{"id":"https://openalex.org/W7223070684","doi":"https://doi.org/10.3389/fragi.2026.1869552","title":"Impact of habitual physical activity and age on T cell metabolism and activation via \u03b22-adrenergic receptor modulation","display_name":"Impact of habitual physical activity and age on T cell metabolism and activation via \u03b22-adrenergic receptor modulation","publication_year":2026,"publication_date":"2026-10-20","ids":{"openalex":"https://openalex.org/W7223070684","doi":"https://doi.org/10.3389/fragi.2026.1869552","pmid":"https://pubmed.ncbi.nlm.nih.gov/42978825","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13727592"},"language":"en","primary_location":{"id":"doi:10.3389/fragi.2026.1869552","doi":"https://doi.org/10.3389/fragi.2026.1869552","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fragi.2026.1869552","pdf_url":"https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2026.1869552/pdf","source":{"id":"https://openalex.org/S4210191507","display_name":"Frontiers in Aging","issn_l":"2673-6217","issn":["2673-6217"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2026.1869552/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087838249","display_name":"Amanda Veiga Sardeli","orcid":"https://orcid.org/0000-0003-0575-7996","observed_orcids":["https://orcid.org/0000-0003-0575-7996","https://orcid.org/0009-0005-7323-5956"]},"institutions":[{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Amanda V. Sardeli","raw_affiliation_strings":["Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham","National Institute for Health and Care Research (NIHR), Biomedical Research Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"National Institute for Health and Care Research (NIHR), Biomedical Research Centre","institution_ids":["https://openalex.org/I34931013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159149877","display_name":"Ana Ramkrapes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Ramkrapes","raw_affiliation_strings":["Laboratory of Exercise Physiology (FISEX), University of Campinas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Exercise Physiology (FISEX), University of Campinas","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159107026","display_name":"Jakob Boyes-Jensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jakob Boyes-Jensen","raw_affiliation_strings":["Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159132980","display_name":"Jon Hazeldine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jon Hazeldine","raw_affiliation_strings":["Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham","National Institute for Health and Care Research (NIHR), Biomedical Research Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"National Institute for Health and Care Research (NIHR), Biomedical Research Centre","institution_ids":["https://openalex.org/I34931013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159148714","display_name":"Helena Batatinha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helena Batatinha","raw_affiliation_strings":["Department of Kinesiology, School of Health and Human Sciences, University of North Carolina Greensboro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology, School of Health and Human Sciences, University of North Carolina Greensboro","institution_ids":["https://openalex.org/I169335092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083267482","display_name":"Niharika Arora Duggal","orcid":"https://orcid.org/0000-0003-4459-4632","observed_orcids":["https://orcid.org/0000-0003-4459-4632"]},"institutions":[{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Niharika A. Duggal","raw_affiliation_strings":["Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham","National Institute for Health and Care Research (NIHR), Biomedical Research Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"National Institute for Health and Care Research (NIHR), Biomedical Research Centre","institution_ids":["https://openalex.org/I34931013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010006233","display_name":"Davide Calebiro","orcid":"https://orcid.org/0000-0002-3811-1553","observed_orcids":["https://orcid.org/0000-0002-3811-1553"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Davide Calebiro","raw_affiliation_strings":["Department of Metabolism and Systems Science, School of Medical Sciences, College of Medicine and Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolism and Systems Science, School of Medical Sciences, College of Medicine and Health","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159157065","display_name":"James E. Turner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James E. Turner","raw_affiliation_strings":["National Institute for Health and Care Research (NIHR), Biomedical Research Centre","School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Health and Care Research (NIHR), Biomedical Research Centre","institution_ids":["https://openalex.org/I34931013"]},{"raw_affiliation_string":"School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham","institution_ids":["https://openalex.org/I79619799"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5087838249"],"corresponding_institution_ids":["https://openalex.org/I34931013","https://openalex.org/I79619799"],"apc_list":{"value":2550,"currency":"CHF","value_usd":3077},"apc_paid":{"value":2550,"currency":"CHF","value_usd":3077},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73200871,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":null,"first_page":"1869552","last_page":"1869552"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5770999789237976,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5770999789237976,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.21580000221729279,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.05339999869465828,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/habitual-physical-activity","display_name":"physical activity behavior","score":0.9760000109672546},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7829999923706055},{"id":"https://openalex.org/keywords/t-cell-metabolism","display_name":"T cell metabolism","score":0.8320000171661377},{"id":"https://openalex.org/keywords/beta2-adrenergic-receptor","display_name":"beta2-adrenergic receptor","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cd8-t-cell-activation","display_name":"CD8+ T cell activation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/glucose-transporter-1","display_name":"glucose transporter 1","score":0.7950000166893005},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.9020000100135803},{"id":"https://openalex.org/keywords/ici-118-551","display_name":"ICI 118,551","score":0.902999997138977},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.7760000228881836},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.6309999823570251},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.4519999921321869},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6583999991416931},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6182000041007996},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5820000171661377},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.538100004196167},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5353999733924866},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.5034000277519226},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4871000051498413},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4837000072002411},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.47040000557899475},{"id":"https://openalex.org/C2777952866","wikidata":"https://www.wikidata.org/wiki/Q24722601","display_name":"GLUT1","level":4,"score":0.4699999988079071},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.4424999952316284},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4408000111579895},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40860000252723694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3407000005245209},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.32690000534057617},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32510000467300415},{"id":"https://openalex.org/C2993002077","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Receptor expression","level":3,"score":0.31779998540878296},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3010999858379364},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.29760000109672546},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2939999997615814},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.2833000123500824},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2768000066280365},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2721000015735626},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2711000144481659}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fragi.2026.1869552","doi":"https://doi.org/10.3389/fragi.2026.1869552","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fragi.2026.1869552","pdf_url":"https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2026.1869552/pdf","source":{"id":"https://openalex.org/S4210191507","display_name":"Frontiers in Aging","issn_l":"2673-6217","issn":["2673-6217"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13727592","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13727592/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13727592/pdf/fragi-07-1869552.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Aging","raw_type":"Text"},{"id":"pmid:42978825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42978825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in aging","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:38837e1929b04f718b3bbcdf65482719","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/38837e1929b04f718b3bbcdf65482719","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Aging, Vol 7 (2026)","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:openaire/5f26681c-1397-4c13-ab64-4bc90edbc503","doi":null,"is_oa":true,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/5f26681c-1397-4c13-ab64-4bc90edbc503","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sardeli, A V, Ramkrapes, A, Boyes-Jensen, J, Hazeldine, J, Batatinha, H, Duggal, N A, Calebiro, D & Turner, J E 2026, 'Impact of habitual physical activity and age on T cell metabolism and activation via \u03b2 2 -adrenergic receptor modulation', Frontiers in Aging, vol. 7, 1869552. https://doi.org/10.3389/fragi.2026.1869552","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3389/fragi.2026.1869552","doi":"https://doi.org/10.3389/fragi.2026.1869552","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fragi.2026.1869552","pdf_url":"https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2026.1869552/pdf","source":{"id":"https://openalex.org/S4210191507","display_name":"Frontiers in Aging","issn_l":"2673-6217","issn":["2673-6217"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320336705","display_name":"Birmingham Biomedical Research Centre","ror":"https://ror.org/05ccjmp23"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223070684.pdf","grobid_xml":"https://content.openalex.org/works/W7223070684.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1553611257","https://openalex.org/W1572554526","https://openalex.org/W1970181962","https://openalex.org/W1976714959","https://openalex.org/W1983463708","https://openalex.org/W1992250154","https://openalex.org/W1996238207","https://openalex.org/W1998205396","https://openalex.org/W2019786374","https://openalex.org/W2042126703","https://openalex.org/W2072628425","https://openalex.org/W2076578321","https://openalex.org/W2130034923","https://openalex.org/W2155502587","https://openalex.org/W2157739158","https://openalex.org/W2167873485","https://openalex.org/W2168007598","https://openalex.org/W2283665483","https://openalex.org/W2790139034","https://openalex.org/W2889061983","https://openalex.org/W2889950184","https://openalex.org/W2948314199","https://openalex.org/W2956084610","https://openalex.org/W3049432428","https://openalex.org/W3108106255","https://openalex.org/W3120346794","https://openalex.org/W3153641190","https://openalex.org/W3164896430","https://openalex.org/W3176874200","https://openalex.org/W3184497073","https://openalex.org/W4214549987","https://openalex.org/W4245455647","https://openalex.org/W4315498263","https://openalex.org/W4362582644","https://openalex.org/W4385877690","https://openalex.org/W4386314087","https://openalex.org/W4386886545","https://openalex.org/W4389179160","https://openalex.org/W4399180747","https://openalex.org/W4402405780","https://openalex.org/W4403098565","https://openalex.org/W4406758026","https://openalex.org/W4409907306","https://openalex.org/W4410607131","https://openalex.org/W4410616914"],"related_works":["https://openalex.org/W4401858367","https://openalex.org/W2000725080","https://openalex.org/W3152972434","https://openalex.org/W4229513305","https://openalex.org/W3041808502","https://openalex.org/W7160408744","https://openalex.org/W2904437342","https://openalex.org/W2955772259","https://openalex.org/W2007241464","https://openalex.org/W2889950184"],"abstract_inverted_index":{"Background":[0],"Ageing":[1],"impairs":[2],"T":[3,13,36,52,76,112,143,156,184,202,221,298],"cell":[4,14,157,185,299],"function":[5,15],"and":[6,10,42,50,154,169,187,229,249,301],"responses":[7],"to":[8,116,123,306,335],"vaccines":[9],"infections.":[11],"Effective":[12],"requires":[16],"rapid":[17],"metabolic":[18,73,302],"switching":[19,303],"towards":[20],"glycolysis,":[21],"which":[22],"becomes":[23],"dysregulated":[24],"with":[25,86,104,129,152,227,245,285],"age.":[26],"We":[27],"have":[28,35,291],"shown":[29],"that":[30,38,64,223,283],"physically":[31],"active":[32],"older":[33,79,207,216,255],"adults":[34,83,179],"cells":[37,53,77,113,144,203,222],"are":[39],"more":[40],"functional":[41],"metabolically":[43],"fit.":[44],"As":[45],"exercise":[46],"acutely":[47],"elevates":[48],"adrenaline":[49],"mobilises":[51],"via":[54],"\u03b2":[55,70,133,170,188,231,268,307,310,318,329],"2":[56,60,71,134,171,189,232,269,311],"-adrenergic":[57],"receptors":[58],"(\u03b2":[59],"-AR),":[61],"we":[62],"hypothesise":[63],"habitual":[65,289],"physical":[66],"activity":[67],"(PA)":[68],"preserves":[69],"-AR-mediated":[72],"stimulation":[74,247],"in":[75,150,194,199,206,241,254,267,295,304,332],"from":[78,215],"adults.":[80],"Methods":[81],"Older":[82,178],"(\u226565":[84],"years)":[85],"habitually":[87,95],"high":[88],"PA":[89,97,290],"(HPA,":[90],"n":[91,99,109],"=":[92,100,110,260],"6)":[93,101],"or":[94,130,273],"moderate":[96],"(MPA,":[98],"were":[102,114,145,175,224,265],"compared":[103,244],"young":[105],"controls":[106],"(18\u201335":[107],"years,":[108],"6).":[111],"exposed":[115],"the":[117,132],"\u03b2-agonist":[118],"isoproterenol":[119,167],"for":[120,147],"30":[121],"min":[122],"mimic":[124],"acute":[125],"exercise-like":[126],"adrenergic":[127],"stimulation,":[128,168,319],"without":[131],"-AR":[135,172,190,233,270,312,331],"blocker":[136],"ICI-118,551.":[137],"Following":[138],"1":[139,330],"h":[140,149],"of":[141,288,328],"rest,":[142],"stimulated":[146,226],"4":[148],"vitro":[151],"PMA":[153,228],"ionomycin.":[155],"activation":[158,186,193,300],"(CD69),":[159],"glucose":[160],"transporter-1":[161],"(Glut1),":[162],"intracellular":[163],"cAMP":[164,276],"concentrations":[165],"under":[166],"mRNA":[173,271],"expression":[174,198,240,272],"assessed.":[176],"Results":[177],"exhibited":[180],"impaired":[181],"CD8":[182,200,219,296],"+":[183,201,220,297],"blockade":[191,234,313],"inhibited":[192],"all":[195,242],"groups.":[196],"Glut1":[197,239],"was":[204,252],"higher":[205,286],"MPA":[208,258],"than":[209,257],"young,":[210],"but":[211],"did":[212,314],"not":[213,225,315],"differ":[214],"HPA.":[217],"In":[218],"ionomycin,":[230],"(with":[235],"\u03b2-AR":[236,246,275],"stimulation)":[237],"increased":[238],"groups":[243],"alone,":[248],"this":[250,333],"increase":[251],"greater":[253],"HPA":[256],"(p":[259],"0.043).":[261],"No":[262],"group":[263],"differences":[264],"observed":[266],"isoproterenol-induced":[274],"responsiveness.":[277],"Conclusion":[278],"These":[279],"exploratory":[280],"findings":[281],"indicate":[282],"individuals":[284],"levels":[287],"lower":[292],"age-associated":[293],"impairments":[294],"response":[305],"stimulation.":[308],"Interestingly,":[309],"fully":[316],"abrogate":[317],"therefore":[320],"future":[321],"studies":[322],"should":[323],"investigate":[324],"a":[325],"potential":[326],"influence":[327],"modulation,":[334],"generate":[336],"definitive":[337],"conclusions.":[338]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-10-21T00:00:00"}