{"id":"https://openalex.org/W7223089700","doi":"https://doi.org/10.3389/fonc.2026.1955800","title":"Machine learning to predict osteoradionecrosis in head and neck cancer","display_name":"Machine learning to predict osteoradionecrosis in head and neck cancer","publication_year":2026,"publication_date":"2026-10-21","ids":{"openalex":"https://openalex.org/W7223089700","doi":"https://doi.org/10.3389/fonc.2026.1955800","pmid":"https://pubmed.ncbi.nlm.nih.gov/42985507","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13732638"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2026.1955800","doi":"https://doi.org/10.3389/fonc.2026.1955800","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1955800","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1955800/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1955800/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5096256756","display_name":"Vit\u00f3ria Tavares de Castro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150729083","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59","country_code":"BR","type":"education","lineage":["https://openalex.org/I150729083"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vitoria Tavares Castro","raw_affiliation_strings":["University of Brasilia, Laboratory of Oral Histopathology, School of Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Brasilia, Laboratory of Oral Histopathology, School of Health Sciences","institution_ids":["https://openalex.org/I150729083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062081562","display_name":"Luan Matheus Trindade Dalmazo","orcid":"https://orcid.org/0000-0002-1589-6482","observed_orcids":["https://orcid.org/0000-0002-1589-6482"]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luan Matheus Trindade Dalmazo","raw_affiliation_strings":["Department of Informatics, Federal University of Parana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Informatics, Federal University of Parana","institution_ids":["https://openalex.org/I52418104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030950306","display_name":"Paula Elaine Diniz dos Reis","orcid":"https://orcid.org/0000-0002-9782-3366","observed_orcids":["https://orcid.org/0000-0002-9782-3366"]},"institutions":[{"id":"https://openalex.org/I150729083","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59","country_code":"BR","type":"education","lineage":["https://openalex.org/I150729083"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paula Elaine Diniz Dos Reis","raw_affiliation_strings":["University of Brasilia, Interdisciplinary Laboratory of Research Applied to Clinical Practice in Oncology, Nursing Department, School of Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Brasilia, Interdisciplinary Laboratory of Research Applied to Clinical Practice in Oncology, Nursing Department, School of Health Sciences","institution_ids":["https://openalex.org/I150729083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081334310","display_name":"Wenzel Castro de Abreu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136843","display_name":"Hospital Universit\u00e1rio de Bras\u00edlia","ror":"https://ror.org/02x2gbe80","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210136843"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Wenzel Castro de Abreu","raw_affiliation_strings":["High-Complexity Oncology Care Center, University Hospital of Brasilia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"High-Complexity Oncology Care Center, University Hospital of Brasilia","institution_ids":["https://openalex.org/I4210136843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005278582","display_name":"Ricardo Gomes dos Reis","orcid":"https://orcid.org/0000-0003-4266-7690","observed_orcids":["https://orcid.org/0000-0003-4266-7690"]},"institutions":[{"id":"https://openalex.org/I4210136843","display_name":"Hospital Universit\u00e1rio de Bras\u00edlia","ror":"https://ror.org/02x2gbe80","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210136843"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ricardo Gomes dos Reis","raw_affiliation_strings":["High-Complexity Oncology Care Center, University Hospital of Brasilia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"High-Complexity Oncology Care Center, University Hospital of Brasilia","institution_ids":["https://openalex.org/I4210136843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157714374","display_name":"Ana Carolina Prado-Ribeiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210088998","display_name":"Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo","ror":"https://ror.org/005vqqr19","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210088998"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Carolina Prado-Ribeiro","raw_affiliation_strings":["Bioengineering Graduate Program, Scientific and Technological Institute, Brazil University","Dental Oncology Service, Instituto Do C\u00e2ncer Do Estado de S\u00e3o Paulo, Faculdade de Medicina da Universidade de S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering Graduate Program, Scientific and Technological Institute, Brazil University","institution_ids":[]},{"raw_affiliation_string":"Dental Oncology Service, Instituto Do C\u00e2ncer Do Estado de S\u00e3o Paulo, Faculdade de Medicina da Universidade de S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210088998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041981172","display_name":"Andr\u00e9 Ferreira Leite","orcid":"https://orcid.org/0000-0002-7803-4740","observed_orcids":["https://orcid.org/0000-0002-7803-4740"]},"institutions":[{"id":"https://openalex.org/I150729083","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59","country_code":"BR","type":"education","lineage":["https://openalex.org/I150729083"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Ferreira Leite","raw_affiliation_strings":["University of Brasilia, Laboratory of Oral Histopathology, School of Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Brasilia, Laboratory of Oral Histopathology, School of Health Sciences","institution_ids":["https://openalex.org/I150729083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027884874","display_name":"Fabiana T. Almeida","orcid":"https://orcid.org/0000-0002-2088-4224","observed_orcids":["https://orcid.org/0000-0002-2088-4224"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fabiana T. Almeida","raw_affiliation_strings":["Mike Petryk School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mike Petryk School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071011123","display_name":"Eliete Neves Silva Guerra","orcid":"https://orcid.org/0000-0002-7622-1550","observed_orcids":["https://orcid.org/0000-0002-7622-1550"]},"institutions":[{"id":"https://openalex.org/I150729083","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59","country_code":"BR","type":"education","lineage":["https://openalex.org/I150729083"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Eliete Neves Silva Guerra","raw_affiliation_strings":["University of Brasilia, Laboratory of Oral Histopathology, School of Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Brasilia, Laboratory of Oral Histopathology, School of Health Sciences","institution_ids":["https://openalex.org/I150729083"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5071011123"],"corresponding_institution_ids":["https://openalex.org/I150729083"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82169127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"1955800","last_page":"1955800"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.04580000042915344,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.02449999935925007,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoradionecrosis","display_name":"osteoradionecrosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/risk-prediction-model","display_name":"risk prediction model","score":0.8009999990463257},{"id":"https://openalex.org/keywords/tumor-location","display_name":"tumor location","score":0.6169999837875366},{"id":"https://openalex.org/keywords/class-imbalance","display_name":"class imbalance","score":0.7379999756813049},{"id":"https://openalex.org/keywords/data-augmentation","display_name":"data augmentation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/threshold-optimization","display_name":"threshold optimization","score":0.7390000224113464},{"id":"https://openalex.org/keywords/tabpfn","display_name":"TabPFN","score":0.7390000224113464},{"id":"https://openalex.org/keywords/catboost","display_name":"CatBoost","score":0.9430000185966492},{"id":"https://openalex.org/keywords/xgboost","display_name":"XGBoost","score":0.8159999847412109},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"support vector machine","score":0.6380000114440918},{"id":"https://openalex.org/keywords/random-forest","display_name":"random forest","score":0.859000027179718},{"id":"https://openalex.org/keywords/logistic-regression","display_name":"logistic regression","score":0.7850000262260437},{"id":"https://openalex.org/keywords/internal-validation","display_name":"internal validation","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C2780037786","wikidata":"https://www.wikidata.org/wiki/Q3357479","display_name":"Osteoradionecrosis","level":3,"score":0.9531999826431274},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.8140000104904175},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7477999925613403},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.6983000040054321},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5540000200271606},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.46650001406669617},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.46369999647140503},{"id":"https://openalex.org/C170964787","wikidata":"https://www.wikidata.org/wiki/Q7611170","display_name":"Stepwise regression","level":2,"score":0.45329999923706055},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.38429999351501465},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.3434999883174896},{"id":"https://openalex.org/C27158222","wikidata":"https://www.wikidata.org/wiki/Q5532422","display_name":"Generalizability theory","level":2,"score":0.3248000144958496},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.3224000036716461},{"id":"https://openalex.org/C53533937","wikidata":"https://www.wikidata.org/wiki/Q185020","display_name":"Histogram","level":3,"score":0.28769999742507935},{"id":"https://openalex.org/C2780198649","wikidata":"https://www.wikidata.org/wiki/Q5299249","display_name":"Dose-volume histogram","level":4,"score":0.2822999954223633},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.2806999981403351},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.27570000290870667},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2732999920845032},{"id":"https://openalex.org/C87227347","wikidata":"https://www.wikidata.org/wiki/Q7100713","display_name":"Ordered logit","level":2,"score":0.26840001344680786},{"id":"https://openalex.org/C45804977","wikidata":"https://www.wikidata.org/wiki/Q7239673","display_name":"Predictive modelling","level":2,"score":0.26829999685287476},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.267300009727478}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2026.1955800","doi":"https://doi.org/10.3389/fonc.2026.1955800","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1955800","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1955800/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13732638","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13732638/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13732638/pdf/fonc-16-1955800.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:42985507","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42985507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:19aa950168474379928c45b55b869c2e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/19aa950168474379928c45b55b869c2e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 16 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2026.1955800","doi":"https://doi.org/10.3389/fonc.2026.1955800","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1955800","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1955800/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223089700.pdf","grobid_xml":"https://content.openalex.org/works/W7223089700.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1522012782","https://openalex.org/W1602160603","https://openalex.org/W1984541015","https://openalex.org/W2088697320","https://openalex.org/W2148143831","https://openalex.org/W2558231804","https://openalex.org/W2735018504","https://openalex.org/W2913997948","https://openalex.org/W2966349638","https://openalex.org/W2999929466","https://openalex.org/W3119056788","https://openalex.org/W3135490782","https://openalex.org/W3212764645","https://openalex.org/W4224028562","https://openalex.org/W4281654575","https://openalex.org/W4286655946","https://openalex.org/W4288081031","https://openalex.org/W4302009014","https://openalex.org/W4313256530","https://openalex.org/W4366774387","https://openalex.org/W4378417908","https://openalex.org/W4380300875","https://openalex.org/W4385513951","https://openalex.org/W4392765123","https://openalex.org/W4393935425","https://openalex.org/W4394857110","https://openalex.org/W4396562490","https://openalex.org/W4398183239","https://openalex.org/W4402066098","https://openalex.org/W4402128718","https://openalex.org/W4403999778","https://openalex.org/W4406505443","https://openalex.org/W4411306975","https://openalex.org/W4412708191","https://openalex.org/W4413768198","https://openalex.org/W7119526948"],"related_works":["https://openalex.org/W3135490782","https://openalex.org/W7164806511","https://openalex.org/W7135952867","https://openalex.org/W4307142994","https://openalex.org/W7134276032","https://openalex.org/W4406365467","https://openalex.org/W4384301682","https://openalex.org/W4414208856","https://openalex.org/W7220799963","https://openalex.org/W4410753146"],"abstract_inverted_index":{"Objective:":[0],"Osteoradionecrosis":[1],"is":[2],"one":[3],"of":[4,11,131,214],"the":[5,47,118,138,147,159,193,199],"most":[6],"severe":[7],"late":[8],"adverse":[9],"effects":[10],"head":[12,61],"and":[13,25,53,62,91,101,143,188,251],"neck":[14,63],"radiotherapy.":[15,68],"Predictive":[16],"models":[17,219],"may":[18],"help":[19],"identify":[20],"patients":[21,65,128],"at":[22],"increased":[23],"risk":[24,225],"support":[26],"personalized":[27],"treatment.":[28],"This":[29],"exploratory":[30,221],"study":[31],"aimed":[32],"to":[33,179],"develop":[34],"a":[35,43,212],"machine":[36,79],"learning-based":[37],"prediction":[38],"model":[39],"for":[40,75,223],"osteoradionecrosis":[41,135],"in":[42,146,240],"real-world":[44],"cohort,":[45,242],"following":[46],"TRIPOD+AI":[48],"statement.":[49],"Methods:":[50],"Clinical":[51],"variables":[52],"mandibular":[54],"dose-volume":[55],"histogram":[56],"parameters":[57],"were":[58,93,129,150,234],"collected":[59],"from":[60,177],"cancer":[64],"treated":[66],"with":[67,104,123,183,236],"Forward":[69],"Stepwise":[70],"Logistic":[71,82,156,186,196],"Regression":[72,157,187,197],"was":[73,110],"used":[74,117],"predictor":[76],"selection.":[77],"Six":[78],"learning":[80,218],"algorithms,":[81],"Regression,":[83],"Random":[84],"Forest,":[85],"Support":[86,189],"Vector":[87,190],"Machine,":[88],"CatBoost,":[89,185],"XGBoost,":[90],"TabPFN,":[92,184],"evaluated":[94],"under":[95,202],"class-weighted":[96],"baseline":[97],"modelling,":[98],"threshold":[99],"optimization,":[100],"data":[102,173],"augmentation":[103],"repeated":[105],"stratified":[106],"5-fold":[107],"cross-validation.":[108],"Performance":[109],"primarily":[111],"assessed":[112],"using":[113],"sensitivity.":[114,171,195],"Pairwise":[115],"comparisons":[116],"Nadeau-Bengio":[119],"corrected":[120],"paired":[121],"t-test":[122],"Holm":[124],"adjustment.":[125],"Results:":[126],"Ninety-seven":[127],"included,":[130],"whom":[132],"8":[133],"developed":[134],"(8.25%).":[136],"Of":[137],"80":[139],"available":[140],"variables,":[141],"V60Gy":[142],"tumor":[144],"location":[145],"oral":[148],"cavity":[149],"selected":[151],"as":[152],"predictors.":[153],"Without":[154],"augmentation,":[155,174],"achieved":[158,198],"highest":[160,194,200],"sensitivity":[161,175],"(0.74":[162],"[95%":[163],"CI:":[164],"0.40-1.00]),":[165],"while":[166],"several":[167],"algorithms":[168],"showed":[169],"poor":[170],"With":[172],"ranged":[176],"0.72":[178],"0.77":[180],"across":[181],"models,":[182],"Machine":[191,217],"reaching":[192,211],"AUC":[201],"both":[203],"strategies":[204,233],"(0.87).":[205],"However,":[206],"F1":[207],"scores":[208],"remained":[209],"modest,":[210],"maximum":[213],"0.48.":[215],"Conclusion:":[216],"demonstrated":[220],"potential":[222],"ORN":[224],"assessment":[226],"within":[227],"an":[228],"internal":[229],"validation":[230,253],"framework.":[231],"Class-imbalance":[232],"associated":[235],"greater":[237],"minority-class":[238],"detection":[239],"this":[241],"but":[243],"their":[244],"generalizability":[245],"remains":[246],"uncertain.":[247],"Larger":[248],"multicenter":[249],"cohorts":[250],"external":[252],"are":[254],"needed":[255],"before":[256],"clinical":[257],"implementation.":[258]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-22T00:00:00"}
