{"id":"https://openalex.org/W7223099388","doi":"https://doi.org/10.1007/s00284-026-05170-z","title":"The Crosstalk Role of Intestinal Barrier Damage in the Gut-Organ Axis and its Potential Therapeutic Implications","display_name":"The Crosstalk Role of Intestinal Barrier Damage in the Gut-Organ Axis and its Potential Therapeutic Implications","publication_year":2026,"publication_date":"2026-10-21","ids":{"openalex":"https://openalex.org/W7223099388","doi":"https://doi.org/10.1007/s00284-026-05170-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/42905293","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13687403"},"language":"en","primary_location":{"id":"doi:10.1007/s00284-026-05170-z","doi":"https://doi.org/10.1007/s00284-026-05170-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00284-026-05170-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00284-026-05170-z.pdf","source":{"id":"https://openalex.org/S2248630","display_name":"Current Microbiology","issn_l":"0343-8651","issn":["0343-8651","1432-0991"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00284-026-05170-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5132976891","display_name":"Jiaxue Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]},{"id":"https://openalex.org/I4210092654","display_name":"Longgang Central Hospital","ror":"https://ror.org/00j5y7k81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092654"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxue Feng","raw_affiliation_strings":["Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China","Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China","institution_ids":["https://openalex.org/I182386381"]},{"raw_affiliation_string":"Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China","institution_ids":["https://openalex.org/I4210092654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132996451","display_name":"Wenwen Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]},{"id":"https://openalex.org/I4210092654","display_name":"Longgang Central Hospital","ror":"https://ror.org/00j5y7k81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092654"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenwen Xie","raw_affiliation_strings":["Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China","Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China","institution_ids":["https://openalex.org/I182386381"]},{"raw_affiliation_string":"Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China","institution_ids":["https://openalex.org/I4210092654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159172446","display_name":"Huifei Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109381","display_name":"Affiliated Hospital of Guizhou Medical University","ror":"https://ror.org/02kstas42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huifei Lu","raw_affiliation_strings":["The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China","institution_ids":["https://openalex.org/I4210109381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122847939","display_name":"Li Tian","orcid":"https://orcid.org/0009-0002-9776-501X","observed_orcids":["https://orcid.org/0009-0002-9776-501X"]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]},{"id":"https://openalex.org/I4210092654","display_name":"Longgang Central Hospital","ror":"https://ror.org/00j5y7k81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092654"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Tian","raw_affiliation_strings":["Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China","Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China","institution_ids":["https://openalex.org/I182386381"]},{"raw_affiliation_string":"Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China","institution_ids":["https://openalex.org/I4210092654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159221487","display_name":"Xiaohang Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]},{"id":"https://openalex.org/I4210092654","display_name":"Longgang Central Hospital","ror":"https://ror.org/00j5y7k81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092654"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohang Shi","raw_affiliation_strings":["Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China","Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China","institution_ids":["https://openalex.org/I182386381"]},{"raw_affiliation_string":"Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China","institution_ids":["https://openalex.org/I4210092654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159184449","display_name":"Jianbin Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]},{"id":"https://openalex.org/I4210092654","display_name":"Longgang Central Hospital","ror":"https://ror.org/00j5y7k81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092654"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianbin Huang","raw_affiliation_strings":["Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China","Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China","institution_ids":["https://openalex.org/I182386381"]},{"raw_affiliation_string":"Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China","institution_ids":["https://openalex.org/I4210092654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159212096","display_name":"Xianhai Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]},{"id":"https://openalex.org/I4210092654","display_name":"Longgang Central Hospital","ror":"https://ror.org/00j5y7k81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092654"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianhai Zeng","raw_affiliation_strings":["Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China","Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China","institution_ids":["https://openalex.org/I182386381"]},{"raw_affiliation_string":"Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China","institution_ids":["https://openalex.org/I4210092654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046170270","display_name":"Zhou Yichi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yichi Zhou","raw_affiliation_strings":["Department of Gastroenterology, Beijing University of Chinese Medicine Shenzhen Hospital (Longgang), Shenzhen, China. zhouyichi1992@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Beijing University of Chinese Medicine Shenzhen Hospital (Longgang), Shenzhen, China. zhouyichi1992@126.com","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130252838","display_name":"Meizhen Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]},{"id":"https://openalex.org/I4210092654","display_name":"Longgang Central Hospital","ror":"https://ror.org/00j5y7k81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092654"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Meizhen Zhao","raw_affiliation_strings":["Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China. zhaomeizhen84@163.com","Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China. zhaomeizhen84@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China. zhaomeizhen84@163.com","institution_ids":["https://openalex.org/I182386381"]},{"raw_affiliation_string":"Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China. zhaomeizhen84@163.com","institution_ids":["https://openalex.org/I4210092654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123539261","display_name":"Baohui Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]},{"id":"https://openalex.org/I4210092654","display_name":"Longgang Central Hospital","ror":"https://ror.org/00j5y7k81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092654"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Baohui Cheng","raw_affiliation_strings":["Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China. chengbaohui@sina.com","Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China. chengbaohui@sina.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China. chengbaohui@sina.com","institution_ids":["https://openalex.org/I182386381"]},{"raw_affiliation_string":"Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China. chengbaohui@sina.com","institution_ids":["https://openalex.org/I4210092654"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5133918889","display_name":"Haotao Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]},{"id":"https://openalex.org/I4210092654","display_name":"Longgang Central Hospital","ror":"https://ror.org/00j5y7k81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092654"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haotao Zeng","raw_affiliation_strings":["Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China. HaotaoZeng@163.com","Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China. HaotaoZeng@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Graduate and Scientific Research, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China. HaotaoZeng@163.com","institution_ids":["https://openalex.org/I182386381"]},{"raw_affiliation_string":"Department of Otolaryngology, Longgang Otolaryngology Hospital & Shenzhen Otolaryngology Research Institute, Shenzhen, 518172, China. HaotaoZeng@163.com","institution_ids":["https://openalex.org/I4210092654"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5046170270","https://openalex.org/A5123539261","https://openalex.org/A5130252838","https://openalex.org/A5133918889"],"corresponding_institution_ids":["https://openalex.org/I17747738","https://openalex.org/I182386381","https://openalex.org/I4210092654"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":{"value":3990,"currency":"USD","value_usd":3990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.48654331,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.05620000138878822,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-barrier-dysfunction","display_name":"intestinal barrier dysfunction","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mucus-layer","display_name":"mucus layer","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.9190000295639038},{"id":"https://openalex.org/keywords/lamina-propria","display_name":"lamina propria","score":0.847000002861023},{"id":"https://openalex.org/keywords/immune-homeostasis","display_name":"immune homeostasis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/microbial-translocation","display_name":"microbial translocation","score":0.753000020980835},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.984000027179718},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.7689999938011169},{"id":"https://openalex.org/keywords/pancreatitis","display_name":"pancreatitis","score":1.0},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8180000185966492},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9940000176429749},{"id":"https://openalex.org/keywords/immune-signaling-pathways","display_name":"immune signaling pathways","score":0.7390000224113464},{"id":"https://openalex.org/keywords/single-cell-omics","display_name":"single-cell omics","score":0.6990000009536743},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.7910000085830688},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"artificial intelligence","score":0.7950000166893005},{"id":"https://openalex.org/keywords/microbiome-based-therapy","display_name":"microbiota-based therapy","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.7940000295639038},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6586999893188477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6190000176429749},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.5932999849319458},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5651000142097473},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.501800000667572},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.4507000148296356},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.41190001368522644},{"id":"https://openalex.org/C2777310793","wikidata":"https://www.wikidata.org/wiki/Q1725675","display_name":"Lamina propria","level":3,"score":0.39910000562667847},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3630000054836273},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36059999465942383},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.35920000076293945},{"id":"https://openalex.org/C2781077229","wikidata":"https://www.wikidata.org/wiki/Q509615","display_name":"Intestinal epithelium","level":3,"score":0.35179999470710754},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.3325999975204468},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.3133000135421753},{"id":"https://openalex.org/C185350488","wikidata":"https://www.wikidata.org/wiki/Q615386","display_name":"Transcytosis","level":4,"score":0.31290000677108765},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.30889999866485596},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.30390000343322754},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2888999879360199},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.26910001039505005},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.25450000166893005}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000095644","descriptor_name":"Intestinal Barrier Function","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00284-026-05170-z","doi":"https://doi.org/10.1007/s00284-026-05170-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00284-026-05170-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00284-026-05170-z.pdf","source":{"id":"https://openalex.org/S2248630","display_name":"Current Microbiology","issn_l":"0343-8651","issn":["0343-8651","1432-0991"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13687403","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13687403/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13687403/pdf/284_2026_Article_5170.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Microbiol","raw_type":"Text"},{"id":"pmid:42905293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42905293","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current microbiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s00284-026-05170-z","doi":"https://doi.org/10.1007/s00284-026-05170-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00284-026-05170-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00284-026-05170-z.pdf","source":{"id":"https://openalex.org/S2248630","display_name":"Current Microbiology","issn_l":"0343-8651","issn":["0343-8651","1432-0991"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5380922604","display_name":null,"funder_award_id":"82474586","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5632056243","display_name":null,"funder_award_id":"82204743","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5783365073","display_name":null,"funder_award_id":"320.6750","funder_id":"https://openalex.org/F4320332531","funder_display_name":"Wu Jieping Medical Foundation"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332531","display_name":"Wu Jieping Medical Foundation","ror":"https://ror.org/05dgwj702"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223099388.pdf","grobid_xml":"https://content.openalex.org/works/W7223099388.grobid-xml"},"referenced_works_count":109,"referenced_works":["https://openalex.org/W1966420007","https://openalex.org/W1967217097","https://openalex.org/W1987241524","https://openalex.org/W1992152055","https://openalex.org/W1993677820","https://openalex.org/W2087243986","https://openalex.org/W2094852093","https://openalex.org/W2103108588","https://openalex.org/W2141300346","https://openalex.org/W2179868244","https://openalex.org/W2186320679","https://openalex.org/W2268544397","https://openalex.org/W2323974245","https://openalex.org/W2464915778","https://openalex.org/W2487359925","https://openalex.org/W2657790599","https://openalex.org/W2753871615","https://openalex.org/W2770717271","https://openalex.org/W2789287723","https://openalex.org/W2810056299","https://openalex.org/W2893322268","https://openalex.org/W2909368149","https://openalex.org/W2912709864","https://openalex.org/W2956129408","https://openalex.org/W2979439559","https://openalex.org/W2980944208","https://openalex.org/W2983105748","https://openalex.org/W2984068003","https://openalex.org/W2989725069","https://openalex.org/W3024738561","https://openalex.org/W3041605919","https://openalex.org/W3045783780","https://openalex.org/W3045859819","https://openalex.org/W3049637905","https://openalex.org/W3083959127","https://openalex.org/W3113591600","https://openalex.org/W3113803118","https://openalex.org/W3125037474","https://openalex.org/W3125321102","https://openalex.org/W3126852367","https://openalex.org/W3131297975","https://openalex.org/W3132033472","https://openalex.org/W3159660404","https://openalex.org/W3179905314","https://openalex.org/W3196757718","https://openalex.org/W3196827879","https://openalex.org/W3203828353","https://openalex.org/W3206007177","https://openalex.org/W3208165440","https://openalex.org/W4200350756","https://openalex.org/W4206433626","https://openalex.org/W4210916786","https://openalex.org/W4220799735","https://openalex.org/W4226232593","https://openalex.org/W4284899705","https://openalex.org/W4292582594","https://openalex.org/W4308463287","https://openalex.org/W4310138355","https://openalex.org/W4311230109","https://openalex.org/W4323046352","https://openalex.org/W4366984915","https://openalex.org/W4383058732","https://openalex.org/W4384816694","https://openalex.org/W4386250989","https://openalex.org/W4387827280","https://openalex.org/W4389055788","https://openalex.org/W4390824530","https://openalex.org/W4391445148","https://openalex.org/W4391542350","https://openalex.org/W4391807089","https://openalex.org/W4392166752","https://openalex.org/W4393379555","https://openalex.org/W4393944012","https://openalex.org/W4394575197","https://openalex.org/W4394604893","https://openalex.org/W4394611002","https://openalex.org/W4394642169","https://openalex.org/W4399360679","https://openalex.org/W4399458355","https://openalex.org/W4400224948","https://openalex.org/W4400351083","https://openalex.org/W4400571800","https://openalex.org/W4401201359","https://openalex.org/W4401362468","https://openalex.org/W4401389100","https://openalex.org/W4402079398","https://openalex.org/W4402690044","https://openalex.org/W4403145339","https://openalex.org/W4403230319","https://openalex.org/W4403305183","https://openalex.org/W4403429007","https://openalex.org/W4403666052","https://openalex.org/W4405492114","https://openalex.org/W4406960802","https://openalex.org/W4406983784","https://openalex.org/W4407131785","https://openalex.org/W4408161720","https://openalex.org/W4408612284","https://openalex.org/W4408725550","https://openalex.org/W4409138300","https://openalex.org/W4409183588","https://openalex.org/W4410826000","https://openalex.org/W4411176475","https://openalex.org/W4411706479","https://openalex.org/W4412640274","https://openalex.org/W4413307414","https://openalex.org/W4414261984","https://openalex.org/W4414406561","https://openalex.org/W7118562365"],"related_works":["https://openalex.org/W7164123847","https://openalex.org/W7160186191","https://openalex.org/W4408308851","https://openalex.org/W4416169509","https://openalex.org/W4200350756","https://openalex.org/W4214729612","https://openalex.org/W4403305183","https://openalex.org/W7160047547","https://openalex.org/W7203820581","https://openalex.org/W3111212010"],"abstract_inverted_index":{"Intestinal":[0],"barrier":[1,49,56,100,127,132,155],"damage":[2],"is":[3],"a":[4,11,149],"pivotal":[5],"mediator":[6],"of":[7,24,55,61,74,90],"gut-organ":[8],"crosstalk":[9],"and":[10,35,41,51,65,71,81,96,105,123,136,157],"key":[12],"contributor":[13],"to":[14],"systemic":[15,69],"disease.":[16],"This":[17,146],"review":[18,147],"systematically":[19],"summarizes":[20],"the":[21,25,29,36,59,72,87,120],"structural":[22],"organization":[23],"intestinal":[26,48,154],"barrier,":[27],"including":[28,77],"mucus":[30],"layer,":[31],"epithelial":[32],"tight":[33],"junctions,":[34],"lamina":[37],"propria":[38],"immune":[39,52,93],"network,":[40],"highlights":[42],"their":[43],"coordinated":[44],"roles":[45,89],"in":[46,99,103],"regulating":[47],"dysfunction":[50],"homeostasis.":[53],"Disruption":[54],"integrity":[57],"facilitates":[58],"translocation":[60],"microbial":[62],"products,":[63],"cytokines,":[64],"metabolites,":[66],"thereby":[67],"promoting":[68],"inflammation":[70],"pathogenesis":[73],"multi-organ":[75],"diseases,":[76],"liver":[78],"injury,":[79],"pancreatitis,":[80],"cardiovascular":[82],"disorders.":[83],"Emerging":[84],"evidence":[85],"underscores":[86],"critical":[88],"gut":[91],"microbiota,":[92],"signaling":[94],"pathways,":[95],"metabolic":[97],"factors":[98],"regulation.":[101],"Advances":[102],"single-cell":[104],"spatial":[106],"omics,":[107],"together":[108],"with":[109],"artificial":[110],"intelligence":[111],"(AI)-driven":[112],"multi-omics":[113],"integration,":[114],"are":[115],"providing":[116],"novel":[117],"insights":[118],"into":[119],"cellular":[121],"heterogeneity":[122],"molecular":[124],"mechanisms":[125],"underlying":[126],"dysfunction.":[128],"Therapeutic":[129],"strategies":[130],"targeting":[131],"restoration-including":[133],"microbiota-based":[134],"interventions":[135],"pharmacological":[137],"approaches-show":[138],"promising":[139],"potential":[140],"but":[141],"require":[142],"further":[143],"clinical":[144],"validation.":[145],"provides":[148],"comprehensive":[150],"framework":[151],"for":[152],"understanding":[153],"biology":[156],"its":[158],"translational":[159],"relevance.":[160]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-22T00:00:00"}