{"id":"https://openalex.org/W7223118359","doi":"https://doi.org/10.1016/j.jaccas.2026.110353","title":"Extremely Severe Aortic Stenosis Mimicking Cardiac Amyloidosis on Multimodality Imaging","display_name":"Extremely Severe Aortic Stenosis Mimicking Cardiac Amyloidosis on Multimodality Imaging","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223118359","doi":"https://doi.org/10.1016/j.jaccas.2026.110353","pmid":"https://pubmed.ncbi.nlm.nih.gov/42910800","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13699046"},"language":"en","primary_location":{"id":"doi:10.1016/j.jaccas.2026.110353","doi":"https://doi.org/10.1016/j.jaccas.2026.110353","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaccas.2026.110353","pdf_url":null,"source":{"id":"https://openalex.org/S4210180918","display_name":"JACC Case Reports","issn_l":"2666-0849","issn":["2666-0849"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jaccas.2026.110353","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5129584841","display_name":"Yu Young Kim","orcid":"https://orcid.org/0009-0002-4308-020X","observed_orcids":["https://orcid.org/0009-0002-4308-020X"]},"institutions":[{"id":"https://openalex.org/I4210115854","display_name":"Pusan National University Hospital","ror":"https://ror.org/027zf7h57","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210115854","https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yu Young Kim","raw_affiliation_strings":["Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0002-4308-020X","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea","institution_ids":["https://openalex.org/I4210115854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014724138","display_name":"Kyoungjune Pak","orcid":"https://orcid.org/0000-0001-5051-1894","observed_orcids":["https://orcid.org/0000-0001-5051-1894"]},"institutions":[{"id":"https://openalex.org/I4210115854","display_name":"Pusan National University Hospital","ror":"https://ror.org/027zf7h57","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210115854","https://openalex.org/I4921948"]},{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyoungjune Pak","raw_affiliation_strings":["Department of Nuclear Medicine, Pusan National University Hospital, Busan, Republic of Korea; School of Medicine, Pusan National University, Busan, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Pusan National University Hospital, Busan, Republic of Korea; School of Medicine, Pusan National University, Busan, Republic of Korea","institution_ids":["https://openalex.org/I4210115854","https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136883271","display_name":"Ji Won Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115854","display_name":"Pusan National University Hospital","ror":"https://ror.org/027zf7h57","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210115854","https://openalex.org/I4921948"]},{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji Won Lee","raw_affiliation_strings":["Department of Radiology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, South Korea","institution_ids":["https://openalex.org/I4210115854","https://openalex.org/I4921948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002948405","display_name":"Jung Hyun Choi","orcid":"https://orcid.org/0000-0001-7171-8843","observed_orcids":["https://orcid.org/0000-0001-7171-8843"]},"institutions":[{"id":"https://openalex.org/I4210115854","display_name":"Pusan National University Hospital","ror":"https://ror.org/027zf7h57","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210115854","https://openalex.org/I4921948"]},{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jung Hyun Choi","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea; Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea. Electronic address: mariahyeon@gmail.com"],"raw_orcid":"https://orcid.org/0000-0001-7171-8843","affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea; Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea. Electronic address: mariahyeon@gmail.com","institution_ids":["https://openalex.org/I4210115854","https://openalex.org/I4921948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002948405"],"corresponding_institution_ids":["https://openalex.org/I4210115854","https://openalex.org/I4921948"],"apc_list":{"value":850,"currency":"USD","value_usd":850},"apc_paid":{"value":850,"currency":"USD","value_usd":850},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.81466395,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"42","first_page":"110353","last_page":"110353"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-aortic-stenosis","display_name":"severe aortic stenosis","score":0.875},{"id":"https://openalex.org/keywords/calcific-aortic-stenosis","display_name":"calcific aortic stenosis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cardiac-amyloidosis","display_name":"cardiac amyloidosis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cardiac-magnetic-resonance-imaging","display_name":"cardiac magnetic resonance imaging","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cardiac-magnetic-resonance-t1-mapping","display_name":"cardiac magnetic resonance T1 mapping","score":0.6830000281333923},{"id":"https://openalex.org/keywords/extracellular-volume","display_name":"extracellular volume","score":0.9620000123977661},{"id":"https://openalex.org/keywords/late-gadolinium-enhancement","display_name":"late gadolinium enhancement","score":0.902999997138977},{"id":"https://openalex.org/keywords/myocardial-biopsy","display_name":"myocardial biopsy","score":0.6970000267028809},{"id":"https://openalex.org/keywords/surgical-aortic-valve-replacement","display_name":"surgical aortic valve replacement","score":0.8339999914169312},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.7630000114440918},{"id":"https://openalex.org/keywords/interstitial-fibrosis","display_name":"interstitial fibrosis","score":0.718999981880188},{"id":"https://openalex.org/keywords/histological-confirmation","display_name":"histopathological confirmation","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8574000000953674},{"id":"https://openalex.org/C2777607188","wikidata":"https://www.wikidata.org/wiki/Q5038315","display_name":"Cardiac amyloidosis","level":3,"score":0.8429999947547913},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.6412000060081482},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5468000173568726},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5149999856948853},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4839000105857849},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4189000129699707},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.40459999442100525},{"id":"https://openalex.org/C2776127602","wikidata":"https://www.wikidata.org/wiki/Q5038319","display_name":"Cardiac imaging","level":2,"score":0.392300009727478},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.3248000144958496},{"id":"https://openalex.org/C2781414266","wikidata":"https://www.wikidata.org/wiki/Q531019","display_name":"Aortic valve stenosis","level":3,"score":0.30250000953674316},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.2825999855995178},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.257099986076355}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jaccas.2026.110353","doi":"https://doi.org/10.1016/j.jaccas.2026.110353","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaccas.2026.110353","pdf_url":null,"source":{"id":"https://openalex.org/S4210180918","display_name":"JACC Case Reports","issn_l":"2666-0849","issn":["2666-0849"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Case Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13699046","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13699046/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13699046/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC Case Rep","raw_type":"Text"},{"id":"pmid:42910800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42910800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC. Case reports","raw_type":"Case Reports"},{"id":"pmh:oai:doaj.org/article:2f4ce0568ad54bd0a53cb1187cf8f2fd","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2f4ce0568ad54bd0a53cb1187cf8f2fd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JACC: Case Reports, Vol 31, Iss 42, Pp 110353- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jaccas.2026.110353","doi":"https://doi.org/10.1016/j.jaccas.2026.110353","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaccas.2026.110353","pdf_url":null,"source":{"id":"https://openalex.org/S4210180918","display_name":"JACC Case Reports","issn_l":"2666-0849","issn":["2666-0849"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223118359.pdf","grobid_xml":"https://content.openalex.org/works/W7223118359.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2740843109","https://openalex.org/W2769228423","https://openalex.org/W2911906141","https://openalex.org/W3103154679","https://openalex.org/W4317761849"],"related_works":["https://openalex.org/W2598140412","https://openalex.org/W4388811580","https://openalex.org/W4387581319","https://openalex.org/W3000488684","https://openalex.org/W4377030884","https://openalex.org/W2998019257","https://openalex.org/W4225836668","https://openalex.org/W1967297920","https://openalex.org/W2462004802","https://openalex.org/W3101522292"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cardiac":[1,60],"amyloidosis":[2,133,158],"is":[3],"increasingly":[4],"recognized":[5],"in":[6,167],"older":[7],"patients":[8],"with":[9,32,71,102,117],"severe":[10,45,127],"aortic":[11,47,99,128,152],"stenosis,":[12,48],"yet":[13],"advanced":[14,118],"pressure-overload":[15,119],"remodeling":[16,120],"can":[17,130,164],"produce":[18],"overlapping":[19],"imaging":[20,63,79,136],"features":[21],"that":[22],"confound":[23],"noninvasive":[24,91,143],"diagnosis.":[25],"CASE":[26],"SUMMARY:":[27],"A":[28],"70-year-old":[29],"woman":[30],"presented":[31],"progressive":[33],"exertional":[34],"dyspnea":[35],"and":[36,54,68,75,110],"markedly":[37],"elevated":[38,65],"cardiac":[39,76,89,132,157],"biomarkers.":[40],"Transthoracic":[41],"echocardiography":[42],"revealed":[43],"extremely":[44],"calcific":[46],"increased":[49],"left":[50],"ventricular":[51],"wall":[52],"thickness,":[53],"severely":[55],"reduced":[56],"global":[57],"longitudinal":[58],"strain.":[59],"magnetic":[61],"resonance":[62],"demonstrated":[64,107],"native":[66],"T1":[67],"extracellular":[69],"volume":[70],"late":[72],"gadolinium":[73],"enhancement,":[74],"amyloid":[77,114],"radionuclide":[78],"showed":[80],"Perugini":[81],"grade":[82],"1":[83],"uptake.":[84],"Despite":[85],"clinical":[86],"suspicion":[87],"of":[88],"amyloidosis,":[90],"findings":[92,144],"remained":[93],"inconclusive.":[94,148],"The":[95],"patient":[96],"underwent":[97],"surgical":[98],"valve":[100],"replacement":[101],"intraoperative":[103],"myocardial":[104],"biopsy,":[105],"which":[106],"cardiomyocyte":[108],"hypertrophy":[109],"interstitial":[111],"fibrosis":[112],"without":[113],"deposition,":[115],"consistent":[116],"rather":[121],"than":[122],"infiltrative":[123],"disease.":[124],"DISCUSSION:":[125],"Extremely":[126],"stenosis":[129,153],"mimic":[131,156],"across":[134],"multiple":[135],"modalities.":[137],"Histologic":[138],"confirmation":[139,163],"remains":[140],"essential":[141],"when":[142],"are":[145],"discordant":[146],"or":[147],"TAKE-HOME":[149],"MESSAGES:":[150],"Severe":[151],"may":[154],"closely":[155],"on":[159],"multimodality":[160],"imaging.":[161],"Histological":[162],"be":[165],"decisive":[166],"resolving":[168],"diagnostic":[169],"uncertainty.":[170]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}