{"id":"https://openalex.org/W7223081806","doi":"https://doi.org/10.1007/s11523-026-01264-7","title":"Efficacy and Safety of Infliximab for Management of Immune-Related Adverse Events: A Retrospective Analysis","display_name":"Efficacy and Safety of Infliximab for Management of Immune-Related Adverse Events: A Retrospective Analysis","publication_year":2026,"publication_date":"2026-10-21","ids":{"openalex":"https://openalex.org/W7223081806","doi":"https://doi.org/10.1007/s11523-026-01264-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/42905330"},"language":"en","primary_location":{"id":"doi:10.1007/s11523-026-01264-7","doi":"https://doi.org/10.1007/s11523-026-01264-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11523-026-01264-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11523-026-01264-7.pdf","source":{"id":"https://openalex.org/S163958984","display_name":"Targeted Oncology","issn_l":"1776-2596","issn":["1776-2596","1776-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Targeted Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11523-026-01264-7.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060626607","display_name":"Filippos Koutroumpakis","orcid":"https://orcid.org/0000-0001-9119-7301","observed_orcids":["https://orcid.org/0000-0001-9119-7301"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Filippos Koutroumpakis","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159184618","display_name":"Yifan Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yifan Xu","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036690278","display_name":"Kevin Xin Shi","orcid":"https://orcid.org/0000-0001-9734-0324","observed_orcids":["https://orcid.org/0000-0001-9734-0324"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Shi","raw_affiliation_strings":["Department of Internal Medicine, The University of Texas Health Science Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, The University of Texas Health Science Center, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111249838","display_name":"Kei Takigawa","orcid":"https://orcid.org/0000-0001-9462-3193","observed_orcids":["https://orcid.org/0000-0001-9462-3193"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kei Takigawa","raw_affiliation_strings":["Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073654955","display_name":"Irene Jeong-Ah Lee","orcid":"https://orcid.org/0000-0003-0552-7429","observed_orcids":["https://orcid.org/0000-0003-0552-7429"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene Jeong-Ah Lee","raw_affiliation_strings":["Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113325967","display_name":"Anirudha Chatterjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anirudha Chatterjee","raw_affiliation_strings":["Department of Internal Medicine, The University of Texas Medical Branch, Galveston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, The University of Texas Medical Branch, Galveston, TX, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014226271","display_name":"Sidra Naz","orcid":"https://orcid.org/0000-0001-6390-9658","observed_orcids":["https://orcid.org/0000-0001-6390-9658"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sidra Naz","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100612792","display_name":"Yilin Song","orcid":"https://orcid.org/0000-0003-2209-1380","observed_orcids":["https://orcid.org/0000-0003-2209-1380"]},"institutions":[{"id":"https://openalex.org/I1315496137","display_name":"University of Maryland Medical Center","ror":"https://ror.org/00sde4n60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315496137","https://openalex.org/I14285509"]},{"id":"https://openalex.org/I4210132871","display_name":"University of Maryland Medical Center Midtown Campus","ror":"https://ror.org/03k0fhh26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4210132871"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yilin Song","raw_affiliation_strings":["Internal Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD, USA","institution_ids":["https://openalex.org/I1315496137","https://openalex.org/I4210132871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021950220","display_name":"Monica Desai","orcid":"https://orcid.org/0000-0003-3090-1929","observed_orcids":["https://orcid.org/0000-0003-3090-1929"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Desai","raw_affiliation_strings":["Division of Cancer Medicine, Department of Genitourinary Medical Oncology, The University of Texas Health Science Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Medicine, Department of Genitourinary Medical Oncology, The University of Texas Health Science Center, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071742593","display_name":"Mohamed Alaa Gouda","orcid":"https://orcid.org/0000-0003-4829-6739","observed_orcids":["https://orcid.org/0000-0003-4829-6739"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed Gouda","raw_affiliation_strings":["Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080142532","display_name":"Jessica R. Philpott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Philpott","raw_affiliation_strings":["Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, OH, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100748557","display_name":"Yinghong Wang","orcid":"https://orcid.org/0000-0002-5148-6130","observed_orcids":["https://orcid.org/0000-0002-5148-6130"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yinghong Wang","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. ywang59@mdanderson.org"],"raw_orcid":"https://orcid.org/0000-0002-5148-6130","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. ywang59@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5100748557"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.78123654,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/infliximab","display_name":"infliximab","score":1.0},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.8619999885559082},{"id":"https://openalex.org/keywords/remission-rate","display_name":"remission rate","score":0.6349999904632568},{"id":"https://openalex.org/keywords/predictors-of-treatment-response","display_name":"predictors of treatment response","score":0.7900000214576721},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.6549999713897705},{"id":"https://openalex.org/keywords/gastrointestinal-toxicity","display_name":"gastrointestinal toxicity","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9717000126838684},{"id":"https://openalex.org/C2777138892","wikidata":"https://www.wikidata.org/wiki/Q415264","display_name":"Infliximab","level":3,"score":0.9049999713897705},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.8263999819755554},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.7669000029563904},{"id":"https://openalex.org/C2777793932","wikidata":"https://www.wikidata.org/wiki/Q1116229","display_name":"Common Terminology Criteria for Adverse Events","level":3,"score":0.6949999928474426},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5408999919891357},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4909000098705292},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3465000092983246},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3407000005245209},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.3328999876976013},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3224000036716461},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.29989999532699585},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2822999954223633},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.25929999351501465}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s11523-026-01264-7","doi":"https://doi.org/10.1007/s11523-026-01264-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11523-026-01264-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11523-026-01264-7.pdf","source":{"id":"https://openalex.org/S163958984","display_name":"Targeted Oncology","issn_l":"1776-2596","issn":["1776-2596","1776-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Targeted Oncology","raw_type":"journal-article"},{"id":"pmid:42905330","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42905330","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Targeted oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s11523-026-01264-7","doi":"https://doi.org/10.1007/s11523-026-01264-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11523-026-01264-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11523-026-01264-7.pdf","source":{"id":"https://openalex.org/S163958984","display_name":"Targeted Oncology","issn_l":"1776-2596","issn":["1776-2596","1776-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Targeted Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223081806.pdf","grobid_xml":"https://content.openalex.org/works/W7223081806.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W2066203385","https://openalex.org/W2078621117","https://openalex.org/W2152803371","https://openalex.org/W2931644395","https://openalex.org/W3009244677","https://openalex.org/W3037088183","https://openalex.org/W3092802874","https://openalex.org/W3210474759","https://openalex.org/W4306709504","https://openalex.org/W4388990536","https://openalex.org/W4410997890"],"related_works":["https://openalex.org/W4417197907","https://openalex.org/W3030378344","https://openalex.org/W4408376448","https://openalex.org/W4399583711","https://openalex.org/W3169354761","https://openalex.org/W4311147048","https://openalex.org/W3127167442","https://openalex.org/W4396990101","https://openalex.org/W4403724870","https://openalex.org/W7095832122"],"abstract_inverted_index":{"BACKGROUND:":[0],"Immune-related":[1],"adverse":[2,90,194],"events":[3,91,195],"(irAEs)":[4],"are":[5,230],"common":[6],"complications":[7],"of":[8,44,50,83,175,181,215],"immune":[9],"checkpoint":[10],"inhibitor":[11],"(ICI)":[12],"therapy":[13],"and":[14,42,46,80,88,116,173,190,207],"frequently":[15],"require":[16],"immunosuppressive":[17],"treatment.":[18],"Infliximab":[19,199],"is":[20,37],"commonly":[21],"used":[22],"for":[23,163,210],"steroid-refractory":[24,212],"irAEs;":[25],"however,":[26],"the":[27,40,48],"optimal":[28,234],"dosing":[29,51,235],"strategy":[30],"remains":[31],"unclear.":[32],"OBJECTIVE:":[33],"The":[34,95],"study":[35,96],"objective":[36],"to":[38,76,147,185,203,232],"evaluate":[39],"efficacy":[41],"safety":[43],"infliximab":[45,77],"assess":[47],"impact":[49],"strategies":[52],"across":[53],"diverse":[54,211],"irAEs.":[55,213],"PATIENTS":[56],"AND":[57],"METHODS:":[58],"We":[59],"retrospectively":[60],"analyzed":[61],"patients":[62,99,107],"treated":[63,102],"at":[64],"our":[65],"institution":[66],"who":[67],"developed":[68],"irAEs":[69,101],"requiring":[70],"infliximab.":[71,104],"Patients":[72,122],"were":[73,92],"grouped":[74],"according":[75],"starting":[78],"dose":[79],"total":[81],"number":[82],"doses":[84,115,126,136,178,218],"received.":[85],"Treatment":[86],"outcomes":[87],"infliximab-related":[89],"assessed.":[93],"RESULTS:":[94],"included":[97],"457":[98],"with":[100,103,221],"Among":[105],"443":[106],"receiving":[108,123,134],"5":[109,200],"mg/kg":[110,187,201],"infliximab,":[111],"342":[112],"received":[113,118],"1-2":[114,135],"101":[117],"\u2265":[119,124,176,216],"3":[120,125,177,217],"doses.":[121],"had":[127],"higher":[128,222],"8-week":[129],"remission":[130,223],"rates":[131,224],"than":[132],"those":[133],"(75":[137],"versus":[138,150],"49%,":[139],"p":[140,153],"<":[141],"0.01)":[142],"despite":[143],"a":[144,205],"longer":[145],"time":[146],"response":[148],"(19":[149],"6":[151],"days,":[152],"=":[154],"0.01).":[155],"Univariate":[156],"analysis":[157],"identified":[158],"baseline":[159],"Common":[160],"Terminology":[161],"Criteria":[162],"Adverse":[164],"Events":[165],"(CTCAE)":[166],"grade,":[167],"combination":[168],"immunotherapy,":[169],"lower":[170],"gastrointestinal":[171],"toxicity,":[172],"receipt":[174],"as":[179],"predictors":[180],"response.":[182],"Dose":[183],"escalation":[184],"10":[186],"was":[188,196,219],"rare,":[189],"no":[191],"increase":[192],"in":[193],"observed.":[197],"CONCLUSIONS:":[198],"appears":[202],"be":[204],"safe":[206],"effective":[208],"treatment":[209],"Receipt":[214],"associated":[220],"without":[225],"increased":[226],"toxicity.":[227],"Prospective":[228],"studies":[229],"needed":[231],"define":[233],"strategies.":[236]},"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2026-10-22T00:00:00"}