{"id":"https://openalex.org/W7223099996","doi":"https://doi.org/10.1016/j.htct.2026.108178","title":"IMPACTO DA CENTRALIZA\u00c7\u00c3O DA HIDROXIUR\u00c9IA NO MT-HEMOCENTRO E DA PARCERIA COM ASSOCIA\u00c7\u00c3O DE PACIENTES NA ADES\u00c3O AO TRATAMENTO DA DOEN\u00c7A FALCIFORME","display_name":"IMPACTO DA CENTRALIZA\u00c7\u00c3O DA HIDROXIUR\u00c9IA NO MT-HEMOCENTRO E DA PARCERIA COM ASSOCIA\u00c7\u00c3O DE PACIENTES NA ADES\u00c3O AO TRATAMENTO DA DOEN\u00c7A FALCIFORME","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223099996","doi":"https://doi.org/10.1016/j.htct.2026.108178"},"language":"en","primary_location":{"id":"doi:10.1016/j.htct.2026.108178","doi":"https://doi.org/10.1016/j.htct.2026.108178","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.108178","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926019255/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciencedirect.com/science/article/pii/S2531137926019255/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081974932","display_name":"Luciano Mafioleti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luciano MAFIOLETI","raw_affiliation_strings":["MT-Hemocentro, Cuiab\u00e1, MT, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MT-Hemocentro, Cuiab\u00e1, MT, Brasil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018338060","display_name":"Susana Sandim Borges","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susana Sandim BORGES","raw_affiliation_strings":["MT-Hemocentro, Cuiab\u00e1, MT, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MT-Hemocentro, Cuiab\u00e1, MT, Brasil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159209537","display_name":"Renata Brand\u00e3o DIAS","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renata Brand\u00e3o DIAS","raw_affiliation_strings":["MT-Hemocentro, Cuiab\u00e1, MT, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MT-Hemocentro, Cuiab\u00e1, MT, Brasil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159182390","display_name":"Mirna Claiton MEDRADO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mirna Claiton MEDRADO","raw_affiliation_strings":["MT-Hemocentro, Cuiab\u00e1, MT, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MT-Hemocentro, Cuiab\u00e1, MT, Brasil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159179273","display_name":"Maria F\u00e1tima QUINTANA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria F\u00e1tima QUINTANA","raw_affiliation_strings":["MT-Hemocentro, Cuiab\u00e1, MT, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MT-Hemocentro, Cuiab\u00e1, MT, Brasil","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159161525","display_name":"Fernando Henrique MODOLO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fernando Henrique MODOLO","raw_affiliation_strings":["MT-Hemocentro, Cuiab\u00e1, MT, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MT-Hemocentro, Cuiab\u00e1, MT, Brasil","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.81760278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":null,"first_page":"108178","last_page":"108178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13915","display_name":"Public Health in Brazil","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.984000027179718},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.7649999856948853},{"id":"https://openalex.org/keywords/patient-associations","display_name":"patient associations","score":0.6439999938011169},{"id":"https://openalex.org/keywords/patient-satisfaction","display_name":"patient satisfaction","score":0.6959999799728394},{"id":"https://openalex.org/keywords/care-cascade","display_name":"cascade of care","score":0.5559999942779541},{"id":"https://openalex.org/keywords/patient-education","display_name":"patient education","score":0.421999990940094},{"id":"https://openalex.org/keywords/mato-grosso","display_name":"Mato Grosso","score":0.5619999766349792},{"id":"https://openalex.org/keywords/hemocenters","display_name":"hemocenters","score":0.5870000123977661},{"id":"https://openalex.org/keywords/retention-in-care","display_name":"retention in care","score":0.3190000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8878999948501587},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4147999882698059},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2386000007390976},{"id":"https://openalex.org/C2776056953","wikidata":"https://www.wikidata.org/wiki/Q1182511","display_name":"De-escalation","level":2,"score":0.21490000188350677},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.15610000491142273},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.1445000022649765},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.12970000505447388},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.1266999989748001},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.1071000024676323},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10320000350475311}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.htct.2026.108178","doi":"https://doi.org/10.1016/j.htct.2026.108178","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.108178","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926019255/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:23108a2cc6c648bdbff4415fa7d07f84","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/23108a2cc6c648bdbff4415fa7d07f84","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 48, Iss , Pp 108178- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.htct.2026.108178","doi":"https://doi.org/10.1016/j.htct.2026.108178","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.108178","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926019255/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223099996.pdf","grobid_xml":"https://content.openalex.org/works/W7223099996.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4306321303","https://openalex.org/W4293064404","https://openalex.org/W7036223214","https://openalex.org/W4403555319","https://openalex.org/W4388508781","https://openalex.org/W7223553891","https://openalex.org/W4233158641","https://openalex.org/W4415669292","https://openalex.org/W7223152704","https://openalex.org/W4415668905"],"abstract_inverted_index":{"Introdu\u00e7\u00e3o":[0],"A":[1,203,255,292,307,375],"doen\u00e7a":[2],"falciforme":[3],"(DF)":[4],"exige":[5],"manejo":[6,342,356],"multidisciplinar":[7],"cont\u00ednuo":[8],"e":[9,37,58,97,109,120,125,142,155,159,191,214,227,285,301,324,333,363,396,415,429,442,468],"elevada":[10,260],"ades\u00e3o":[11,107,149,250,305,393,464],"\u00e0":[12,27,64,150,219,228,382,421,462],"hidroxiureia":[13],"(HU).":[14],"At\u00e9":[15],"2024,":[16],"a":[17,69,106,110,183,192,249,268,311,318,334,365,385,402,471],"dispensa\u00e7\u00e3o":[18,51,92,186,378],"em":[19,80,133,137,157,304,361],"Mato":[20,77],"Grosso":[21,78],"dependia":[22],"do":[23,25,56,270],"deslocamento":[24],"paciente":[26],"Farm\u00e1cia":[28],"de":[29,50,71,76,82,103,129,135,148,161,185,187,195,201,205,210,222,257,274,281,315,322,359,371,387,404,439,458],"\u2018Alto":[30],"Custo\u2019":[31],"(Componente":[32],"Especializado),":[33],"impondo":[34],"barreiras":[35,425],"geogr\u00e1ficas":[36],"burocr\u00e1ticas":[38],"que":[39,424],"favoreciam":[40],"o":[41,46,87,180,199,246,330,369,435],"abandono":[42],"terap\u00eautico.":[43],"Em":[44],"2025,":[45],"MT-Hemocentro":[47,96],"implantou":[48],"fluxo":[49],"centralizada,":[52],"com":[53,68,73,101,114,131,242,272,310,317,353,384],"capta\u00e7\u00e3o":[54],"institucional":[55],"medicamento":[57],"entrega":[59],"na":[60,276,286,392,397,426,430,455,466],"pr\u00f3pria":[61],"unidade,":[62],"associado":[63],"intensifica\u00e7\u00e3o":[65],"da":[66,89,91,93,98,216,262,288,294,296,344,347,357,377,379],"parceria":[67,383],"Associa\u00e7\u00e3o":[70],"Pessoas":[72],"Doen\u00e7a":[74],"Falciforme":[75],"(ASFAMT)":[79],"a\u00e7\u00f5es":[81,325],"educa\u00e7\u00e3o":[83],"continuada.":[84],"Objetivos":[85],"Avaliar":[86],"impacto":[88,436],"centraliza\u00e7\u00e3o":[90,263,293,376],"HU":[94,136,151,297,380],"no":[95,117,279,341,460,469],"articula\u00e7\u00e3o":[99],"sistem\u00e1tica":[100],"associa\u00e7\u00e3o":[102,386],"pacientes":[104,130,166,241,352,388],"sobre":[105,198],"terap\u00eautica":[108,394],"satisfa\u00e7\u00e3o":[111,258,398],"dos":[112,189,225,234,237,336,399,411],"usu\u00e1rios":[113],"DF":[115,132],"acompanhados":[116],"MT-Hemocentro.":[118],"Material":[119],"M\u00e9todos":[121],"Estudo":[122],"observacional,":[123],"longitudinal":[124],"retrospectivo,":[126],"comparando":[127],"indicadores":[128],"uso":[134],"dois":[138],"per\u00edodos:":[139],"pr\u00e9-interven\u00e7\u00e3o":[140],"(2024)":[141],"p\u00f3s-interven\u00e7\u00e3o":[143],"(2026).":[144],"Desfechos":[145],"prim\u00e1rios:":[146],"taxa":[147,184],"(regularidade":[152],"das":[153],"retiradas":[154],"registros":[156],"prontu\u00e1rio)":[158],"n\u00edvel":[160],"satisfa\u00e7\u00e3o.":[162],"Resultados":[163],"Dos":[164],"586":[165],"eleg\u00edveis":[167,412],"para":[168,267,283,329,349],"HU,":[169],"321":[170],"(54,78%)":[171],"receberam":[172,413],"prescri\u00e7\u00e3o":[173,232,348,414],"m\u00e9dica.":[174],"Entre":[175,239],"estes,":[176],"179":[177],"retiraram":[178],"efetivamente":[179],"medicamento,":[181],"correspondendo":[182],"55,76%":[188],"prescritos":[190],"acesso":[193,364,419,470],"efetivo":[194,420],"30,55%":[196,417],"(179/586)":[197],"total":[200],"eleg\u00edveis.":[202],"cascata":[204,403],"cuidado":[206,405],"revelou":[207,406],"perda":[208],"acumulada":[209],"69,45%":[211],"entre":[212],"elegibilidade":[213],"obten\u00e7\u00e3o":[215],"medica\u00e7\u00e3o,":[217,422],"atribu\u00edda":[218],"n\u00e3o":[220,229,463],"emiss\u00e3o":[221],"receita":[223],"(45,22%":[224],"eleg\u00edveis)":[226],"retirada":[230,243,295,431,467],"ap\u00f3s":[231,245],"(24,23%":[233],"eleg\u00edveis;":[235],"44,24%":[236],"prescritos).":[238],"os":[240,351],"regular":[244],"novo":[247],"fluxo,":[248],"ao":[251],"tratamento":[252],"atingiu":[253],"89,7%.":[254],"avalia\u00e7\u00e3o":[256],"evidenciou":[259],"aprova\u00e7\u00e3o":[261],"como":[264,368],"fator":[265],"determinante":[266],"continuidade":[269],"tratamento,":[271],"oportunidades":[273],"melhoria":[275],"infraestrutura":[277],"f\u00edsica,":[278],"tempo":[280],"espera":[282],"consultas":[284],"amplia\u00e7\u00e3o":[287,346],"equipe":[289],"multidisciplinar.":[290],"DISCUSS\u00c3O":[291],"eliminou":[298],"gargalos":[299],"log\u00edsticos":[300],"burocr\u00e1ticos,":[302],"refletindo-se":[303],"(89,7%).":[306],"atua\u00e7\u00e3o":[308],"integrada":[309],"ASFAMT,":[312],"por":[313],"meio":[314],"reuni\u00f5es":[316],"gest\u00e3o":[319,440],"institucional,":[320],"rodas":[321],"conversa":[323],"educativas,":[326],"\u00e9":[327],"importante":[328],"controle":[331],"social":[332],"autonomia":[335],"pacientes.":[337],"Persistem,":[338],"contudo,":[339],"desafios":[340],"global":[343],"doen\u00e7a:":[345],"todos":[350],"indica\u00e7\u00e3o":[354],"cl\u00ednica,":[355],"sobrecarga":[358],"ferro":[360],"politransfundidos":[362],"terapias":[366,472],"curativas,":[367],"Transplante":[370],"C\u00e9lulas-Tronco":[372],"Hematopo\u00e9ticas.":[373],"Conclus\u00e3o":[374],"associada":[381],"promoveu":[389],"incremento":[390],"expressivo":[391],"(89,7%)":[395],"usu\u00e1rios.":[400],"Contudo,":[401],"perdas":[407],"significativas:":[408],"apenas":[409],"54,78%":[410],"somente":[416],"alcan\u00e7aram":[418],"evidenciando":[423],"etapa":[427],"elegibilidade-prescri\u00e7\u00e3o":[428],"p\u00f3s-receita":[432],"ainda":[433],"limitam":[434],"populacional.":[437],"Estrat\u00e9gias":[438],"log\u00edstica":[441],"suporte":[443],"socioeducacional":[444],"mostram-se":[445],"t\u00e3o":[446],"determinantes":[447],"quanto":[448],"as":[449],"interven\u00e7\u00f5es":[450],"farmacol\u00f3gicas,":[451],"sendo":[452],"necess\u00e1rio":[453],"avan\u00e7ar":[454],"busca":[456],"ativa":[457],"prescri\u00e7\u00f5es,":[459],"combate":[461],"prim\u00e1ria":[465],"curativas.":[473]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-22T00:00:00"}