{"id":"https://openalex.org/W7223088697","doi":"https://doi.org/10.3389/fphar.2026.1965339","title":"Potential drug-drug interaction risks of selective serotonin reuptake inhibitors in outpatients: a retrospective analysis using two screening databases","display_name":"Potential drug-drug interaction risks of selective serotonin reuptake inhibitors in outpatients: a retrospective analysis using two screening databases","publication_year":2026,"publication_date":"2026-10-21","ids":{"openalex":"https://openalex.org/W7223088697","doi":"https://doi.org/10.3389/fphar.2026.1965339","pmid":"https://pubmed.ncbi.nlm.nih.gov/42985085","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13731344"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2026.1965339","doi":"https://doi.org/10.3389/fphar.2026.1965339","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1965339","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1965339/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1965339/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101688813","display_name":"Shanshan Xu","orcid":"https://orcid.org/0000-0003-3489-9141","observed_orcids":["https://orcid.org/0000-0003-3489-9141"]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanshan Xu","raw_affiliation_strings":["Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123525504","display_name":"Zhihui Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihui Song","raw_affiliation_strings":["Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101422784","display_name":"Yiman Li","orcid":"https://orcid.org/0009-0000-7243-6784","observed_orcids":["https://orcid.org/0009-0000-7243-6784"]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiman Li","raw_affiliation_strings":["Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101422218","display_name":"Jie Bai","orcid":"https://orcid.org/0009-0003-4320-9082","observed_orcids":["https://orcid.org/0009-0003-4320-9082"]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Bai","raw_affiliation_strings":["Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159180276","display_name":"Dong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Wang","raw_affiliation_strings":["Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062702348","display_name":"Ente Wang","orcid":"https://orcid.org/0000-0001-8096-3154","observed_orcids":["https://orcid.org/0000-0001-8096-3154"]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ente Wang","raw_affiliation_strings":["Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159199370","display_name":"Jiawei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiawei Wang","raw_affiliation_strings":["Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5159199370"],"corresponding_institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.78149883,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1965339","last_page":"1965339"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.972000002861023},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":1.0},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"polypharmacy","score":0.8339999914169312},{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.6940000057220459},{"id":"https://openalex.org/keywords/qt-interval-prolongation","display_name":"QT prolongation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/serotonin-syndrome","display_name":"serotonin syndrome","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.6639999747276306},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cytochrome-p450-interactions","display_name":"cytochrome P450 interactions","score":0.8460000157356262},{"id":"https://openalex.org/keywords/outpatients","display_name":"outpatients","score":0.6079999804496765},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.621999979019165},{"id":"https://openalex.org/keywords/psychiatric-patients","display_name":"psychiatric patients","score":0.3269999921321869},{"id":"https://openalex.org/keywords/micromedex","display_name":"Micromedex","score":0.7440000176429749},{"id":"https://openalex.org/keywords/lexi-interact","display_name":"Lexi-Interact","score":0.9950000047683716},{"id":"https://openalex.org/keywords/drug-safety-testing","display_name":"drug safety testing","score":0.39399999380111694},{"id":"https://openalex.org/keywords/concomitant-medications","display_name":"concomitant medications","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8335000276565552},{"id":"https://openalex.org/C36434225","wikidata":"https://www.wikidata.org/wiki/Q1895998","display_name":"Polypharmacy","level":2,"score":0.7457000017166138},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6419000029563904},{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.5623000264167786},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5152000188827515},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4528999924659729},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.41190001368522644},{"id":"https://openalex.org/C2777828372","wikidata":"https://www.wikidata.org/wiki/Q408471","display_name":"Paroxetine","level":4,"score":0.41119998693466187},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40220001339912415},{"id":"https://openalex.org/C2780092697","wikidata":"https://www.wikidata.org/wiki/Q7455053","display_name":"Serotonin reuptake inhibitor","level":4,"score":0.39640000462532043},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.3822999894618988},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.3774000108242035},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.3765999972820282},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.3522000014781952},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.34880000352859497},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.34689998626708984},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.3456999957561493},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.3440000116825104},{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.3418000042438507},{"id":"https://openalex.org/C2781081902","wikidata":"https://www.wikidata.org/wiki/Q3539074","display_name":"Tricyclic","level":2,"score":0.34150001406669617},{"id":"https://openalex.org/C2777669559","wikidata":"https://www.wikidata.org/wiki/Q407617","display_name":"Sertraline","level":4,"score":0.335999995470047},{"id":"https://openalex.org/C97320921","wikidata":"https://www.wikidata.org/wiki/Q718753","display_name":"Drug interaction","level":3,"score":0.325300008058548},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.3246000111103058},{"id":"https://openalex.org/C2776466888","wikidata":"https://www.wikidata.org/wiki/Q898407","display_name":"Venlafaxine","level":4,"score":0.3199000060558319},{"id":"https://openalex.org/C2776619155","wikidata":"https://www.wikidata.org/wiki/Q201872","display_name":"Olanzapine","level":3,"score":0.3165000081062317},{"id":"https://openalex.org/C2780179036","wikidata":"https://www.wikidata.org/wiki/Q616181","display_name":"Serotonin syndrome","level":5,"score":0.2980000078678131},{"id":"https://openalex.org/C2778176773","wikidata":"https://www.wikidata.org/wiki/Q2976049","display_name":"Drug class","level":3,"score":0.2962999939918518},{"id":"https://openalex.org/C2780057945","wikidata":"https://www.wikidata.org/wiki/Q412443","display_name":"Risperidone","level":3,"score":0.29510000348091125},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.29030001163482666},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.2897999882698059},{"id":"https://openalex.org/C23276603","wikidata":"https://www.wikidata.org/wiki/Q158230","display_name":"Pharmacoepidemiology","level":3,"score":0.28380000591278076},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.2809999883174896},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.27950000762939453},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.2734000086784363},{"id":"https://openalex.org/C2776865356","wikidata":"https://www.wikidata.org/wiki/Q1182681","display_name":"Defined daily dose","level":3,"score":0.26829999685287476},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.2680000066757202},{"id":"https://openalex.org/C2780836401","wikidata":"https://www.wikidata.org/wiki/Q868658","display_name":"Perampanel","level":3,"score":0.25029999017715454}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2026.1965339","doi":"https://doi.org/10.3389/fphar.2026.1965339","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1965339","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1965339/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13731344","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13731344/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13731344/pdf/fphar-17-1965339.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:42985085","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42985085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:65cd478691c54a69878ecd7d190fb6bc","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/65cd478691c54a69878ecd7d190fb6bc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2026.1965339","doi":"https://doi.org/10.3389/fphar.2026.1965339","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1965339","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1965339/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223088697.pdf","grobid_xml":"https://content.openalex.org/works/W7223088697.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1586065247","https://openalex.org/W1976624390","https://openalex.org/W1981395380","https://openalex.org/W2014252886","https://openalex.org/W2026864077","https://openalex.org/W2039848755","https://openalex.org/W2061913829","https://openalex.org/W2078247782","https://openalex.org/W2081280649","https://openalex.org/W2085393530","https://openalex.org/W2137135318","https://openalex.org/W2158234286","https://openalex.org/W2313892311","https://openalex.org/W2401627901","https://openalex.org/W2403162773","https://openalex.org/W2535564244","https://openalex.org/W2582472590","https://openalex.org/W2741716061","https://openalex.org/W2754537739","https://openalex.org/W2964901817","https://openalex.org/W2972962621","https://openalex.org/W3016862200","https://openalex.org/W3029239100","https://openalex.org/W3120024279","https://openalex.org/W3132844587","https://openalex.org/W3192281797","https://openalex.org/W3201518797","https://openalex.org/W3217788064","https://openalex.org/W4282837128","https://openalex.org/W4283267067","https://openalex.org/W4290943419","https://openalex.org/W4311543772","https://openalex.org/W4316193316","https://openalex.org/W4318777087","https://openalex.org/W4389561680","https://openalex.org/W4390689458","https://openalex.org/W4392782683","https://openalex.org/W4398785196","https://openalex.org/W4407085984","https://openalex.org/W4409798360","https://openalex.org/W4414449645","https://openalex.org/W7151932338"],"related_works":["https://openalex.org/W4220755832","https://openalex.org/W2074704459","https://openalex.org/W4407392333","https://openalex.org/W4414449645","https://openalex.org/W4311543772","https://openalex.org/W2898161295","https://openalex.org/W2057262891","https://openalex.org/W2092788405","https://openalex.org/W4402929123","https://openalex.org/W4417180942"],"abstract_inverted_index":{"Introduction:":[0],"Potential":[1],"drug-drug":[2],"interactions":[3,146],"(pDDIs)":[4],"involving":[5,121,260],"selective":[6],"serotonin":[7,223],"reuptake":[8],"inhibitors":[9],"(SSRIs)":[10],"pose":[11],"significant":[12],"risks":[13],"in":[14,47,126],"psychiatric":[15,274,312],"care,":[16],"where":[17],"polypharmacy":[18,246],"often":[19],"exacerbates":[20],"pharmacokinetic":[21],"and":[22,39,74,87,94,97,110,165,209,228,235,245],"pharmacodynamic":[23],"effects":[24],"through":[25],"cytochrome":[26],"P450":[27],"enzyme":[28],"pathways.":[29],"This":[30,255],"retrospective":[31,53,256],"study":[32,54,257],"aimed":[33],"to":[34,58,65,91,102,282,308],"assess":[35],"the":[36,127,171,183,297],"prevalence,":[37],"characteristics,":[38],"risk":[40],"factors":[41],"of":[42,112,118,131,138,145],"pDDIs":[43,93,140,259],"associated":[44,249],"with":[45,76,135,232,250],"SSRIs":[46,261],"outpatients.":[48],"Methods:":[49],"We":[50],"conducted":[51],"a":[52,268],"on":[55,174,290],"outpatients":[56],"admitted":[57],"Beijing":[59],"Tongren":[60],"Hospital":[61],"from":[62],"January":[63],"2023":[64],"December":[66],"2024.":[67],"The":[68],"patients":[69,123,289],"were":[70,89,124,150,161,187,247],"\u226718":[71],"years":[72],"old":[73],"treated":[75],"two":[77,172],"or":[78,275],"more":[79],"drugs":[80],"including":[81],"at":[82],"least":[83],"one":[84],"SSRI.":[85],"Micromedex\u00ae":[86,149],"Lexi-Interact\u00ae":[88],"used":[90],"identify":[92,103],"their":[95],"severities,":[96],"logistic":[98],"regression":[99],"was":[100,133,176],"employed":[101],"demographic":[104],"predictors":[105],"such":[106],"as":[107,152,163,167],"gender,":[108,240],"age,":[109],"number":[111],"concomitant":[113],"medications.":[114],"Results:":[115],"A":[116,129],"total":[117],"3476":[119],"prescriptions":[120],"1186":[122],"included":[125,195],"analysis.":[128],"prevalence":[130],"19.68%":[132],"observed,":[134],"an":[136],"average":[137],"2.05":[139],"per":[141],"affected":[142],"prescription.":[143],"98.83%":[144],"detected":[147,157],"by":[148,158,189],"classified":[151,162],"major,":[153],"whereas":[154],"among":[155,264,286],"those":[156],"Lexi-Interact\u00ae,":[159],"68.76%":[160],"moderate":[164],"21.50%":[166],"minor.":[168],"Agreement":[169],"between":[170,293],"databases":[173,295],"severity":[175],"poor":[177],"(Cohen's":[178],"\u03ba":[179],"=":[180],"0.034)":[181],"when":[182],"same":[184],"drug":[185,193],"pairs":[186],"rated":[188],"both.":[190],"Common":[191],"interacting":[192],"classes":[194],"antipsychotics":[196],"(292":[197],"instances),":[198],"other":[199],"antidepressants":[200],"(207),":[201,205,230],"blood":[202],"glucose-lowering":[203],"agents":[204,207],"antithrombotic":[206],"(193),":[208],"calcium":[210],"channel":[211],"blockers":[212],"(157).":[213],"Predominant":[214],"clinical":[215],"consequences":[216],"encompassed":[217],"QT":[218],"interval":[219],"prolongation":[220],"(569":[221],"cases),":[222],"syndrome":[224],"(390),":[225],"bleeding":[226],"(229),":[227],"hypoglycemia":[229],"aligning":[231],"serotonergic":[233],"excess":[234],"platelet":[236],"function":[237],"theories.":[238],"Female":[239],"middle":[241],"age":[242],"(40-64":[243],"years),":[244],"significantly":[248],"higher":[251],"pDDI":[252],"risks.":[253],"Conclusion:":[254],"found":[258],"relatively":[262],"uncommon":[263],"general":[265],"hospital":[266],"outpatients,":[267],"broader,":[269],"less-studied":[270],"population":[271],"than":[272],"prior":[273],"nursing":[276],"home":[277],"cohorts,":[278],"yet":[279],"still":[280],"linked":[281],"severe":[283],"outcomes,":[284],"especially":[285],"female,":[287],"middle-aged":[288],"polypharmacy.":[291],"Discrepancies":[292],"interaction-severity":[294],"underscored":[296],"need":[298],"for":[299],"multi-tool":[300],"assessment.":[301],"Future":[302],"prospective,":[303],"multi-centre":[304],"studies":[305],"are":[306],"needed":[307],"inform":[309],"safer":[310],"outpatient":[311],"prescribing.":[313]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-22T00:00:00"}
