{"id":"https://openalex.org/W7223089388","doi":"https://doi.org/10.64898/2026.10.20.760399","title":"Polyglutamine-expanded TBP rewires neuronal and muscle proteomes beyond transcription in a Drosophila model of SCA17","display_name":"Polyglutamine-expanded TBP rewires neuronal and muscle proteomes beyond transcription in a Drosophila model of SCA17","publication_year":2026,"publication_date":"2026-10-21","ids":{"openalex":"https://openalex.org/W7223089388","doi":"https://doi.org/10.64898/2026.10.20.760399"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.20.760399","doi":"https://doi.org/10.64898/2026.10.20.760399","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.10.20.760399","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13738574/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059521824","display_name":"Matthew V. Prifti","orcid":"https://orcid.org/0000-0001-8052-4063","observed_orcids":["https://orcid.org/0000-0001-8052-4063"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew V. Prifti","raw_affiliation_strings":["Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035294093","display_name":"Kristin Richardson","orcid":"https://orcid.org/0000-0002-9146-8017","observed_orcids":["https://orcid.org/0000-0002-9146-8017"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin Richardson","raw_affiliation_strings":["Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138752870","display_name":"Fatimah H Hussein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fatimah H. Hussein","raw_affiliation_strings":["Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115079681","display_name":"Truman Kula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Truman Kula","raw_affiliation_strings":["Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062052747","display_name":"Anna Stephan","orcid":"https://orcid.org/0000-0002-3032-1396","observed_orcids":["https://orcid.org/0000-0002-3032-1396"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Stephan","raw_affiliation_strings":["Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159183572","display_name":"Yong-Dong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong-Dong Wang","raw_affiliation_strings":["Department of Cell and Molecular Biology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159207630","display_name":"Wei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Center for Proteomics and Metabolomics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Proteomics and Metabolomics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006730060","display_name":"Anthony A. High","orcid":"https://orcid.org/0000-0003-2323-5649","observed_orcids":["https://orcid.org/0000-0003-2323-5649"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony A. High","raw_affiliation_strings":["Center for Proteomics and Metabolomics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Proteomics and Metabolomics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103113959","display_name":"Suresh Poudel","orcid":"https://orcid.org/0000-0002-8025-9607","observed_orcids":["https://orcid.org/0000-0002-8025-9607"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suresh Poudel","raw_affiliation_strings":["Department of Immunology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078070376","display_name":"Fabio Demontis","orcid":"https://orcid.org/0000-0002-8698-9555","observed_orcids":["https://orcid.org/0000-0002-8698-9555"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabio Demontis","raw_affiliation_strings":["Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA"],"raw_orcid":"https://orcid.org/0000-0002-8698-9555","affiliations":[{"raw_affiliation_string":"Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015909717","display_name":"Sokol V. Todi","orcid":"https://orcid.org/0000-0003-4399-5549","observed_orcids":["https://orcid.org/0000-0003-4399-5549"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sokol V. Todi","raw_affiliation_strings":["Department of Neurology, Wayne State University School of Medicine, Detroit MI 48201, USA","Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA"],"raw_orcid":"https://orcid.org/0000-0003-4399-5549","affiliations":[{"raw_affiliation_string":"Department of Neurology, Wayne State University School of Medicine, Detroit MI 48201, USA","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA","institution_ids":["https://openalex.org/I185443292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015909717"],"corresponding_institution_ids":["https://openalex.org/I185443292"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinocerebellar-ataxia-type-17","display_name":"spinocerebellar ataxia type 17","score":0.996999979019165},{"id":"https://openalex.org/keywords/tata-binding-protein","display_name":"TATA-binding protein","score":0.9399999976158142},{"id":"https://openalex.org/keywords/polyglutamine-expansion","display_name":"polyglutamine expansion","score":0.9819999933242798},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7210000157356262},{"id":"https://openalex.org/keywords/drosophila-model","display_name":"Drosophila model","score":0.7720000147819519},{"id":"https://openalex.org/keywords/proteomic-profiling","display_name":"proteomic profiling","score":0.5609999895095825},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8579999804496765},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/ribosome-biogenesis","display_name":"ribosome biogenesis","score":0.6000000238418579},{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.8330000042915344},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9470000267028809},{"id":"https://openalex.org/keywords/xenobiotic-metabolism","display_name":"xenobiotic metabolism","score":0.8379999995231628},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.6470000147819519},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.7889999747276306},{"id":"https://openalex.org/keywords/disease-modifiers","display_name":"disease modifiers","score":0.4790000021457672},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6985999941825867},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.6474000215530396},{"id":"https://openalex.org/C2779500118","wikidata":"https://www.wikidata.org/wiki/Q899726","display_name":"Spinocerebellar ataxia","level":3,"score":0.6226000189781189},{"id":"https://openalex.org/C166252455","wikidata":"https://www.wikidata.org/wiki/Q6736610","display_name":"Trinucleotide repeat expansion","level":4,"score":0.6222000122070312},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6097000241279602},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5677000284194946},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.551800012588501},{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.49390000104904175},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.4756999909877777},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.42500001192092896},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.4205000102519989},{"id":"https://openalex.org/C182325514","wikidata":"https://www.wikidata.org/wiki/Q7322425","display_name":"Ribosome profiling","level":5,"score":0.4205000102519989},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.40529999136924744},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.36980000138282776},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.35269999504089355},{"id":"https://openalex.org/C2780906641","wikidata":"https://www.wikidata.org/wiki/Q213373","display_name":"Ataxia","level":2,"score":0.3041999936103821},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2757999897003174},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.27480000257492065},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.27129998803138733},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.2703999876976013},{"id":"https://openalex.org/C2779314966","wikidata":"https://www.wikidata.org/wiki/Q409999","display_name":"Frataxin","level":4,"score":0.2680000066757202},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.26080000400543213},{"id":"https://openalex.org/C136961756","wikidata":"https://www.wikidata.org/wiki/Q7431879","display_name":"Schneider 2 cells","level":5,"score":0.25049999356269836}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.64898/2026.10.20.760399","doi":"https://doi.org/10.64898/2026.10.20.760399","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.10.20.760399","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13738574","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13738574/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13738574","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13738574/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W402147902","https://openalex.org/W1483702648","https://openalex.org/W1594280279","https://openalex.org/W1878624693","https://openalex.org/W1977823813","https://openalex.org/W1979128845","https://openalex.org/W1986022352","https://openalex.org/W2004377729","https://openalex.org/W2007788777","https://openalex.org/W2012143380","https://openalex.org/W2012168167","https://openalex.org/W2013980278","https://openalex.org/W2028526974","https://openalex.org/W2029281553","https://openalex.org/W2031710534","https://openalex.org/W2048975879","https://openalex.org/W2074912858","https://openalex.org/W2076745544","https://openalex.org/W2080828566","https://openalex.org/W2090652319","https://openalex.org/W2097978324","https://openalex.org/W2108712717","https://openalex.org/W2115326044","https://openalex.org/W2124141726","https://openalex.org/W2138745251","https://openalex.org/W2153373821","https://openalex.org/W2157702310","https://openalex.org/W2161252246","https://openalex.org/W2163331386","https://openalex.org/W2169482727","https://openalex.org/W2312785503","https://openalex.org/W2432158008","https://openalex.org/W2774686915","https://openalex.org/W2791710742","https://openalex.org/W2794874880","https://openalex.org/W2887748872","https://openalex.org/W2901914802","https://openalex.org/W2946131331","https://openalex.org/W2960641374","https://openalex.org/W2995428139","https://openalex.org/W3020038147","https://openalex.org/W3105659382","https://openalex.org/W3160368117","https://openalex.org/W4210904960","https://openalex.org/W4225012870","https://openalex.org/W4225265321","https://openalex.org/W4295279790","https://openalex.org/W4296764656","https://openalex.org/W4383873820","https://openalex.org/W4385157089","https://openalex.org/W4385660188","https://openalex.org/W4388652852","https://openalex.org/W4399888672","https://openalex.org/W4402891947","https://openalex.org/W4405238465","https://openalex.org/W4406956155","https://openalex.org/W4407164733","https://openalex.org/W4408971753","https://openalex.org/W4412628376","https://openalex.org/W4413989440","https://openalex.org/W4415491845","https://openalex.org/W4417104917","https://openalex.org/W7128017107","https://openalex.org/W7130592203","https://openalex.org/W7160954619","https://openalex.org/W7167472290","https://openalex.org/W7169682426","https://openalex.org/W7211996688","https://openalex.org/W7213425884"],"related_works":["https://openalex.org/W4385660188","https://openalex.org/W2107663569","https://openalex.org/W2515700719","https://openalex.org/W2960641374","https://openalex.org/W2129194953","https://openalex.org/W2124141726","https://openalex.org/W2022491801","https://openalex.org/W2080828566","https://openalex.org/W2749196262","https://openalex.org/W2146901537"],"abstract_inverted_index":{"ABSTRACT":[0],"Spinocerebellar":[1],"ataxia":[2],"type":[3],"17":[4],"(SCA17)":[5,47],"is":[6,21],"an":[7],"age-related":[8],"neurodegenerative":[9],"disorder":[10],"caused":[11],"by":[12],"polyglutamine":[13,28,142],"expansion":[14,29],"in":[15,49,97,103],"the":[16,98],"TATA-binding":[17],"protein":[18],"(TBP).":[19],"TBP":[20,48,136],"a":[22],"core":[23],"transcription":[24],"factor,":[25],"but":[26,100],"pathogenic":[27,46],"likely":[30],"rewires":[31],"cellular":[32],"programs":[33],"beyond":[34],"transcription.":[35],"Here,":[36],"we":[37,55],"utilized":[38],"Drosophila":[39],"strains":[40],"that":[41],"express":[42],"wild-type":[43],"(WT)":[44],"or":[45,51],"neurons":[50],"skeletal":[52],"muscle,":[53],"which":[54],"analyzed":[56],"vs.":[57],"controls":[58],"via":[59],"TMT":[60],"mass":[61],"spectrometry,":[62],"profiling":[63],"of":[64,113,120,129],"eight":[65],"post-translational":[66],"modifications,":[67],"and":[68,72,78,88,94,144],"RNA-seq.":[69],"Shared":[70],"TBP-WT":[71],"TBP-SCA17":[73],"responses":[74,143],"predominated,":[75],"impacting":[76],"ribosomes":[77],"mitochondria":[79],"while":[80],"repressing":[81],"innate":[82],"immunity.":[83],"Disease-specific":[84],"effects":[85,138],"were":[86],"narrower":[87],"tissue-dependent:":[89],"SCA17":[90,130],"activated":[91],"xenobiotic,":[92],"retinoid,":[93],"glutathione-redox":[95],"pathways":[96],"CNS,":[99],"attenuated":[101],"anabolism":[102],"muscle":[104],"compared":[105],"to":[106],"TBP-WT.":[107],"Many":[108],"proteomic":[109],"changes":[110],"occurred":[111],"independently":[112],"mRNA":[114],"changes,":[115],"implicating":[116],"post-transcriptional":[117],"mechanisms.":[118],"Knockdown":[119],"select":[121],"SCA17-regulated":[122],"proteins":[123],"reduced":[124],"cytotoxicity,":[125],"validating":[126],"omics-identified":[127],"modifiers":[128],"pathology.":[131],"These":[132],"findings":[133],"distinguish":[134],"shared":[135],"dosage":[137],"from":[139],"disease-linked,":[140],"tissue-specific":[141],"identify":[145],"evolutionarily":[146],"conserved":[147],"targets":[148],"for":[149],"SCA17.":[150]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-22T00:00:00"}
