{"id":"https://openalex.org/W7223093554","doi":"https://doi.org/10.1016/j.htct.2026.106565","title":"DIAGN\u00d3STICO INCIDENTAL DE HEMOGLOBIN\u00daRIA PAROX\u00cdSTICA NOTURNA EM PACIENTE JOVEM: RELATO DE CASO EM TRATAMENTO DE ECULIZUMABE","display_name":"DIAGN\u00d3STICO INCIDENTAL DE HEMOGLOBIN\u00daRIA PAROX\u00cdSTICA NOTURNA EM PACIENTE JOVEM: RELATO DE CASO EM TRATAMENTO DE ECULIZUMABE","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223093554","doi":"https://doi.org/10.1016/j.htct.2026.106565"},"language":"en","primary_location":{"id":"doi:10.1016/j.htct.2026.106565","doi":"https://doi.org/10.1016/j.htct.2026.106565","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.106565","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926003123/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciencedirect.com/science/article/pii/S2531137926003123/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5099435387","display_name":"FERNANDA NYARI ZBOROWSKI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16371252","display_name":"Universidade de Passo Fundo","ror":"https://ror.org/01cwd8p12","country_code":"BR","type":"education","lineage":["https://openalex.org/I16371252"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fernanda Nyari ZBOROWSKI","raw_affiliation_strings":["Universidade de Passo Fundo (UPF), Faculdade de Medicina, Passo Fundo, RS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de Passo Fundo (UPF), Faculdade de Medicina, Passo Fundo, RS, Brasil","institution_ids":["https://openalex.org/I16371252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159174248","display_name":"Izadora Luiza KUNLZER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16371252","display_name":"Universidade de Passo Fundo","ror":"https://ror.org/01cwd8p12","country_code":"BR","type":"education","lineage":["https://openalex.org/I16371252"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Izadora Luiza KUNLZER","raw_affiliation_strings":["Universidade de Passo Fundo (UPF), Faculdade de Medicina, Passo Fundo, RS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de Passo Fundo (UPF), Faculdade de Medicina, Passo Fundo, RS, Brasil","institution_ids":["https://openalex.org/I16371252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111172864","display_name":"Denise Ramos de Almeida","orcid":"https://orcid.org/0000-0003-3844-155X","observed_orcids":["https://orcid.org/0000-0003-3844-155X"]},"institutions":[{"id":"https://openalex.org/I16371252","display_name":"Universidade de Passo Fundo","ror":"https://ror.org/01cwd8p12","country_code":"BR","type":"education","lineage":["https://openalex.org/I16371252"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Denise Ramos de ALMEIDA","raw_affiliation_strings":["Universidade de Passo Fundo (UPF), Faculdade de Medicina, Passo Fundo, RS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de Passo Fundo (UPF), Faculdade de Medicina, Passo Fundo, RS, Brasil","institution_ids":["https://openalex.org/I16371252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033819363","display_name":"Luciano de Oliveira Siqueira","orcid":"https://orcid.org/0000-0002-0415-2226","observed_orcids":["https://orcid.org/0000-0002-0415-2226"]},"institutions":[{"id":"https://openalex.org/I16371252","display_name":"Universidade de Passo Fundo","ror":"https://ror.org/01cwd8p12","country_code":"BR","type":"education","lineage":["https://openalex.org/I16371252"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luciano De Oliveira SIQUEIRA","raw_affiliation_strings":["Universidade de Passo Fundo (UPF), Faculdade de Medicina, Passo Fundo, RS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de Passo Fundo (UPF), Faculdade de Medicina, Passo Fundo, RS, Brasil","institution_ids":["https://openalex.org/I16371252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113075480","display_name":"Bruna Accorsi Machado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111429","display_name":"Hospital S\u00e3o Vicente de Paulo","ror":"https://ror.org/01pmf1z12","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210111429"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bruna Accorsi MACHADO","raw_affiliation_strings":["Hospital S\u00e3o Vicente de Paulo (HSVP), Servi\u00e7o de Hemoterapia, Passo Fundo, RS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital S\u00e3o Vicente de Paulo (HSVP), Servi\u00e7o de Hemoterapia, Passo Fundo, RS, Brasil","institution_ids":["https://openalex.org/I4210111429"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025997893","display_name":"Jaqueline Sold\u00e1 Palaoro","orcid":"https://orcid.org/0000-0001-9642-4518","observed_orcids":["https://orcid.org/0000-0001-9642-4518"]},"institutions":[{"id":"https://openalex.org/I4210111429","display_name":"Hospital S\u00e3o Vicente de Paulo","ror":"https://ror.org/01pmf1z12","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210111429"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jaqueline Sold\u00e1 PALAORO","raw_affiliation_strings":["Hospital S\u00e3o Vicente de Paulo (HSVP), Servi\u00e7o de Hemoterapia, Passo Fundo, RS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital S\u00e3o Vicente de Paulo (HSVP), Servi\u00e7o de Hemoterapia, Passo Fundo, RS, Brasil","institution_ids":["https://openalex.org/I4210111429"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159206350","display_name":"Luiz Ot\u00e1vio Felin SANTI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16371252","display_name":"Universidade de Passo Fundo","ror":"https://ror.org/01cwd8p12","country_code":"BR","type":"education","lineage":["https://openalex.org/I16371252"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luiz Ot\u00e1vio Felin SANTI","raw_affiliation_strings":["Universidade de Passo Fundo (UPF), Faculdade de Medicina, Passo Fundo, RS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de Passo Fundo (UPF), Faculdade de Medicina, Passo Fundo, RS, Brasil","institution_ids":["https://openalex.org/I16371252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119114867","display_name":"MAURICIO RAMOS BOFF","orcid":"https://orcid.org/0009-0005-1037-5708","observed_orcids":["https://orcid.org/0009-0005-1037-5708"]},"institutions":[{"id":"https://openalex.org/I16371252","display_name":"Universidade de Passo Fundo","ror":"https://ror.org/01cwd8p12","country_code":"BR","type":"education","lineage":["https://openalex.org/I16371252"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mauricio Ramos BOFF","raw_affiliation_strings":["Universidade de Passo Fundo (UPF), Faculdade de Medicina, Passo Fundo, RS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de Passo Fundo (UPF), Faculdade de Medicina, Passo Fundo, RS, Brasil","institution_ids":["https://openalex.org/I16371252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077773607","display_name":"Cristiane da Silva Rodrigues de Ara\u00fajo","orcid":"https://orcid.org/0000-0002-0771-6234","observed_orcids":["https://orcid.org/0000-0002-0771-6234","https://orcid.org/0000-0003-4935-7505"]},"institutions":[{"id":"https://openalex.org/I16371252","display_name":"Universidade de Passo Fundo","ror":"https://ror.org/01cwd8p12","country_code":"BR","type":"education","lineage":["https://openalex.org/I16371252"]},{"id":"https://openalex.org/I4210111429","display_name":"Hospital S\u00e3o Vicente de Paulo","ror":"https://ror.org/01pmf1z12","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210111429"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Cristiane Da Silva Rodrigues de ARA\u00daJO","raw_affiliation_strings":["Hospital S\u00e3o Vicente de Paulo (HSVP), Servi\u00e7o de Hemoterapia; Universidade de Passo Fundo (UPF) Faculdade de Medicina, Passo Fundo, RS, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital S\u00e3o Vicente de Paulo (HSVP), Servi\u00e7o de Hemoterapia; Universidade de Passo Fundo (UPF) Faculdade de Medicina, Passo Fundo, RS, Brasil","institution_ids":["https://openalex.org/I16371252","https://openalex.org/I4210111429"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73275992,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":null,"first_page":"106565","last_page":"106565"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pig-a-mutation","display_name":"PIG-A mutation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/eculizumab","display_name":"eculizumab","score":0.9110000133514404},{"id":"https://openalex.org/keywords/complement-dysregulation","display_name":"complement dysregulation","score":0.5239999890327454},{"id":"https://openalex.org/keywords/cd55","display_name":"CD55","score":0.6869999766349792},{"id":"https://openalex.org/keywords/cd59","display_name":"CD59","score":0.9980000257492065},{"id":"https://openalex.org/keywords/intravascular-hemolysis","display_name":"intravascular hemolysis","score":0.753000020980835},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.453000009059906},{"id":"https://openalex.org/keywords/reticulocytosis","display_name":"reticulocytosis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/flow-cytometry-diagnosis","display_name":"flow cytometry diagnosis","score":0.5730000138282776},{"id":"https://openalex.org/keywords/incidental-diagnosis","display_name":"incidental diagnosis","score":0.5770000219345093},{"id":"https://openalex.org/keywords/young-adults","display_name":"young adults","score":0.3970000147819519},{"id":"https://openalex.org/keywords/iron-deficiency","display_name":"iron deficiency","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9781000018119812},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.31700000166893005},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3160000145435333},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.24420000612735748},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.22540000081062317},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.17730000615119934},{"id":"https://openalex.org/C529618451","wikidata":"https://www.wikidata.org/wiki/Q234904","display_name":"Ultrasonography","level":2,"score":0.13459999859333038},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1339000016450882},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.12399999797344208},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.12110000103712082}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.htct.2026.106565","doi":"https://doi.org/10.1016/j.htct.2026.106565","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.106565","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926003123/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:e5d83f47d426462082f760ca3ac487ac","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e5d83f47d426462082f760ca3ac487ac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 48, Iss , Pp 106565- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.htct.2026.106565","doi":"https://doi.org/10.1016/j.htct.2026.106565","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.106565","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926003123/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223093554.pdf","grobid_xml":"https://content.openalex.org/works/W7223093554.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387748904","https://openalex.org/W2966948591","https://openalex.org/W7223094479","https://openalex.org/W4387737399","https://openalex.org/W3213205619","https://openalex.org/W4415670229","https://openalex.org/W4403554076","https://openalex.org/W7215490313","https://openalex.org/W4415670951","https://openalex.org/W4415670826"],"abstract_inverted_index":{"Introdu\u00e7\u00e3o":[0],"A":[1,144,155,208,268,375,428,452],"Hemoglobin\u00faria":[2],"Parox\u00edstica":[3],"Noturna":[4],"(HPN)":[5],"\u00e9":[6,172,470],"uma":[7],"doen\u00e7a":[8,95],"clonal":[9],"adquirida":[10],"da":[11,363],"c\u00e9lula-tronco":[12],"hematopoi\u00e9tica,":[13],"decorrente":[14],"de":[15,24,45,58,76,82,106,123,142,153,162,183,195,215,217,221,236,252,262,338,343,349,380,408,410,413,454,463,477],"muta\u00e7\u00e3o":[16],"no":[17,448],"gene":[18],"PIGA,":[19],"que":[20,91,175,202,334,396],"leva":[21],"\u00e0":[22,292],"defici\u00eancia":[23,141],"prote\u00ednas":[25],"reguladoras":[26],"do":[27,66,104,273,310,401],"complemento":[28],"ancoradas":[29],"por":[30,213,387,392],"GPI":[31],"(CD55":[32],"e":[33,102,135,225,242,277,345,461,468,475],"CD59).":[34],"Por":[35],"cursar":[36],"com":[37,140,168,233,249,259,326,329,372,378,417,437,456],"manifesta\u00e7\u00f5es":[38],"inespec\u00edficas,":[39],"seu":[40],"diagn\u00f3stico":[41,75,187,355,473],"exige":[42],"alto":[43],"\u00edndice":[44],"suspei\u00e7\u00e3o,":[46],"sobretudo":[47],"em":[48,99,238,244,254,264,295,422,433,441],"pacientes":[49],"jovens":[50,101,423,442],"sem":[51,72,86,368,424,444],"queixas":[52,88],"hematol\u00f3gicas":[53],"pr\u00e9vias,":[54],"sendo":[55],"a":[56,94,178,191,205,271,278,284,307,347,383,398,406],"citometria":[57,214,453],"fluxo":[59,216,455],"o":[60,201,297,317,336,354,359,395],"m\u00e9todo":[61],"padr\u00e3o-ouro":[62],"para":[63,84,159,180,365,472],"confirma\u00e7\u00e3o.":[64],"Descri\u00e7\u00e3o":[65],"Caso":[67],"Paciente":[68],"masculino,":[69],"26":[70],"anos,":[71],"comorbidades,":[73],"teve":[74],"HPN":[77,230,411,429],"incidental,":[78],"durante":[79],"avalia\u00e7\u00e3o":[80],"pr\u00e9-uso":[81],"isotretino\u00edna":[83],"acne,":[85],"outras":[87],"\u2012":[89],"cen\u00e1rio":[90],"ilustra":[92],"como":[93,198,447],"pode":[96,203],"permanecer":[97],"subdiagnosticada":[98],"indiv\u00edduos":[100],"assintom\u00e1ticos":[103],"ponto":[105],"vista":[107],"hematol\u00f3gico.":[108,426],"Exames":[109],"iniciais":[110],"(07/01/2025):":[111],"hemoglobina":[112,364],"6,9":[113],"g/dL,":[114,367],"hemat\u00f3crito":[115],"23,5%,":[116],"DHL":[117,169,418,438],"2.119":[118],"U/L,":[119],"haptoglobina":[120],"indetect\u00e1vel,":[121],"reticulocitose":[122],"9,2%":[124],"(248.000/mm":[125],"3":[126],"),":[127],"Coombs":[128],"direto":[129],"negativo,":[130],"ferro":[131],"s\u00e9rico":[132],"78":[133],"\u00b5g/dL":[134],"ferritina":[136],"16,6":[137],"ng/mL,":[138],"compat\u00edveis":[139],"ferro.":[143],"endoscopia":[145],"digestiva":[146],"alta":[147,218],"n\u00e3o":[148,185,390],"evidenciou":[149],"altera\u00e7\u00f5es":[150],"ou":[151],"fonte":[152],"sangramento.":[154],"triagem":[156],"etiol\u00f3gica":[157],"negativa":[158],"causas":[160,192],"secund\u00e1rias":[161],"hem\u00f3lise,":[163],"associada":[164],"ao":[165],"padr\u00e3o":[166],"Coombs-negativo":[167],"desproporcionalmente":[170],"elevado,":[171,420],"um":[173,332],"achado":[174,333,449],"deve":[176,430],"elevar":[177],"suspei\u00e7\u00e3o":[179],"hem\u00f3lise":[181,320,342,373,376,384],"intravascular":[182],"causa":[184],"imune,":[186],"diferencial":[188],"subestimado":[189],"frente":[190],"mais":[193],"prevalentes":[194],"anemia":[196,414,434],"hemol\u00edtica,":[197],"as":[199],"autoimunes,":[200],"retardar":[204],"investiga\u00e7\u00e3o":[206],"direcionada.":[207],"confirma\u00e7\u00e3o":[209],"(03/02/2025)":[210],"foi":[211],"feita":[212],"sensibilidade":[219],"(limite":[220],"0,01%;":[222],"500.000":[223],"hem\u00e1cias":[224,232,288],"250.000":[226],"leuc\u00f3citos/tubo),":[227],"evidenciando":[228],"clones":[229,280,465],"trilineares:":[231],"perda":[234,250,260],"total":[235,251,261],"CD59":[237],"15%":[239],"(clone":[240,246,256,266],"III)":[241],"parcial":[243],"20%":[245],"II);":[247],"neutr\u00f3filos":[248],"CD24/FLAER":[253],"94,5%":[255],"III);":[257],"mon\u00f3citos":[258],"CD14/FLAER":[263],"92%":[265],"III).":[267],"discrep\u00e2ncia":[269],"entre":[270,323],"magnitude":[272],"clone":[274,311],"eritrocit\u00e1rio":[275],"(15%)":[276],"dos":[279],"granuloc\u00edtico/monoc\u00edtico":[281],"(>90%)":[282],"reflete":[283,382],"maior":[285],"suscetibilidade":[286],"das":[287],"PNH":[289],"tipo":[290],"III":[291],"destrui\u00e7\u00e3o":[293],"complemento-mediada":[294],"circula\u00e7\u00e3o,":[296],"que,":[298],"se":[299],"avaliado":[300],"isoladamente":[301],"pelo":[302],"compartimento":[303],"eritr\u00f3ide,":[304,466],"poderia":[305],"subestimar":[306],"real":[308],"extens\u00e3o":[309],"HPN.":[312],"Enquanto":[313],"aguardava":[314],"terapia":[315],"direcionada,":[316],"paciente":[318],"manteve":[319],"oscilante":[321],"(DHL":[322],"880\u20133.652":[324],"U/L),":[325],"pico":[327],"coincidindo":[328],"infec\u00e7\u00e3o":[330],"respirat\u00f3ria,":[331],"corrobora":[335],"papel":[337],"gatilhos":[339],"infecciosos":[340],"na":[341],"escape":[344],"refor\u00e7a":[346,405],"necessidade":[348],"vigil\u00e2ncia":[350],"cl\u00ednica":[351],"mesmo":[352,421,440],"ap\u00f3s":[353],"estabelecido.":[356],"Ap\u00f3s":[357],"iniciar":[358],"eculizumabe,":[360],"houve":[361],"eleva\u00e7\u00e3o":[362],"10\u201311,7":[366],"eventos":[369],"tromboemb\u00f3licos,":[370],"ainda":[371],"residual.":[374],"residual":[377],"inibidores":[379],"C5":[381],"extravascular":[385],"mediada":[386],"C3,":[388],"mecanismo":[389],"bloqueado":[391],"esses":[393],"agentes,":[394],"justifica":[397],"inibi\u00e7\u00e3o":[399],"proximal":[400],"complemento.":[402],"O":[403],"caso":[404],"import\u00e2ncia":[407],"suspeitar":[409],"diante":[412],"hemol\u00edtica":[415,435],"Coombs-negativa":[416,436],"muito":[419],"hist\u00f3rico":[425,445],"Conclus\u00e3o":[427],"ser":[431],"investigada":[432],"desproporcional,":[439],"oligossintom\u00e1ticos":[443],"hematol\u00f3gico,":[446],"incidental":[450],"pr\u00e9-isotretino\u00edna.":[451],"FLAER,":[457],"sens\u00edvel":[458],"at\u00e9":[459],"0,01%":[460],"capaz":[462],"caracterizar":[464],"granuloc\u00edtico":[467],"monoc\u00edtico,":[469],"essencial":[471],"precoce":[474],"preven\u00e7\u00e3o":[476],"complica\u00e7\u00f5es":[478],"graves.":[479]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}
