{"id":"https://openalex.org/W7223116166","doi":"https://doi.org/10.1016/j.htct.2026.107774","title":"LINFOMA DE C\u00c9LULAS DO MANTO CL\u00c1SSICO COM APRESENTA\u00c7\u00c3O INICIAL MIMETIZANDO DOEN\u00c7A RELACIONADA A IGG4: UM RELATO DE CASO","display_name":"LINFOMA DE C\u00c9LULAS DO MANTO CL\u00c1SSICO COM APRESENTA\u00c7\u00c3O INICIAL MIMETIZANDO DOEN\u00c7A RELACIONADA A IGG4: UM RELATO DE CASO","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223116166","doi":"https://doi.org/10.1016/j.htct.2026.107774"},"language":"en","primary_location":{"id":"doi:10.1016/j.htct.2026.107774","doi":"https://doi.org/10.1016/j.htct.2026.107774","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107774","pdf_url":"https://www.sciencedirect.com/science/article/pii/S253113792601521X/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciencedirect.com/science/article/pii/S253113792601521X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159164537","display_name":"Ana Virg\u00ednia Lopes DE SOUZA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Beatriz Ara\u00fajo SOUZA","raw_affiliation_strings":["Universidade de S\u00e3o Paulo (USP-SP), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo (USP-SP), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159205727","display_name":"Andr\u00e9 Gois ARRUDA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Gois ARRUDA","raw_affiliation_strings":["Universidade de S\u00e3o Paulo (USP-SP), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo (USP-SP), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014249925","display_name":"ARTHUR FRANCO COTIA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Arthur Franco COTIA","raw_affiliation_strings":["Universidade de S\u00e3o Paulo (USP-SP), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo (USP-SP), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070867182","display_name":"Gabriel Melo Ferraz Pessoa","orcid":"https://orcid.org/0000-0002-1825-1479","observed_orcids":["https://orcid.org/0000-0002-1825-1479"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gabriel Melo Ferraz PESSOA","raw_affiliation_strings":["Universidade de S\u00e3o Paulo (USP-SP), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo (USP-SP), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159168653","display_name":"Maria Eduarda Lisboa MARQUES","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Eduarda Lisboa MARQUES","raw_affiliation_strings":["Universidade de S\u00e3o Paulo (USP-SP), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de S\u00e3o Paulo (USP-SP), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84299172,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":null,"first_page":"107774","last_page":"107774"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11576","display_name":"IgG4-Related and Inflammatory Diseases","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igg4-related-disease","display_name":"IgG4-related disease","score":0.9089999794960022},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.6940000057220459},{"id":"https://openalex.org/keywords/orbital-involvement","display_name":"orbital involvement","score":0.5659999847412109},{"id":"https://openalex.org/keywords/salivary-gland-enlargement","display_name":"salivary gland enlargement","score":0.8230000138282776},{"id":"https://openalex.org/keywords/submandibular-gland","display_name":"submandibular gland","score":0.7009999752044678},{"id":"https://openalex.org/keywords/proptosis","display_name":"proptosis","score":0.6499999761581421},{"id":"https://openalex.org/keywords/extranodal-lymphoma","display_name":"extranodal lymphoma","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.871999979019165},{"id":"https://openalex.org/keywords/polyclonal-hypergammaglobulinemia","display_name":"polyclonal hypergammaglobulinemia","score":0.8529999852180481},{"id":"https://openalex.org/keywords/lymphadenopathy","display_name":"lymphadenopathy","score":0.4869999885559082},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9531000256538391},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.4047999978065491},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.2037000060081482},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.1551000028848648},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.12030000239610672},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.10949999839067459},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.09560000151395798},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.09160000085830688},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.08510000258684158},{"id":"https://openalex.org/C2780714494","wikidata":"https://www.wikidata.org/wiki/Q148925","display_name":"Thais","level":2,"score":0.08380000293254852}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.htct.2026.107774","doi":"https://doi.org/10.1016/j.htct.2026.107774","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107774","pdf_url":"https://www.sciencedirect.com/science/article/pii/S253113792601521X/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:9be01369db554095b45d07cc8674ac18","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9be01369db554095b45d07cc8674ac18","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 48, Iss , Pp 107774- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.htct.2026.107774","doi":"https://doi.org/10.1016/j.htct.2026.107774","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107774","pdf_url":"https://www.sciencedirect.com/science/article/pii/S253113792601521X/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223116166.pdf","grobid_xml":"https://content.openalex.org/works/W7223116166.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403568965","https://openalex.org/W7202033233","https://openalex.org/W2107398067","https://openalex.org/W4415669254","https://openalex.org/W4403569110","https://openalex.org/W2064161641","https://openalex.org/W2258225204","https://openalex.org/W4206744343","https://openalex.org/W3206340850","https://openalex.org/W4403554918"],"abstract_inverted_index":{"Introdu\u00e7\u00e3o":[0],"O":[1,28,301],"linfoma":[2],"de":[3,19,40,62,73,82,91,96,101,103,109,127,168,174,202,224,232,258,299,328,334,349,387,394],"c\u00e9lulas":[4],"do":[5,351],"manto":[6],"(LCM)":[7],"representa":[8,367],"5-7%":[9],"dos":[10,35,311,356],"linfomas":[11,364],"n\u00e3o":[12],"Hodgkin,":[13],"caracterizando-se":[14],"pela":[15],"t(11;14)(q13;q32),":[16],"com":[17,59,76,89,119,143,192,200,255,313,332,358,378],"superexpress\u00e3o":[18],"ciclina":[20,237],"D1":[21],"e":[22,39,45,65,68,94,113,130,134,137,147,155,166,171,178,189,195,204,221,227,242,250,261,266,289,295,317,337,365,397,402],"apresenta\u00e7\u00e3o":[23,77,253],"frequentemente":[24],"em":[25,32,286,309,354,384],"est\u00e1gio":[26],"avan\u00e7ado.":[27],"acometimento":[29,302,333],"extranodal":[30],"ocorre":[31],"at\u00e9":[33],"75%":[34],"casos.":[36],"Envolvimento":[37],"orbital":[38,303],"gl\u00e2ndulas":[41,63,97,128,169,214,259],"salivares":[42],"\u00e9":[43,306,382],"raro":[44],"pode":[46],"simular":[47],"condi\u00e7\u00f5es":[48],"inflamat\u00f3rias,":[49],"como":[50],"doen\u00e7a":[51,320,398],"relacionada":[52],"\u00e0":[53,319],"IgG4":[54],"(DR-IgG4),":[55],"que":[56],"classicamente":[57],"cursa":[58],"aumento":[60,92,126,164,256,388],"bilateral":[61,136,165,257],"lacrimais":[64,170,260],"salivares,":[66,172,215,262],"linfadenopatia":[67,132],"hipergamaglobulinemia":[69,156,264],"policlonal.":[70],"Relatamos":[71],"caso":[72,83,326],"LCM":[74,233,305,329],"cl\u00e1ssico":[75,273],"inicial":[78],"mimetizando":[79,330],"DR-IgG4.":[80],"Relato":[81],"Homem,":[84],"53":[85],"anos,":[86],"previamente":[87],"h\u00edgido,":[88],"hist\u00f3ria":[90],"progressivo":[93],"indolor":[95],"submandibulares":[98,129],"bilateralmente,":[99],"seguido":[100],"surgimento":[102],"massa":[104],"retrorbit\u00e1ria":[105],"bilateral,":[106,125,185,390],"perda":[107],"ponderal":[108],"10":[110],"kg,":[111],"febre":[112],"sudorese":[114],"noturna.":[115],"Apresentou":[116],"melhora":[117],"parcial":[118],"corticoide.":[120],"Ao":[121],"exame,":[122],"havia":[123],"proptose":[124,182],"sublinguais,":[131],"cervical":[133],"axilar":[135],"esplenomegalia.":[138],"Hemograma":[139],"sem":[140,158],"citopenias":[141],"significativas,":[142],"linfocitose":[144],"relativa;":[145],"DHL":[146],"fun\u00e7\u00e3o":[148],"renal":[149],"normais;":[150],"beta-2":[151],"microglobulina":[152],"discretamente":[153],"elevada":[154],"policlonal,":[157],"pico":[159],"monoclonal.":[160],"Tomografia":[161],"computadorizada":[162],"revelou":[163],"sim\u00e9trico":[167],"espessamento":[173,201],"musculatura":[175],"ocular":[176],"extr\u00ednseca":[177],"nervo":[179,216,343],"\u00f3ptico":[180,217,344],"direito,":[181,218],"grau":[183],"III":[184],"linfonodomegalias":[186,219,284],"disseminadas":[187,220,285],"supra":[188],"infradiafragm\u00e1ticas,":[190],"hepatoesplenomegalia":[191],"n\u00f3dulos":[193],"espl\u00eanicos":[194],"tecido":[196],"s\u00f3lido":[197],"perivascular":[198],"mesent\u00e9rico,":[199],"ceco":[203],"\u00edleo":[205],"terminal.":[206],"PET-CT":[207,346],"confirmou":[208],"hipermetabolismo":[209],"intenso":[210],"nas":[211],"les\u00f5es":[212],"periorbit\u00e1rias,":[213],"ba\u00e7o.":[222],"Bi\u00f3psias":[223],"gl\u00e2ndula":[225,335],"submandibular":[226],"linfonodo":[228],"supraclavicular":[229],"revelaram":[230],"diagn\u00f3stico":[231,370,401],"cl\u00e1ssico:":[234],"CD20+,":[235],"CD5+,":[236],"D1+,":[238],"BCL2+,":[239],"CD10\u2212,":[240],"BCL6\u2212":[241],"Ki-67":[243],"50%.":[244],"Estadiamento":[245],"Ann":[246],"Arbor":[247],"IV.":[248],"Discuss\u00e3o":[249],"conclus\u00e3o":[251],"A":[252,339,360,375],"cl\u00ednica":[254],"proptose,":[263],"policlonal":[265],"resposta":[267],"a":[268],"corticoide":[269],"mimetiza":[270],"o":[271],"fen\u00f3tipo":[272],"da":[274],"DR-IgG4,":[275],"constituindo":[276],"armadilha":[277],"diagn\u00f3stica":[278],"relevante.":[279],"No":[280],"entanto,":[281],"sintomas":[282,395],"B,":[283],"m\u00faltiplas":[287],"cadeias":[288],"esplenomegalia":[290],"s\u00e3o":[291],"at\u00edpicos":[292],"para":[293],"DR-IgG4":[294,331,366],"devem":[296],"levantar":[297],"suspeita":[298,348],"linfoma.":[300],"pelo":[304],"raro,":[307],"descrito":[308],"2\u20137%":[310],"casos,":[312],"predile\u00e7\u00e3o":[314],"por":[315],"homens":[316],"associa\u00e7\u00e3o":[318],"avan\u00e7ada.":[321],"Hayashi":[322],"et":[323],"al.":[324],"descreveram":[325],"semelhante":[327],"lacrimal":[336],"salivar.":[338],"capta\u00e7\u00e3o":[340],"focal":[341],"no":[342],"ao":[345],"levanta":[347],"infiltra\u00e7\u00e3o":[350],"SNC,":[352],"descrita":[353],"4\u201322%":[355],"pacientes":[357],"LCM.":[359],"sobreposi\u00e7\u00e3o":[361],"cl\u00ednico-radiol\u00f3gica":[362],"entre":[363],"um":[368],"desafio":[369],"crescentemente":[371],"reconhecido":[372],"na":[373],"literatura.":[374],"investiga\u00e7\u00e3o":[376],"histopatol\u00f3gica":[377],"painel":[379],"imuno-histoqu\u00edmico":[380],"abrangente":[381],"mandat\u00f3ria":[383],"apresenta\u00e7\u00f5es":[385],"at\u00edpicas":[386],"glandular":[389],"particularmente":[391],"quando":[392],"acompanhadas":[393],"constitucionais":[396],"disseminada,":[399],"permitindo":[400],"tratamento":[403],"oportunos.":[404]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}