{"id":"https://openalex.org/W7223097151","doi":"https://doi.org/10.1016/j.htct.2026.107557","title":"APRESENTA\u00c7\u00c3O AT\u00cdPICA E O DESAFIO DO MANEJO DE LLA B PH LIKE (CRLF2+) + IKAROS (IKZF1DEL)","display_name":"APRESENTA\u00c7\u00c3O AT\u00cdPICA E O DESAFIO DO MANEJO DE LLA B PH LIKE (CRLF2+) + IKAROS (IKZF1DEL)","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223097151","doi":"https://doi.org/10.1016/j.htct.2026.107557"},"language":"en","primary_location":{"id":"doi:10.1016/j.htct.2026.107557","doi":"https://doi.org/10.1016/j.htct.2026.107557","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107557","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926013040/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciencedirect.com/science/article/pii/S2531137926013040/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159219491","display_name":"L\u00edvia Beatriz SOARES MONTEIRO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L\u00edvia Beatriz SOARES MONTEIRO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159172822","display_name":"Eduardo Marchon Le\u00e3o Burlamaqui CAMPOS","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eduardo MARCHON LE\u00c3O BURLAMAQUI CAMPOS","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159163090","display_name":"Maria Fernanda ROSA DEZAN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Fernanda ROSA DEZAN","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159199178","display_name":"Gabriele RITTER FELIPE","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriele RITTER FELIPE","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159201868","display_name":"Lucas DA SILVA LOPES","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucas DA SILVA LOPES","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159191948","display_name":"Rafael Augusto FAUST MACHADO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rafael Augusto FAUST MACHADO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159206317","display_name":"Lucas SALVIANO DE ABREU","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucas SALVIANO DE ABREU","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159164759","display_name":"Paula CIVIDANES RIBEIRO CABRAL","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paula CIVIDANES RIBEIRO CABRAL","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120973409","display_name":"Maria Carolina Rebou\u00e7as de Azevedo Marques","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Carolina REBOU\u00c7AS DE AZEVEDO MARQUES","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159188136","display_name":"Luiza PIRES MIRANDA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luiza PIRES MIRANDA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159187926","display_name":"Israelita Tihara DE ALMEIDA SUSSUARANA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Israelita Tihara DE ALMEIDA SUSSUARANA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159212419","display_name":"Karine VICENZI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Karine VICENZI","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, SP, Brasil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159168573","display_name":"Pedro Henrique ARRUDA DE MORAES","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pedro Henrique ARRUDA DE MORAES","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159184767","display_name":"Fernanda SANTOS AZEVEDO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fernanda SANTOS AZEVEDO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159211931","display_name":"Roberta SHCOLNIK SZOR","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberta SHCOLNIK SZOR","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027759912","display_name":"Luana Pompeu dos Santos Rocha","orcid":"https://orcid.org/0000-0002-5864-973X","observed_orcids":["https://orcid.org/0000-0002-5864-973X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luana POMPEU DOS SANTOS ROCHA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159208018","display_name":"Vin\u00edcius CAMPOS DE MOLLA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vin\u00edcius CAMPOS DE MOLLA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159169899","display_name":"Cain\u00e3 DABBOUS DE LIZ","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cain\u00e3 DABBOUS DE LIZ","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5159174571","display_name":"Celso ARRAIS RODRIGUES","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Celso ARRAIS RODRIGUES","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.77979112,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":null,"first_page":"107557","last_page":"107557"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-acute-lymphoblastic-leukemia","display_name":"B-cell acute lymphoblastic leukemia","score":0.7549999952316284},{"id":"https://openalex.org/keywords/ikzf1-deletion","display_name":"IKZF1 deletion","score":0.8410000205039978},{"id":"https://openalex.org/keywords/crlf2","display_name":"CRLF2","score":0.531000018119812},{"id":"https://openalex.org/keywords/bcr-abl1-negative","display_name":"BCR-ABL1-negative","score":0.5289999842643738},{"id":"https://openalex.org/keywords/bone-lesions","display_name":"bone lesions","score":0.30300000309944153},{"id":"https://openalex.org/keywords/osteoclast-activation","display_name":"osteoclast activation","score":0.703000009059906},{"id":"https://openalex.org/keywords/parathyroid-hormone-related-protein","display_name":"parathyroid hormone-related protein","score":0.8830000162124634},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.7310000061988831},{"id":"https://openalex.org/keywords/dasatinib","display_name":"dasatinib","score":0.5419999957084656},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8528000116348267},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.3849000036716461},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.18539999425411224},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.16830000281333923},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.1624000072479248},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.16019999980926514},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.15629999339580536},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.14920000731945038},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.13809999823570251},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.12070000171661377}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.htct.2026.107557","doi":"https://doi.org/10.1016/j.htct.2026.107557","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107557","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926013040/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:abedc48954874095832ca01658244a90","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/abedc48954874095832ca01658244a90","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 48, Iss , Pp 107557- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.htct.2026.107557","doi":"https://doi.org/10.1016/j.htct.2026.107557","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.107557","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926013040/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223097151.pdf","grobid_xml":"https://content.openalex.org/works/W7223097151.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387748315","https://openalex.org/W4415669389","https://openalex.org/W7120639404","https://openalex.org/W3096372457","https://openalex.org/W4403568719","https://openalex.org/W4307942656","https://openalex.org/W7198548370","https://openalex.org/W4387747967","https://openalex.org/W7125645621","https://openalex.org/W4296750019"],"abstract_inverted_index":{"Introdu\u00e7\u00e3o":[0],"A":[1],"Leucemia":[2,229],"Linfobl\u00e1stica":[3,230],"Aguda":[4],"B":[5,231],"(LLA-B)":[6],"Philadelphia-like,":[7],"com":[8,24,53,72,90,173,199,215,234,280,322,343,351,383,390],"alta":[9],"frequ\u00eancia":[10],"de":[11,35,41,45,49,56,68,77,79,97,107,110,122,131,168,175,189,201,217,224,226,265,289,315,341,345,353,361,421,450,459,463],"altera\u00e7\u00e3o":[12],"no":[13,100,141,270,298,307,309,326,397,431],"gene":[14],"IKZF1":[15],"(70-80%),":[16],"\u00e9":[17,442],"um":[18,87,425],"subtipo":[19],"cl\u00ednica":[20,158],"e":[21,81,93,124,128,197,236,245,255,285,365,394,454],"biologicamente":[22],"heterog\u00eaneo,":[23],"preval\u00eancia":[25],"em":[26,32,74,263,403,410],"20":[27],"a":[28,66,105,318,356,418,448,452],"24%":[29],"dos":[30],"casos":[31],"adultos":[33],"acima":[34],"40":[36],"anos,":[37,194],"apresentando":[38,313],"alto":[39],"potencial":[40],"morbimortalidade":[42],"neste":[43],"perfil":[44,48,55,144,420],"pacientes.":[46],"Este":[47],"doen\u00e7a":[50,146,406,438],"apresenta":[51],"semelhan\u00e7a":[52],"o":[54,84,112,129,379,408,434],"express\u00e3o":[57],"g\u00eanica":[58],"da":[59,102,145,181,220,274,311,338,367,399,405],"LLA":[60],"Ph":[61],"positiva,":[62],"mas":[63],"n\u00e3o":[64,381],"expressa":[65],"prote\u00edna":[67],"fus\u00e3o":[69],"BCR-ABL1":[70,240],"t(9;22),":[71],"rearranjos":[73],"v\u00e1rias":[75],"classes":[76],"receptores":[78],"citocinas":[80],"tirosina":[82],"quinases,":[83,111],"que":[85,207],"confere":[86],"pior":[88],"progn\u00f3stico":[89],"quimioterapia":[91],"convencional":[92],"uma":[94,156],"maior":[95],"incid\u00eancia":[96],"DRM":[98,306,374,395],"positiva":[99,396],"fim":[101,398,449],"indu\u00e7\u00e3o.":[103,400],"Com":[104],"variedade":[106],"les\u00f5es":[108,151,294,456],"ativadoras":[109],"surgimento":[113],"das":[114,282],"terapias":[115],"alvos,":[116],"anticorpos":[117],"biespec\u00edficos,":[118],"possibilitam":[119],"melhores":[120],"taxas":[121],"respostas":[123],"menores":[125],"toxicidades":[126],"associadas,":[127],"transplante":[130],"c\u00e9lulas-tronco":[132],"hematopoi\u00e9ticas":[133],"(TCTH)":[134],"alog\u00eanico":[135],"permanece":[136],"como":[137,140],"terapia":[138,453],"padr\u00e3o":[139],"caso":[142,190],"do":[143,250,276,324,336,363,371,388],"citada":[147],"acima.":[148],"Al\u00e9m":[149],"disso,":[150],"l\u00edticas":[152,296],"\u00f3sseas":[153,295],"assintom\u00e1ticas":[154],"s\u00e3o":[155],"manifesta\u00e7\u00e3o":[157],"raramente":[159],"evidenciada,":[160],"cuja":[161],"fisiopatologia":[162],"pode":[163],"ser":[164],"explicada":[165],"pela":[166],"ativa\u00e7\u00e3o":[167],"osteoclastos":[169],"induzida":[170],"por":[171,328,348,446],"linfoblastos,":[172],"secre\u00e7\u00e3o":[174],"PTHrP":[176],"(prote\u00edna":[177],"relacionada":[178,332],"ao":[179,259],"horm\u00f4nio":[180],"paratireoide),":[182],"fen\u00f4meno":[183],"mais":[184],"descrito":[185],"in":[186],"vitro.":[187],"Relato":[188],"Paciente":[191],"masculino,":[192],"47":[193],"previamente":[195],"hipertenso":[196],"dislipid\u00eamico,":[198],"relato":[200],"pet\u00e9quias":[202],"difusas,":[203],"sendo":[204,376],"realizado":[205],"hemograma":[206],"evidenciou":[208],"anemia":[209],"(Hb:":[210],"8,8":[211],"g/dL),":[212],"leucocitose":[213],"(14.290/mm\u00b3),":[214],"40%":[216],"blastos.":[218],"Imunofenotipagem":[219],"medula":[221],"\u00f3ssea":[222,268],"(IMF-MO)":[223],"julho":[225],"2025":[227],"evidenciando":[228],"(LLA":[232],"pr\u00f3-B),":[233],"cari\u00f3tipo":[235],"FISH":[237],"sem":[238,248,256],"altera\u00e7\u00f5es,":[239],"negativo,":[241],"Painel":[242],"NGS:":[243],"CRLF2+":[244],"Del":[246],"IKZF1,":[247],"infiltra\u00e7\u00e3o":[249],"sistema":[251],"nervoso":[252],"central":[253],"(SNC)":[254],"massa":[257],"bulky":[258],"diagn\u00f3stico,":[260],"por\u00e9m":[261,321],"evidenciado":[262],"tomografia":[264,288],"cr\u00e2nio":[266],"les\u00e3o":[267],"l\u00edtica":[269],"aspecto":[271],"posterior":[272],"paramediano":[273],"d\u00edploe":[275],"osso":[277],"parietal":[278],"direito,":[279],"rotura":[281],"corticais":[283],"interna":[284],"externa.":[286],"Na":[287],"coluna":[290],"total,":[291],"foram":[292],"evidenciadas":[293],"esparsas":[297],"esqueleto":[299],"axial.":[300],"Iniciado":[301],"protocolo":[302,325],"ECOG-ACRIN":[303],"1910.":[304],"Realizado":[305],"D27":[308],"C1":[310],"indu\u00e7\u00e3o,":[312],"34,4%":[314],"blastos;":[316],"procedida":[317],"indu\u00e7\u00e3o":[319],"C2,":[320],"suspens\u00e3o":[323],"D3C2":[327],"toxicidade":[329],"hep\u00e1tica":[330],"provavelmente":[331],"\u00e0":[333,437],"mercaptopurina.":[334],"Diante":[335],"resultado":[337],"nova":[339],"imunofenotipagem":[340],"DRM,":[342],"1%":[344],"blastos,":[346],"optou-se":[347],"iniciar":[349],"blinatumumabe,":[350],"necessidade":[352],"interrup\u00e7\u00e3o":[354],"devido":[355],"CRS":[357],"grau":[358],"III,":[359],"seguida":[360],"resolu\u00e7\u00e3o":[362],"quadro":[364,426],"retorno":[366],"terapia.":[368],"Ao":[369],"final":[370],"tratamento,":[372,460],"apresentou":[373],"negativa,":[375],"conduzido":[377],"para":[378,428,466],"TCTH":[380],"aparentado,":[382],"condicionamento":[384],"mieloablativo":[385],"FluBu3,":[386],"diante":[387],"diagn\u00f3stico":[389],"biologia":[391],"molecular":[392],"desfavor\u00e1vel":[393],"Atualmente":[401],"encontra-se":[402],"remiss\u00e3o":[404],"at\u00e9":[407],"momento,":[409],"seguimento":[411],"ambulatorial.":[412],"Conclus\u00e3o":[413],"As":[414],"altera\u00e7\u00f5es":[415],"gen\u00e9ticas":[416,457],"associadas":[417],"este":[419],"doen\u00e7a,":[422],"LLA-B,":[423],"representam":[424],"desafiador":[427],"os":[429],"hematologistas,":[430],"qual":[432],"atualmente":[433],"tratamento":[435],"direcionado":[436],"residual":[439],"m\u00ednima":[440],"(DRM)":[441],"fundamental,":[443],"via":[444],"NGS,":[445],"exemplo,":[447],"direcionar":[451],"rastrear":[455],"pass\u00edveis":[458],"ainda":[461],"necessitando":[462],"estudos":[464],"prospectivos":[465],"avaliar":[467],"potenciais":[468],"inibidores":[469],"dessas":[470],"quinases.":[471]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}