{"id":"https://openalex.org/W7223096836","doi":"https://doi.org/10.1016/j.htct.2026.106769","title":"ASPERGILOSE INVASIVA RINOFACIAL EM PACIENTE COM LEUCEMIA LINFOC\u00cdTICA CR\u00d4NICA REFRAT\u00c1RIA: RELATO DE CASO E DESAFIO DIAGN\u00d3STICO-TERAP\u00caUTICO","display_name":"ASPERGILOSE INVASIVA RINOFACIAL EM PACIENTE COM LEUCEMIA LINFOC\u00cdTICA CR\u00d4NICA REFRAT\u00c1RIA: RELATO DE CASO E DESAFIO DIAGN\u00d3STICO-TERAP\u00caUTICO","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223096836","doi":"https://doi.org/10.1016/j.htct.2026.106769"},"language":"en","primary_location":{"id":"doi:10.1016/j.htct.2026.106769","doi":"https://doi.org/10.1016/j.htct.2026.106769","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.106769","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1016/j.htct.2026.106769","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5143880670","display_name":"Agatha Aline Hofmann","orcid":"https://orcid.org/0009-0000-6331-3096","observed_orcids":["https://orcid.org/0009-0000-6331-3096"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agatha Aline HOFMANN","raw_affiliation_strings":["Funda\u00e7\u00e3o Hospitalar Santa Terezinha de Erechim (FHSTE), Erechim, RS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Funda\u00e7\u00e3o Hospitalar Santa Terezinha de Erechim (FHSTE), Erechim, RS, Brasil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147283494","display_name":"Lucas Maciel Dal Pr\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucas Maciel DAL PRA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159172600","display_name":"Laura Skomra PEZZINI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149719","display_name":"Universidade Regional Integrada do Alto Uruguai e das Miss\u00f5es","ror":"https://ror.org/05bnh4739","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210149719"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Laura Skomra PEZZINI","raw_affiliation_strings":["Universidade Regional Integrada do Alto Uruguai e das Miss\u00f5es (URI), Erechim, RS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Regional Integrada do Alto Uruguai e das Miss\u00f5es (URI), Erechim, RS, Brasil","institution_ids":["https://openalex.org/I4210149719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019980674","display_name":"Carolina Fusinato Molin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carolina Fusinato MOLIN","raw_affiliation_strings":["Funda\u00e7\u00e3o Hospitalar Santa Terezinha de Erechim (FHSTE), Erechim, RS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Funda\u00e7\u00e3o Hospitalar Santa Terezinha de Erechim (FHSTE), Erechim, RS, Brasil","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5129124244","display_name":"Luiza Trevisan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149719","display_name":"Universidade Regional Integrada do Alto Uruguai e das Miss\u00f5es","ror":"https://ror.org/05bnh4739","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210149719"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luiza TREVISAN","raw_affiliation_strings":["Universidade Regional Integrada do Alto Uruguai e das Miss\u00f5es (URI), Erechim, RS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Regional Integrada do Alto Uruguai e das Miss\u00f5es (URI), Erechim, RS, Brasil","institution_ids":["https://openalex.org/I4210149719"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.8048737,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":null,"first_page":"106769","last_page":"106769"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12297","display_name":"Otolaryngology and Infectious Diseases","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/invasive-aspergillosis","display_name":"invasive aspergillosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/refractory-leukemia","display_name":"refractory leukemia","score":0.75},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7670000195503235},{"id":"https://openalex.org/keywords/acalabrutinib","display_name":"acalabrutinib","score":0.8130000233650208},{"id":"https://openalex.org/keywords/voriconazole","display_name":"voriconazole","score":0.6330000162124634},{"id":"https://openalex.org/keywords/amphotericin-b","display_name":"amphotericin B","score":0.9789999723434448},{"id":"https://openalex.org/keywords/maxillary-antrostomy","display_name":"maxillary antrostomy","score":0.7419999837875366},{"id":"https://openalex.org/keywords/surgical-debridement","display_name":"surgical debridement","score":0.7739999890327454},{"id":"https://openalex.org/keywords/opportunistic-fungal-infection","display_name":"opportunistic fungal infection","score":0.6439999938011169},{"id":"https://openalex.org/keywords/proptosis","display_name":"proptosis","score":0.6129999756813049},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9857000112533569},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4413999915122986},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.23579999804496765},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22529999911785126},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.22050000727176666},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.20250000059604645},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.19539999961853027},{"id":"https://openalex.org/C2989236134","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Patient care","level":2,"score":0.14890000224113464},{"id":"https://openalex.org/C2994186709","wikidata":"https://www.wikidata.org/wiki/Q29483","display_name":"Palliative care","level":2,"score":0.1462000012397766},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.13899999856948853}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.htct.2026.106769","doi":"https://doi.org/10.1016/j.htct.2026.106769","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.106769","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:a02440640af645e293c42666102733d4","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a02440640af645e293c42666102733d4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 48, Iss , Pp 106769- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.htct.2026.106769","doi":"https://doi.org/10.1016/j.htct.2026.106769","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.106769","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403569132","https://openalex.org/W7223086406","https://openalex.org/W2107190258","https://openalex.org/W2165339362","https://openalex.org/W2325809124","https://openalex.org/W7063928100","https://openalex.org/W4399108845","https://openalex.org/W2571258374","https://openalex.org/W2319109976","https://openalex.org/W2316231710"],"abstract_inverted_index":{"Introdu\u00e7\u00e3o":[0],"A":[1,163,254],"aspergilose":[2,80,255,346],"invasiva":[3,81,256,347],"\u00e9":[4,328],"uma":[5],"importante":[6],"causa":[7],"de":[8,18,28,60,67,73,79,97,173,218,227,289,294,356,359,362,385],"morbimortalidade":[9],"em":[10,83,135,348,366],"pacientes":[11,349],"com":[12,46,85,105,110,124,130,143,195,204,350],"neoplasias":[13],"hematol\u00f3gicas,":[14],"especialmente":[15],"na":[16,158,308],"presen\u00e7a":[17],"imunossupress\u00e3o":[19],"prolongada.":[20],"Embora":[21],"o":[22,25,71,140,249,287,331],"pulm\u00e3o":[23],"seja":[24],"principal":[26],"s\u00edtio":[27],"acometimento,":[29],"apresenta\u00e7\u00f5es":[30,395],"rinossinusais":[31],"e":[32,36,42,57,69,92,113,132,148,154,156,184,198,236,270,286,313,322,352,372],"cut\u00e2neas":[33],"s\u00e3o":[34,379],"incomuns":[35],"frequentemente":[37],"associadas":[38],"\u00e0":[39,55,169,192,225,279,284],"r\u00e1pida":[40,271,375],"progress\u00e3o":[41,119,144,212,231],"elevada":[43,343,393],"letalidade.":[44],"Pacientes":[45],"leucemia":[47],"linfoc\u00edtica":[48],"cr\u00f4nica":[49],"(LLC)":[50],"apresentam":[51],"disfun\u00e7\u00e3o":[52],"imunol\u00f3gica":[53],"inerente":[54],"doen\u00e7a":[56],"risco":[58],"adicional":[59],"infec\u00e7\u00f5es":[61,301],"oportunistas,":[62],"particularmente":[63],"ap\u00f3s":[64,248],"m\u00faltiplas":[65],"linhas":[66],"tratamento":[68,123,319,377],"durante":[70],"uso":[72,288],"terapias-alvo.":[74],"Objetivo":[75],"Relatar":[76],"um":[77],"caso":[78,98],"rinofacial":[82,257],"paciente":[84,242],"LLC":[86,106,351],"refrat\u00e1ria,":[87],"enfatizando":[88],"os":[89],"desafios":[90],"diagn\u00f3sticos":[91],"terap\u00eauticos":[93],"dessa":[94],"complica\u00e7\u00e3o.":[95],"Relato":[96],"Paciente":[99,202],"do":[100,238,376],"sexo":[101],"masculino,":[102],"53":[103],"anos,":[104],"refrat\u00e1ria":[107],"previamente":[108],"tratada":[109],"fludarabina,":[111],"ciclofosfamida":[112],"rituximabe":[114],"(FCR),":[115],"foi":[116],"internado":[117],"por":[118,265,315],"da":[120,161,207,213,216,232,251,291,345,387],"doen\u00e7a,":[121,280],"iniciando":[122],"acalabrutinibe.":[125],"Durante":[126],"a":[127,185,211,244,276,281,298,300,342,354,373,390],"interna\u00e7\u00e3o,":[128],"evoluiu":[129,243],"febre":[131],"les\u00e3o":[133],"dolorosa":[134],"hemiface":[136],"direita,":[137],"inicialmente":[138],"envolvendo":[139],"seio":[141],"maxilar,":[142],"para":[145,381],"cavidade":[146],"oral":[147],"\u00f3rbita.":[149],"Ao":[150],"exame,":[151],"apresentava":[152],"edema":[153],"hiperemia":[155],"necrose":[157,268],"regi\u00e3o":[159],"central":[160],"les\u00e3o.":[162],"videonasofibroscopia":[164],"evidenciou":[165],"crostas":[166],"enegrecidas":[167],"aderidas":[168],"mucosa":[170],"nasal,":[171],"sugestivas":[172],"infec\u00e7\u00e3o":[174],"f\u00fangica":[175],"invasiva.":[176],"O":[177,241,304,369],"exame":[178],"micol\u00f3gico":[179],"direto":[180],"demonstrou":[181],"fungo":[182],"filamentoso":[183],"cultura":[186],"confirmou":[187],"Aspergillus":[188],"spp.":[189],"Foi":[190],"submetido":[191],"antrostomia":[193],"maxilar":[194],"debridamento":[196,324],"cir\u00fargico":[197,325],"iniciado":[199],"voriconazol":[200],"intravenoso.":[201],"progrediu":[203],"proptose,":[205],"redu\u00e7\u00e3o":[206],"motilidade":[208],"ocular":[209],"associado":[210,317],"infec\u00e7\u00e3o,":[214,388],"diante":[215,361],"aus\u00eancia":[217],"resposta":[219],"cl\u00ednica,":[220,310],"instituiu-se":[221],"anfotericina":[222],"B,":[223],"associada":[224],"antibioticoterapia":[226],"amplo":[228],"espectro,":[229],"mantendo":[230],"necrose,":[233],"acometimento":[234],"\u00f3sseo":[235],"perda":[237],"globo":[239],"ocular.":[240],"\u00f3bito":[245],"dois":[246],"meses":[247],"diagn\u00f3stico":[250,305],"infec\u00e7\u00e3o.":[252],"Discuss\u00e3o":[253],"representa":[258],"manifesta\u00e7\u00e3o":[259],"rara,":[260],"por\u00e9m":[261],"altamente":[262],"agressiva,":[263],"caracterizada":[264],"invas\u00e3o":[266],"vascular,":[267],"tecidual":[269],"dissemina\u00e7\u00e3o":[272],"local.":[273],"Na":[274],"LLC,":[275],"imunodefici\u00eancia":[277],"relacionada":[278],"exposi\u00e7\u00e3o":[282],"pr\u00e9via":[283],"quimioimunoterapia":[285],"inibidores":[290],"tirosina":[292],"quinase":[293],"Bruton":[295],"podem":[296],"aumentar":[297,382],"suscetibilidade":[299],"f\u00fangicas":[302],"invasivas.":[303],"precoce,":[306],"baseado":[307],"suspei\u00e7\u00e3o":[309,360],"confirma\u00e7\u00e3o":[311],"microbiol\u00f3gica":[312],"avalia\u00e7\u00e3o":[314],"imagem,":[316],"ao":[318,323],"antif\u00fangico":[320],"imediato":[321],"quando":[326],"indicado,":[327],"fundamental,":[329],"embora":[330,389],"progn\u00f3stico":[332],"permane\u00e7a":[333,392],"reservado":[334],"nos":[335],"casos":[336],"avan\u00e7ados.":[337],"Conclus\u00e3o":[338],"Este":[339],"relato":[340],"evidencia":[341],"gravidade":[344],"refor\u00e7a":[353],"necessidade":[355],"alto":[357],"grau":[358],"les\u00f5es":[363],"rinofaciais":[364],"necr\u00f3ticas":[365],"indiv\u00edduos":[367],"imunocomprometidos.":[368],"reconhecimento":[370],"precoce":[371],"institui\u00e7\u00e3o":[374],"multidisciplinar":[378],"essenciais":[380],"as":[383],"chances":[384],"controle":[386],"mortalidade":[391],"nas":[394],"extensas.":[396]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}
