{"id":"https://openalex.org/W7223091971","doi":"https://doi.org/10.1016/j.htct.2026.108403","title":"ESTUDO DO MICROAMBIENTE DA LEUCEMIA LINFOBL\u00c1STICA AGUDA DE PRECURSOR B POR CITOMETRIA DE FLUXO MULTIPARAM\u00c9TRICA","display_name":"ESTUDO DO MICROAMBIENTE DA LEUCEMIA LINFOBL\u00c1STICA AGUDA DE PRECURSOR B POR CITOMETRIA DE FLUXO MULTIPARAM\u00c9TRICA","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7223091971","doi":"https://doi.org/10.1016/j.htct.2026.108403"},"language":"en","primary_location":{"id":"doi:10.1016/j.htct.2026.108403","doi":"https://doi.org/10.1016/j.htct.2026.108403","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.108403","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926021504/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciencedirect.com/science/article/pii/S2531137926021504/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159169466","display_name":"Suyane MARCULINO DE SOUZA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Suyane MARCULINO DE SOUZA","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159171890","display_name":"Leonardo MOREIRA DE OLIVEIRA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Leonardo MOREIRA DE OLIVEIRA","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159209585","display_name":"Sophia JI YEON LEE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sophia JI YEON LEE","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159218207","display_name":"David Aaron AYRES DA MOTTA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"David Aaron AYRES DA MOTTA","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159212947","display_name":"Daniella RIBEIRO NEY GARCIA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Daniella RIBEIRO NEY GARCIA","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159210981","display_name":"Amanda FARIA DE FIGUEIREDO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Amanda FARIA DE FIGUEIREDO","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055210686","display_name":"Marcelo Gerardin Poirot Land","orcid":"https://orcid.org/0000-0001-9792-3167","observed_orcids":["https://orcid.org/0000-0001-9792-3167"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo GERARDIN POIROT LAND","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159202123","display_name":"Elen DE OLIVEIRA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Elen DE OLIVEIRA","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159161260","display_name":"Elaine SOBRAL DA COSTA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Elaine SOBRAL DA COSTA","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil","institution_ids":["https://openalex.org/I122140584"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I122140584"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.77809236,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":null,"first_page":"108403","last_page":"108403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9340000152587891},{"id":"https://openalex.org/keywords/b-cell-precursor-acute-lymphoblastic-leukemia","display_name":"B-cell precursor acute lymphoblastic leukemia","score":0.7609999775886536},{"id":"https://openalex.org/keywords/leukemia-microenvironment","display_name":"leukemia microenvironment","score":0.7039999961853027},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8019999861717224},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8180000185966492},{"id":"https://openalex.org/keywords/mesenchymal-cells","display_name":"mesenchymal cells","score":0.8159999847412109},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.875},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.6710000038146973},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.4740000069141388},{"id":"https://openalex.org/keywords/long-term-survival","display_name":"long-term survival","score":0.5220000147819519},{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.5720000267028809},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6539999842643738},{"id":"https://openalex.org/keywords/cd34","display_name":"CD34","score":0.4359999895095825},{"id":"https://openalex.org/keywords/cd10","display_name":"CD10","score":0.6949999928474426},{"id":"https://openalex.org/keywords/cd73","display_name":"CD73","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cd81","display_name":"CD81","score":0.597000002861023},{"id":"https://openalex.org/keywords/cd45","display_name":"CD45","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7459999918937683},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6122999787330627},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.3732999861240387},{"id":"https://openalex.org/C152987353","wikidata":"https://www.wikidata.org/wiki/Q2351880","display_name":"Stopped flow","level":4,"score":0.17499999701976776},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1615999937057495},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.1429000049829483},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.14100000262260437},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.1379999965429306},{"id":"https://openalex.org/C2985213535","wikidata":"https://www.wikidata.org/wiki/Q1626599","display_name":"Reference values","level":2,"score":0.12860000133514404},{"id":"https://openalex.org/C2908755955","wikidata":"https://www.wikidata.org/wiki/Q744962","display_name":"Chromosomal Abnormality","level":5,"score":0.12479999661445618}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.htct.2026.108403","doi":"https://doi.org/10.1016/j.htct.2026.108403","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.108403","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926021504/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:7d6d5a66d91e40d088f3c16702cb07a1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7d6d5a66d91e40d088f3c16702cb07a1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hematology, Transfusion and Cell Therapy, Vol 48, Iss , Pp 108403- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.htct.2026.108403","doi":"https://doi.org/10.1016/j.htct.2026.108403","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2026.108403","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2531137926021504/pdf","source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223091971.pdf","grobid_xml":"https://content.openalex.org/works/W7223091971.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362700333","https://openalex.org/W4306319781","https://openalex.org/W4415670504","https://openalex.org/W7133443931","https://openalex.org/W7206756970","https://openalex.org/W4387747931","https://openalex.org/W7133422526","https://openalex.org/W7036280840","https://openalex.org/W7120302450","https://openalex.org/W1983606910"],"abstract_inverted_index":{"A":[0,201,233,260,283],"Leucemia":[1],"Linfobl\u00e1stica":[2],"Aguda":[3],"\u00e9":[4,93],"a":[5,30,35,52,109,136,177,185,288,305,311,319,324,349,370,416,429],"neoplasia":[6],"mais":[7],"frequente":[8],"da":[9,97,154,236,265],"inf\u00e2ncia.":[10],"Atualmente,":[11],"fatores":[12],"cl\u00ednicos":[13],"e":[14,27,63,79,145,150,197,209,220,248,279,297,407,471],"laboratoriais":[15],"s\u00e3o":[16],"utilizados":[17],"para":[18,28,163,176,184,323,382,415,428,468,473,481],"predizer":[19],"recidiva":[20,417],"(exemplo:":[21],"doen\u00e7a":[22,58],"residual":[23],"mensur\u00e1vel":[24],"-":[25,156],"DRM)":[26],"guiar":[29],"intensidade":[31],"do":[32,281,337,425,440,448,485],"tratamento.":[33],"Recentemente,":[34],"propor\u00e7\u00e3o":[36,98,306],"de":[37,48,57,65,70,73,99,106,116,121,125,128,134,143,158,165,171,179,187,207,214,226,231,239,257,262,270,307,326,329,342,351,354,362,374,396,410,431,442,461],"c\u00e9lulas":[38,180,188,194,198,355],"endoteliais":[39,195,356],"(CEs)":[40],"na":[41,101,103,357],"medula":[42],"\u00f3ssea":[43],"(MO)":[44],"no":[45,141,151,274,277,331,365],"dia":[46,332,366],"+78":[47,367],"terapia":[49],"foi":[50,173,203,222,238,269,285,368],"associada":[51,287,369],"uma":[53,64,82,126,289,320,434,482],"menor":[54,290,321],"sobrevida":[55],"livre":[56,105],"em":[59,167,267,419,488],"2":[60],"coortes":[61],"pedi\u00e1tricas":[62],"adultos.":[66],"Entretanto,":[67],"o":[68,95,212,224,360,402,446],"tempo":[69,255],"seguimento":[71],"mediano":[72,256],"acompanhamento":[74],"era":[75],"curto":[76],"(2,5":[77],"anos)":[78],"n\u00e3o":[80,472],"permitia":[81],"avalia\u00e7\u00e3o":[83],"com":[84,114,131,205,211,339,359,491],"rela\u00e7\u00e3o":[85],"\u00e0s":[86],"reca\u00eddas":[87],"tardias.":[88],"O":[89,160],"foco":[90],"deste":[91],"trabalho":[92],"avaliar":[94],"impacto":[96],"CEs":[100,308,330,438,458],"MO":[102,358],"sobreviv\u00eancia":[104,202],"reca\u00edda":[107,312,383,432,469,474],"(SLR)":[108],"longo":[110],"prazo":[111],"das":[112],"crian\u00e7as":[113,130],"LLA":[115],"precursores":[117],"B":[118],"(LLA-pB).":[119],"Trata-se":[120],"estudo":[122,398,454],"descritivo,":[123],"observacional":[124],"coorte":[127,237,266],"99":[129],"LLA-pB":[132,168],"diagnosticadas":[133],"2014":[135],"2019":[137],"(acompanhamento":[138],"at\u00e9":[139],"2026)":[140],"Instituto":[142],"Puericultura":[144],"Pediatria":[146],"Martag\u00e3o":[147],"Gesteira":[148],"(IPPMG/UFRJ)":[149],"Hospital":[152],"Federal":[153],"Lagoa":[155],"Rio":[157],"Janeiro.":[159],"painel":[161],"EuroFlow":[162],"detec\u00e7\u00e3o":[164],"DRM":[166,263,284,363],"por":[169,253],"citometria":[170],"fluxo":[172],"utilizado":[174],"tanto":[175],"identifica\u00e7\u00e3o":[178],"residuais":[181],"leuc\u00eamicas":[182],"quanto":[183],"quantifica\u00e7\u00e3o":[186],"estromais":[189],"(CD45-/CD81++/CD73++),":[190],"dentre":[191],"elas":[192],"havendo":[193],"(CD34++)":[196],"mesenquimais":[199],"(CD10++).":[200],"avaliada":[204],"curvas":[206],"Kaplan-Meier,":[208],"comparadas":[210],"teste":[213],"Long-Rank.":[215],"Para":[216],"as":[217,437,457],"an\u00e1lises":[218],"univariada":[219],"multivariada,":[221],"realizado":[223],"m\u00e9todo":[225],"regress\u00e3o":[227],"dos":[228,272],"riscos":[229],"proporcionais":[230],"Cox.":[232],"idade":[234],"mediana":[235],"5,5":[240],"anos":[241],"(0\u221214":[242],"anos),":[243],"sendo":[244,385],"52%":[245],"(sexo":[246,250],"masculino)":[247],"47%":[249],"feminino),":[251],"acompanhada":[252],"um":[254,371,387,465],"6.9":[258],"anos.":[259],"frequ\u00eancia":[261],"+":[264],"geral":[268],"89,7%":[271],"casos":[273],"D+15,":[275],"56,6%":[276],"D+33":[278,293],"9%":[280],"D+78.":[282],"significativamente":[286],"SLR":[291,322],"nos":[292],"(p":[294,299],"=":[295,345],"0,007)":[296],"D+78":[298],"<":[300,340,380],"0,001).":[301],"Observamos":[302],"tamb\u00e9m":[303],"que":[304,401,436,444,456],"impactou":[309],"apenas":[310],"precoce.":[313],"Dessa":[314],"forma,":[315],"encontramos":[316],"associa\u00e7\u00e3o":[317],"significativa":[318],"presen\u00e7a":[325],"\u2265":[327,352,408],"32%":[328,341,353,409],"78+":[333],"(72%":[334],"vs":[335],"92%":[336],"grupo":[338],"CEs,":[343],"p":[344,379],"0,016).":[346],"Al\u00e9m":[347],"disso,":[348],"combina\u00e7\u00e3o":[350],"status":[361],"positiva":[364],"risco":[372],"relativo":[373],"26,6":[375],"(IC":[376],"95%:":[377],"4,4-161,03,":[378],"0,001)":[381],"precoce,":[384,470],"considerado":[386],"fator":[388,466],"progn\u00f3stico":[389,467],"independente.":[390],"Nossos":[391],"dados":[392,478],"corroboram":[393],"os":[394],"achados":[395],"nosso":[397,453],"anterior,":[399],"visto":[400],"valor":[403],"preditivo":[404],"adicional":[405],"(D+78":[406],"CEs)":[411],"mostrou":[412],"ser":[413],"significativo":[414],"precoce":[418],"LLA-pB.":[420,492],"Isso":[421],"indica":[422,455],"contribui\u00e7\u00e3o":[423],"consider\u00e1vel":[424],"microambiente":[426,486],"vascular":[427],"incid\u00eancia":[430],"medular,":[433],"vez":[435],"participam":[439],"processo":[441],"angiog\u00eanese":[443],"favorece":[445],"desenvolvimento":[447],"nicho":[449],"leuc\u00eamico.":[450],"Em":[451],"resumo,":[452],"podem":[459,479],"atuar":[460],"forma":[462],"robusta":[463],"como":[464],"tardia.":[475],"Portanto,":[476],"nossos":[477],"contribuir":[480],"melhor":[483],"compreens\u00e3o":[484],"tumoral":[487],"pacientes":[489],"pedi\u00e1tricos":[490]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}
