{"id":"https://openalex.org/W7223091835","doi":"https://doi.org/10.3390/cimb48101091","title":"BGC-XPLORER: Exploring Biosynthetic Gene Clusters with Gene-Level Functional Annotation and AI-Assisted Summarization","display_name":"BGC-XPLORER: Exploring Biosynthetic Gene Clusters with Gene-Level Functional Annotation and AI-Assisted Summarization","publication_year":2026,"publication_date":"2026-10-21","ids":{"openalex":"https://openalex.org/W7223091835","doi":"https://doi.org/10.3390/cimb48101091","pmid":"https://pubmed.ncbi.nlm.nih.gov/42939629","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13702941"},"language":"en","primary_location":{"id":"doi:10.3390/cimb48101091","doi":"https://doi.org/10.3390/cimb48101091","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48101091","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/cimb48101091","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075929213","display_name":"Vesselin Baev","orcid":"https://orcid.org/0000-0002-5224-9145","observed_orcids":["https://orcid.org/0000-0002-5224-9145"]},"institutions":[{"id":"https://openalex.org/I192878625","display_name":"Plovdiv University","ror":"https://ror.org/0545p3742","country_code":"BG","type":"education","lineage":["https://openalex.org/I192878625"]}],"countries":["BG"],"is_corresponding":true,"raw_author_name":"Vesselin Baev","raw_affiliation_strings":["Department of Molecular Biology, Faculty of Biology, University of Plovdiv, Tzar Assen 24, 4000 Plovdiv, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0002-5224-9145","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Faculty of Biology, University of Plovdiv, Tzar Assen 24, 4000 Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I192878625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057182436","display_name":"Elena Apostolova","orcid":"https://orcid.org/0000-0003-1094-8009","observed_orcids":["https://orcid.org/0000-0003-1094-8009"]},"institutions":[{"id":"https://openalex.org/I192878625","display_name":"Plovdiv University","ror":"https://ror.org/0545p3742","country_code":"BG","type":"education","lineage":["https://openalex.org/I192878625"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Elena Apostolova","raw_affiliation_strings":["Department of Molecular Biology, Faculty of Biology, University of Plovdiv, Tzar Assen 24, 4000 Plovdiv, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0003-1094-8009","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Faculty of Biology, University of Plovdiv, Tzar Assen 24, 4000 Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I192878625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027484248","display_name":"Mariyana Gozmanova","orcid":"https://orcid.org/0000-0001-5281-424X","observed_orcids":["https://orcid.org/0000-0001-5281-424X"]},"institutions":[{"id":"https://openalex.org/I192878625","display_name":"Plovdiv University","ror":"https://ror.org/0545p3742","country_code":"BG","type":"education","lineage":["https://openalex.org/I192878625"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Mariyana Gozmanova","raw_affiliation_strings":["Department of Molecular Biology, Faculty of Biology, University of Plovdiv, Tzar Assen 24, 4000 Plovdiv, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0001-5281-424X","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Faculty of Biology, University of Plovdiv, Tzar Assen 24, 4000 Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I192878625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007435123","display_name":"\u0418. \u0418\u043b\u0438\u0435\u0432","orcid":"https://orcid.org/0000-0002-2381-3165","observed_orcids":["https://orcid.org/0000-0002-2381-3165"]},"institutions":[{"id":"https://openalex.org/I192878625","display_name":"Plovdiv University","ror":"https://ror.org/0545p3742","country_code":"BG","type":"education","lineage":["https://openalex.org/I192878625"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Ivan Iliev","raw_affiliation_strings":["Department of Biochemistry and Microbiology, Faculty of Biology, University of Plovdiv, Tzar Assen 24, 4000 Plovdiv, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0002-2381-3165","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, Faculty of Biology, University of Plovdiv, Tzar Assen 24, 4000 Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I192878625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044603875","display_name":"Velizar Gochev","orcid":"https://orcid.org/0000-0002-2284-2984","observed_orcids":["https://orcid.org/0000-0002-2284-2984"]},"institutions":[{"id":"https://openalex.org/I192878625","display_name":"Plovdiv University","ror":"https://ror.org/0545p3742","country_code":"BG","type":"education","lineage":["https://openalex.org/I192878625"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Velizar Gochev","raw_affiliation_strings":["Department of Biochemistry and Microbiology, Faculty of Biology, University of Plovdiv, Tzar Assen 24, 4000 Plovdiv, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, Faculty of Biology, University of Plovdiv, Tzar Assen 24, 4000 Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I192878625"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002462678","display_name":"Galina T. Yahubyan","orcid":"https://orcid.org/0000-0003-4278-5275","observed_orcids":["https://orcid.org/0000-0003-4278-5275"]},"institutions":[{"id":"https://openalex.org/I192878625","display_name":"Plovdiv University","ror":"https://ror.org/0545p3742","country_code":"BG","type":"education","lineage":["https://openalex.org/I192878625"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Galina Yahubyan","raw_affiliation_strings":["Department of Molecular Biology, Faculty of Biology, University of Plovdiv, Tzar Assen 24, 4000 Plovdiv, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Faculty of Biology, University of Plovdiv, Tzar Assen 24, 4000 Plovdiv, Bulgaria","institution_ids":["https://openalex.org/I192878625"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075929213"],"corresponding_institution_ids":["https://openalex.org/I192878625"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82138149,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":"10","first_page":"1091","last_page":"1091"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosynthetic-gene-clusters","display_name":"biosynthetic gene clusters","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bacterial-genome-annotation","display_name":"bacterial genome annotation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/antismash","display_name":"antiSMASH","score":0.675000011920929},{"id":"https://openalex.org/keywords/bakta","display_name":"Bakta","score":0.8389999866485596},{"id":"https://openalex.org/keywords/gecco","display_name":"GECCO","score":0.8539999723434448},{"id":"https://openalex.org/keywords/mibig","display_name":"MIBiG","score":0.7900000214576721},{"id":"https://openalex.org/keywords/actinomycetes","display_name":"actinomycetes","score":0.7770000100135803},{"id":"https://openalex.org/keywords/streptomyces-albidoflavus","display_name":"Streptomyces albidoflavus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/snakemake-workflow","display_name":"Snakemake workflow","score":0.8149999976158142},{"id":"https://openalex.org/keywords/docker-containerization","display_name":"Docker containerization","score":0.5640000104904175},{"id":"https://openalex.org/keywords/gene-function-annotation","display_name":"gene function annotation","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.7924000024795532},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.7383000254631042},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.703000009059906},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6552000045776367},{"id":"https://openalex.org/C170858558","wikidata":"https://www.wikidata.org/wiki/Q1394144","display_name":"Automatic summarization","level":2,"score":0.6187000274658203},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5271999835968018},{"id":"https://openalex.org/C3742359","wikidata":"https://www.wikidata.org/wiki/Q4839988","display_name":"Bacterial genome size","level":4,"score":0.5134000182151794},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48260000348091125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46799999475479126},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4499000012874603},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4494999945163727},{"id":"https://openalex.org/C36857842","wikidata":"https://www.wikidata.org/wiki/Q1501261","display_name":"Gene cluster","level":3,"score":0.42719998955726624},{"id":"https://openalex.org/C89566754","wikidata":"https://www.wikidata.org/wiki/Q2273828","display_name":"Genome project","level":4,"score":0.36090001463890076},{"id":"https://openalex.org/C2908923196","wikidata":"https://www.wikidata.org/wiki/Q5205742","display_name":"Gene Annotation","level":4,"score":0.33399999141693115},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.2904999852180481},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.2865000069141388},{"id":"https://openalex.org/C164866538","wikidata":"https://www.wikidata.org/wiki/Q367351","display_name":"Cluster (spacecraft)","level":2,"score":0.2743000090122223},{"id":"https://openalex.org/C122735190","wikidata":"https://www.wikidata.org/wiki/Q715789","display_name":"Gene mapping","level":4,"score":0.263700008392334},{"id":"https://openalex.org/C192953774","wikidata":"https://www.wikidata.org/wiki/Q7307127","display_name":"Reference genome","level":4,"score":0.25220000743865967}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/cimb48101091","doi":"https://doi.org/10.3390/cimb48101091","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48101091","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13702941","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13702941/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13702941/pdf/cimb-48-01091.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Issues Mol Biol","raw_type":"Text"},{"id":"pmid:42939629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42939629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current issues in molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0a0f240eef4241e3b6df3c7bcbcec0cf","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0a0f240eef4241e3b6df3c7bcbcec0cf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Issues in Molecular Biology, Vol 48, Iss 10, p 1091 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cimb48101091","doi":"https://doi.org/10.3390/cimb48101091","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48101091","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309480","display_name":"Nvidia","ror":"https://ror.org/03jdj4y14"},{"id":"https://openalex.org/F4320311225","display_name":"Plovdiv University \"Paisii Hilendarski\"","ror":"https://ror.org/0545p3742"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223091835.pdf","grobid_xml":"https://content.openalex.org/works/W7223091835.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W2112364185","https://openalex.org/W2138122982","https://openalex.org/W2142678478","https://openalex.org/W2143485490","https://openalex.org/W2575750030","https://openalex.org/W2610680882","https://openalex.org/W2775564272","https://openalex.org/W2788228074","https://openalex.org/W2951254987","https://openalex.org/W2967688728","https://openalex.org/W2990471452","https://openalex.org/W3024784786","https://openalex.org/W3026412036","https://openalex.org/W3091334475","https://openalex.org/W3095583226","https://openalex.org/W3114849352","https://openalex.org/W3121081543","https://openalex.org/W3122109253","https://openalex.org/W3143063265","https://openalex.org/W3162905226","https://openalex.org/W3192040753","https://openalex.org/W3203343200","https://openalex.org/W3208304752","https://openalex.org/W4225416490","https://openalex.org/W4367598489","https://openalex.org/W4367833791","https://openalex.org/W4378232632","https://openalex.org/W4396494616","https://openalex.org/W4403924741","https://openalex.org/W4405220977","https://openalex.org/W4409781688","https://openalex.org/W4411592574","https://openalex.org/W4416308800","https://openalex.org/W7160534219","https://openalex.org/W7160933421","https://openalex.org/W7165181415"],"related_works":["https://openalex.org/W4396494616","https://openalex.org/W2990471452","https://openalex.org/W7170862560","https://openalex.org/W4229073727","https://openalex.org/W2941821699","https://openalex.org/W2948090592","https://openalex.org/W3121081543","https://openalex.org/W7055548317","https://openalex.org/W7162788336","https://openalex.org/W4386122263"],"abstract_inverted_index":{"Turning":[0],"one":[1],"newly":[2,136],"sequenced":[3,137],"bacterial":[4,39],"genome":[5,53],"into":[6],"a":[7,31,36,48,67,161,177,193,199],"view":[8],"of":[9,150,176],"its":[10],"biosynthetic":[11],"potential":[12],"still":[13],"means":[14],"running":[15],"several":[16],"cluster":[17],"detectors":[18],"and":[19,22,45,59,61,87,92,102,164],"annotation":[20],"tools":[21],"comparing":[23],"their":[24,63],"output":[25],"by":[26,69],"hand.":[27],"We":[28],"present":[29],"BGC-XPLORER,":[30],"containerized":[32],"Snakemake":[33],"workflow":[34,146,190],"for":[35,195],"single":[37,128,178],"assembled":[38],"genome,":[40],"deployed":[41],"locally":[42],"with":[43,54,99],"Docker":[44],"operated":[46],"through":[47],"browser.":[49],"It":[50],"annotates":[51],"the":[52,70,118,135,145,187],"Bakta,":[55,85],"runs":[56],"antiSMASH,":[57],"GECCO":[58],"DeepBGC,":[60],"groups":[62],"predictions":[64],"gene-by-gene,":[65],"defining":[66],"locus":[68,80,179],"genes":[71],"that":[72,202],"at":[73,122,156],"least":[74,123,157],"two":[75,116,158],"callers":[76],"agree":[77],"on.":[78],"Each":[79],"carries":[81],"gene-resolved":[82],"evidence":[83],"from":[84,115,155],"eggNOG":[86],"dbCAN,":[88],"ARTS":[89,167],"self-resistance":[90],"hits":[91],"MIBiG":[93,108,162],"comparisons":[94],"in":[95,111,130],"an":[96,166,183],"interactive":[97],"report":[98],"searchable":[100],"tables":[101],"annotated":[103],"gene":[104],"maps.":[105],"Against":[106],"42":[107],"reference":[109],"loci":[110],"four":[112],"actinomycete":[113],"genomes":[114],"genera,":[117],"grouping":[119],"recovered":[120],"41,":[121],"as":[124,126,182],"many":[125],"any":[127],"caller":[129],"every":[131],"genome.":[132],"Applied":[133],"to":[134,185],"soil":[138],"isolate":[139],"Streptomyces":[140],"albidoflavus":[141],"STR-S001":[142],"(GenBank":[143],"CP158056),":[144],"reported":[147],"49":[148],"loci,":[149],"which":[151],"27":[152],"had":[153],"support":[154],"callers,":[159],"22":[160],"comparison":[163],"five":[165],"known-resistance":[168],"hit.":[169],"An":[170],"optional,":[171],"remotely":[172],"generated":[173],"AI":[174],"summary":[175],"is":[180,191],"offered":[181],"aid":[184],"reading":[186],"report.":[188],"The":[189],"not":[192],"replacement":[194],"laboratory":[196],"verification":[197],"but":[198],"complementary":[200],"step":[201],"precedes":[203],"it.":[204]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-22T00:00:00"}