{"id":"https://openalex.org/W7223099671","doi":"https://doi.org/10.1515/biol-2025-1392","title":"Taxifolin targets HMGCR, LDLR and APOB to ameliorate hyperlipidemia: insights from systems pharmacology and nanoemulsion-based delivery","display_name":"Taxifolin targets HMGCR, LDLR and APOB to ameliorate hyperlipidemia: insights from systems pharmacology and nanoemulsion-based delivery","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7223099671","doi":"https://doi.org/10.1515/biol-2025-1392","pmid":"https://pubmed.ncbi.nlm.nih.gov/42910376","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13686381"},"language":"en","primary_location":{"id":"doi:10.1515/biol-2025-1392","doi":"https://doi.org/10.1515/biol-2025-1392","is_oa":true,"landing_page_url":"https://doi.org/10.1515/biol-2025-1392","pdf_url":null,"source":{"id":"https://openalex.org/S119941230","display_name":"Open Life Sciences","issn_l":"1895-104X","issn":["1895-104X","1644-3632","2391-5412"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1515/biol-2025-1392","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063575575","display_name":"Abdullah R. Alanzi","orcid":"https://orcid.org/0009-0000-2565-6573","observed_orcids":["https://orcid.org/0009-0000-2565-6573"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Abdullah R. Alanzi","raw_affiliation_strings":["Department of Pharmacognosy , College of Pharmacy , King Saud University , 11451 Riyadh , Saudi Arabia"],"raw_orcid":"https://orcid.org/0009-0000-2565-6573","affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy , College of Pharmacy , King Saud University , 11451 Riyadh , Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159173340","display_name":"Iman Fatima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142204992","display_name":"University of Lahore","ror":"https://ror.org/051jrjw38","country_code":"PK","type":"education","lineage":["https://openalex.org/I142204992"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Iman Fatima","raw_affiliation_strings":["Faculty of Pharmacy , The University of Lahore , Lahore , Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy , The University of Lahore , Lahore , Pakistan","institution_ids":["https://openalex.org/I142204992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017211373","display_name":"Muhammad Umer Ashraf","orcid":"https://orcid.org/0000-0002-8372-9424","observed_orcids":["https://orcid.org/0000-0002-8372-9424","https://orcid.org/0000-0002-7016-9181"]},"institutions":[{"id":"https://openalex.org/I142204992","display_name":"University of Lahore","ror":"https://ror.org/051jrjw38","country_code":"PK","type":"education","lineage":["https://openalex.org/I142204992"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Umer Ashraf","raw_affiliation_strings":["Faculty of Pharmacy , The University of Lahore , Lahore , Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy , The University of Lahore , Lahore , Pakistan","institution_ids":["https://openalex.org/I142204992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086617764","display_name":"Muhammad Nasir Hayat Malik","orcid":"https://orcid.org/0000-0002-2657-9810","observed_orcids":["https://orcid.org/0000-0002-2657-9810"]},"institutions":[{"id":"https://openalex.org/I142204992","display_name":"University of Lahore","ror":"https://ror.org/051jrjw38","country_code":"PK","type":"education","lineage":["https://openalex.org/I142204992"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Nasir Hayat Malik","raw_affiliation_strings":["Faculty of Pharmacy , The University of Lahore , Lahore , Pakistan"],"raw_orcid":"https://orcid.org/0000-0002-2657-9810","affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy , The University of Lahore , Lahore , Pakistan","institution_ids":["https://openalex.org/I142204992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159185122","display_name":"Rashed N. Herqash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Rashed N. Herqash","raw_affiliation_strings":["Center for Research on Medicinal, Aromatic, and Poisonous Plants, DSR, King Saud University , P.O. Box 2457 , Riyadh , Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research on Medicinal, Aromatic, and Poisonous Plants, DSR, King Saud University , P.O. Box 2457 , Riyadh , Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037191428","display_name":"Mostafa E. Abugrain","orcid":"https://orcid.org/0009-0004-5073-3904","observed_orcids":["https://orcid.org/0009-0004-5073-3904"]},"institutions":[{"id":"https://openalex.org/I23906160","display_name":"University of Tripoli","ror":"https://ror.org/00taa2s29","country_code":"LY","type":"education","lineage":["https://openalex.org/I23906160"]}],"countries":["LY"],"is_corresponding":false,"raw_author_name":"Mostafa E. Abugrain","raw_affiliation_strings":["Department of Pharmacognosy, Faculty of Pharmacy , University of Tripoli , Tripoli , Libya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, Faculty of Pharmacy , University of Tripoli , Tripoli , Libya","institution_ids":["https://openalex.org/I23906160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101998646","display_name":"Muhammad Atif","orcid":"https://orcid.org/0000-0001-5741-2194","observed_orcids":["https://orcid.org/0000-0001-5741-2194"]},"institutions":[{"id":"https://openalex.org/I142204992","display_name":"University of Lahore","ror":"https://ror.org/051jrjw38","country_code":"PK","type":"education","lineage":["https://openalex.org/I142204992"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Atif","raw_affiliation_strings":["Faculty of Pharmacy , The University of Lahore , Lahore , Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy , The University of Lahore , Lahore , Pakistan","institution_ids":["https://openalex.org/I142204992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075643370","display_name":"Munawar Abbas","orcid":"https://orcid.org/0009-0001-9847-7936","observed_orcids":["https://orcid.org/0009-0001-9847-7936"]},"institutions":[{"id":"https://openalex.org/I36152291","display_name":"Henan University of Technology","ror":"https://ror.org/05sbgwt55","country_code":"CN","type":"education","lineage":["https://openalex.org/I36152291"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Munawar Abbas","raw_affiliation_strings":["College of Food Science and Technology , Henan University of Technology , Zhengzhou , Henan , 450001 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food Science and Technology , Henan University of Technology , Zhengzhou , Henan , 450001 , China","institution_ids":["https://openalex.org/I36152291"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037631176","display_name":"Gideon F. B. Solre","orcid":"https://orcid.org/0000-0002-2861-0674","observed_orcids":["https://orcid.org/0000-0002-2861-0674","https://orcid.org/0009-0004-9411-1410"]},"institutions":[{"id":"https://openalex.org/I149743910","display_name":"University of Liberia","ror":"https://ror.org/0440cy367","country_code":"LR","type":"education","lineage":["https://openalex.org/I149743910"]}],"countries":["LR"],"is_corresponding":true,"raw_author_name":"Gideon F.B. Solre","raw_affiliation_strings":["Department of Chemistry, Thomas J.\u00a0R. Faulkner College of Science and Technology , University of Liberia , Monrovia , Montserrado County , Liberia"],"raw_orcid":"https://orcid.org/0000-0002-2861-0674","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Thomas J.\u00a0R. Faulkner College of Science and Technology , University of Liberia , Monrovia , Montserrado County , Liberia","institution_ids":["https://openalex.org/I149743910"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5037631176"],"corresponding_institution_ids":["https://openalex.org/I149743910"],"apc_list":{"value":2100,"currency":"EUR","value_usd":2373},"apc_paid":{"value":2100,"currency":"EUR","value_usd":2373},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.71323283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"1","first_page":"20251392","last_page":"20251392"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.4359999895095825,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.4359999895095825,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.33959999680519104,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.16699999570846558,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/taxifolin","display_name":"taxifolin","score":1.0},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":1.0},{"id":"https://openalex.org/keywords/hmgcr","display_name":"HMGCR","score":0.984000027179718},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.9639999866485596},{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apolipoprotein-a-i","display_name":"apolipoprotein A-I","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.746999979019165},{"id":"https://openalex.org/keywords/ldl-clearance","display_name":"LDL clearance","score":0.9160000085830688},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.8119999766349792},{"id":"https://openalex.org/keywords/liver-dysfunction","display_name":"liver dysfunction","score":0.7699999809265137},{"id":"https://openalex.org/keywords/multi-target-drug-mechanism","display_name":"multi-target drug mechanism","score":0.656000018119812},{"id":"https://openalex.org/keywords/network-pharmacology","display_name":"network pharmacology","score":0.6179999709129333},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.7398999929428101},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.6277999877929688},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.569599986076355},{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.5504999756813049},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5396999716758728},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.5347999930381775},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.531499981880188},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.45890000462532043},{"id":"https://openalex.org/C2778719679","wikidata":"https://www.wikidata.org/wiki/Q412191","display_name":"Taxifolin","level":4,"score":0.45879998803138733},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4381999969482422},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.43639999628067017},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.40220001339912415},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.3610999882221222},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.328000009059906},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.31619998812675476},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3156000077724457},{"id":"https://openalex.org/C56623246","wikidata":"https://www.wikidata.org/wiki/Q14916272","display_name":"Apolipoprotein C2","level":5,"score":0.30379998683929443},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.29760000109672546},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.2971999943256378},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.29319998621940613},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.29170000553131104},{"id":"https://openalex.org/C2779120738","wikidata":"https://www.wikidata.org/wiki/Q2711291","display_name":"Familial hypercholesterolemia","level":3,"score":0.2578999996185303},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.2572000026702881},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.2538999915122986}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1515/biol-2025-1392","doi":"https://doi.org/10.1515/biol-2025-1392","is_oa":true,"landing_page_url":"https://doi.org/10.1515/biol-2025-1392","pdf_url":null,"source":{"id":"https://openalex.org/S119941230","display_name":"Open Life Sciences","issn_l":"1895-104X","issn":["1895-104X","1644-3632","2391-5412"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Life Sciences","raw_type":"journal-article"},{"id":"pmid:42910376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42910376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open life sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13686381","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13686381/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Life Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2b8342e9d4594f329366ab179daa0f40","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2b8342e9d4594f329366ab179daa0f40","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Life Sciences, Vol 21, Iss 1, Pp 61-39 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1515/biol-2025-1392","doi":"https://doi.org/10.1515/biol-2025-1392","is_oa":true,"landing_page_url":"https://doi.org/10.1515/biol-2025-1392","pdf_url":null,"source":{"id":"https://openalex.org/S119941230","display_name":"Open Life Sciences","issn_l":"1895-104X","issn":["1895-104X","1644-3632","2391-5412"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Life Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1541546919","https://openalex.org/W1635278082","https://openalex.org/W1973737559","https://openalex.org/W1978077064","https://openalex.org/W1981307220","https://openalex.org/W1987096050","https://openalex.org/W1990488060","https://openalex.org/W1996186320","https://openalex.org/W2024306244","https://openalex.org/W2045054080","https://openalex.org/W2051802124","https://openalex.org/W2056840085","https://openalex.org/W2064387909","https://openalex.org/W2067690301","https://openalex.org/W2070855777","https://openalex.org/W2077610643","https://openalex.org/W2081175887","https://openalex.org/W2083049470","https://openalex.org/W2091875032","https://openalex.org/W2104916446","https://openalex.org/W2110227562","https://openalex.org/W2134068835","https://openalex.org/W2159728029","https://openalex.org/W2164089346","https://openalex.org/W2735383739","https://openalex.org/W2754562397","https://openalex.org/W2785827727","https://openalex.org/W2943683582","https://openalex.org/W2969244347","https://openalex.org/W2976529470","https://openalex.org/W3000696688","https://openalex.org/W3034814303","https://openalex.org/W3093425793","https://openalex.org/W3120625224","https://openalex.org/W3129180352","https://openalex.org/W3136173721","https://openalex.org/W3191405580","https://openalex.org/W3195336608","https://openalex.org/W3205604113","https://openalex.org/W4210345396","https://openalex.org/W4224066461","https://openalex.org/W4224295508","https://openalex.org/W4226371412","https://openalex.org/W4285145577","https://openalex.org/W4297458751","https://openalex.org/W4307410701","https://openalex.org/W4311093179","https://openalex.org/W4384401175","https://openalex.org/W4387603436","https://openalex.org/W4389178794","https://openalex.org/W4391111375","https://openalex.org/W4391686951","https://openalex.org/W4391909301","https://openalex.org/W4392661532","https://openalex.org/W4393146524","https://openalex.org/W4395955376","https://openalex.org/W4399105030","https://openalex.org/W4400017105","https://openalex.org/W4400231214","https://openalex.org/W4400645796","https://openalex.org/W4405694336","https://openalex.org/W4406104048","https://openalex.org/W4407391707","https://openalex.org/W4407797955","https://openalex.org/W4407803685","https://openalex.org/W4409326118","https://openalex.org/W4409667751","https://openalex.org/W4409705864","https://openalex.org/W7163572285"],"related_works":["https://openalex.org/W4408391424","https://openalex.org/W7134128490","https://openalex.org/W4362705056","https://openalex.org/W3209827181","https://openalex.org/W7162021750","https://openalex.org/W4412197308","https://openalex.org/W4413115411","https://openalex.org/W4403156307","https://openalex.org/W1993472695","https://openalex.org/W6949409822"],"abstract_inverted_index":{"Abstract":[0],"Hyperlipidemia":[1],"is":[2],"a":[3,73,179],"major":[4,74],"risk":[5],"factor":[6],"for":[7,13,189],"cardiovascular":[8],"disease,":[9],"highlighting":[10],"the":[11,22],"need":[12],"safer":[14],"and":[15,28,36,47,60,95,116,122,129,144,154,192],"effective":[16],"therapeutic":[17,156,187],"options.":[18],"This":[19],"study":[20],"evaluated":[21],"anti-hyperlipidemic":[23],"potential":[24,104,188],"of":[25,82,127,134,138],"taxifolin":[26],"(TXF)":[27],"its":[29,186],"nanoemulsion":[30],"formulation":[31],"(TXF-NE)":[32],"using":[33],"integrated":[34],"computational":[35],"experimental":[37],"approaches.":[38],"Network":[39],"pharmacology":[40],"identified":[41],"177":[42],"common":[43],"targets":[44,54],"between":[45],"TXF":[46,83,105,110,175],"hyperlipidemia,":[48],"with":[49,84,132],"enrichment":[50],"analyses":[51,124],"linking":[52],"these":[53,171],"to":[55,159],"lipid":[56,86,114,168],"metabolism,":[57],"cholesterol":[58,139],"regulation,":[59],"inflammatory":[61],"pathways.":[62],"Protein-protein":[63],"interaction":[64],"analysis":[65],"revealed":[66],"key":[67],"lipid-regulating":[68],"genes,":[69],"including":[70,90],"HMGCR":[71,128],"as":[72,162],"hub":[75],"target.":[76],"Molecular":[77],"docking":[78],"predicted":[79,98],"favorable":[80],"interactions":[81,99],"several":[85],"metabolism":[87],"related":[88],"proteins,":[89],"HMGCR,":[91],"LDLR,":[92,135],"APOB,":[93],"APOA1,":[94],"ACSM2A.":[96],"The":[97],"provide":[100],"structural":[101],"hypotheses":[102],"regarding":[103],"protein":[106,123],"associations.":[107],"In-vivo":[108],",":[109],"significantly":[111],"improved":[112],"serum":[113],"profiles":[115],"liver":[117],"function":[118],"enzymes.":[119],"Gene":[120],"expression":[121],"exhibited":[125,150],"downregulation":[126],"APOB":[130],"along":[131],"upregulation":[133],"indicating":[136],"suppression":[137],"synthesis,":[140],"reduced":[141],"lipoprotein":[142],"production,":[143],"enhanced":[145],"LDL":[146],"clearance.":[147],"Notably,":[148],"TXF-NE":[149],"high":[151],"drug":[152],"content":[153],"better":[155],"efficacy":[157],"relative":[158],"free":[160],"TXF,":[161],"reflected":[163],"by":[164],"greater":[165],"improvements":[166],"in":[167],"parameters.":[169],"Overall,":[170],"findings":[172],"demonstrate":[173],"that":[174],"alleviates":[176],"hyperlipidemia":[177,191],"through":[178],"multi-target":[180],"mechanism,":[181],"while":[182],"nanoemulsion-based":[183],"delivery":[184],"enhances":[185],"managing":[190],"associated":[193],"hepatic":[194],"dysfunction.":[195]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-10-22T00:00:00"}