{"id":"https://openalex.org/W7223087210","doi":"https://doi.org/10.1136/bmj-2026-100872","title":"Acetic acid chromoendoscopy for detection of neoplastic Barrett\u2019s oesophagus: stepped wedge cluster randomised controlled trial (ACID-trial)","display_name":"Acetic acid chromoendoscopy for detection of neoplastic Barrett\u2019s oesophagus: stepped wedge cluster randomised controlled trial (ACID-trial)","publication_year":2026,"publication_date":"2026-10-21","ids":{"openalex":"https://openalex.org/W7223087210","doi":"https://doi.org/10.1136/bmj-2026-100872","pmid":"https://pubmed.ncbi.nlm.nih.gov/42907095"},"language":"en","primary_location":{"id":"doi:10.1136/bmj-2026-100872","doi":"https://doi.org/10.1136/bmj-2026-100872","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmj-2026-100872","pdf_url":null,"source":{"id":"https://openalex.org/S4393917726","display_name":"BMJ","issn_l":"1756-1833","issn":["1756-1833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1136/bmj-2026-100872","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075454624","display_name":"Ilse N. Beaufort","orcid":"https://orcid.org/0000-0002-5334-6609","observed_orcids":["https://orcid.org/0000-0002-5334-6609"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"I N Beaufort","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, St Antonius Hospital, Nieuwegein, Netherlands","Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-5334-6609","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, St Antonius Hospital, Nieuwegein, Netherlands","institution_ids":["https://openalex.org/I4210103448"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159196848","display_name":"L S Boer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"L S Boer","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, St Antonius Hospital, Nieuwegein, Netherlands","Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, St Antonius Hospital, Nieuwegein, Netherlands","institution_ids":["https://openalex.org/I4210103448"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159201548","display_name":"A N Milne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A N Milne","raw_affiliation_strings":["Department of Pathology, St Antonius Hospital, Nieuwegein, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, St Antonius Hospital, Nieuwegein, Netherlands","institution_ids":["https://openalex.org/I4210103448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074352597","display_name":"Yasser A. Alderlieste","orcid":"https://orcid.org/0009-0001-7679-9280","observed_orcids":["https://orcid.org/0009-0001-7679-9280"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y A Alderlieste","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Beatrix Hospital, Gorinchem, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Beatrix Hospital, Gorinchem, Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159202567","display_name":"J E Baars","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105981","display_name":"Amphia Ziekenhuis","ror":"https://ror.org/01g21pa45","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210105981"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J E Baars","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Amphia Hospital, Breda, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Amphia Hospital, Breda, Netherlands","institution_ids":["https://openalex.org/I4210105981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159176354","display_name":"P R Bos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124011","display_name":"Ziekenhuis Gelderse Vallei","ror":"https://ror.org/03862t386","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210124011"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P R Bos","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Hospital Gelderse Vallei, Ede, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Hospital Gelderse Vallei, Ede, Netherlands","institution_ids":["https://openalex.org/I4210124011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079400359","display_name":"Jordy P. W. Burger","orcid":"https://orcid.org/0000-0002-7548-0075","observed_orcids":["https://orcid.org/0000-0002-7548-0075"]},"institutions":[{"id":"https://openalex.org/I4210152306","display_name":"Rijnstate Hospital","ror":"https://ror.org/0561z8p38","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210152306"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J P W Burger","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Rijnstate Hospital, Arnhem, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Rijnstate Hospital, Arnhem, Netherlands","institution_ids":["https://openalex.org/I4210152306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159219452","display_name":"N C M van Heel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800996342","display_name":"Gelre Hospitals","ror":"https://ror.org/05275vm15","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800996342"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"N C M van Heel","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Gelre Hospital, Apeldoorn, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Gelre Hospital, Apeldoorn, Netherlands","institution_ids":["https://openalex.org/I2800996342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082459083","display_name":"Michiel Ledeboer","orcid":"https://orcid.org/0000-0001-9243-6378","observed_orcids":["https://orcid.org/0000-0001-9243-6378"]},"institutions":[{"id":"https://openalex.org/I4210156224","display_name":"Deventer Ziekenhuis","ror":"https://ror.org/05w8df681","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210156224"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M Ledeboer","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Deventer Hospital, Deventer, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Deventer Hospital, Deventer, Netherlands","institution_ids":["https://openalex.org/I4210156224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159203536","display_name":"R J Lieverse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149617","display_name":"Ziekenhuis Groep Twente","ror":"https://ror.org/04grrp271","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210149617"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R J Lieverse","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Hospital Group Twente, Almelo, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Hospital Group Twente, Almelo, Netherlands","institution_ids":["https://openalex.org/I4210149617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084624878","display_name":"Paul C. van de Meeberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093680","display_name":"Slingeland Ziekenhuis","ror":"https://ror.org/00jw56w10","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210093680"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P C van de Meeberg","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Slingeland Hospital, Doetinchem, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Slingeland Hospital, Doetinchem, Netherlands","institution_ids":["https://openalex.org/I4210093680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159193028","display_name":"J J Meeuse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133415","display_name":"Ziekenhuis Rivierenland","ror":"https://ror.org/03xwgfg33","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210133415"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J J Meeuse","raw_affiliation_strings":["Department of Internal Medicine, Hospital Rivierenland, Tiel, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Hospital Rivierenland, Tiel, Netherlands","institution_ids":["https://openalex.org/I4210133415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110192489","display_name":"A.H.J. Naber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147058","display_name":"Tergooi","ror":"https://ror.org/045nawc23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210147058"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A H J Naber","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Tergooi Hospital, Hilversum, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Tergooi Hospital, Hilversum, Netherlands","institution_ids":["https://openalex.org/I4210147058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019247975","display_name":"Hendrikus J.M. Pullens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158428","display_name":"Meander Medisch Centrum","ror":"https://ror.org/04n1xa154","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210158428"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H J M Pullens","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Meander Medical Center, Amersfoort, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Meander Medical Center, Amersfoort, Netherlands","institution_ids":["https://openalex.org/I4210158428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013378593","display_name":"Robert C.H. Scheffer","orcid":"https://orcid.org/0009-0007-7084-0047","observed_orcids":["https://orcid.org/0009-0007-7084-0047"]},"institutions":[{"id":"https://openalex.org/I4210160169","display_name":"Jeroen Bosch Ziekenhuis","ror":"https://ror.org/04rr42t68","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210160169"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R C H Scheffer","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Jeroen Bosch Hospital, \u2018s-Hertogenbosch, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Jeroen Bosch Hospital, \u2018s-Hertogenbosch, Netherlands","institution_ids":["https://openalex.org/I4210160169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072171299","display_name":"Marjolein Sikkema","orcid":"https://orcid.org/0009-0002-1108-8522","observed_orcids":["https://orcid.org/0009-0002-1108-8522"]},"institutions":[{"id":"https://openalex.org/I4210149554","display_name":"Elisabeth-TweeSteden Ziekenhuis","ror":"https://ror.org/04gpfvy81","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210149554"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M Sikkema","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Elisabeth-TweeSteden Hospital, Tilburg, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Elisabeth-TweeSteden Hospital, Tilburg, Netherlands","institution_ids":["https://openalex.org/I4210149554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159219775","display_name":"M F J Stolk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M F J Stolk","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, St Antonius Hospital, Nieuwegein, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, St Antonius Hospital, Nieuwegein, Netherlands","institution_ids":["https://openalex.org/I4210103448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159163611","display_name":"R E Verbeek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141521","display_name":"Groene Hart Ziekenhuis","ror":"https://ror.org/0582y1e41","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210141521"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R E Verbeek","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Groene Hart Hospital, Gouda, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Groene Hart Hospital, Gouda, Netherlands","institution_ids":["https://openalex.org/I4210141521"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008519282","display_name":"Marc A. M. T. Verhagen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106388","display_name":"Diakonessenhuis hospital","ror":"https://ror.org/01nrpzj54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210106388"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M A M T Verhagen","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Diakonessenhuis, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Diakonessenhuis, Utrecht, Netherlands","institution_ids":["https://openalex.org/I4210106388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110806783","display_name":"Wim van de Vrie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091119","display_name":"Albert Schweitzer Ziekenhuis","ror":"https://ror.org/00e8ykd54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210091119"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"W van de Vrie","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Albert Schweitzer Hospital, Dordrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Albert Schweitzer Hospital, Dordrecht, Netherlands","institution_ids":["https://openalex.org/I4210091119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159219310","display_name":"M Willems","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Willems","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, St Jansdal Hospital, Harderwijk, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, St Jansdal Hospital, Harderwijk, Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030171913","display_name":"Cornelis H. van Werkhoven","orcid":"https://orcid.org/0000-0002-0626-4635","observed_orcids":["https://orcid.org/0000-0002-0626-4635"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C H van Werkhoven","raw_affiliation_strings":["Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159218074","display_name":"B L A M Weusten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210103448","display_name":"St. Antonius Ziekenhuis","ror":"https://ror.org/01jvpb595","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4210103448"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"B L A M Weusten","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, St Antonius Hospital, Nieuwegein, Netherlands","Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, St Antonius Hospital, Nieuwegein, Netherlands","institution_ids":["https://openalex.org/I4210103448"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":18,"corresponding_author_ids":["https://openalex.org/A5075454624"],"corresponding_institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916","https://openalex.org/I4210103448"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.83113383,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"395","issue":null,"first_page":"e100872","last_page":"e100872"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11658","display_name":"Esophageal and GI Pathology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/barrett-s-esophagus","display_name":"Barrett's esophagus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/esophageal-adenocarcinoma","display_name":"esophageal adenocarcinoma","score":0.9330000281333923},{"id":"https://openalex.org/keywords/dysplasia-detection","display_name":"dysplasia detection","score":0.7860000133514404},{"id":"https://openalex.org/keywords/surveillance-endoscopy","display_name":"endoscopic surveillance","score":0.8820000290870667},{"id":"https://openalex.org/keywords/targeted-biopsy","display_name":"targeted biopsy","score":0.8080000281333923},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.5820000171661377},{"id":"https://openalex.org/keywords/stepped-wedge-cluster-randomized-trial","display_name":"stepped-wedge cluster randomized trial","score":0.7070000171661377},{"id":"https://openalex.org/keywords/endoscopist-training","display_name":"endoscopist training","score":0.6520000100135803},{"id":"https://openalex.org/keywords/community-hospitals","display_name":"community hospitals","score":0.4020000100135803}],"concepts":[{"id":"https://openalex.org/C2777490804","wikidata":"https://www.wikidata.org/wiki/Q5113878","display_name":"Chromoendoscopy","level":5,"score":0.9354000091552734},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8711000084877014},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6897000074386597},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6883999705314636},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.5770000219345093},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5336999893188477},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4932999908924103},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4438999891281128},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39239999651908875},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.37229999899864197},{"id":"https://openalex.org/C2776141087","wikidata":"https://www.wikidata.org/wiki/Q2161551","display_name":"Watchful waiting","level":4,"score":0.34360000491142273},{"id":"https://openalex.org/C2910380887","wikidata":"https://www.wikidata.org/wiki/Q808892","display_name":"Barrett's oesophagus","level":4,"score":0.3246999979019165},{"id":"https://openalex.org/C2780639617","wikidata":"https://www.wikidata.org/wiki/Q6516972","display_name":"Quadrant (abdomen)","level":2,"score":0.32249999046325684},{"id":"https://openalex.org/C2777661416","wikidata":"https://www.wikidata.org/wiki/Q1035645","display_name":"Carcinoma in situ","level":3,"score":0.31369999051094055},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.31360000371932983},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.3025999963283539},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.26499998569488525},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C202953159","wikidata":"https://www.wikidata.org/wiki/Q382695","display_name":"Intention-to-treat analysis","level":3,"score":0.25920000672340393},{"id":"https://openalex.org/C2778451229","wikidata":"https://www.wikidata.org/wiki/Q212809","display_name":"Endoscopy","level":2,"score":0.25699999928474426}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004945","descriptor_name":"Esophagoscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019342","descriptor_name":"Acetic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1136/bmj-2026-100872","doi":"https://doi.org/10.1136/bmj-2026-100872","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmj-2026-100872","pdf_url":null,"source":{"id":"https://openalex.org/S4393917726","display_name":"BMJ","issn_l":"1756-1833","issn":["1756-1833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ","raw_type":"journal-article"},{"id":"pmid:42907095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42907095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ (Clinical research ed.)","raw_type":"Journal Article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/492491","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/492491","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1136/bmj-2026-100872","doi":"https://doi.org/10.1136/bmj-2026-100872","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmj-2026-100872","pdf_url":null,"source":{"id":"https://openalex.org/S4393917726","display_name":"BMJ","issn_l":"1756-1833","issn":["1756-1833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1999430665","https://openalex.org/W2032929818","https://openalex.org/W2033365771","https://openalex.org/W2058898741","https://openalex.org/W2059338543","https://openalex.org/W2059549380","https://openalex.org/W2068455995","https://openalex.org/W2093274439","https://openalex.org/W2106886331","https://openalex.org/W2110283488","https://openalex.org/W2117981040","https://openalex.org/W2120897869","https://openalex.org/W2132746146","https://openalex.org/W2134262764","https://openalex.org/W2147556962","https://openalex.org/W2161179649","https://openalex.org/W2161840081","https://openalex.org/W2170852882","https://openalex.org/W2173609033","https://openalex.org/W2551926009","https://openalex.org/W2594369353","https://openalex.org/W2606632569","https://openalex.org/W2759747949","https://openalex.org/W2889752388","https://openalex.org/W2891790120","https://openalex.org/W2944553030","https://openalex.org/W2969502958","https://openalex.org/W2981276300","https://openalex.org/W2997517443","https://openalex.org/W3013311028","https://openalex.org/W4210481348","https://openalex.org/W4317514645","https://openalex.org/W4361218531","https://openalex.org/W4387444889","https://openalex.org/W4387521155","https://openalex.org/W4409067478"],"related_works":["https://openalex.org/W4408894458","https://openalex.org/W2132746146","https://openalex.org/W2464651703","https://openalex.org/W2741556092","https://openalex.org/W2336643181","https://openalex.org/W2979824426","https://openalex.org/W2020298794","https://openalex.org/W2334914360","https://openalex.org/W2066848203","https://openalex.org/W2134262764"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"the":[3,12,93,99,126,191,238],"added":[4],"value":[5],"of":[6,14,101,138,259,265],"acetic":[7],"acid":[8],"chromoendoscopy":[9],"(AAC)":[10],"for":[11,42,214],"detection":[13,95,128,193,241,264],"dysplasia":[15],"and":[16,110,148,181,217],"oesophageal":[17,111,184],"adenocarcinoma":[18,112],"during":[19],"Barrett's":[20,43,218,270],"oesophagus":[21,44,219,271],"surveillance":[22,41,60,145,152,274],"endoscopies.":[23],"DESIGN:":[24],"Prospective,":[25],"open":[26],"label,":[27],"stepped":[28],"wedge":[29],"cluster,":[30],"randomised":[31],"trial.":[32],"SETTING:":[33],"18":[34],"Dutch":[35],"community":[36],"hospitals.":[37],"PARTICIPANTS:":[38],"Patients":[39],"undergoing":[40,272],"were":[45,74,78,84,136,142,223],"eligible,":[46],"excluding":[47],"those":[48],"with":[49,67,103,153,197,269],"known":[50],"or":[51],"previously":[52],"treated":[53],"dysplasia.":[54],"INTERVENTIONS:":[55],"Hospitals":[56],"randomly":[57],"shifted":[58],"from":[59],"without":[61,146,202,234],"AAC":[62,65,147,155,186,198,230,235,260],"(control)":[63],"to":[64,144,151,211,255],"(intervention),":[66],"endoscopists":[68],"trained":[69],"before":[70],"implementation.":[71],"Targeted":[72],"biopsies":[73,83],"obtained":[75],"if":[76],"lesions":[77,222],"present;":[79],"random":[80],"four":[81],"quadrant":[82],"conducted.":[85],"MAIN":[86],"OUTCOME":[87],"MEASURES:":[88],"The":[89,122],"primary":[90],"endpoint":[91,124],"was":[92,125,156,165,243],"neoplasia":[94,127,164,192,240,266],"rate,":[96],"defined":[97],"as":[98],"percentage":[100],"participants":[102,135,170,228],"low":[104,173],"grade":[105,108,174,179],"dysplasia,":[106,109,175,180],"high":[107,178],"in":[113,130,158,167,225,267,275],"any":[114],"biopsy,":[115],"confirmed":[116],"by":[117],"an":[118],"experienced":[119],"gastrointestinal":[120],"pathologist.":[121],"secondary":[123],"rate":[129,194,242],"targeted":[131,239],"biopsies.":[132],"RESULTS:":[133],"2267":[134],"included,":[137],"whom":[139],"1438":[140],"(63%)":[141],"allocated":[143,161],"829":[149],"(37%)":[150],"AAC;":[154,203],"applied":[157],"679":[159],"(82%)":[160],"participants.":[162],"Overall,":[163],"diagnosed":[166],"163":[168],"(7.2%)":[169],"(111":[171],"(4.9%)":[172],"30":[176],"(1.3%)":[177],"22":[182],"(1.0%)":[183],"adenocarcinoma).":[185],"use":[187],"did":[188,261],"not":[189,244,262],"increase":[190],"(7.4%":[195],"(50/679)":[196],"versus":[199,231,248],"7.1%":[200],"(113/1588)":[201],"odds":[204,251],"ratio":[205,252],"0.97,":[206],"95%":[207],"confidence":[208],"interval":[209],"0.65":[210],"1.44;":[212],"adjusted":[213],"calendar":[215],"time":[216],"length).":[220],"Suspected":[221],"detected":[224],"95":[226],"(14.0%)":[227],"receiving":[229],"101":[232],"(6.4%)":[233],"(P<0.001),":[236],"but":[237],"higher":[245],"(2.1%":[246],"(14/679)":[247],"1.8%":[249],"(29/1588);":[250],"1.05,":[253],"0.49":[254],"2.24).":[256],"CONCLUSIONS:":[257],"Use":[258],"improve":[263],"patients":[268],"endoscopic":[273],"routine":[276],"clinical":[277],"practice.":[278],"TRIAL":[279],"REGISTRATION:":[280],"www.onderzoekmetmensen.nl;":[281],"NL-OMON25059":[282],"(prospective":[283],"registration;":[284],"4":[285],"Dec":[286],"2019).":[287]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-22T00:00:00"}