{"id":"https://openalex.org/W7223124679","doi":"https://doi.org/10.1016/j.htct.2026.107339","title":"S\u00cdNDROME DE HIPER-HEM\u00d3LISE E CHOQUE S\u00c9PTICO EM PACIENTE COM DOEN\u00c7A FALCIFORME EM UM SERVI\u00c7O DE REFER\u00caNCIA DE HEMATOLOGIA E HEMOTERAPIA NO NORDESTE","display_name":"S\u00cdNDROME DE HIPER-HEM\u00d3LISE E CHOQUE S\u00c9PTICO EM PACIENTE COM DOEN\u00c7A FALCIFORME EM UM SERVI\u00c7O DE REFER\u00caNCIA DE HEMATOLOGIA E HEMOTERAPIA NO NORDESTE","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223124679","doi":"https://doi.org/10.1016/j.htct.2026.107339"},"language":"en","primary_location":{"id":"doi:10.1016/j.htct.2026.107339","doi":"https://doi.org/10.1016/j.htct.2026.107339","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107339","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926010862/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciencedirect.com/science/article/pii/S2531137926010862/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5126427034","display_name":"Alessandra Manuelle Cordeiro Silva Duarte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessandra Manuelle Cordeiro Silva DUARTE","raw_affiliation_strings":["Funda\u00e7\u00e3o de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Funda\u00e7\u00e3o de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brasil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159216940","display_name":"Barbara Torquarto ALVES","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Torquarto ALVES","raw_affiliation_strings":["Funda\u00e7\u00e3o de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Funda\u00e7\u00e3o de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brasil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159204270","display_name":"Vitor Manoel Rodrigues Ferreira de LIMA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vitor Manoel Rodrigues Ferreira DE LIMA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159206471","display_name":"Larissa Edilza de Lima LEITE","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Larissa Edilza De Lima LEITE","raw_affiliation_strings":["Funda\u00e7\u00e3o de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Funda\u00e7\u00e3o de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brasil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159177404","display_name":"Gabriel Fernades DE SOUZA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel Fernades DE SOUZA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159220372","display_name":"Cariele Cristina Silva DUTRA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cariele Cristina Silva DUTRA","raw_affiliation_strings":["Funda\u00e7\u00e3o de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Funda\u00e7\u00e3o de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brasil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045572538","display_name":"Jeanille Seixas Xavier Abrantes Diniz","orcid":"https://orcid.org/0000-0003-1573-8203","observed_orcids":["https://orcid.org/0000-0003-1573-8203"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeanille Seixas Xavier Abrantes DINIZ","raw_affiliation_strings":["Funda\u00e7\u00e3o de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Funda\u00e7\u00e3o de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brasil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159196191","display_name":"Fabia Michelle R. de Araujo DE CALLADO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabia Michelle R. de Araujo DE CALLADO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159209833","display_name":"Lays Clemente CAVALCANTI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lays Clemente CAVALCANTI","raw_affiliation_strings":["Funda\u00e7\u00e3o de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Funda\u00e7\u00e3o de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, PE, Brasil","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159209473","display_name":"Igor Paiva DOS SANTOS","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Igor Paiva DOS SANTOS","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.81924409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":null,"first_page":"107339","last_page":"107339"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/transfusion-related-hemolysis","display_name":"transfusion-related hemolysis","score":0.5929999947547913},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.7960000038146973},{"id":"https://openalex.org/keywords/alloimmunization","display_name":"alloimmunization","score":0.781000018119812},{"id":"https://openalex.org/keywords/eculizumab","display_name":"eculizumab","score":0.7080000042915344},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.9539999961853027},{"id":"https://openalex.org/keywords/immunoglobulins","display_name":"immunoglobulins","score":0.5339999794960022},{"id":"https://openalex.org/keywords/methylprednisolone","display_name":"methylprednisolone","score":0.7080000042915344},{"id":"https://openalex.org/keywords/crossmatch-incompatibility","display_name":"crossmatch incompatibility","score":0.5910000205039978},{"id":"https://openalex.org/keywords/acute-chest-syndrome","display_name":"acute chest syndrome","score":0.4230000078678131},{"id":"https://openalex.org/keywords/respiratory-failure","display_name":"respiratory failure","score":0.4519999921321869},{"id":"https://openalex.org/keywords/hematuria","display_name":"hematuria","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7813000082969666},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.24570000171661377},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.2020999938249588},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.18930000066757202},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.1526000052690506},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.1307000070810318},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.12849999964237213},{"id":"https://openalex.org/C2992940845","wikidata":"https://www.wikidata.org/wiki/Q4915134","display_name":"Medical waste","level":2,"score":0.10890000313520432},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.1046999990940094},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.10409999638795853}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.htct.2026.107339","doi":"https://doi.org/10.1016/j.htct.2026.107339","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107339","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926010862/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:c8455a546122410aa3fdb05af2e5c25b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c8455a546122410aa3fdb05af2e5c25b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 48, Iss , Pp 107339- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.htct.2026.107339","doi":"https://doi.org/10.1016/j.htct.2026.107339","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107339","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926010862/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223124679.pdf","grobid_xml":"https://content.openalex.org/works/W7223124679.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4221060873","https://openalex.org/W4415669109","https://openalex.org/W3209417462","https://openalex.org/W4403569560","https://openalex.org/W4387763869","https://openalex.org/W2069016126","https://openalex.org/W7223154071","https://openalex.org/W4306319719","https://openalex.org/W4403568258","https://openalex.org/W7223105769"],"abstract_inverted_index":{"Introdu\u00e7\u00e3o/Objetivo":[0],"A":[1,145,272,363,374],"S\u00edndrome":[2],"de":[3,23,46,63,75,78,85,105,107,112,116,165,186,209,215,245,253,255,287,291,318,340,354,386,407,428],"Hiper-hem\u00f3lise":[4],"(SHH)":[5],"\u00e9":[6,41,58],"uma":[7],"complica\u00e7\u00e3o":[8],"transfusional":[9,198],"rara":[10],"e":[11,27,51,93,103,140,149,160,167,177,206,213,220,227,238,260,306,313,330,347,359,424],"potencialmente":[12],"fatal":[13],"na":[14,338],"Doen\u00e7a":[15],"Falciforme":[16],"(DF,":[17],"HbSS).":[18],"Caracteriza-se":[19],"pela":[20],"destrui\u00e7\u00e3o":[21],"maci\u00e7a":[22],"hem\u00e1cias":[24,108,134,292,311],"do":[25,28,304,307,334,352,371,376],"doador":[26],"receptor,":[29],"resultando":[30],"em":[31,73,243,248,398],"anemia":[32,94,282],"grave":[33],"com":[34,48,54,90,100,133,138,152,179,211,224,241,251,400],"n\u00edveis":[35],"inferiores":[36],"aos":[37],"pr\u00e9-transfusionais.":[38],"O":[39,56,323],"manejo":[40,61,324],"desafiador":[42],"pelo":[43,316],"alto":[44],"risco":[45,286],"mortalidade":[47,288],"novas":[49,345],"transfus\u00f5es":[50,233],"frequente":[52],"associa\u00e7\u00e3o":[53],"aloimuniza\u00e7\u00e3o.":[55],"objetivo":[57],"relatar":[59],"o":[60,285,380,401],"intensivo":[62],"SHH":[64,273],"deflagrada":[65],"por":[66,196,234,281,289],"transfus\u00e3o,":[67],"associada":[68],"a":[69,181,269,278,297,301,367,384,391,395,426],"choque":[70,161,377],"s\u00e9ptico":[71,162,378],"pulmonar,":[72,163],"servi\u00e7o":[74],"refer\u00eancia.":[76],"Relato":[77],"caso":[79],"Paciente":[80],"feminina,":[81],"19":[82],"anos,":[83],"portadora":[84],"DF,":[86],"politransfundida,":[87],"foi":[88,147,327],"admitida":[89],"crise":[91],"\u00e1lgica":[92],"(Hb":[95],"5,6":[96],"g/dL).":[97],"Foi":[98],"tratada":[99],"analgesia,":[101],"hidrata\u00e7\u00e3o":[102],"transfus\u00e3o":[104,132,146],"concentrado":[106],"fenotipadas,":[109],"atingindo":[110],"Hb":[111,124,242],"7,2":[113],"g/dL.":[114,126],"Cerca":[115],"cinco":[117],"dias":[118,155],"ap\u00f3s,":[119,156],"apresentou":[120],"queda":[121],"abrupta":[122],"para":[123,264,343,390,420],"3,9":[125],"Diante":[127],"da":[128,360],"piora,":[129],"realizou-se":[130],"nova":[131],"aliquotadas,":[135],"evoluindo":[136],"imediatamente":[137],"hemat\u00faria":[139],"hem\u00f3lise":[141,298,361],"grave,":[142],"configurando":[143],"SHH.":[144],"suspensa":[148],"iniciou-se":[150],"pulsoterapia":[151],"Metilprednisolona.":[153],"Dois":[154],"desenvolveu":[157],"insufici\u00eancia":[158],"respirat\u00f3ria":[159],"necessitando":[164],"intuba\u00e7\u00e3o":[166],"UTI.":[168],"Classificada":[169],"como":[170,417],"A+,":[171],"fen\u00f3tipo":[172],"E(-),":[173],"K(-),":[174],"Jk\u1d43(-),":[175],"N(-)":[176],"PAI":[178],"Anti-Kell,":[180],"reavalia\u00e7\u00e3o":[182],"imuno-hematol\u00f3gica":[183],"revelou":[184],"surgimento":[185],"anticorpo":[187],"adicional":[188],"n\u00e3o":[189,321],"identificado,":[190],"mantendo":[191],"provas":[192],"cruzadas":[193],"incompat\u00edveis.":[194],"Optou-se":[195],"restri\u00e7\u00e3o":[197],"estrita.":[199],"Na":[200],"UTI,":[201],"recebeu":[202],"Metilprednisolona,":[203],"Imunoglobulina,":[204],"Rituximabe":[205,337],"Eculizumabe,":[207],"al\u00e9m":[208],"suporte":[210],"eritropoetina":[212,364],"antibioticoterapia":[214,385],"amplo":[216,387],"espectro":[217,388],"(Meropenem,":[218],"Vancomicina":[219],"Polimixina":[221],"B).":[222],"Evoluiu":[223],"estabiliza\u00e7\u00e3o":[225],"cl\u00ednica":[226],"extuba\u00e7\u00e3o":[228],"bem-sucedida.":[229],"Atualmente,":[230],"mant\u00e9m-se":[231],"sem":[232,239],"incompatibilidade,":[235],"hemodinamicamente":[236],"est\u00e1vel":[237],"vasoativos,":[240],"torno":[244],"4,0":[246],"g/dL":[247],"oxigenoterapia":[249],"suplementar,":[250],"Ensaio":[252],"Monocamada":[254],"Mon\u00f3citos":[256],"(MMA)":[257],"resultado":[258],"negativo":[259,404],"aguardando":[261],"genotipagem":[262,396],"eritrocit\u00e1ria":[263,397],"decis\u00f5es":[265],"terap\u00eauticas":[266],"futuras":[267],"relacionadas":[268],"transfus\u00e3o.":[270],"Discuss\u00e3o":[271],"estabelece":[274],"um":[275],"impasse":[276],"transfusional:":[277],"hip\u00f3xia":[279],"tecidual":[280],"extrema":[283],"versus":[284],"lise":[290],"transfundidas.":[293],"Sua":[294],"fisiopatologia":[295],"engloba":[296],"bystander,":[299],"onde":[300],"ativa\u00e7\u00e3o":[302],"desenfreada":[303],"complemento":[305],"sistema":[308,335],"monoc\u00edtico-macrof\u00e1gico":[309],"destr\u00f3i":[310],"aut\u00f3logas":[312],"heter\u00f3logas,":[314],"exacerbada":[315],"aparecimento":[317],"novos":[319],"aloanticorpos":[320],"identificados.":[322],"imunomodulador":[325],"multimodal":[326],"determinante:":[328],"corticoterapia":[329],"IVIG":[331],"no":[332,350],"bloqueio":[333,351],"reticuloendotelial;":[336],"supress\u00e3o":[339],"linf\u00f3citos":[341],"B":[342],"conter":[344],"aloimuniza\u00e7\u00f5es;":[346],"Eculizumabe":[348],"(anti-C5)":[349],"complexo":[353],"ataque":[355],"\u00e0":[356],"membrana":[357],"(MAC)":[358],"intravascular.":[362],"otimizada":[365],"resgatou":[366],"eritropoiese":[368],"pr\u00f3pria":[369],"diante":[370],"consumo":[372],"perif\u00e9rico.":[373],"sobreposi\u00e7\u00e3o":[375],"agravou":[379],"estresse":[381],"metab\u00f3lico,":[382],"tornando":[383],"vital":[389],"estabiliza\u00e7\u00e3o.":[392],"Por":[393],"fim,":[394],"conjunto":[399],"ensaio":[402],"MMA":[403],"\u2014":[405,415],"indicativo":[406],"menor":[408],"reatividade":[409],"funcional":[410],"in":[411],"vitro":[412],"dos":[413],"anticorpos":[414],"surgem":[416],"ferramentas":[418],"decisivas":[419],"desvendar":[421],"variantes":[422],"al\u00e9licas":[423],"orientar":[425],"seguran\u00e7a":[427],"eventual":[429],"reexposi\u00e7\u00e3o":[430],"transfusional.":[431]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-22T00:00:00"}
