{"id":"https://openalex.org/W7223104604","doi":"https://doi.org/10.1002/cns.71216","title":"Cerebral Artery Stenosis, Glymphatic Dysfunction, and Cognitive Trajectories: A Longitudinal Cohort Study of Community\u2010Dwelling Older Adults","display_name":"Cerebral Artery Stenosis, Glymphatic Dysfunction, and Cognitive Trajectories: A Longitudinal Cohort Study of Community\u2010Dwelling Older Adults","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223104604","doi":"https://doi.org/10.1002/cns.71216","pmid":"https://pubmed.ncbi.nlm.nih.gov/42904869","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13685670"},"language":"en","primary_location":{"id":"doi:10.1002/cns.71216","doi":"https://doi.org/10.1002/cns.71216","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cns.71216","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cns.71216","source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cns.71216","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022127228","display_name":"Weizhuang Yuan","orcid":"https://orcid.org/0000-0002-3152-497X","observed_orcids":["https://orcid.org/0000-0002-3152-497X"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weizhuang Yuan","raw_affiliation_strings":["Department of Neurology The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China","Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases  Guangzhou China","National Key Clinical Department and Key Discipline of Neurology  Guangzhou China"],"raw_orcid":"https://orcid.org/0000-0002-3152-497X","affiliations":[{"raw_affiliation_string":"Department of Neurology The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases  Guangzhou China","institution_ids":[]},{"raw_affiliation_string":"National Key Clinical Department and Key Discipline of Neurology  Guangzhou China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067373964","display_name":"Xingyang Niu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingyang Niu","raw_affiliation_strings":["Department of Neurology The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China","Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases  Guangzhou China","National Key Clinical Department and Key Discipline of Neurology  Guangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases  Guangzhou China","institution_ids":[]},{"raw_affiliation_string":"National Key Clinical Department and Key Discipline of Neurology  Guangzhou China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088690376","display_name":"Linfang Lan","orcid":"https://orcid.org/0000-0003-0044-8350","observed_orcids":["https://orcid.org/0000-0003-0044-8350"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linfang Lan","raw_affiliation_strings":["Department of Neurology The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China","Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases  Guangzhou China","National Key Clinical Department and Key Discipline of Neurology  Guangzhou China"],"raw_orcid":"https://orcid.org/0000-0003-0044-8350","affiliations":[{"raw_affiliation_string":"Department of Neurology The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases  Guangzhou China","institution_ids":[]},{"raw_affiliation_string":"National Key Clinical Department and Key Discipline of Neurology  Guangzhou China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5134539920","display_name":"Xinran Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinran Chen","raw_affiliation_strings":["Department of Neurology The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China","Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases  Guangzhou China","National Key Clinical Department and Key Discipline of Neurology  Guangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases  Guangzhou China","institution_ids":[]},{"raw_affiliation_string":"National Key Clinical Department and Key Discipline of Neurology  Guangzhou China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022127228"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"],"apc_list":{"value":4140,"currency":"USD","value_usd":4140},"apc_paid":{"value":4140,"currency":"USD","value_usd":4140},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.79524526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"10","first_page":"e71216","last_page":"e71216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.5889000296592712,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.5889000296592712,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.2759000062942505,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-artery-stenosis","display_name":"cerebral artery stenosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glymphatic-dysfunction","display_name":"glymphatic dysfunction","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.8820000290870667},{"id":"https://openalex.org/keywords/perivascular-spaces","display_name":"perivascular spaces","score":0.7300000190734863},{"id":"https://openalex.org/keywords/dti-alps-index","display_name":"DTI-ALPS index","score":0.7509999871253967},{"id":"https://openalex.org/keywords/clinical-dementia-rating-sum-of-boxes","display_name":"CDR-SB","score":0.5450000166893005},{"id":"https://openalex.org/keywords/dementia-progression","display_name":"dementia progression","score":0.6840000152587891},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7059999704360962},{"id":"https://openalex.org/keywords/mediation-analysis","display_name":"mediation analysis","score":0.4959999918937683},{"id":"https://openalex.org/keywords/community-dwelling","display_name":"community-dwelling","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7264999747276306},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.6553000211715698},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5967000126838684},{"id":"https://openalex.org/C101054994","wikidata":"https://www.wikidata.org/wiki/Q15474254","display_name":"Glymphatic system","level":3,"score":0.5756999850273132},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5519000291824341},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5187000036239624},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.49459999799728394},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.44200000166893005},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4262999892234802},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4117000102996826},{"id":"https://openalex.org/C2778212899","wikidata":"https://www.wikidata.org/wiki/Q907325","display_name":"Magnetic resonance angiography","level":3,"score":0.41110000014305115},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.37720000743865967},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.3711000084877014},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.33469998836517334},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.32829999923706055},{"id":"https://openalex.org/C89798072","wikidata":"https://www.wikidata.org/wiki/Q1141779","display_name":"Wechsler Adult Intelligence Scale","level":3,"score":0.31279999017715454},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2953999936580658},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.2948000133037567},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.287200003862381},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.25049999356269836},{"id":"https://openalex.org/C166047926","wikidata":"https://www.wikidata.org/wiki/Q170277","display_name":"Intelligence quotient","level":3,"score":0.2502000033855438}],"mesh":[{"descriptor_ui":"D000077502","descriptor_name":"Glymphatic System","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002539","descriptor_name":"Cerebral Arterial Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002539","descriptor_name":"Cerebral Arterial Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D002539","descriptor_name":"Cerebral Arterial Diseases","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D003251","descriptor_name":"Constriction, Pathologic","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018810","descriptor_name":"Magnetic Resonance Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057187","descriptor_name":"Independent Living","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/cns.71216","doi":"https://doi.org/10.1002/cns.71216","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cns.71216","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cns.71216","source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmid:42904869","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42904869","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS neuroscience & therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13685670","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13685670/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neurosci Ther","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/cns.71216","doi":"https://doi.org/10.1002/cns.71216","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cns.71216","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cns.71216","source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience &amp; Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G539490489","display_name":"DRIVING PERFORMANCE IN PRECLINICAL ALZHEIMER'S DISEASE","funder_award_id":"R01AG043434","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7163257988","display_name":"Healthy Aging and Senile Dementia","funder_award_id":"P01AG003991","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G725115302","display_name":"Washington University Institute of Clinical and Translational Sciences","funder_award_id":"UL1TR000448","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7831108753","display_name":null,"funder_award_id":"P30NS09857781","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000112288","display_name":null,"funder_award_id":"P50 AG00561","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000115080","display_name":null,"funder_award_id":"TR000448","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000883349","display_name":"Alzheimer's Disease Research Center","funder_award_id":"P30AG066444","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000893777","display_name":"Washington University Institute of Clinical and Translational Sciences","funder_award_id":"UL1TR002345","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000907710","display_name":"THE XNAT IMAGING INFORMATICS PLATFORM","funder_award_id":"R01EB009352","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G9000915971","display_name":"Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study","funder_award_id":"P01AG026276","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320331088","display_name":"Natural Science Foundation for Young Scientists of Shanxi Province","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333592","display_name":"Avid Radiopharmaceuticals","ror":"https://ror.org/00szax507"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223104604.pdf","grobid_xml":"https://content.openalex.org/works/W7223104604.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W2047641191","https://openalex.org/W2102391253","https://openalex.org/W2157731727","https://openalex.org/W2162258689","https://openalex.org/W2167720733","https://openalex.org/W2323822120","https://openalex.org/W2520567684","https://openalex.org/W2560269372","https://openalex.org/W2601611244","https://openalex.org/W2901611171","https://openalex.org/W2948007219","https://openalex.org/W2995808388","https://openalex.org/W3179943121","https://openalex.org/W3191053553","https://openalex.org/W3193911061","https://openalex.org/W4206219224","https://openalex.org/W4290793582","https://openalex.org/W4296343725","https://openalex.org/W4312703859","https://openalex.org/W4386510197","https://openalex.org/W4390951991","https://openalex.org/W4391123083","https://openalex.org/W4392959526","https://openalex.org/W4401224959","https://openalex.org/W4405794594","https://openalex.org/W4405952529","https://openalex.org/W4406269195","https://openalex.org/W4408899725","https://openalex.org/W4413337997","https://openalex.org/W4415554387","https://openalex.org/W7117353108"],"related_works":["https://openalex.org/W4415554387","https://openalex.org/W7134896554","https://openalex.org/W7164154415","https://openalex.org/W4382794037","https://openalex.org/W7126024909","https://openalex.org/W4406993814","https://openalex.org/W2363650700","https://openalex.org/W4283463194","https://openalex.org/W4410641508","https://openalex.org/W4404745700"],"abstract_inverted_index":{"AIMS:":[0],"We":[1],"aimed":[2],"to":[3,28,168,195],"investigate":[4],"the":[5,11,43,60,66,135,147,196],"role":[6],"of":[7,70,146,164],"glymphatic":[8,158,174,191],"dysfunction":[9,192],"in":[10,50],"association":[12,136,197],"between":[13,137,198],"stenosis":[14,32,138,155,171,182,201],"and":[15,47,65,78,87,120,131,140,156,179,202],"cognition.":[16],"METHODS:":[17],"Older":[18],"adults":[19],"from":[20],"a":[21,110,161],"longitudinal":[22,79,151],"cohort":[23],"underwent":[24],"magnetic":[25],"resonance":[26],"angiography":[27],"quantify":[29],"cerebral":[30,103,199],"artery":[31,200],"burden.":[33],"Glymphatic":[34],"function":[35,159,175],"was":[36,57,107],"evaluated":[37],"using":[38,59,84],"diffusion":[39],"tensor":[40],"imaging-analysis":[41],"along":[42],"perivascular":[44],"space":[45],"(DTI-ALPS)":[46],"free":[48],"water":[49],"white":[51],"matter":[52],"(FW-WM).":[53],"Global":[54],"cognitive":[55,80,203],"performance":[56],"assessed":[58],"Mini-Mental":[61],"State":[62],"Examination":[63],"(MMSE)":[64],"Clinical":[67],"Dementia":[68],"Rating-Sum":[69],"Boxes":[71],"(CDR-SB).":[72],"Mediation":[73],"analyses":[74],"examined":[75],"indirect":[76],"effects,":[77],"outcomes":[81],"were":[82],"analyzed":[83],"linear":[85],"mixed-effects":[86],"Cox":[88],"proportional":[89],"hazards":[90],"models.":[91],"RESULTS:":[92],"Among":[93],"346":[94],"participants,":[95],"87":[96],"(25.1%)":[97],"had":[98,160],"at":[99],"least":[100],"one":[101],"stenotic":[102],"artery.":[104],"Stenosis":[105],"burden":[106,139],"associated":[108],"with":[109,154,170],"lower":[111],"DTI-ALPS":[112,130],"index":[113],"(\u03b2":[114,123],"=":[115,118,124,127],"-0.04,":[116],"p":[117,126],"0.003)":[119],"higher":[121,162],"FW-WM":[122,132],"0.01,":[125],"0.022).":[128],"Both":[129],"significantly":[133],"mediated":[134],"baseline":[141],"MMSE,":[142],"accounting":[143],"for":[144],"13.06%-17.19%":[145],"total":[148],"effect.":[149],"In":[150],"analyses,":[152],"participants":[153],"impaired":[157],"risk":[163],"CDR-SB":[165],"worsening":[166],"relative":[167],"those":[169,180],"but":[172],"preserved":[173],"(hazard":[176,183],"ratios":[177,184],"1.35-2.96)":[178],"without":[181],"3.27-4.70).":[185],"CONCLUSION:":[186],"These":[187],"findings":[188],"suggest":[189],"that":[190],"may":[193],"contribute":[194],"deterioration.":[204]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-22T00:00:00"}
