{"id":"https://openalex.org/W7223106592","doi":"https://doi.org/10.1002/joa3.70500","title":"Conduction System Pacing Versus Biventricular Pacing for Cardiac Resynchronization Therapy: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials","display_name":"Conduction System Pacing Versus Biventricular Pacing for Cardiac Resynchronization Therapy: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223106592","doi":"https://doi.org/10.1002/joa3.70500","pmid":"https://pubmed.ncbi.nlm.nih.gov/42909950","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13685677"},"language":"en","primary_location":{"id":"doi:10.1002/joa3.70500","doi":"https://doi.org/10.1002/joa3.70500","is_oa":true,"landing_page_url":"https://doi.org/10.1002/joa3.70500","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/joa3.70500","source":{"id":"https://openalex.org/S207372207","display_name":"Journal of Arrhythmia","issn_l":"1880-4276","issn":["1880-4276","1883-2148"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Arrhythmia","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/joa3.70500","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023587680","display_name":"Shreyas Singireddy","orcid":"https://orcid.org/0000-0002-9635-7658","observed_orcids":["https://orcid.org/0000-0002-9635-7658"]},"institutions":[{"id":"https://openalex.org/I4210130227","display_name":"Peoria campus of the University of Illinois System","ror":"https://ror.org/02qrdc062","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210130227"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shreyas Singireddy","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine University of Illinois College of Medicine at Peoria  Peoria Illinois USA"],"raw_orcid":"https://orcid.org/0000-0002-9635-7658","affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine University of Illinois College of Medicine at Peoria  Peoria Illinois USA","institution_ids":["https://openalex.org/I4210130227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008331523","display_name":"Sami J. Shoura","orcid":"https://orcid.org/0000-0001-5015-0814","observed_orcids":["https://orcid.org/0000-0001-5015-0814"]},"institutions":[{"id":"https://openalex.org/I4210130227","display_name":"Peoria campus of the University of Illinois System","ror":"https://ror.org/02qrdc062","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210130227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sami Shoura","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine University of Illinois College of Medicine at Peoria  Peoria Illinois USA"],"raw_orcid":"https://orcid.org/0000-0001-5015-0814","affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine University of Illinois College of Medicine at Peoria  Peoria Illinois USA","institution_ids":["https://openalex.org/I4210130227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002412771","display_name":"Darshine Venugopal","orcid":"https://orcid.org/0009-0003-6134-0586","observed_orcids":["https://orcid.org/0009-0003-6134-0586"]},"institutions":[{"id":"https://openalex.org/I4210130227","display_name":"Peoria campus of the University of Illinois System","ror":"https://ror.org/02qrdc062","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210130227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darshine Venugopal","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine University of Illinois College of Medicine at Peoria  Peoria Illinois USA"],"raw_orcid":"https://orcid.org/0009-0003-6134-0586","affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine University of Illinois College of Medicine at Peoria  Peoria Illinois USA","institution_ids":["https://openalex.org/I4210130227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093062427","display_name":"Ragavendar Saravanabavanandan","orcid":"https://orcid.org/0009-0006-7078-6960","observed_orcids":["https://orcid.org/0009-0006-7078-6960"]},"institutions":[{"id":"https://openalex.org/I4210130227","display_name":"Peoria campus of the University of Illinois System","ror":"https://ror.org/02qrdc062","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210130227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ragavendar Saravanabavanandan","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine University of Illinois College of Medicine at Peoria  Peoria Illinois USA"],"raw_orcid":"https://orcid.org/0009-0006-7078-6960","affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine University of Illinois College of Medicine at Peoria  Peoria Illinois USA","institution_ids":["https://openalex.org/I4210130227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056755299","display_name":"Kyle Coombes","orcid":"https://orcid.org/0000-0002-5121-4346","observed_orcids":["https://orcid.org/0000-0002-5121-4346"]},"institutions":[{"id":"https://openalex.org/I4210130227","display_name":"Peoria campus of the University of Illinois System","ror":"https://ror.org/02qrdc062","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210130227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle Coombes","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine University of Illinois College of Medicine at Peoria  Peoria Illinois USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine University of Illinois College of Medicine at Peoria  Peoria Illinois USA","institution_ids":["https://openalex.org/I4210130227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037906491","display_name":"Timir S. Baman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130227","display_name":"Peoria campus of the University of Illinois System","ror":"https://ror.org/02qrdc062","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210130227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timir Baman","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine University of Illinois College of Medicine at Peoria  Peoria Illinois USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine University of Illinois College of Medicine at Peoria  Peoria Illinois USA","institution_ids":["https://openalex.org/I4210130227"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100685099","display_name":"Siddharth Shah","orcid":"https://orcid.org/0000-0001-8702-3026","observed_orcids":["https://orcid.org/0000-0001-8702-3026"]},"institutions":[{"id":"https://openalex.org/I4210130227","display_name":"Peoria campus of the University of Illinois System","ror":"https://ror.org/02qrdc062","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210130227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siddharth Shah","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine University of Illinois College of Medicine at Peoria  Peoria Illinois USA"],"raw_orcid":"https://orcid.org/0000-0001-8702-3026","affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine University of Illinois College of Medicine at Peoria  Peoria Illinois USA","institution_ids":["https://openalex.org/I4210130227"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023587680"],"corresponding_institution_ids":["https://openalex.org/I4210130227"],"apc_list":{"value":1540,"currency":"USD","value_usd":1540},"apc_paid":{"value":1540,"currency":"USD","value_usd":1540},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60935829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"5","first_page":"e70500","last_page":"e70500"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/conduction-system-pacing","display_name":"conduction system pacing","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cardiac-resynchronization-therapy","display_name":"cardiac resynchronization therapy","score":1.0},{"id":"https://openalex.org/keywords/left-bundle-branch-block","display_name":"left bundle branch block","score":0.9390000104904175},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.9890000224113464},{"id":"https://openalex.org/keywords/nyha-functional-class","display_name":"NYHA functional class","score":0.7990000247955322},{"id":"https://openalex.org/keywords/heart-failure-hospitalization","display_name":"heart failure hospitalization","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pacing-complications","display_name":"pacing complications","score":0.43799999356269836},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9409999847412109},{"id":"https://openalex.org/C2776034619","wikidata":"https://www.wikidata.org/wiki/Q3428020","display_name":"Cardiac resynchronization therapy","level":4,"score":0.7928000092506409},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.7401999831199646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7081999778747559},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6700999736785889},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5864999890327454},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.5552999973297119},{"id":"https://openalex.org/C111773187","wikidata":"https://www.wikidata.org/wiki/Q1969239","display_name":"QRS complex","level":2,"score":0.5462999939918518},{"id":"https://openalex.org/C2992910135","wikidata":"https://www.wikidata.org/wiki/Q372713","display_name":"Cardiac pacing","level":2,"score":0.4011000096797943},{"id":"https://openalex.org/C3020135794","wikidata":"https://www.wikidata.org/wiki/Q372713","display_name":"Ventricular pacing","level":3,"score":0.3781999945640564},{"id":"https://openalex.org/C3018260909","wikidata":"https://www.wikidata.org/wiki/Q1322871","display_name":"Exploratory analysis","level":2,"score":0.3312999904155731},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.33090001344680786},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.26249998807907104},{"id":"https://openalex.org/C104397207","wikidata":"https://www.wikidata.org/wiki/Q72711","display_name":"Electrical conduction system of the heart","level":3,"score":0.26019999384880066},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.2554999887943268},{"id":"https://openalex.org/C2780069185","wikidata":"https://www.wikidata.org/wiki/Q7977945","display_name":"Equivalence (formal languages)","level":2,"score":0.2517000138759613}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/joa3.70500","doi":"https://doi.org/10.1002/joa3.70500","is_oa":true,"landing_page_url":"https://doi.org/10.1002/joa3.70500","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/joa3.70500","source":{"id":"https://openalex.org/S207372207","display_name":"Journal of Arrhythmia","issn_l":"1880-4276","issn":["1880-4276","1883-2148"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Arrhythmia","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13685677","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13685677/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13685677/pdf/JOA3-42-e70500.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Arrhythm","raw_type":"Text"},{"id":"pmid:42909950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42909950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of arrhythmia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/joa3.70500","doi":"https://doi.org/10.1002/joa3.70500","is_oa":true,"landing_page_url":"https://doi.org/10.1002/joa3.70500","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/joa3.70500","source":{"id":"https://openalex.org/S207372207","display_name":"Journal of Arrhythmia","issn_l":"1880-4276","issn":["1880-4276","1883-2148"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Arrhythmia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223106592.pdf","grobid_xml":"https://content.openalex.org/works/W7223106592.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W2100224535","https://openalex.org/W2464924628","https://openalex.org/W4220837239","https://openalex.org/W4296301564","https://openalex.org/W7154173899","https://openalex.org/W7160543610"],"related_works":["https://openalex.org/W7214771582","https://openalex.org/W7163706025","https://openalex.org/W7202375702","https://openalex.org/W4380877542","https://openalex.org/W7202404581","https://openalex.org/W7127577636","https://openalex.org/W4402933094","https://openalex.org/W7167342902","https://openalex.org/W7221012051","https://openalex.org/W4225092865"],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"Conduction":[2],"system":[3],"pacing":[4,12],"(CSP)":[5],"is":[6],"an":[7],"emerging":[8],"alternative":[9],"to":[10,104,168,189],"biventricular":[11],"(BVP)":[13],"for":[14,48,217],"cardiac":[15],"resynchronization":[16],"therapy":[17],"(CRT).":[18],"Recent":[19],"randomized":[20,203],"controlled":[21],"trials":[22,156,204],"(RCTs)":[23],"have":[24],"yielded":[25],"divergent":[26],"results,":[27],"creating":[28],"uncertainty":[29],"about":[30],"the":[31,179,227],"comparative":[32],"effectiveness.":[33],"Methods":[34],"We":[35],"performed":[36],"a":[37,59,115],"systematic":[38],"review":[39],"and":[40,53,77,128,148,215,226],"meta\u2010analysis":[41],"of":[42,202,205],"RCTs":[43,83],"comparing":[44],"CSP":[45,113,162,214],"with":[46,74,249],"BVP":[47,216],"CRT,":[49,206],"searching":[50],"PubMed,":[51],"Embase,":[52],"CENTRAL":[54],"through":[55],"May":[56],"2026":[57],"(updating":[58],"prior":[60],"review).":[61],"The":[62,154],"primary":[63],"outcome":[64],"was":[65,211,224],"change":[66],"in":[67,178,259],"left":[68],"ventricular":[69],"ejection":[70],"fraction":[71],"(\u0394LVEF),":[72],"analyzed":[73],"random\u2010effects":[75],"models":[76],"prediction":[78],"intervals.":[79],"Results":[80],"Eight":[81],"parallel\u2010group":[82],"including":[84],"799":[85],"patients":[86,160,248],"(396":[87],"CSP,":[88],"403":[89],"BVP)":[90],"were":[91,230],"included.":[92],"Pooled":[93],"\u0394LVEF":[94],"did":[95,151],"not":[96,152,235],"differ":[97],"significantly":[98],"(MD":[99,122,163,184],"+2.40%,":[100],"95%":[101,165,186],"CI":[102,166,187],"\u22120.49":[103],"5.29,":[105],"p":[106,125,134,170,191],"=":[107,111,126,135,171,175,192,196],"0.091;":[108],"I":[109,173,194],"2":[110,174,195],"75%).":[112],"showed":[114],"non\u2010significant":[116],"trend":[117],"toward":[118],"shorter":[119],"paced":[120],"QRS":[121],"\u22127.6":[123],"ms,":[124],"0.14)":[127],"improved":[129],"NYHA":[130],"class":[131],"(SMD":[132],"\u22120.33,":[133],"0.12).":[136],"Heart":[137],"failure":[138],"hospitalization":[139],"(RR":[140,143,146],"0.69),":[141],"mortality":[142],"1.17),":[144],"complications":[145],"0.84),":[147],"procedure":[149],"time":[150],"differ.":[153],"four":[155],"enrolling":[157],"exclusively":[158],"LBBB":[159,250],"favored":[161],"+5.00%,":[164],"3.01":[167],"6.98,":[169],"0.004;":[172],"0%),":[176],"consistent":[177],"three":[180],"using":[181],"confirmed":[182],"LBBAP/LBBP":[183,252],"+5.37%,":[185],"3.23":[188],"7.52,":[190],"0.008;":[193],"0%).":[197],"Conclusions":[198],"In":[199],"this":[200],"analysis":[201],"no":[207,221],"statistically":[208],"significant":[209],"difference":[210],"observed":[212],"between":[213],"any":[218],"outcome.":[219],"Because":[220],"non\u2010inferiority":[222],"margin":[223],"prespecified":[225],"clinical\u2010event":[228],"analyses":[229,245],"underpowered,":[231],"these":[232],"findings":[233],"should":[234],"be":[236],"interpreted":[237],"as":[238],"establishing":[239],"equivalence":[240],"or":[241],"comparable":[242],"safety.":[243],"Exploratory":[244],"suggest":[246],"that":[247],"undergoing":[251],"may":[253],"derive":[254],"incremental":[255],"benefit,":[256],"warranting":[257],"confirmation":[258],"adequately":[260],"powered":[261],"trials.":[262]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-22T00:00:00"}
