{"id":"https://openalex.org/W7223115665","doi":"https://doi.org/10.1016/j.htct.2026.107637","title":"MANEJO MULTIMODAL DA LEUCOSTASE EM LEUCEMIA LINFOBL\u00c1STICA AGUDA DE C\u00c9LULAS T: UM RELATO DE CASO","display_name":"MANEJO MULTIMODAL DA LEUCOSTASE EM LEUCEMIA LINFOBL\u00c1STICA AGUDA DE C\u00c9LULAS T: UM RELATO DE CASO","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223115665","doi":"https://doi.org/10.1016/j.htct.2026.107637"},"language":"en","primary_location":{"id":"doi:10.1016/j.htct.2026.107637","doi":"https://doi.org/10.1016/j.htct.2026.107637","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107637","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1016/j.htct.2026.107637","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078011748","display_name":"Thomas Azevedo do Carmo","orcid":"https://orcid.org/0000-0001-8458-9315","observed_orcids":["https://orcid.org/0000-0001-8458-9315"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Thomas Azevedo CARMO","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159174530","display_name":"Luize Meloti FIORIO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luize Meloti FIORIO","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159206435","display_name":"Jorge Lima FILHO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jorge Lima FILHO","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159184764","display_name":"Isaac Batista COSTA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Isaac Batista COSTA","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159183339","display_name":"Ca\u00edque Lucas Nogueira GOMES","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ca\u00edque Lucas Nogueira GOMES","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073889154","display_name":"Vitor Lima da Costa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vitor Lima COSTA","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159168240","display_name":"Laura Faria de Moraes OLIVATTO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Laura Faria Moraes OLIVATTO","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159161585","display_name":"Lucas Arraes ARAG\u00c3O","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lucas Arraes ARAG\u00c3O","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051260187","display_name":"Fabio Rodrigues Kerbauy","orcid":"https://orcid.org/0000-0002-2819-2783","observed_orcids":["https://orcid.org/0000-0002-2819-2783"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"F\u00e1bio Rodrigues KERBAUY","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108615967","display_name":"Karin Zattar Cecyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Karin Zattar CECYN","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I88273585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I88273585"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.78734114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":null,"first_page":"107637","last_page":"107637"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12845","display_name":"Methemoglobinemia and Tumor Lysis Syndrome","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leukostasis","display_name":"leukostasis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/t-cell-acute-lymphoblastic-leukemia","display_name":"T-cell acute lymphoblastic leukemia","score":0.8679999709129333},{"id":"https://openalex.org/keywords/leukapheresis","display_name":"leukapheresis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/leukocyte-reduction","display_name":"leukocyte reduction","score":0.4390000104904175},{"id":"https://openalex.org/keywords/leukocytosis","display_name":"leukocytosis","score":0.6060000061988831},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.7979999780654907},{"id":"https://openalex.org/keywords/disseminated-intravascular-coagulation","display_name":"disseminated intravascular coagulation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/deep-vein-thrombosis","display_name":"deep vein thrombosis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cytoreduction","display_name":"cytoreduction","score":0.5590000152587891},{"id":"https://openalex.org/keywords/immunophenotyping","display_name":"immunophenotyping","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9757999777793884},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.2847000062465668},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.2766999900341034},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.21080000698566437},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2061000019311905},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.17569999396800995},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.15639999508857727},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.14820000529289246},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.13860000669956207},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.13779999315738678}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.htct.2026.107637","doi":"https://doi.org/10.1016/j.htct.2026.107637","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107637","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:58ea5245f17244b7b7a2357654c58479","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/58ea5245f17244b7b7a2357654c58479","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 48, Iss , Pp 107637- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.htct.2026.107637","doi":"https://doi.org/10.1016/j.htct.2026.107637","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107637","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403554269","https://openalex.org/W3136435239","https://openalex.org/W4415669127","https://openalex.org/W4403568695","https://openalex.org/W7223149659","https://openalex.org/W1966951559","https://openalex.org/W3210808320","https://openalex.org/W4391647038","https://openalex.org/W4403569001","https://openalex.org/W4304150512"],"abstract_inverted_index":{"Paciente":[0],"feminina,":[1],"28":[2],"anos,":[3],"previamente":[4],"h\u00edgida,":[5],"admitida":[6],"devido":[7],"quadro":[8,170],"de":[9,50,67,75,80,85,89,113,120,130,134,142,149,154,171,186,213,241],"dor":[10],"abdominal":[11],"difusa,":[12],"sudorese":[13],"noturna,":[14],"equimoses":[15],"espont\u00e2neas":[16],"em":[17,98,224,246],"tronco":[18],"e":[19,22,57,73,91,94,124,137,165,230],"membros":[20,135],"inferiores":[21],"sangramento":[23],"uterino":[24],"anormal":[25],"com":[26,48,176,227],"in\u00edcio":[27,209],"h\u00e1":[28],"uma":[29,174,242],"semana.":[30],"Ao":[31],"exame":[32],"f\u00edsico,":[33],"apresentava":[34],"esplenomegalia":[35,90],"maci\u00e7a":[36],"(12":[37],"cm":[38],"do":[39,126,169,200],"rebordo":[40],"costal).":[41],"O":[42],"hemograma":[43],"inicial":[44,235],"evidenciou":[45],"hiperleucocitose":[46,184],"(623.020/\u03bcL,":[47],"predom\u00ednio":[49],"blastos,":[51],"90%),":[52],"anemia":[53],"(Hb":[54],"7,9":[55],"g/dL)":[56],"plaquetopenia":[58],"(70.000/\u03bcL).":[59],"A":[60,107,140,221,233],"avalia\u00e7\u00e3o":[61],"oftalmol\u00f3gica":[62],"por":[63,78,118],"fundoscopia":[64],"revelou":[65,109],"sinais":[66,84],"hiperviscosidade":[68,105],"(tortuosidade":[69],"vascular,":[70],"hemorragias":[71],"retinianas":[72],"manchas":[74],"Roth),":[76],"corroborados":[77],"exames":[79],"imagem":[81],"que":[82],"evidenciaram":[83],"leucostase":[86],"pulmonar,":[87],"al\u00e9m":[88,129],"linfonodomegalias":[92],"abdominais":[93],"mediastinais,":[95],"achados":[96,111],"que,":[97],"conjunto,":[99],"ilustram":[100],"o":[101,250],"car\u00e1ter":[102],"sist\u00eamico":[103],"da":[104,183,211,252],"leucocit\u00e1ria.":[106],"investiga\u00e7\u00e3o":[108],"ainda":[110],"sugestivos":[112],"coagula\u00e7\u00e3o":[114],"intravascular":[115],"disseminada,":[116],"marcados":[117],"consumo":[119],"fibrinog\u00eanio":[121],"(108":[122],"mg/dL)":[123],"altera\u00e7\u00e3o":[125],"INR":[127],"(1,99),":[128],"trombose":[131],"venosa":[132],"profunda":[133],"superior":[136],"inferior":[138],"direitos.":[139],"imunofenotipagem":[141],"medula":[143],"\u00f3ssea":[144],"confirmou":[145],"leucemia":[146],"linfobl\u00e1stica":[147],"aguda":[148],"c\u00e9lulas":[150],"T":[151],"cortical":[152],"(48,7%":[153],"blastos":[155],"expressando":[156],"CD7,":[157],"CD2,":[158],"CD5,":[159],"CD1a,":[160],"CD3":[161],"citoplasm\u00e1tico,":[162],"CD45,":[163],"CD34":[164],"TdT":[166],"nuclear).":[167],"Diante":[168],"leucostase,":[172],"iniciou-se":[173],"pr\u00e9-fase":[175],"corticoterapia":[177],"visando":[178],"citorredu\u00e7\u00e3o,":[179],"por\u00e9m":[180],"houve":[181],"persist\u00eancia":[182],"(pico":[185],"671.520/\u03bcL),":[187],"sendo":[188],"a":[189,192,239],"paciente":[190,222],"submetida":[191],"leucocitaf\u00e9rese":[193],"emergencial":[194],"(produto":[195],"afer\u00e9tico:":[196],"1.506.500/\u03bcL":[197],"leuc\u00f3citos).":[198],"Apesar":[199],"procedimento,":[201],"manteve":[202],"leucometria":[203],"global":[204],">":[205],"400.000/\u03bcL,":[206],"optando-se":[207],"pelo":[208],"imediato":[210],"quimioterapia":[212],"indu\u00e7\u00e3o":[214,253],"(protocolo":[215],"COG-AALL0434)":[216],"frente":[217],"\u00e0":[218,236],"refratariedade":[219,234],"inicial.":[220],"segue":[223],"tratamento":[225],"quimioter\u00e1pico,":[226],"melhora":[228],"cl\u00ednica":[229],"laboratorial":[231],"progressiva.":[232],"citorredu\u00e7\u00e3o":[237],"destacou":[238],"necessidade":[240],"interven\u00e7\u00e3o":[243],"multimodal":[244],"agressiva":[245],"casos":[247],"selecionados,":[248],"refor\u00e7ando":[249],"papel":[251],"quimioter\u00e1pica":[254],"precoce":[255],"como":[256],"pilar":[257],"fundamental":[258],"no":[259],"manejo":[260],"desta":[261],"urg\u00eancia":[262],"oncohematol\u00f3gica.":[263]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}
