doi.org/10.1016/j.htct.2026.107713","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107713","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926014604/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciencedirect.com/science/article/pii/S2531137926014604/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159179764","display_name":"Gabriel Vin\u00edcius DE OLIVEIRA ALVES","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel Vin\u00edcius DE OLIVEIRA ALVES","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159185348","display_name":"Camila BEZERRA ARRUDA LEDA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Camila Bezerra ARRUDA LEDA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159175743","display_name":"Raissa Hellen PRATES SILVEIRA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raissa Hellen PRATES SILVEIRA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159185633","display_name":"Rafael Gerage ROCHELLE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093009","display_name":"Hospital de C\u00e2ncer de Barretos","ror":"https://ror.org/00f2kew86","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210093009"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafael Gerage ROCHELLE","raw_affiliation_strings":["Hospital do C\u00e2ncer de Barretos, Barretos, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital do C\u00e2ncer de Barretos, Barretos, SP, Brasil","institution_ids":["https://openalex.org/I4210093009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123748925","display_name":"Karolline Gon\u00e7alves Fernandes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093009","display_name":"Hospital de C\u00e2ncer de Barretos","ror":"https://ror.org/00f2kew86","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210093009"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Karolline Gon\u00e7alves FERNANDES","raw_affiliation_strings":["Hospital do C\u00e2ncer de Barretos, Barretos, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital do C\u00e2ncer de Barretos, Barretos, SP, Brasil","institution_ids":["https://openalex.org/I4210093009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159208856","display_name":"Julia Ristow DE ASSUN\u00c7\u00c3O","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia Ristow DE ASSUN\u00c7\u00c3O","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159202319","display_name":"Isabelle Adjani SANTOS PLENTZ","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabelle Adjani SANTOS PLENTZ","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159188460","display_name":"Gilberto se Freitas COLLI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093009","display_name":"Hospital de C\u00e2ncer de Barretos","ror":"https://ror.org/00f2kew86","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210093009"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gilberto se Freitas COLLI","raw_affiliation_strings":["Hospital do C\u00e2ncer de Barretos, Barretos, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital do C\u00e2ncer de Barretos, Barretos, SP, Brasil","institution_ids":["https://openalex.org/I4210093009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159198207","display_name":"Isabela Assis DE SIQUIERA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabela Assis DE SIQUIERA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5159210356","display_name":"Mariana Bianchi CARNEIRO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093009","display_name":"Hospital de C\u00e2ncer de Barretos","ror":"https://ror.org/00f2kew86","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210093009"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mariana Bianchi CARNEIRO","raw_affiliation_strings":["Hospital do C\u00e2ncer de Barretos, Barretos, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital do C\u00e2ncer de Barretos, Barretos, SP, Brasil","institution_ids":["https://openalex.org/I4210093009"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84446774,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":null,"first_page":"107713","last_page":"107713"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.7226999998092651,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.7226999998092651,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12426","display_name":"Lymphatic Disorders and Treatments","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vanishing-bile-duct-syndrome","display_name":"vanishing bile duct syndrome","score":0.8339999914169312},{"id":"https://openalex.org/keywords/hodgkin-lymphoma","display_name":"Hodgkin's disease","score":0.9210000038146973},{"id":"https://openalex.org/keywords/thymoma","display_name":"thymoma","score":0.8690000176429749},{"id":"https://openalex.org/keywords/mediastinal-mass","display_name":"mediastinal mass","score":0.6710000038146973},{"id":"https://openalex.org/keywords/nodular-sclerosis-hodgkin-lymphoma","display_name":"nodular sclerosis Hodgkin lymphoma","score":0.6639999747276306},{"id":"https://openalex.org/keywords/transarterial-chemoembolization","display_name":"transarterial chemoembolization","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.983299970626831},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.5192999839782715},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3188000023365021},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.22429999709129333},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2240999937057495},{"id":"https://openalex.org/C3018130915","wikidata":"https://www.wikidata.org/wiki/Q1752284","display_name":"Neoplasm staging","level":3,"score":0.21789999306201935},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.19449999928474426},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.17649999260902405},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.1543000042438507},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1468999981880188}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.htct.2026.107713","doi":"https://doi.org/10.1016/j.htct.2026.107713","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107713","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926014604/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:70192776b6df435a89b828c19dc6ac87","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/70192776b6df435a89b828c19dc6ac87","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 48, Iss , Pp 107713- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.htct.2026.107713","doi":"https://doi.org/10.1016/j.htct.2026.107713","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107713","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926014604/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223127366.pdf","grobid_xml":"https://content.openalex.org/works/W7223127366.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7223152518","https://openalex.org/W2145432248","https://openalex.org/W4387737315","https://openalex.org/W4285495537","https://openalex.org/W4252039884","https://openalex.org/W4414157524","https://openalex.org/W4378901380","https://openalex.org/W2408593851","https://openalex.org/W1494492879","https://openalex.org/W4410571397"],"abstract_inverted_index":{"Objetivo":[0],"Descrever":[1],"o":[2,241,251,255,262,330],"caso":[3,32,244,353],"de":[4,12,21,23,31,45,68,73,79,108,116,121,137,155,159,166,198,207,234,264,271,276,278,283,287,291,312,348,358,363,372,376,390],"uma":[5,177,309,355,364],"paciente":[6,162],"jovem":[7],"com":[8,39,57,209,240,298,383],"colestase":[9,186,359,384],"paraneopl\u00e1sica":[10,179,360],"sugestiva":[11],"s\u00edndrome":[13],"do":[14,102,127],"ducto":[15],"biliar":[16],"desaparecente":[17],"(VBDS)":[18],"em":[19,91,163,281,380],"vig\u00eancia":[20,290],"Linfoma":[22],"Hodgkin":[24],"(LH)":[25],"cl\u00e1ssico":[26],"concomitante":[27],"a":[28,205,299,319,370,396],"timoma.":[29],"Relato":[30],"Mulher,":[33],"32":[34],"anos,":[35],"apresentou":[36],"linfonodomegalia":[37],"cervical":[38],"regress\u00e3o":[40],"espont\u00e2nea;":[41],"tomografia":[42],"computadorizada":[43],"(TC)":[44],"t\u00f3rax":[46],"evidenciou":[47,87],"massa":[48],"mediastinal":[49,93],"(7,4":[50],"cm),":[51],"sem":[52,246],"investiga\u00e7\u00e3o":[53],"complementar.":[54],"Posteriormente,":[55],"iniciou":[56],"dor":[58],"abdominal,":[59],"diarreia,":[60],"icter\u00edcia":[61],"progressiva,":[62],"prurido":[63],"difuso":[64],"e":[65,75,101,119,141,150,157,171,257,294,305,322,394],"perda":[66],"ponderal":[67],"16":[69],"kg.":[70],"A":[71,96,174,217,301],"TC":[72],"abdome":[74],"colangiorresson\u00e2ncia":[76],"exclu\u00edram":[77],"dilata\u00e7\u00e3o":[78,277],"vias":[80,279],"biliares":[81,194,280],"intra":[82],"ou":[83],"extra-hep\u00e1ticas.":[84],"O":[85],"PET-CT":[86],"volumoso":[88],"conglomerado":[89],"linfonodal":[90],"regi\u00e3o":[92],"anterior,":[94],"hipermetab\u00f3lico.":[95],"revis\u00e3o":[97],"diagn\u00f3stica":[98],"da":[99],"bi\u00f3psia":[100],"painel":[103],"imuno-histoqu\u00edmico":[104],"identificou":[105],"distribui\u00e7\u00e3o":[106],"heterog\u00eanea":[107],"duas":[109,326],"neoplasias":[110],"concomitantes":[111],"no":[112,345,361],"mesmo":[113,387],"esp\u00e9cime:":[114],"componente":[115,120],"timoma":[117,208,304],"B2":[118],"LHc":[122],"subtipo":[123],"esclerose":[124],"nodular.":[125],"Diante":[126],"diagn\u00f3stico,":[128],"optou-se":[129],"por":[130,185,269],"quimioterapia":[131,404],"sist\u00eamica.":[132,405],"Inicialmente,":[133],"realizados":[134],"dois":[135],"ciclos":[136],"COP":[138],"(ciclofosfamida,":[139],"vincristina":[140],"prednisona)":[142],"para":[143,378],"citorredu\u00e7\u00e3o.":[144],"Ap\u00f3s,":[145],"iniciado":[146],"ICE":[147],"(ifosfamida,":[148],"carboplatina":[149],"etopos\u00eddeo)":[151],"devido":[152],"\u00e0":[153,189,229,403],"manuten\u00e7\u00e3o":[154],"hiperbilirrubinemia":[156],"altera\u00e7\u00e3o":[158],"canaliculares.":[160],"Atualmente,":[161],"terceiro":[164],"ciclo":[165],"ICE,":[167],"apresentando":[168],"melhora":[169,295],"cl\u00ednica":[170],"laboratorial.":[172],"Discuss\u00e3o":[173],"VBDS":[175,265,379],"\u00e9":[176,308],"manifesta\u00e7\u00e3o":[178],"rara":[180,357],"associada":[181],"ao":[182],"LH,":[183],"caracterizada":[184],"progressiva":[187,297],"secund\u00e1ria":[188],"destrui\u00e7\u00e3o":[190],"imunomediada":[191],"dos":[192,219,226],"ductos":[193],"interlobulares,":[195],"na":[196,232,388],"aus\u00eancia":[197,233,275,286,389],"infiltra\u00e7\u00e3o":[199,235,288],"hep\u00e1tica":[200,248],"direta":[201],"pelo":[202],"tumor.1":[203],"Adicionalmente,":[204],"coexist\u00eancia":[206],"LH":[210,292,306,331],"t\u00edmico":[211,307,332],"constitui":[212],"associa\u00e7\u00e3o":[213,365],"tumoral":[214,366],"extremamente":[215],"rara.3":[216],"ativa\u00e7\u00e3o":[218],"linf\u00f3citos":[220],"T":[221],"citot\u00f3xicos":[222],"que":[223,329,401],"promovem":[224],"apoptose":[225],"colangi\u00f3citos,":[227],"levando":[228],"ductopenia,":[230],"geralmente":[231],"linfomatosa":[236],"hep\u00e1tica,":[237,289],"padr\u00e3o":[238],"compat\u00edvel":[239],"observado":[242],"neste":[243],"(PET-CT":[245],"capta\u00e7\u00e3o":[247],"an\u00f4mala).1,2":[249],"Embora":[250],"diagn\u00f3stico":[252,263],"histol\u00f3gico":[253],"seja":[254],"padr\u00e3o-ouro":[256],"n\u00e3o":[258],"tenha":[259],"sido":[260],"realizado,":[261],"prov\u00e1vel":[266],"se":[267,343],"sustenta":[268],"crit\u00e9rios":[270],"exclus\u00e3o":[272],"bem":[273],"documentados:":[274],"exames":[282],"imagem":[284],"seriados,":[285],"ativo":[293],"bioqu\u00edmica":[296,398],"quimioterapia.":[300],"concomit\u00e2ncia":[302],"entre":[303,324],"segunda":[310],"camada":[311],"raridade":[313],"deste":[314],"caso,":[315],"sendo":[316],"tamb\u00e9m":[317],"desafiadora":[318],"distin\u00e7\u00e3o":[320],"radiol\u00f3gica":[321],"histol\u00f3gica":[323,392],"as":[325],"entidades,":[327],"j\u00e1":[328],"pode":[333],"estimular":[334],"hiperplasia":[335],"epitelial":[336],"reativa":[337],"simulando":[338],"um":[339],"timoma.3":[340],"Este":[341,352],"desafio":[342],"refletiu":[344],"pr\u00f3prio":[346],"estadiamento":[347],"nossa":[349],"paciente.":[350],"Conclus\u00e3o":[351],"ilustra":[354],"apresenta\u00e7\u00e3o":[356],"contexto":[362],"igualmente":[367],"incomum,":[368],"refor\u00e7ando":[369],"import\u00e2ncia":[371],"manter":[373],"alto":[374],"\u00edndice":[375],"suspei\u00e7\u00e3o":[377],"pacientes":[381],"oncol\u00f3gicos":[382],"inexplicada":[385],"\u2014":[386,393],"confirma\u00e7\u00e3o":[391],"destacando":[395],"resposta":[397],"favor\u00e1vel,":[399],"ainda":[400],"parcial,":[402]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}